Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells

Toxicology and Applied Pharmacology

Volumn 257, Issue 1, 2011, Pages 1-13

  Wnek, Shawn M ^a   Kuhlman, Christopher L ^a   Camarillo, Jeannie M ^a   Medeiros, Matthew K ^a   Liu, Ke J ^c   Lau, Serrine S ^a,b   Gandolfi, A J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Arsenic; Bladder cancer; Genotoxicity; Monomethylarsonous acid; Poly(ADP ribose) polymerase 1; UROtsa

Indexed keywords

ARSENIC DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; MESSENGER RNA; MONOMETHYLARSONOUS ACID III; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; POLY(ADENOSINE DIPHOSPHATE RIBOSE)POLYMERASE 1 ZINC FINGER DOMAIN PEPTIDE; REACTIVE OXYGEN METABOLITE; SYNTHETIC PEPTIDE; THIOL GROUP; UNCLASSIFIED DRUG; ZINC CHLORIDE; ZINC ION;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; INHIBITION KINETICS; MALIGNANT TRANSFORMATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; UROTHELIUM; ZINC FINGER MOTIF;

EID: 81255185302     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.08.029     Document Type: Article

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