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Volumn 88, Issue 2, 2014, Pages 249-261

Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic

Author keywords

Arsenic; Cancer; Malignant transformation; Oxidative DNA damage

Indexed keywords

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ARSENIC POISONING; ARSENICALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; HUMANS; LIVER; MALE; METHYLATION; OXIDATION-REDUCTION; PROSTATE; PTEN PHOSPHOHYDROLASE; RATS; TOXICITY TESTS, CHRONIC;

EID: 84893908884     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1141-2     Document Type: Article
Times cited : (21)

References (58)
  • 1
    • 0037132695 scopus 로고    scopus 로고
    • Inorganic arsenite induced malignant transformation of human prostate epithelial cells
    • 1:CAS:528:DC%2BD3sXlsFyisQ%3D%3D 12488483 10.1093/jnci/94.24.1888
    • Achanzar WE, Brambila EM, Diwan BA, Webber MM, Waalkes MP (2002) Inorganic arsenite induced malignant transformation of human prostate epithelial cells. J Natl Cancer Inst 94:1888-1891
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1888-1891
    • Achanzar, W.E.1    Brambila, E.M.2    Diwan, B.A.3    Webber, M.M.4    Waalkes, M.P.5
  • 2
    • 22544437866 scopus 로고    scopus 로고
    • Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: Aberrant genomic DNA methylation and K-ras oncogene activation
    • 1:CAS:528:DC%2BD2MXmsVWgur8%3D 16039940 10.1016/j.taap.2004.11.017
    • Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP (2005) Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol 206:288-298
    • (2005) Toxicol Appl Pharmacol , vol.206 , pp. 288-298
    • Benbrahim-Tallaa, L.1    Waterland, R.A.2    Styblo, M.3    Achanzar, W.E.4    Webber, M.M.5    Waalkes, M.P.6
  • 3
    • 33748745385 scopus 로고    scopus 로고
    • Monomethylarsonous acid induces transformation of human bladder cells
    • 1:CAS:528:DC%2BD28XpvV2mtbs%3D 2851136 16806342 10.1016/j.taap.2006.04. 011
    • Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi AJ (2006) Monomethylarsonous acid induces transformation of human bladder cells. Toxicol Appl Pharmacol 216:69-79
    • (2006) Toxicol Appl Pharmacol , vol.216 , pp. 69-79
    • Bredfeldt, T.G.1    Jagadish, B.2    Eblin, K.E.3    Mash, E.A.4    Gandolfi, A.J.5
  • 4
    • 77953800122 scopus 로고    scopus 로고
    • Reduced reactive oxygen species-generating capacity contributes to the enhanced growth of arsenic-transformed epithelial cells
    • 1:CAS:528:DC%2BC3cXntlKltbg%3D 20516118 10.1158/0008-5472.CAN-10-0007
    • Chang C, Pan J, Wang X, Zhang Z, Chen F, Shi X (2010) Reduced reactive oxygen species-generating capacity contributes to the enhanced growth of arsenic-transformed epithelial cells. Cancer Res 70:5127-5135
    • (2010) Cancer Res , vol.70 , pp. 5127-5135
    • Chang, C.1    Pan, J.2    Wang, X.3    Zhang, Z.4    Chen, F.5    Shi, X.6
  • 5
    • 1342281549 scopus 로고    scopus 로고
    • Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver
    • 1:CAS:528:DC%2BD2cXhs1CntA%3D%3D 14713550 10.1080/01926230490261348
    • Cui X, Li S, Shraim A, Kobayashi Y, Hayakawa T, Kanno S, Yamamoto M, Hirano S (2004) Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver. Toxicol Pathol 32:64-72
    • (2004) Toxicol Pathol , vol.32 , pp. 64-72
    • Cui, X.1    Li, S.2    Shraim, A.3    Kobayashi, Y.4    Hayakawa, T.5    Kanno, S.6    Yamamoto, M.7    Hirano, S.8
  • 6
    • 0034681264 scopus 로고    scopus 로고
    • The multiple roles of PTEN in tumor suppression
    • 10693755 10.1016/S0092-8674(00)80674-1
    • Di Cristofano A, Pandolfi PP (2000) The multiple roles of PTEN in tumor suppression. Cell 100:387-390
    • (2000) Cell , vol.100 , pp. 387-390
    • Di Cristofano, A.1    Pandolfi, P.P.2
  • 8
    • 79955867370 scopus 로고    scopus 로고
    • Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism
    • 3040604 21247820 10.1289/ehp.1002471
    • Engström K, Vahter M, Mlakar SJ, Concha G, Nermell B, Raqib R, Cardozo A, Broberg K (2011) Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect 119:182-188
    • (2011) Environ Health Perspect , vol.119 , pp. 182-188
    • Engström, K.1    Vahter, M.2    Mlakar, S.J.3    Concha, G.4    Nermell, B.5    Raqib, R.6    Cardozo, A.7    Broberg, K.8
  • 9
    • 84865589453 scopus 로고    scopus 로고
    • Hallmarks of cancer: Of all cancer cells, all the time?
    • 1:CAS:528:DC%2BC38XhtlaisLbP 22795735 10.1016/j.molmed.2012.06.005
    • Floor SL, Dumont JE, Meanhaut C, Raspe E (2012) Hallmarks of cancer: of all cancer cells, all the time? Trends Mol Med 18:509-515
    • (2012) Trends Mol Med , vol.18 , pp. 509-515
    • Floor, S.L.1    Dumont, J.E.2    Meanhaut, C.3    Raspe, E.4
  • 10
    • 28644432831 scopus 로고    scopus 로고
    • Induction of DNA damage by free radicals generated either by organic or inorganic arsenic (AsIII, MMAIII, and DMAIII) in cultures of B and T lymphocytes
    • 10.1385/BTER:108:1-3:115
    • Gomez SE, del Razo LM, Munoz Sanchez JL (2006) Induction of DNA damage by free radicals generated either by organic or inorganic arsenic (AsIII, MMAIII, and DMAIII) in cultures of B and T lymphocytes. Biol Trace Elem Res 108:115-126
    • (2006) Biol Trace Elem Res , vol.108 , pp. 115-126
    • Gomez, S.E.1    Del Razo, L.M.2    Munoz Sanchez, J.L.3
  • 11
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP dependent transporters
    • 1:CAS:528:DC%2BD38XhvF2jtL8%3D 11902585 10.1038/nrc706
    • Gottesman MM, Fojo T, Bates SE (2002) Multidrug resistance in cancer: role of ATP dependent transporters. Nat Rev Cancer 2:48-58
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 12
    • 79952284127 scopus 로고    scopus 로고
    • The hallmarks of cancer: The next generation
    • 10.1016/j.cell.2011.02.013
    • Hanahan D, Weinberg RA (2011) The hallmarks of cancer: the next generation. Cell 44:646-674
    • (2011) Cell , vol.44 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 13
    • 79651474218 scopus 로고    scopus 로고
    • Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells
    • 1:CAS:528:DC%2BC3MXhvFeks7c%3D 21167264 10.1016/j.toxlet.2010.12.006
    • Huang YC, Hung WC, Chen WT, Yu HS, Chai CY (2011) Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells. Toxicol Lett 201:62-71
    • (2011) Toxicol Lett , vol.201 , pp. 62-71
    • Huang, Y.C.1    Hung, W.C.2    Chen, W.T.3    Yu, H.S.4    Chai, C.Y.5
  • 16
    • 79954642381 scopus 로고    scopus 로고
    • Advances in metal-induced oxidative stress and human disease
    • 1:CAS:528:DC%2BC3MXltFemsrs%3D 21414382 10.1016/j.tox.2011.03.001
    • Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283:65-87
    • (2011) Toxicology , vol.283 , pp. 65-87
    • Jomova, K.1    Valko, M.2
  • 17
    • 0034721764 scopus 로고    scopus 로고
    • The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic
    • 1:CAS:528:DC%2BD3cXnvVOqu7o%3D 10938093 10.1074/jbc.M007030200
    • Kala SV, Neely MW, Kala G, Prater CI, Atwood DW, Rice JS, Lieberman MW (2000) The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J Biol Chem 275:33404-33408
    • (2000) J Biol Chem , vol.275 , pp. 33404-33408
    • Kala, S.V.1    Neely, M.W.2    Kala, G.3    Prater, C.I.4    Atwood, D.W.5    Rice, J.S.6    Lieberman, M.W.7
  • 18
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Regulators of the tumor microenvironment
    • 10.1016/j.cell.2010.03.015
    • Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:53-67
    • (2010) Cell , vol.141 , pp. 53-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 19
    • 77049126844 scopus 로고    scopus 로고
    • Arsenic-induced carcinogenesis - Oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment
    • 1:CAS:528:DC%2BD1MXhs1SrurrI 20035570 10.1021/tx900343d
    • Kitchin KT, Conolly R (2010) Arsenic-induced carcinogenesis - oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment. Chem Res Toxicol 23:327-335
    • (2010) Chem Res Toxicol , vol.23 , pp. 327-335
    • Kitchin, K.T.1    Conolly, R.2
  • 20
    • 79959963304 scopus 로고    scopus 로고
    • Oxidative stress and oxidative damage in chemical carcinogenesis
    • 1:CAS:528:DC%2BC3MXoslaktL0%3D 21296097 10.1016/j.taap.2009.11.028
    • Klaunig JE, Wang Z, Pu X, Zhou S (2011) Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol Appl Pharmacol 254:86-99
    • (2011) Toxicol Appl Pharmacol , vol.254 , pp. 86-99
    • Klaunig, J.E.1    Wang, Z.2    Pu, X.3    Zhou, S.4
  • 22
    • 79956191022 scopus 로고    scopus 로고
    • Role of oxidative stress and DNA damage in human carcinogenesis
    • 1:CAS:528:DC%2BC3MXmsVGgs78%3D 21216256 10.1016/j.mrfmmm.2010.12.016
    • Kryston TB, Georgiev AB, Pissis P, Georgakilas AG (2011) Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 711:193-201
    • (2011) Mutat Res , vol.711 , pp. 193-201
    • Kryston, T.B.1    Georgiev, A.B.2    Pissis, P.3    Georgakilas, A.G.4
  • 23
    • 0038146898 scopus 로고    scopus 로고
    • Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    • 1:CAS:528:DC%2BD3sXisVOns7k%3D 12556532 10.1074/jbc.M211558200
    • Lee JM, Calkins MJ, Chan K, Kan YW, Johnson JA (2003) Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 278:12029-12038
    • (2003) J Biol Chem , vol.278 , pp. 12029-12038
    • Lee, J.M.1    Calkins, M.J.2    Chan, K.3    Kan, Y.W.4    Johnson, J.A.5
  • 24
    • 0025753514 scopus 로고
    • Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells
    • 1:CAS:528:DyaK38XhvFSitQ%3D%3D 2013093 10.1016/0092-8674(91)90404-M
    • Leone A, Flatow U, King CR, Sandeen MA, Marguiles IMK, Liotta LA, Steeg PS (1991) Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 65:25-35
    • (1991) Cell , vol.65 , pp. 25-35
    • Leone, A.1    Flatow, U.2    King, C.R.3    Sandeen, M.A.4    Marguiles, I.M.K.5    Liotta, L.A.6    Steeg, P.S.7
  • 25
    • 3543045528 scopus 로고    scopus 로고
    • Arsenic transport by the human multidrug resistance protein (MRP1/ABCC1): Evidence that a tri-glutathione conjugate is required
    • 1:CAS:528:DC%2BD2cXmtVChtLg%3D 15161912 10.1074/jbc.M404912200
    • Leslie EM, Haimeur A, Waalkes MP (2004) Arsenic transport by the human multidrug resistance protein (MRP1/ABCC1): evidence that a tri-glutathione conjugate is required. J Biol Chem 279:32700-32708
    • (2004) J Biol Chem , vol.279 , pp. 32700-32708
    • Leslie, E.M.1    Haimeur, A.2    Waalkes, M.P.3
  • 26
    • 79958140770 scopus 로고    scopus 로고
    • Molecular changes during arsenic-induced cell transformation
    • 1:CAS:528:DC%2BC3MXht1Sqtb3E 21344382 10.1002/jcp.22683
    • Li G, Lee LS, Li M, Tsao SW, Chiu JF (2011) Molecular changes during arsenic-induced cell transformation. J Cell Physiol 226:3225-3232
    • (2011) J Cell Physiol , vol.226 , pp. 3225-3232
    • Li, G.1    Lee, L.S.2    Li, M.3    Tsao, S.W.4    Chiu, J.F.5
  • 27
    • 0034925678 scopus 로고    scopus 로고
    • Overexpression of glutathione S-transferase II and multidrug resistant transport proteins is associated with acquired arsenic tolerance to inorganic arsenic
    • 1:CAS:528:DC%2BD3MXlsFansbk%3D 11455017
    • Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, Klaassen CD, Waalkes MP (2001) Overexpression of glutathione S-transferase II and multidrug resistant transport proteins is associated with acquired arsenic tolerance to inorganic arsenic. Mol Pharmacol 60:302-309
    • (2001) Mol Pharmacol , vol.60 , pp. 302-309
    • Liu, J.1    Chen, H.2    Miller, D.S.3    Saavedra, J.E.4    Keefer, L.K.5    Johnson, D.R.6    Klaassen, C.D.7    Waalkes, M.P.8
  • 29
    • 30044447244 scopus 로고    scopus 로고
    • Apoptosis evasion: The role of survival pathways in prostate cancer progression and therapeutic resistance
    • 1:CAS:528:DC%2BD28XivV2lsg%3D%3D 2274918 16216007 10.1002/jcb.20634
    • McKenzie S, Kyprianou N (2006) Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance. J Cell Biochem 97:18-32
    • (2006) J Cell Biochem , vol.97 , pp. 18-32
    • McKenzie, S.1    Kyprianou, N.2
  • 30
    • 84862815940 scopus 로고    scopus 로고
    • PTEN in DNA damage repair
    • 1:CAS:528:DC%2BC38XhvVGksbw%3D 3326178 22266095 10.1016/j.canlet.2012.01. 003
    • Ming M, He Y-Y (2012) PTEN in DNA damage repair. Cancer Lett 319:125-129
    • (2012) Cancer Lett , vol.319 , pp. 125-129
    • Ming, M.1    He, Y.-Y.2
  • 32
    • 0036908787 scopus 로고    scopus 로고
    • DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species
    • 1:CAS:528:DC%2BD38XovFynsb8%3D 12482246 10.1021/tx025598y
    • Nesnow S, Roop BC, Lambert G, Kadiiska M, Mason RP, Cullen WR, Mass MJ (2002) DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem Res Toxicol 15:1627-1634
    • (2002) Chem Res Toxicol , vol.15 , pp. 1627-1634
    • Nesnow, S.1    Roop, B.C.2    Lambert, G.3    Kadiiska, M.4    Mason, R.P.5    Cullen, W.R.6    Mass, M.J.7
  • 33
    • 34249060044 scopus 로고    scopus 로고
    • Molecular mechanisms of the diabetogenic effects of arsenic: Inhibition of insulin signaling by arsenite and methylarsonous acid
    • 1:CAS:528:DC%2BD2sXmt1Sksbw%3D 1867998 17520061 10.1289/ehp.9867
    • Paul DS, Harmon AW, Devesa V, Thomas DJ, Styblo M (2007) Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid. Environ Health Perspect 115:734-742
    • (2007) Environ Health Perspect , vol.115 , pp. 734-742
    • Paul, D.S.1    Harmon, A.W.2    Devesa, V.3    Thomas, D.J.4    Styblo, M.5
  • 34
    • 48449084354 scopus 로고    scopus 로고
    • Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2
    • 1:CAS:528:DC%2BD1cXpslWrs78%3D 2658531 18572023 10.1016/j.freeradbiomed. 2008.05.020
    • Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, Styblo M, Waalkes MP (2008) Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med 45:651-658
    • (2008) Free Radic Biol Med , vol.45 , pp. 651-658
    • Pi, J.1    Diwan, B.A.2    Sun, Y.3    Liu, J.4    Qu, W.5    He, Y.6    Styblo, M.7    Waalkes, M.P.8
  • 35
    • 31744434089 scopus 로고    scopus 로고
    • Immuno-spin trapping of DNA radicals
    • 1:CAS:528:DC%2BD28Xmtl2rtg%3D%3D 16432522 10.1038/nmeth852
    • Ramirez DC, Mejiba SE, Mason RP (2006) Immuno-spin trapping of DNA radicals. Nat Methods 3:123-127
    • (2006) Nat Methods , vol.3 , pp. 123-127
    • Ramirez, D.C.1    Mejiba, S.E.2    Mason, R.P.3
  • 36
    • 34347255753 scopus 로고    scopus 로고
    • Immuno-spin trapping analysis of DNA radicals
    • 1:CAS:528:DC%2BD2sXhtFGntbnI 2711897 17406615 10.1038/nprot.2007.5
    • Ramirez DC, Gomez-Mejiba SE, Mason RP (2007) Immuno-spin trapping analysis of DNA radicals. Nat Protoc 2:512-522
    • (2007) Nat Protoc , vol.2 , pp. 512-522
    • Ramirez, D.C.1    Gomez-Mejiba, S.E.2    Mason, R.P.3
  • 37
    • 0034071776 scopus 로고    scopus 로고
    • Studies on the mechanisms of arsenic-induced self tolerance developed in liver epithelial cells through continuous low-level arsenite exposure
    • 1:CAS:528:DC%2BD3cXitlaitbc%3D 10774833 10.1093/toxsci/54.2.500
    • Romach EH, Zhao CQ, Del Razo LM, Cebrian ME, Waalkes MP (2000) Studies on the mechanisms of arsenic-induced self tolerance developed in liver epithelial cells through continuous low-level arsenite exposure. Toxicol Sci 54:500-508
    • (2000) Toxicol Sci , vol.54 , pp. 500-508
    • Romach, E.H.1    Zhao, C.Q.2    Del Razo, L.M.3    Cebrian, M.E.4    Waalkes, M.P.5
  • 38
    • 0037972159 scopus 로고    scopus 로고
    • Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA
    • 1:CAS:528:DC%2BD3sXkt1Wrs7s%3D 12771042 10.1093/carcin/bgg018
    • Schwerdtle T, Walter I, Mackiw I, Hartwig A (2003) Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA. Carcinogenesis 24:967-974
    • (2003) Carcinogenesis , vol.24 , pp. 967-974
    • Schwerdtle, T.1    Walter, I.2    Mackiw, I.3    Hartwig, A.4
  • 39
    • 2342637859 scopus 로고    scopus 로고
    • A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel
    • 1:CAS:528:DC%2BD2cXjvVyhs7Y%3D 15096609 10.1073/pnas.0401604101
    • Shimizu T, Numata T, Okada Y (2004) A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel. Proc Natl Acad Sci 101:6770-6773
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 6770-6773
    • Shimizu, T.1    Numata, T.2    Okada, Y.3
  • 41
    • 84861010990 scopus 로고    scopus 로고
    • Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells
    • 10.1016/j.taap.2012.04.003
    • Stueckel TA, Lu Y, Davis ME, Wang L, Jiang BH, Holaskova I, Schafer R, Barnett JB, Rojanasakul Y (2012) Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol 261:204-216
    • (2012) Toxicol Appl Pharmacol , vol.261 , pp. 204-216
    • Stueckel, T.A.1    Lu, Y.2    Davis, M.E.3    Wang, L.4    Jiang, B.H.5    Holaskova, I.6    Schafer, R.7    Barnett, J.B.8    Rojanasakul, Y.9
  • 43
    • 80052366402 scopus 로고    scopus 로고
    • Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response
    • 1:CAS:528:DC%2BC3MXhtV2itrvP 3169845 21820459 10.1016/j.taap.2011.07.006
    • Sun Y, Kojima C, Chignell C, Mason RM, Waalkes MP (2011) Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response. Toxicol Appl Pharmacol 255:242-250
    • (2011) Toxicol Appl Pharmacol , vol.255 , pp. 242-250
    • Sun, Y.1    Kojima, C.2    Chignell, C.3    Mason, R.M.4    Waalkes, M.P.5
  • 44
    • 84555189064 scopus 로고    scopus 로고
    • Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic
    • 1:CAS:528:DC%2BC38XitFOjtrw%3D 22011395 10.1093/toxsci/kfr282
    • Sun Y, Tokar EJ, Waalkes MP (2012) Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic. Toxicol Sci 125:20-29
    • (2012) Toxicol Sci , vol.125 , pp. 20-29
    • Sun, Y.1    Tokar, E.J.2    Waalkes, M.P.3
  • 46
    • 24744447722 scopus 로고    scopus 로고
    • Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells
    • 1:CAS:528:DC%2BD28XlsFWjurw%3D 16158255 10.1007/s10585-005-8393-z
    • Tokar EJ, Webber MM (2005) Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells. Clin Exp Metastasis 22:275-284
    • (2005) Clin Exp Metastasis , vol.22 , pp. 275-284
    • Tokar, E.J.1    Webber, M.M.2
  • 47
    • 77149162672 scopus 로고    scopus 로고
    • Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype
    • 1:CAS:528:DC%2BC3cXhsVSisL0%3D 2831952 20056578
    • Tokar EJ, Diwan BA, Waalkes MP (2010a) Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. Environ Health Perspect 118:108-115
    • (2010) Environ Health Perspect , vol.118 , pp. 108-115
    • Tokar, E.J.1    Diwan, B.A.2    Waalkes, M.P.3
  • 48
    • 77958013778 scopus 로고    scopus 로고
    • Cancer in experimental animals exposed to arsenic and arsenic compounds
    • 1:CAS:528:DC%2BC3cXht12ns7zF 3076186 20812815 10.3109/10408444.2010. 506641
    • Tokar EJ, Benbrahim-Tallaa L, Ward JM, Lunn R, Sams RL II, Waalkes MP (2010b) Cancer in experimental animals exposed to arsenic and arsenic compounds. Crit Rev Toxicol 40:912-927
    • (2010) Crit Rev Toxicol , vol.40 , pp. 912-927
    • Tokar, E.J.1    Benbrahim-Tallaa, L.2    Ward, J.M.3    Lunn, R.4    Sams, I.I.R.L.5    Waalkes, M.P.6
  • 49
    • 77952074045 scopus 로고    scopus 로고
    • Arsenic-specific stem cell selection during malignant transformation
    • 1:CAS:528:DC%2BC3cXlvVWqtr8%3D 20339138 10.1093/jnci/djq093
    • Tokar EJ, Qu W, Liu J, Liu W, Webber MM, Phang JM, Waalkes MP (2010c) Arsenic-specific stem cell selection during malignant transformation. J Natl Cancer Inst 102:638-649
    • (2010) J Natl Cancer Inst , vol.102 , pp. 638-649
    • Tokar, E.J.1    Qu, W.2    Liu, J.3    Liu, W.4    Webber, M.M.5    Phang, J.M.6    Waalkes, M.P.7
  • 50
    • 78650607855 scopus 로고    scopus 로고
    • Carcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 mice
    • 1:CAS:528:DC%2BC3cXhsF2rsbnL 20937726 10.1093/toxsci/kfq315
    • Tokar EJ, Diwan BA, Ward JM, Delker DA, Waalkes MP (2011) Carcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 mice. Toxicol Sci 119:73-83
    • (2011) Toxicol Sci , vol.119 , pp. 73-83
    • Tokar, E.J.1    Diwan, B.A.2    Ward, J.M.3    Delker, D.A.4    Waalkes, M.P.5
  • 51
    • 84866032672 scopus 로고    scopus 로고
    • Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 mice
    • 1:CAS:528:DC%2BC38XjsVWntrc%3D 3459060 22398986 10.1007/s00204-012-0820-8
    • Tokar EJ, Diwan BA, Thomas DJ, Waalkes MP (2012) Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 mice. Arch Toxicol 86:975-982
    • (2012) Arch Toxicol , vol.86 , pp. 975-982
    • Tokar, E.J.1    Diwan, B.A.2    Thomas, D.J.3    Waalkes, M.P.4
  • 52
    • 32444433202 scopus 로고    scopus 로고
    • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    • 1:CAS:528:DC%2BD28XhsF2hsrY%3D 16430879 10.1016/j.cbi.2005.12.009
    • Valko M, Rhodes CJ, Moncol J, Isakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160:1-40
    • (2006) Chem Biol Interact , vol.160 , pp. 1-40
    • Valko, M.1    Rhodes, C.J.2    Moncol, J.3    Isakovic, M.4    Mazur, M.5
  • 53
    • 34547611245 scopus 로고    scopus 로고
    • Transplacental arsenic carcinogenesis in mice
    • 1:CAS:528:DC%2BD2sXovFKqurc%3D 1995036 17306315 10.1016/j.taap.2006.12. 034
    • Waalkes MP, Liu J, Diwan BA (2007) Transplacental arsenic carcinogenesis in mice. Toxicol Appl Pharmacol 222:271-280
    • (2007) Toxicol Appl Pharmacol , vol.222 , pp. 271-280
    • Waalkes, M.P.1    Liu, J.2    Diwan, B.A.3
  • 54
    • 54249136831 scopus 로고    scopus 로고
    • Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics
    • 1:CAS:528:DC%2BD1cXht1CmsbzJ 2652700 18922899 10.1158/0008-5472.CAN-08- 2099
    • Waalkes MP, Liu J, Germolec DR, Trempus CS, Cannon RE, Tokar EJ, Tennant RW, Ward JM, Diwan BA (2008) Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics. Cancer Res 68:8278-8285
    • (2008) Cancer Res , vol.68 , pp. 8278-8285
    • Waalkes, M.P.1    Liu, J.2    Germolec, D.R.3    Trempus, C.S.4    Cannon, R.E.5    Tokar, E.J.6    Tennant, R.W.7    Ward, J.M.8    Diwan, B.A.9
  • 55
    • 77954370016 scopus 로고    scopus 로고
    • Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure
    • 1:CAS:528:DC%2BC3cXnvVOltrw%3D 20375083 10.1093/toxsci/kfq106
    • Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi AJ (2010) Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure. Toxicol Sci 116:44-57
    • (2010) Toxicol Sci , vol.116 , pp. 44-57
    • Wnek, S.M.1    Jensen, T.J.2    Severson, P.L.3    Futscher, B.W.4    Gandolfi, A.J.5
  • 56
    • 81255185302 scopus 로고    scopus 로고
    • Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells
    • 1:CAS:528:DC%2BC3MXhsV2lsrrN 3220758 21925530 10.1016/j.taap.2011.08.029
    • Wnek SM, Kuhlman CL, Camarillo JM, Medeiros MK, Liu KJ, Lau SS, Gandolfi JA (2011) Interdependent genotoxic mechanisms of monomethylarsonous acid: role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicol Appl Pharmacol 257:1-13
    • (2011) Toxicol Appl Pharmacol , vol.257 , pp. 1-13
    • Wnek, S.M.1    Kuhlman, C.L.2    Camarillo, J.M.3    Medeiros, M.K.4    Liu, K.J.5    Lau, S.S.6    Gandolfi, J.A.7
  • 57
    • 84862001935 scopus 로고    scopus 로고
    • Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype
    • 1:CAS:528:DC%2BC38XhtVOjtrfL 3385457 22472196 10.1289/ehp.1204987
    • Xu Y, Tokar EJ, Sun Y, Waalkes MP (2012) Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype. Environ Health Perspect 120:865-871
    • (2012) Environ Health Perspect , vol.120 , pp. 865-871
    • Xu, Y.1    Tokar, E.J.2    Sun, Y.3    Waalkes, M.P.4
  • 58
    • 0030885707 scopus 로고    scopus 로고
    • Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression
    • 1:CAS:528:DyaK2sXmtlCnsL4%3D 9380733 10.1073/pnas.94.20.10907
    • Zhao CQ, Young MR, Diwan BA, Coogan TP, Waalkes MP (1997) Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc Natl Acad Sci 94:10907-10912
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 10907-10912
    • Zhao, C.Q.1    Young, M.R.2    Diwan, B.A.3    Coogan, T.P.4    Waalkes, M.P.5


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