Na/Ca exchange in heart failure contractile dysfunction and arrhythmogenesis

Annals of the New York Academy of Sciences

Volumn 976, Issue , 2002, Pages 454-465

  Pogwizd, Steven M ^a   Bers, Donald M ^b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Arrhythmia; Cardiomyopathy; Contractile dysfunction; Heart failure; Na Ca exchanger; Tachycardia

Indexed keywords

SODIUM CALCIUM EXCHANGE PROTEIN;

ADRENERGIC SYSTEM; ARRHYTHMOGENESIS; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE ARRHYTHMIA; INCIDENCE; MEMBRANE CURRENT; MEMBRANE STEADY POTENTIAL; NONHUMAN; RABBIT; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; SUDDEN DEATH;

ITI; ORYCTOLAGUS CUNICULUS;

EID: 0036971308     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04775.x     Document Type: Conference Paper

References (36)

1. PACKER, M. 1985. Sudden unexpected death in patients with congestive heart failure: a second frontier. Circulation 72: 681-685.
2. PIESKE, B., B. KRETSCHMANN, M. MEYER, et al. 1995. Alterations in intracellular calcium handling associated with the inverse force-frequency relation in human dilated cardiomyopathy. Circulation 92: 1169-1178.
3. O'ROURKE, B., D.A. KASS, G.F. TOMASELLI, et al. 1999. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. I. Experimental studies. Circ. Res. 84: 562-570.
4. GÓMEZ, A.M., H.H. VALDIVIA, H. CHENG, et al. 1997. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276: 800-806.
5. MARX, S.O., S. REIKEN, Y. HISAMATSU, et al. 2000. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101: 365-376.
6. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ. Res. 85: 1009-1019.
7. 2+-ATPase gene expression in the human ventricle during end-stage heart failure. J. Clin. Invest. 85: 305-309.
8. ARAI, M., N.R. ALPERT, D.H. MACLENNAN, et al. 1993. Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium. Circ. Res. 72: 463-469.
9. 2+ exchanger in end-stage human heart failure. Circ. Res. 75: 443-453.
10. 2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation 99: 641-648.
11. POGWIZD, S.M. 1995. Nonreentrant mechanism underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits. Circulation 92: 1034-1048.
12. POGWIZD, S.M., K. SCHLOTTHAUER, L. LI, et al. 2001. Arrhythmogenesis and contractile dysfunction in heart failure. Roles of sodium-calcium exchange, inward rectifier potassium current, and residual β-adrenergic responsiveness. Circ. Res. 88: 1159-1167.
13. WIT, A.L. & M.R. ROSEN. 1992. Afterdepolarizations and triggered activity: distinction from automaticity as an arrhythmogenic mechanism. In: Heart and Cardiovascular System: Scientific Foundations. H.A. Fozzard, E. Habert, R.B. Jennings, A.M. Katz & H.E. Morgan, Eds.: 2113-2163. 2nd ed. Raven Press. New York.
14. POGWIZD, S.M., J.P. MCKENZIE & M.E. CAIN. 1998. Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy. Circulation 98: 2404-2414.
15. VERMEULEN, J.T., M.A. MCGUIRE, T. OPTHOF, et al. 1994. Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts. Cardiovasc. Res. 28: 1547-1554.
16. BASSANI, J.W.M., R.A. BASSANI & D.M. BERS. 1994. Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms. J. Physiol. 476: 279-293.
17. BERS, D.M. 2001. Excitation-Contraction Coupling and Cardiac Contractile Force. 2nd ed. Kluwer Academic Press. Dordrecht, The Netherlands.
18. HOBAI, I.A. & B. O'ROURKE. 2001. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation 103: 1577-1584.
19. LINDNER, M., E. ERDMANN & D.J. BEUCKELMANN. 1998. Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure. J. Mol. Cell. Cardiol. 30: 743-749.
20. 2+ current. Circ. Res. 64: 977-990.
21. COLQUHOUN, D., E. NEHER, H. REUTER & C.F. STEVENS. 1981. Inward current channels activated by intracellular Ca in cultured cardiac cells. Nature 294: 752-754.
22. Cl(Ca) contribute to isoproterenol-induced delayed afterdepolarizations in midmycardial cells. Am. J. Physiol. 275: H1979-H1992.
23. 2+ release causes myocyte depolarization - underlying mechanism and threshold for triggered action potentials. Circ. Res. 87: 774-780.
24. FOWLER, M.B., J.A. LASER, G.L. HOPKINS, et al. 1986. Assessment of β-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response. Circulation 74: 1290-1302.
25. KJEKSHUS, J. 1990. Arrhythmias and mortality in congestive heart failure. Am. J. Cardiol. 65: 421-481.
26. BRISTOW, M.R., R. GINSBURG, W. MINOBE, et al. 1982. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N. Engl. J. Med. 307: 205-211.
27. MERIT-HF STUDY GROUP. 1999. Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL randomised intervention trial in congestive heart failure (MERIT-HF). Lancet 353: 2001-2007.
28. PUGLISI, J.L. & D.M. BERS. 2001. LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. Am. J. Physiol. 281: C2049-C2060.
29. MINAMISAWA, S., M. HOSHIJIMA, G. CHU, et al. 1999. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99: 313-322.
30. MIYAMOTO, M.I., F. DEL MONTE, U. SCHMIDT, et al. 2000. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. USA 97: 793-798.
31. PACKER, M., J.R. CARVER, R.J. RODEHEFFER, et al. 1991. Effect of oral Milrinone on mortality in severe chronic heart failure. N. Engl. J. Med. 325: 1468-1475.
32. AI, X., S.R. REIKEN, A.R. MARKS, et al. 2001. Altered calcium release channel expression and RyR2 hyperphosphorylation in an arrhythmogenic rabbit model of heart failure. Circulation 104: II-131.
33. DESPA, S., M.A. ISLAM, S.M. POGWIZD & D.M. BERS. 2002. Intracellular [Na] is elevated in heart failure, but sodium-pump function is not the primary cause. Circulation 105: 2543-2548.
34. 2+ transient of failing human ventricular myocytes. Circ. Res. 84: 435-444.
35. 2+ exchanger. J. Physiol. 512: 651-667.
36. 2+ exchanger. Circ. Res. 87: 581-587.