Quinoxaline chemistry. Part 11.3-Phenyl-2[phenoxy- and phenoxymethyl]- 6(7) or 6,8-substituted quinoxalines and n-[4-(6(7)-substituted or 6,8- disubstituted-3-phenylquinoxalin-2,yl) hydroxy or hydroxymethyl] benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity and enzymatic inhibitory activity against dihydrofolate reductase and thymidylate synthase

Farmaco

Volumn 53, Issue 7, 1998, Pages 480-493

  Corona, Paola ^a   Vitale, Gabriella ^a   Loriga, Mario ^a   Paglietti, Giuseppe ^a   Costi, Maria Paola ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Anticancer agents; Antifolate agents; Dihydrofolate reductase; Enzyme inhibition

Indexed keywords

ACETIC ACID; ALCOHOL; BROMINE; CHLORINE DERIVATIVE; DIHYDROFOLATE REDUCTASE INHIBITOR; FLUORINE DERIVATIVE; GLUTAMIC ACID DERIVATIVE; GLUTAMIC ACID DIETHYL ESTER; HYDROCHLORIC ACID; N,N DIMETHYLFORMAMIDE; PHENOL DERIVATIVE; QUINOXALINE DERIVATIVE; SODIUM HYDROXIDE; THYMIDYLATE SYNTHASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LACTOBACILLUS CASEI;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; MOLECULAR STRUCTURE; QUINOXALINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0032581439     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(98)00054-8     Document Type: Article

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