Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 19, 2012, Pages 8318-8329

  Corona, Paola ^b   Gibellini, Federica ^a   Cavalli, Andrea ^c,d   Saxena, Puneet ^a   Carta, Antonio ^b   Loriga, Mario ^b   Luciani, Rosaria ^a   Paglietti, Giuseppe ^b   Guerrieri, Davide ^a   Nerini, Erika ^a   Gupta, Shreedhara ^e   Hannaert, Véronique ^e   Michels, Paul A M ^e   Ferrari, Stefania ^a   Costi, Paola M ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^e DE DUVE INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [(2,4 DIAMINOPTERIDIN 6 YL)METHYLAMINO]BENZOYL]PIPERIDINE 4 CARBOXAMIDE; ANTILEISHMANIAL AGENT; DIHYDROPTERIDINE REDUCTASE; METHYL 1 [4 (2,4 DIAMINOPTERIDIN 6 YLMETHYLAMINO)BENZOYL]PIPERIDINE 4 CARBOXYLATE; METHYL 1 [4 [(2,4 DIAMINOPTERIDIN 6 YL)METHYLAMINO] 3 ETHYLBENZOYL]PIPERIDINE 4 CARBOXYLATE; METHYL 1 [4 [(2,4 DIAMINOPTERIDIN 6 YL)METHYLAMINO]BENZOYL]PIPERIDINE 4 CARBOXYLIC ACID; METHYL 1 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](2 ETHOXY 2 OXOETHYL)AMINO]BENZOYL]PIPERIDINE 4 CARBOXYLATE; METHYL 1 [4 [[(2,4 DIAMINOPTERIDIN 6 YL)METHYL](2 HYDROXYETHYL)AMINO]BENZOYL]PIPERIDINE 4 CARBOXYLATE; METHYL 1 [5 [(2,4 DIAMINOPTERIDIN 6 YL)METHYLAMINO] 2 ETHYLBENZOYL]PIPERIDINE 4 CARBOXYLATE; METHYL 1 [5 [(2,4 DIAMINOPTERIDIN 6 YL)METHYLAMINO]PICOLINOYL]PIPERIDINE 4 CARBOXYLATE; PIPERIDINE DERIVATIVE; PTERIDINE DERIVATIVE; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENTIATION; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; LEISHMANIA; MOLECULAR DOCKING; NONHUMAN; OXIDATIVE STRESS;

CELL LINE; DRUG SYNERGISM; FIBROBLASTS; FOLIC ACID; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LEISHMANIA; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; MOLECULAR DOCKING SIMULATION; OXIDATIVE STRESS; OXIDOREDUCTASES; PROTEIN BINDING; PYRIMETHAMINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS;

EID: 84867340229     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300563f     Document Type: Article

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