Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: Evaluation of in vitro anti-cancer and anti-folate activities

European Journal of Medicinal Chemistry

Volumn 43, Issue 1, 2008, Pages 189-203

  Corona, Paola ^a   Loriga, Mario ^a   Costi, M Paola ^b   Ferrari, Stefania ^b   Paglietti, Giuseppe ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

5,7 Diaminoquinoxaline; Anti folate; Leukemia; Ovarian carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; METHOTREXATE; N (5,7 DIAMINO 3 PHENYLQUINOXALIN 2 YL) 3,4,5 ANILINE; N [4 [5,7 DIAMINO 3 (PHENYLQUINOXALIN 2 YL)AMINO]BENZOYL]GLUTAMIC ACID DIETHYL ESTER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; FOLIC ACID ANTAGONISTS; GLUTAMATES; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINOXALINES;

EID: 38149024232     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.03.035     Document Type: Article

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