Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: Formulation and in vitro and in vivo evaluation

Molecular Pharmaceutics

Volumn 8, Issue 4, 2011, Pages 1209-1223

  Navath, Raghavendra S ^a,b,c   Menjoge, Anupa R ^a,b   Dai, Hui ^b,d   Romero, Roberto ^b   Kannan, Sujatha ^b,d   Kannan, Rangaramanujam M ^a,b  

^a Wayne State University   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c ETHICON INC   (United States)

^d CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

biodegradable hydrogel; formulation; in vitro and in vivo evaluation; injectable hydrogels; pregnancy; pregnant guinea pig model; sustained release of amoxicillin; treatment of genital infections

Indexed keywords

AMOXICILLIN; DENDRIMER; GLYCEROL; MACROGOL; POLYAMIDOAMINE; POVIDONE; THIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BIODEGRADATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; DENSITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG RETENTION; DRUG SYNTHESIS; DRUG TOLERABILITY; DRUG TRANSPORT; EPITHELIUM CELL; EXPERIMENTAL GUINEA PIG; FEMALE; FETUS; FETUS MEMBRANE; GENITAL TRACT INFECTION; HISTOLOGY; HYDROGEL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE TRANSPORT; NONHUMAN; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STOICHIOMETRY; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; UTERINE CERVIX; UTERUS; VAGINA;

AMOXICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DENDRIMERS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENITAL DISEASES, FEMALE; GUINEA PIGS; HYDROGELS; INJECTIONS; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; PREGNANCY;

EID: 79961084368     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200027z     Document Type: Article

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