Role of apoptotic proteins in REC-2006 mediated radiation protection in hepatoma cell lines

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Singh, Pankaj Kumar ^a   Kumar, Raj ^a   Sharma, Ashok ^a   Arora, Rajesh ^a   Chawla, Raman ^a   Jain, Swatantra Kumar ^b   Tripathi, Rajendra Prasad ^a   Sharma, Rakesh Kumar ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; ATM PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; HERBACEOUS AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P53; REC 2006; UNCLASSIFIED DRUG;

ARTICLE; GAMMA RADIATION; HEPATOMA CELL; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; RADIATION PROTECTION;

EID: 79955096206     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/neq059     Document Type: Article

References (38)

1. Mell L. K., Movsas B., Pharmacologic normal tissue protection in clinical radiation oncology: focus on amifostine Expert Opinion on Drug Metabolism and Toxicology 2008 4 10 1341 1350
2. Singh P. K., Kumar R., Sharma A., Arora R., Chawla R., Jain S. K., Podophyllum hexandrum fraction (REC-2006) shows higher radioprotective efficacy in the p53-carrying hepatoma cell line: a role of cell cycle regulatory proteins Integrative Cancer Therapies 2009 8 261 72
3. Singh P. K., Kumar R., Sharma A., Arora R., Jain S. K., Sharma R. K., Pifithrin- decreases the radioprotective efficacy of a Podophyllum hexandrum (Himalayan mayapple) fraction (REC-2006) in HepG2 cells Biotechnology and Applied Biochemistry 2009 54 1 53 64
4. Burdelya L. G., Krivokrysenko V. I., Tallant T. C., Strom E., Gleiberman A. S., Gupta D., Kurnasov O. V., Fort F. L., Osterman A. L., DiDonato J. A., Feinstein E., Gudkov A. V., An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models Science 2008 320 5873 226 230 (Pubitemid 351521417)
5. Gupta D., Arora R., Garg A. P., Goel H. C., Radiation protection of mitochondrial system by Podophyllum hexandrum Royale in vivo Molecular and Cellular Biochemistry 2004 266 65 77 (Pubitemid 39562308)
6. Amundson S. A., Bittner M., Fornace A. J. Jr., Functional genomics as a window on radiation stress signaling Oncogene 2003 22 37 5828 5833 (Pubitemid 37176703)
7. Harkin D. P., Hall P. A., Measuring a cell's response to stress: the p53 pathway Genome Biology 2000 1 105.1 105.4
8. Oren M., Decision making by p53: life, death and cancer Cell Death and Differentiation 2003 10 4 431 442 (Pubitemid 36626355)
9. Leist M., Jttel M., Four deaths and a funeral: from caspases to alternative mechanisms Nature Reviews Molecular Cell Biology 2001 2 8 589 598 (Pubitemid 33674010)
10. Zou H., Li Y., Liu X., Wang X., An APAf-1 cytochrome C multimeric complex is a functional apoptosome that activates procaspase-9 Journal of Biological Chemistry 1999 274 17 11549 11556
11. Li P., Nijhawan D., Budihardjo I., Srinivasula S. M., Ahmad M., Alnemri E. S., Wang X., Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 1997 91 4 479 489 (Pubitemid 27508237)
12. Joza N., Susin S. A., Daugas E., Stanford W. L., Cho S. K., Li C. Y. J., Sasaki T., Elia A. J., Cheng H.-Y. M., Ravagnan L., Ferri K. F., Zamzami N., Wakeham A., Hakem R., Yoshida H., Kong Y.-Y., Mak T. W., Ziga-Pflcker J. C., Kroemer G., Penninger J. M., Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death Nature 2001 410 6828 549 554 (Pubitemid 32267191)
13. Sakahira H., Enari M., Nagata S., Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis Nature 1998 391 6662 96 99 (Pubitemid 28079223)
14. Aguilar-Quesada R., Muoz-Gmez J. A., Martn-Oliva D., Peralta A., Valenzuela M. T., Matnez-Romero R., Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition BMC Molecular Biology 2007 8 29
15. Smith G. C. M., Di Fagagna F. D., Lakin N. D., Jackson S. P., Cleavage and inactivation of ATM during apoptosis Molecular and Cellular Biology 1999 19 9 6076 6084 (Pubitemid 29399313)
16. D'Amours D., Desnoyers S., D'Silva I., Poirier G. G., Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions Biochemical Journal 1999 342 2 249 268 (Pubitemid 29425344)
17. De Murcia J. M., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M., Oliver F. J., Masson M., Dierich A., Lemeur M., Walztinger C., Chambon P., De Murcia G., Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells Proceedings of the National Academy of Sciences of the United States of America 1997 94 14 7303 7307 (Pubitemid 27345310)
18. Bossy-Wetzel E., Newmeyer D. D., Green D. R., Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization EMBO Journal 1998 17 1 37 49 (Pubitemid 28041046)
19. Kluck R. M., Bossy-Wetzel E., Green D. R., Newmeyer D. D., The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis Science 1997 275 5303 1132 1136 (Pubitemid 27097313)
20. Li C.-Y., Lee J.-S., Ko Y.-G., Kim J.-I., Seo J.-S., Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation Journal of Biological Chemistry 2000 275 33 25665 25671
21. Kumar R., Singh P. K., Sharma A., Prasad J., Sagar R., Singh S., Arora R., Sharma R. K., Podophyllum hexandrum (Himalayan mayapple) extract provides radioprotection by modulating the expression of proteins associated with apoptosis Biotechnology and Applied Biochemistry 2005 42 1 81 92 (Pubitemid 41117208)
22. Kumar R., Singh P. K., Arora R., Sharma A., Prasad J., Sagar R., Singh S., Sharma R. K., Radioprotection by Podophyllum hexandrum in the liver of mice: a mechanistic approach Environmental Toxicology and Pharmacology 2005 20 2 326 334 (Pubitemid 41058788)
23. Kumar R., Singh P. K., Arora R., Sharma A., Sharma R. K., Govil J. N., Singh V. K., Bhardwaj R., Modulation of vital proteins expression in intestine of mice by Podophyllum hexandrum: implication in radiation protection Recent Progress in Medicinal Plants. Vol. 16. Phytomedicine 2006 Houston, Texas, USA Studium Press 221 36
24. Vousden K. H., Lu X., Live or let die: the cell's response to p53 Nature Reviews Cancer 2002 2 8 594 604 (Pubitemid 37328926)
25. Goel H. C., Prasad J., Sharma A., Singh B., Antitumour and radioprotective action of Podophyllum hexandrum Indian Journal of Experimental Biology 1998 36 6 583 587
26. Arora R., Chwala R., Puri S. C., Sagar R., Singh S., Kumar R., Radioprotective and antioxident properties of low-altitude Podophyllum hexandrum (LAPH) Journal of Environmental Pathology, Toxicology and Oncology 2005 24 299 314
27. Sagar R. K., Chawla R., Arora R., Singh S., Krishna B., Sharma R. K., Puri S. C., Singh P., Kumar R., Sharma A. K., Singh S., Prasad J., Gupta V., Ahmed B., Dhar K. L., Khan H. A., Gupta M. L., Qazi G. N., Protection of the hemopoietic system by Podophyllum hexandrum against gamma radiation-induced damage Planta Medica 2006 72 2 114 120 (Pubitemid 43293864)
28. Kumar R., Singh P. K., Arora R., Chawla R., Sharma R. K., An insight into the molecular mechanisms of radioprotective activities of Podophyllum hexandrum Trees for Life 2009 4 1 9
29. Chawla R., Arora R., Kumar R., Sharma A., Prasad J., Singh S., Sagar R., Chaudhary P., Shukla S., Kaur G., Sharma R. K., Puri S. C., Dhar K. L., Handa G., Gupta V. K., Qazi G. N., Antioxidant activity of fractionated extracts of rhizomes of high-altitude Podophyllum hexandrum: role in radiation protection Molecular and Cellular Biochemistry 2005 273 1-2 193 208 (Pubitemid 40766801)
30. Chawla R., Arora R., Singh S., Sagar R. K., Sharma R. K., Kumar R., Sharma A., Tripathi R. P., Puri S. C., Khan H. A., Shawl A. S., Sultan P., Krishan T., Qazi G. N., Podophyllum hexandrum offers radioprotection by modulating free radical flux: role of aryl-tetralin lignans Evidence-Based Complementary and Alternative Medicine 2006 3 4 503 511 (Pubitemid 44899989)
31. Chaudhary P., Shukla S. K., Sharma R. K., REC-2006-a fractionated extract of Podophyllum hexandrum protects cellular dna from radiation-induced damage by reducing the initial damage and enhancing its repair in vivo Evidence-Based Complementary and Alternative Medicine
32. Sankhwar S., Gupta M. L., Gupta V., Verma S., Suri K. A., Devi M., Podophyllum hexandrum -mediated survival protection and restoration of other cellular injuries in lethally irradiated mice Evidence-Based Complementary and Alternative Medicine
33. Thacker J., Cellular radiosensitivity in ataxia-telangiectasia International Journal of Radiation Biology 1994 66 6 S87 S96
34. Haince J. F., Kozlov S., Dawson V. L., Dawson T. M., Hendzel M. J., Lavin M. F., Atexia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents The Journal of Biological Chemistry 2007 282 16441 16453 (Pubitemid 47100334)
35. Watanabe F., Fukazawa H., Masutani M., Suzuki H., Teraoka H., Mizutani S., Uehara Y., Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response Biochemical and Biophysical Research Communications 2004 319 2 596 602 (Pubitemid 38725988)
36. Ravagnan L., Gurbuxani S., Susin S. A., Maisse C., Daugas E., Zamzami N., Mak T., Jttel M., Penninger J. M., Garrido C., Kroemer G., Heat-shock protein 70 antagonizes apoptosis-inducing factor Nature Cell Biology 2001 3 9 839 843 (Pubitemid 32842690)
37. Lui J. C.-K., Kong S.-K., Heat shock protein 70 inhibits the nuclear import of apoptosis-inducing factor to avoid DNA fragmentation in TF-1 cells during erythropoiesis FEBS Letters 2007 581 1 109 117 (Pubitemid 44960289)
38. Jiang X., Wang X., Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 Journal of Biological Chemistry 2000 275 40 31199 31203