The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms

British Journal of Pharmacology

Volumn 147, Issue 4, 2006, Pages 422-429

  Lewandowicz, Anna M ^a   Vepsäläinen, Jouko ^a   Laitinen, Jarmo T ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

35S GTP S autoradiography; Allosteric modulator; Cysteine; Dithiotreitol; G protein coupled receptor; Heterotrimeric G protein; SCH 202676; Sulphydryl; Thiadiazole; Thiol

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ADENOSINE A1 RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; CANNABINOID 1 RECEPTOR; DITHIOTHREITOL; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LYSOPHOSPHATIDIC ACID RECEPTOR; METHYLAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M4 RECEPTOR; N (2,3 DIPHENYL 1,2,4 THIADIAZOL 5(2H) YLIDENE)METHANAMINE; N [2,3 DIPHENYL 1,2,4 THIADIAZOL 5(2H)YLIDENE]METHANAMINE; PURINE P2 RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN TISSUE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; FROZEN SECTION; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; ANIMALS; AUTORADIOGRAPHY; BRAIN CHEMISTRY; CELL MEMBRANE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; THIAZOLES;

EID: 33644547054     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706624     Document Type: Article

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