4-Substituted anilino imidazo[1,2-a] and triazolo[4,3-a]quinoxalines. Synthesis and evaluation of in vitro biological activity

European Journal of Medicinal Chemistry

Volumn 41, Issue 9, 2006, Pages 1102-1107

  Corona, Paola ^a   Vitale, Gabriella ^a   Loriga, Mario ^a   Paglietti, Giuseppe ^a   La Colla, Paolo ^b   Collu, Gabriella ^b   Sanna, Giuseppina ^b   Loddo, Roberta ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b Dipartimento di Scienze e Tecnologie Biomediche   (Italy)

Author keywords

Biological activity; Imidazo 1,2 a quinoxalines; Triazolo 4,3 a quinoxalines

Indexed keywords

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; IMIDAZO[1,2 A]QUINOXALINE; QUINOXALINE DERIVATIVE; TRIAZOLO[4,3 A]QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACTERIAL STRAIN; CANDIDA ALBICANS; CELL STRAIN; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MYCOBACTERIUM; MYCOBACTERIUM FORTUITUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SALMONELLA; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; VIRUS INHIBITION;

CELL LINE; CELL PROLIFERATION; HUMANS; IMIDAZOLES; MOLECULAR STRUCTURE; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 33748506842     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.05.015     Document Type: Article

References (30)

1. Kompis I.M., Islam K., and Then R.L. Chem. Rev. 105 (2005) 593-620
2. Loriga M., and Paglietti G. J. Chem. Res. (1986) 16-17 (s)
3. Paglietti G., and Loriga M. J. Chem. Res. (1986) 284-285 (s)
4. Loriga M., Nuvole A., and Paglietti G. J. Chem. Res. (1989) 202-203 (s)
5. Loriga M., Fiore M., Sanna P., and Paglietti G. Farmaco 50 (1997) 289-301
6. Loriga M., Fiore M., Sanna P., and Paglietti G. Farmaco 51 (1996) 559-568
7. Piras S., Loriga M., Paglietti G., Demontis M.P., Varoni M.V., Fattaccio M.C., and Anania V. Farmaco 51 (1996) 569-577
8. Loriga M., Piras S., Sanna P., and Paglietti G. Farmaco 52 3 (1997) 157-166
9. Loriga M., Moro P., Sanna P., and Paglietti G. Farmaco 52 8-9 (1997) 531-537
10. Vitale G., Corona P., Loriga M., and Paglietti G. Farmaco 53 (1998) 139-149
11. Vitale G., Corona P., Loriga M., and Paglietti G. Farmaco 53 (1998) 150-159
12. Corona P., Vitale G., Loriga M., Paglietti G., and Costi M.P. Farmaco 53 (1998) 480-493
13. Vitale G., Corona P., Loriga M., and Paglietti G. Farmaco 53 (1998) 594-601
14. Corona P., Vitale G., Loriga M., and Paglietti G. Farmaco 55 (2000) 77-86
15. Piras S., Loriga M., and Paglietti G. Farmaco 57 (2002) 1-8
16. Loriga M., Piras S., Paglietti G., Costi M.P., and Venturelli A. Farmaco 58 (2003) 51-61
17. Piras S., Loriga M., and Paglietti G. Farmaco 59 (2004) 189-194
18. Nickell P.V., Ward Jr. H.E., and Booth R.G. In: Wolff M.E. (Ed). Anti Anxiety Agents in Burger's Medicinal Chemistry and Drug Chemistry, Fifth ed., Vol. 5 (1997), J. Wiley & Sons, New York 153 (and references cited therein)
19. G. Campiani, A. Cappelli, V. Nacci, M. Anzini, S. Vomero, M. Hamon, A. Cagnotto, C. Fracasso, C. Uboldi, S. Caccia, S. Consolo, T. Mennini, J. Med. Chem. 40 (1997) 3670-3678; G. Campiani, E.Morelli, S. Gemma, V. Nacci, S. Butini, M. Hamon, E. Novellino, G. Greco, M.Goegan, L. Nervo, F. Della Valle, A. Cagnotto, C. Fracasso, S. Caccia, T. Mennini, J. Med. Chem. 42 (1999) 4362-4379.
20. Guillon J., Dallemagne P., Pfeiffer B., Renard P., Manechez D., Kervran A., and Rault S. Eur. J. Med. Chem. 33 (1998) 293-308
21. Trivedi B.K., and Bruns R.F. J. Med. Chem. 31 (1988) 1011-1014
22. Catarzi D., Cecchi L., Colotta V., Melani F., Filacchioni G., Martini C., Giusti L., and Lucacchini A. J. Med. Chem. 37 (1994) 2846-2850
23. Ceccarelli S., D'Alessandro A., Prinzivalli M., and Zanarella S. Eur. J. Med. Chem. 33 (1998) 943-955
24. Stratford I.J., Stephens M.A., Naylor M.A., Fielden E.M., and Adams G.E. Br. J. Cancer 65 Suppl. XVI (1992) 17 (Abstract D1)
25. Alleca S., Corona P., Loriga M., Paglietti G., Loddo R., Mascia V., Busonera B., and La Colla P. Farmaco 58 (2003) 639-650
26. Preston P.N. Commercial Applications of Benzimidazoles in Benzimidazoles and Congeneric Tricyclic Compounds from The Chemistry of Heterocyclic Compounds (1980), J. Wiley & Sons, New York 531 (and references cited therein)
27. Islip P.J. Antihelmintic agents, in: Burger's Medicinal Chemistry and Drug Discovery, vol. 4: Therapeutic Agents, fifth ed (1997), Wiley J & Sons, New York 398 (and references cited therein)
28. Bastow K.F., and Akanitapichat P. Antiviral agents. Burger's Medicinal Chemistry and Drug Discovery, vol. 4: Therapeutic Agents, fifth ed (1997), Wiley J & sons, New York 542 (and references cited therein)
29. Sarges R., Howard H.R., Browne R.G., Lebel L.A., Seymour P.A., and Koe B.K. J. Med. Chem. 33 (1990) 2240-2254
30. Denizot F., and Lang R. J. Immunolo. Methods 89 (1986) 271-277