Quinoxaline chemistry. Part 15. 4-[2-Quinoxalylmethylenimino]- benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]- benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro evaluation of antifolate and anticancer activities

Farmaco

Volumn 58, Issue 1, 2003, Pages 51-61

  Loriga, Mario ^a   Piras, Sandra ^a   Paglietti, Giuseppe ^a   Costi, Maria Paola ^b   Venturelli, Alberto ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

1H and 13C NMR trifluoromethylquinoxalines; Anticancer agents; Antifolate agents; Dihydrofolate reductase and tymidylate synthase inhibitors; Enzyme inhibition

Indexed keywords

BENZOIC ACID DERIVATIVE; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; GLUTAMIC ACID DERIVATIVE; QUINOXALINE DERIVATIVE; SCHIFF BASE; THYMIDYLATE SYNTHASE; ANTINEOPLASTIC AGENT;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CONFORMATION; DRUG INHIBITION; DRUG SCREENING; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; METASTASIS INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; CELL CULTURE; CHEMISTRY; DRUG EFFECT; HUMAN; METHODOLOGY;

ANTINEOPLASTIC AGENTS; DRUG EVALUATION, PRECLINICAL; FOLIC ACID ANTAGONISTS; GLUTAMATES; HUMANS; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0041967063     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)00005-8     Document Type: Article

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