Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor

Journal of Physiology

Volumn 591, Issue 17, 2013, Pages 4287-4299

  Arnáiz Cot, Juan José ^a   Damon, Brooke James ^a,b   Zhang, Xiao Hua ^a   Cleemann, Lars ^a   Yamaguchi, Naohiro ^a,b   Meissner, Gerhard ^c   Morad, Martin ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CALCIUM ION; CALMODULIN; RYANODINE RECEPTOR 2; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM ION; RYANODINE RECEPTOR; RYANODINE RECEPTOR 2. MOUSE;

ARRHYTHMOGENESIS; ARTICLE; CALCIUM ION LOAD; CALCIUM ION SPARK; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL MUTANT; CONTROLLED STUDY; ENZYME ISOLATION; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; ION CURRENT; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; ACTION POTENTIAL; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; CAFFEINE; CALCIUM SIGNALING; CALMODULIN; MICE; MUTATION; MYOCYTES, CARDIAC; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SODIUM-CALCIUM EXCHANGER;

EID: 84883276797     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.256123     Document Type: Article

References (26)

1. 2+ channels and ryanodine receptors in rat ventricular myocytes. J Gen Physiol 108, 435-454.
2. 2+ current in rabbit ventricular myocytes. Circ Res 75, 854-861.
3. Balshaw DM, Yamaguchi N & Meissner G (2002). Modulation of intracellular calcium-release channels by calmodulin. J Membr Biol 185, 1-8.
4. 2+ transients in rat cardiac myocytes: possible mechanisms and role of mitochondria. J Physiol 586, 1379-1397.
5. 2+ transients and contraction. J Physiol 432, 283-312.
6. 2+ release sites in rat cardiac myocytes. Proc Natl Acad Sci U S A 95, 10984-10989.
7. Fatima A, Xu G, Shao K, Papadopoulos S, Lehmann M, Arnaiz-Cot JJ, Rosa AO, Nguemo F, Matzkies M, Dittmann S, Stone SL, Linke M, Zechner U, Beyer V, Hennies HC, Rosenkranz S, Klauke B, Parwani AS, Haverkamp W, Pfitzer G, Farr M, Cleemann L, Morad M, Milting H, Hescheler J & Saric T (2011). In vitro modelling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell Physiol Biochem 28, 579-592.
8. Fill M & Copello JA (2002). Ryanodine receptor calcium release channels. Physiol Rev 82, 893-922.
9. Franzini-Armstrong C & Protasi F (1997). Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions. Physiol Rev 77, 699-729.
10. George CH, Jundi H, Thomas NL, Fry DL & Lai FA (2007). Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies. J Mol Cell Cardiol 42, 34-50.
11. Hamill OP, Marty A, Neher E, Sakmann B & Sigworth FJ (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100.
12. 2+ signalling in transgenic mouse cardiac myocytes overexpressing calsequestrin. J Clin Invest 101, 1385-1393.
13. Knollmann BC, Knollmann-Ritschel BE, Weissman NJ, Jones LR & Morad M (2000). Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J Physiol 525 Pt 2, 483-498.
14. Lanner JT, Georgiou DK, Joshi AD & Hamilton SL (2010). Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol 2, a003996.
15. Li P & Chen SR (2001). Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor). J Gen Physiol 118, 33-44.
16. 2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res 73, 631-640.
17. 2+ release channels and their regulation by endogenous effectors. Annu Rev Physiol 56, 485-508.
18. Mitra R & Morad M (1985). A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates. Am J Physiol Heart Circ Physiol 249, H1056-1060.
19. Saimi Y & Kung C (2002). Calmodulin as an ion channel subunit. Annu Rev Physiol 64, 289-311.
20. Simmerman HK & Jones LR (1998). Phospholamban: protein structure, mechanism of action, and role in cardiac function. Physiol Rev 78, 921-947.
21. Tang W, Sencer S & Hamilton SL (2002). Calmodulin modulation of proteins involved in excitation-contraction coupling. Front Biosci 7, d1583-1589.
22. 2+ release channel (ryanodine receptor). Biophys J 86, 797-804.
23. Yamaguchi N, Xu L, Pasek DA, Evans KE & Meissner G (2003). Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor). J Biol Chem 278, 23480-23486.
24. Yamaguchi N, Takahashi N, Xu L, Smithies O & Meissner G (2007). Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest 117, 1344-1353.
25. Yamaguchi N, Chakraborty A, Pasek DA, Molkentin JD & Meissner G (2011). Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signalling molecules. Am J Physiol Heart Circ Physiol 300, H2187-2195.
26. Yan X, Gao S, Tang M, Xi J, Gao L, Zhu M, Luo H, Hu X, Zheng Y, Hescheler J & Liang H (2011). Adenylyl cyclase/cAMP-PKA-mediated phosphorylation of basal L-type Ca(2+) channels in mouse embryonic ventricular myocytes. Cell Calcium 50, 433-443.