Tumors and proliferative lesions in adult oVspring after maternal exposure to methylarsonous acid during gestation in CD1 mice

Archives of Toxicology

Volumn 86, Issue 6, 2012, Pages 975-982

  Tokar, Erik J ^a,b   Diwan, Bhalchandra A ^c   Thomas, David J ^d   Waalkes, Michael P ^a,b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c SAIC FREDERICK INC   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Carcinogenesis; Methylated arsenical; Mice; Transplacental exposure

Indexed keywords

METHANEARSONIC ACID;

ADRENAL CORTEX ADENOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER SURVIVAL; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GESTATION PERIOD; HYPERPLASIA; LEYDIG CELL TUMOR; LIVER CELL CARCINOMA; LUNG ADENOCARCINOMA; MALE; MOUSE; NONHUMAN; OVIDUCT HYPERPLASIA; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; SURVIVAL TIME; TESTIS CARCINOMA; TOXICITY TESTING; UTERUS TUMOR;

ADENOCARCINOMA; ADENOMA; ADRENAL GLAND NEOPLASMS; ANIMALS; ARSENIC; ARSENICALS; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LIVER NEOPLASMS; LUNG NEOPLASMS; MALE; MATERNAL EXPOSURE; MICE; NEOPLASMS; OVARIAN NEOPLASMS; PREGNANCY; PREGNANCY COMPLICATIONS, NEOPLASTIC; PRENATAL EXPOSURE DELAYED EFFECTS; TESTICULAR NEOPLASMS; UTERINE NEOPLASMS;

MUS;

EID: 84866032672     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0820-8     Document Type: Article

References (37)

1. Anderson LM, Diwan BA, Fear NT et al (2000) Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models. Environ Health Perspect 108(Suppl 3):573-594
2. Chen Y, O'Brien T, Del Razo LM et al (2008) Tissue levels of arsenicals and skin tumor response following administration of monomethylarsonous acid and arsenite to K6/ODC mice. J Environ Pathol Toxicol Oncol 27:43-52
3. Cohen SM, Ohnishi T, Arnold LL et al (2007) Arsenic-induced bladder cancer in an animal model. Toxicol Appl Pharmacol 222:258-263
4. Devesa V, Adair BM, Liu J et al (2006) Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite. Toxicology 224:147-155
5. Eblin KE, Bredfeldt TG, GandolW AJ (2008) Immortalized human urothelial cells as a model of arsenic-induced bladder cancer. Toxicology 248:67-76
6. Hirano S, Kobayashi Y, Cui X et al (2004) The accumulation and toxicity of methylated arsenicals in endothelial cells: important roles of thiol compounds. Toxicol Appl Pharmacol 198:458-467
7. Hood RD, Vedel-Macrander GC, Zaworotko MJ et al (1987) Distribution, metabolism, and fetal uptake of pentavalent arsenic in pregnant mice following oral or intraperitoneal administration. Teratology 35:19-25
8. Institute of Laboratory Animal Resources (1996) Guide for the care and use of laboratory animals, 7th edn. National Academy Press, Washington
9. International Agency for Research on Cancer (IARC) (2004) monographs on the evaluation of carcinogenic risks to humans. Some drinking-water disinfectants and contaminants, including arsenic, arsenic in drinking-water, vol 84. IARC Press, Lyon, pp 3-267
10. International Agency for Research on Cancer (IARC) (2011) Monographs on the evaluation of carcinogenic risks to humans. A review of human carcinogens: arsenic, metals, Wbres, and dusts, vol 100C. IARC Press, Lyon, pp 41-93
11. Jin Y, Xi S, Li X et al (2006) Arsenic speciation transported through the placenta from mother mice to their newborn pups. Environ Res 101:349-355
12. Kitchin KT (2001) Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol 172:249-261
13. Liaw J, Marshall G, Yuan Y (2008) Increased childhood liver cancer mortality and arsenic in drinking water in Chile. Cancer Epidemiol Biomarkers Prev 17:1982-1987
14. National Toxicology Program (NTP) (2011) Report on carcinogens, 12th edition: arsenic and inorganic arsenic compounds. US Department of Health and Human Services, Research Triangle Park, NC, USA, pp 50-53
15. Newbold RR, Bullock BC, McLachlan JA (1985) Lesions of the rete testis in mice exposed prenatally to diethylstilbestrol. Cancer Res 45:5145-5150
16. Newbold RR, Bullock BC, McLachlan JA (1987) Testicular tumors in mice exposed in utero to diethylstilbestrol. J Urol 138:1446-1450
17. Newbold RR, Hanson RB, JeVerson WN et al (2000) Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 21:1355-1363
18. Shen J, Liu J, Xie Y et al (2007) Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure. Toxicol Sci 95:313-320
19. Smith AH, Marshall G, Yuan Y et al (2006) Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ Health Perspect 114:1293-1296
20. Tennant AH, Kligerman AD (2011) Superoxide dismutase protects cells from DNA damage induced by trivalent methylated arsenicals. Environ Mol Mutagen 52:238-243
21. Thomas DJ (2007) Molecular processes in cellular arsenic metabolism. Toxicol Appl Pharmacol 222:365-373
22. Thomas DJ, Li J, Waters SB et al (2007) Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals. Exp Biol Med 232:3-13
23. Tokar EJ, Benbrahim-Tallaa L, Ward JM et al (2010a) Cancer in experimental animals exposed to arsenic and arsenic compounds. Crit Rev Toxicol 40:912-927
24. Tokar EJ, Diwan BA, Waalkes MP (2010b) Arsenic exposure in utero and nonepidermal proliferative response in adulthood in Tg.AC mice. Int J Toxicol 29:291-296
25. Tokar EJ, Qu W, Waalkes MP (2011) Arsenic, stem cells, and the developmental basis of adult cancer. Toxicol Sci 120(Suppl 1):S192-S203
26. Waalkes MP, Ward JM, Liu J et al (2003) Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary and adrenal tumors in mice. Toxicol Appl Pharmacol 186:7-17
27. Waalkes MP, Ward JM, Diwan BA (2004a) Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional eVects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers. Carcinogenesis 25:133-141
28. Waalkes MP, Liu J, Chen H et al (2004b) Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J Natl Cancer Inst 96:466-474
29. Waalkes MP, Liu J, Ward JM et al (2006a) Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen. Toxicol Appl Pharmacol 215:295-305
30. Waalkes MP, Liu J, Ward JM et al (2006b) Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment. Cancer Res 66:1337-1345
31. Waalkes MP, Liu J, Diwan BA (2007) Transplacental arsenic carcinogenesis in mice. Toxicol Appl Pharmacol 222:271-280
32. Waalkes MP, Liu J, Germolec DR et al (2008) Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics. Cancer Res 68:8278-8285
33. Wnek SM, Kuhlman CL, Camarillo JM et al (2011) Interdependent genotoxic mechanisms of monomethylarsonous acid: role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicol Appl Pharmacol. doi:10.1016/j.taap.2011.08.029
34. Xi S, Jin Y, Lv X et al (2010) Distribution and speciation of arsenic by transplacental and early life exposure to inorganic arsenic in oVspring rats. Biol Trace Elem Res 134:84-97
35. Yorifuji T, Tsuda T, Grandjean P (2010) Unusual cancer excess after neonatal arsenic exposure from contaminated milk powder. J Natl Cancer Inst 102:360-361
36. Yorifuji T, Tsuda T, Doi H et al (2011) Cancer excess after arsenic exposure from contaminated milk powder. Environ Health Prev Med 16:164-170
37. Yuan Y, Marshall G, Ferreccio C et al (2010) Kidney cancer mortality: Wfty-year latency patterns related to arsenic exposure. Epidemiology 21:103-108