An overview on dry eye treatment: Approaches for cyclosporin A delivery

The Scientific World Journal

Volumn 2012, Issue , 2012, Pages

  Yavuz, Burçin ^a   Bozdaǧ Pehlivan, Sibel ^a   Ünlü, Nurşen ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL TEAR; CHITOSAN; COLLAGEN; CYCLOSPORIN A; DICLOFENAC; KETOROLAC; LIPOSOME; MICROSPHERE; NANOCAPSULE; NANOPARTICLE; NON PRESCRIPTION DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; OPTIMMUNE; UNCLASSIFIED DRUG; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ANAPHYLACTIC SHOCK; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLINDNESS; CONTACT LENS; CORNEA ULCER; DISEASE COURSE; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG TARGETING; EVAPORATION; EYE INFECTION; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IMPLANT; KERATOCONJUNCTIVITIS SICCA; LIPOSOMAL DELIVERY; MICELLE; NEPHROTOXICITY; NONHUMAN; OCULAR SURFACE DISEASE; TEAR FILM; TEAR FLOW; DRUG DOSAGE FORM; REVIEW;

CYCLOSPORINE; DOSAGE FORMS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KERATOCONJUNCTIVITIS SICCA;

EID: 84861033042     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/194848     Document Type: Article

References (106)

1. Schwartz G. F., Kotak S., Mardekian J., Fain J. M., Incidence of new coding for dry eye and ocular infection in open-angle glaucoma and ocular hypertension patients treated with prostaglandin analogs: retrospective analysis of three medical/pharmacy claims databases BMC Ophthalmology 2011 11 1, article 14
2. Report of the dry eye workshop 2007. http://www.tearfilm.org/dewsreport/
3. O'Brien P. D., Collum L. M. T., Dry eye: diagnosis and current treatment strategies Current Allergy and Asthma Reports 2004 4 4 314 319 (Pubitemid 39359533)
4. Pflugfelder S. C., Prevalence, burden, and pharmacoeconomics of dry eye disease American Journal of Managed Care 2008 14 3, supplement S102 S106
5. Pflugfelder S. C., Antiinflammatory therapy for dry eye American Journal of Ophthalmology 2004 137 2 337 342 (Pubitemid 38221009)
6. Stern M. E., Pflugfelder S. C., Inflammation in dry eye Ocular Surface 2004 2 2 124 130 (Pubitemid 41263879)
7. Liu H., Wang Y., Li S., Advanced delivery of ciclosporin A: present state and perspective Expert Opinion on Drug Delivery 2007 4 4 349 358 (Pubitemid 47249136)
8. Aksungur P., Demirbilek M., Denkba E. B., Vandervoort J., Ludwig A., Ünlü N., Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: cellular toxicity, uptake, and kinetic studies Journal of Controlled Release 2011 151 3 286 294
9. Gupta C., Chauhan A., Ophthalmic delivery of cyclosporine A by punctal plugs Journal of Controlled Release 2011 150 1 70 76
10. Peng C. C., Chauhan A., Extended cyclosporine delivery by silicone-hydrogel contact lenses Journal of Controlled Release 2011 154 3 267 274
11. Lemp M. A., Recent developments in dry eye management Ophthalmology 1987 94 10 1299 1304 (Pubitemid 17149340)
12. Lemp M. A., Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes The CLAO Journal 1995 21 4 221 232
13. Mertzanis P., Abetz L., Rajagopalan K., Espindle D., Chalmers R., Snyder C., Caffery B., Edrington T., Simpson T., Nelson J. D., Begley C., The relative burden of dry eye in patients' lives: comparisons to a U.S. normative sample Investigative Ophthalmology Visual Science 2005 46 1 46 50 (Pubitemid 40041177)
14. Stern M. E., Beuerman R. W., Fox R. I., Gao J., Mircheff A. K., Pflugfelder S. C., The pathology of dry eye: the interaction between the ocular surface and lacrimal glands Cornea 1998 17 6 584 589 (Pubitemid 28511901)
15. Graham E. M., Ellis C. J. K., Sanders M. D., McDonald W. I., Optic neuropathy in sarcoidosis Journal of Neurology Neurosurgery and Psychiatry 1986 49 7 756 763 (Pubitemid 16100411)
16. Kunert K. S., Tisdale A. S., Stern M. E., Smith J. A., Gipson I. K., Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes Archives of Ophthalmology 2000 118 11 1489 1496
17. Anderson L. G., Talal N., The spectrum of benign to malignant lymphoproliferation in Sjgren's syndrome Clinical and Experimental Immunology 1972 10 2 199 221
18. Suwan-apichon O., Rizen M., Rangsin R., Herretes S., Reyes J. M. G., Lekhanont K., Chuck R. S., Botulinum toxin B-induced mouse model of keratoconjunctivitis sicca Investigative Ophthalmology Visual Science 2006 47 1 133 139 (Pubitemid 46780805)
19. Petcher T. J., Weber H. P., Rueegger A., Crystal and molecular structure of an iodo derivative of the cyclic undecapeptide cyclosporin A Helvetica Chimica Acta 1976 59 5 1480 1488
20. El Tayar N., Mark A. E., Vallat P., Brunne R. M., Testa B., van Gunsteren W. F., Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations Journal of Medicinal Chemistry 1993 36 24 3757 3764 (Pubitemid 24006703)
21. Nussenblatt R. B., Palestine A. G., Chan C. C., Stevens G. Jr., Mellow S. D., Green S. B., Randomized, double-masked study of cyclosporine compared to prednisolone in the treatment of endogenous uveitis American Journal of Ophthalmology 1991 112 2 138 146
22. Noble S., Markham A., Cyclosporin: a review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral) Drugs 1995 50 5 924 941
23. Donnenfeld E., Pflugfelder S. C., Topical ophthalmic cyclosporine: pharmacology andclinical uses Survey of Ophthalmology 2009 54 3 321 338
24. Sall K., Stevenson O. D., Mundorf T. K., Reis B. L., Two multicenter randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease Ophthalmology 2000 107 4 631 639 (Pubitemid 30191329)
25. Wilson S. E., Perry H. D., Long-term resolution of chronic dry eye symptoms and signs after topical cyclosporine treatment Ophthalmology 2007 114 1 76 79 (Pubitemid 46014291)
26. Kuwano M., Ibuki H., Morikawa N., Ota A., Kawashima Y., Cyclosporine A formulation affects its ocular distribution in rabbits Pharmaceutical Research 2002 19 1 108 111 (Pubitemid 34075115)
27. Perry H. D., Solomon R., Donnenfeld E. D., Perry A. R., Wittpenn J. R., Greenman H. E., Savage H. E., Evaluation of topical cyclosporine for the treatment of dry eye disease Archives of Ophthalmology 2008 126 8 1046 1050
28. Behrens A., Doyle J. J., Stern L., Chuck R. S., McDonnell P. J., Azar D. T., Dua H. S., Hom M., Karpecki P. M., Laibson P. R., Lemp M. A., Meisler D. M., Castillo J. M. D., O'Brien T. P., Pflugfelder S. C., Rolando M., Schein O. D., Seitz B., Tseng S. C., Setten G. V., Wilson S. E., Yiu S. C., Dysfunctional tear syndrome: a Delphi approach to treatment recommendations Cornea 2006 25 8 900 907 (Pubitemid 44763848)
29. Lemp M. A., Management of dry eye disease American Journal of Managed Care 2008 14 3, supplement S88 S110
30. Utine C. A., Akpek E. K., What ophthalmologists should know about Sjgrens syndrome European Ophtalmic Review 2010 4 1 77 81
31. Macri A., Rolando M., Pflugfelder S., A standardized visual scale for elevation of tear fluorescein clearance Ophthalmology 2000 107 7 1338 1343
32. Calonge M., The treatment of dry eye Survey of Ophthalmology 2001 45 supplement 2 S227 S239
33. Toda I., Shinozaki N., Tsubota K., Hydroxypropyl methylcellulose for the treatment of severe dry eye associated with Sjgren's syndrome Cornea 1996 15 2 120 128
34. Murube J., Murube A., Zhuo C., Classification of artificial tearsII: additives and commercial formulas Advances in Experimental Medicine and Biology 1998 438 705 715
35. Oechsner M., Keipert S., Polyacrylic acid/polyvinylpyrrolidone bipolymeric systemsI. Rheological and mucoadhesive properties of formulations potentially useful for the treatment of dry-eye-syndrome European Journal of Pharmaceutics and Biopharmaceutics 1999 47 2 113 118 (Pubitemid 29185113)
36. Ludwig A., Unlu N., van Ooteghem M., Evaluation of viscous ophthalmic vehicles containing carbomer by slit-lamp fluorophotometry in humans International Journal of Pharmaceutics 1990 61 1-2 15 25 (Pubitemid 20201601)
37. Unlu N., Ludwib A., van Ooteghem M., Hincal A. A., Formulation of Carbopol 940 ophthalmic vehicles, and in vitro evaluation of the influence of simulated lacrimal fluid on their physico-chemical properties Pharmazie 1991 46 11 784 788
38. Unlu N., Ludwig A., van Ooteghem M., Hincal A. A., A comparative rheological study on carbopol viscous solutions and, the evaluation of their suitability as the ophthalmic vehicles and artificial tears Pharmaceutica Acta Helvetiae 1992 67 1 5 10
39. Ubels J. L., McCartney M. D., Lantz W. K., Beaird J., Dayalan A., Edelhauser H. F., Effects of preservative-free artificial tear solutions on corneal epithelial structure and function Archives of Ophthalmology 1995 113 3 371 378
40. Geerling G., MacLennan S., Hartwig D., Autologous serum eye drops for ocular surface disorders British Journal of Ophthalmology 2004 88 11 1467 1474 (Pubitemid 39424732)
41. Schrader S., Wedel T., Moll R., Geerling G., Combination of serum eye drops with hydrogel bandage contact lenses in the treatment of persistent epithelial defects Graefe's Archive for Clinical and Experimental Ophthalmology 2006 244 10 1345 1349 (Pubitemid 44463476)
42. Burgess P. I., Koay P., Clark P., SmartPlug versus silicone punctal plug therapy for dry eye: a prospective randomized trial Cornea 2008 27 4 391 394 (Pubitemid 351591473)
43. Yen M. T., Pflugfelder S. C., Feuer W. J., The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects American Journal of Ophthalmology 2001 131 3 314 323 (Pubitemid 32184516)
44. Pflugfelder S. C., Jones D., Ji Z., Afonso A., Monroy D., Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca Current Eye Research 1999 19 3 201 211 (Pubitemid 29500267)
45. Foulks G. N., The evolving treatment of dry eye Ophthalmology Clinics of North America 2003 16 1 29 35 (Pubitemid 36384124)
46. Quarterman M. J., Johnson D. W., Abele D. C., Lesher J. L. Jr., Hull D. S., Davis L. S., Ocular rosacea: signs, symptoms, and tear studies before and after treatment with doxycycline Archives of Dermatology 1997 133 1 49 54 (Pubitemid 27044305)
47. Mathers W. D., Stovall D., Lane J. A., Zimmerman M. B., Johnson S., Menopause and tear function: the influence of prolactin and sex hormones on human tear production Cornea 1998 17 4 353 358 (Pubitemid 28307498)
48. Sahlin S., Chen E., Kaugesaar T., Almqvist H., Kjellberg K., Lennerstrand G., Effect of eyelid botulinum toxin injection on lacrimal drainage American Journal of Ophthalmology 2000 129 4 481 486 (Pubitemid 30184919)
49. Avisar R., Robinson A., Appel I., Yassur Y., Weinberger D., Diclofenac sodium, 0.1 (Voltaren Ophtha), versus sodium chloride, 5, in the treatment of filamentary keratitis Cornea 2000 19 2 145 147 (Pubitemid 30140815)
50. Schechter B. A., Ketorolac during the induction phase of cyclosporin-A therapy Journal of Ocular Pharmacology and Therapeutics 2006 22 2 150 154 (Pubitemid 43742952)
51. Mathers W. D., Dolney A. M., Objective demonstration of tear stimulation with oral pilocarpine in dry eye patients Investigative Ophthalmology Visual Science 2000 41 4, article S60
52. Kim E. C., Choi J. S., Joo C. K., A comparison of vitamin A and cyclosporine A 0.05 eye drops for treatment of dry eye syndrome American Journal of Ophthalmology 2009 147 2 206 213
53. Selek H., Ünlü N., Hincal A. A., An ophthalmic emulsion of retinoic acid S.T.P. Pharma Sciences 1998 8 5 323 326 (Pubitemid 28562409)
54. Selek H., Ünlü N., Orhan M., Irke M., Evaluation of retinoic acid ophthalmic emulsion in dry eye European Journal of Ophthalmology 2000 10 2 121 127 (Pubitemid 30439110)
55. Çirpanli Y., Ünlü N., Çaliş S., Hincal A. A., Formulation and in-vitro characterization of retinoic acid loaded poly (lactic-co-glycolic acid) microspheres Journal of Microencapsulation 2005 22 8 877 889 (Pubitemid 43158189)
56. Sthelin H. F., The history of cyclosporin a (Sandimmune) revisited: another point of view Experientia 1996 52 1 5 13
57. Wenger R. M., Synthesis of cyclosporine. Total syntheses of cyclosporin A and cyclosporin H, two fungal metabolites isolated from the species Tolypocladium inflatum GAMS Helvetica Chimica Acta 1984 67 2 502 525 (Pubitemid 14199426)
58. Williams D. L., A comparative approach to topical cyclosporine therapy Eye 1997 11 4 453 464 (Pubitemid 27434976)
59. BenEzra D., Maftzir G., de Courten C., Timonen P., Ocular penetration of cyclosporin AIII: the human eye British Journal of Ophthalmology 1990 74 6 350 352 (Pubitemid 20191167)
60. Olivero D. K., Davidson M. G., English R. V., Nasisse M. P., Jamieson V. E., Gerig T. M., Clinical evaluation of 1 cyclosporine for topical treatment of keratoconjunctivitis sicca in dogs Journal of the American Veterinary Medical Association 1991 199 8 1039 1042
61. Newton C., Gebhardt B. M., Kaufman H. E., Topically applied cyclosporine in azone prolongs corneal allograft survival Investigative Ophthalmology Visual Science 1988 29 2 208 215 (Pubitemid 18057568)
62. Cheeks L., Kaswan R. L., Green K., Influence of vehicle and anterior chamber protein concentration on cyclosporine penetration through the isolated rabbit cornea Current Eye Research 1992 11 7 641 649
63. Furrer P., Mayer J. M., Plazonnet B., Gurny R., Ocular tolerance of preservatives on the murine cornea European Journal of Pharmaceutics and Biopharmaceutics 1999 47 2 105 112 (Pubitemid 29185112)
64. Tang-Liu D. D. S., Richman J. B., Weinkam R. J., Takruri H., Effects of four penetration enhancers on corneal permeability of drugs in vitro Journal of Pharmaceutical Sciences 1994 83 1 85 90 (Pubitemid 24233737)
65. Hickok S., Wade A., Paul W., Polyoxyethylene stearate Handbook of Pharmaceutical Excipients 1994 London, UK The Pharmaceutical Press 379 384
66. Milani J. K., Pleyer U., Dukes A., Chou H. J., Lutz S., Ruckert D., Schmidt-K. H., Mondino B. J., Prolongation of corneal allograft survival with liposome-encapsulated cyclosporine in the rat eye Ophthalmology 1993 100 6 890 896 (Pubitemid 23163500)
67. Ding S., Irvine C. A., Nonirritating emulsions for sensitive tissue. U.S. Patent 5,474,979, 1995
68. Zimmer A., Kreuter J., Robinson J. R., Studies on the transport pathway of PBCA nanoparticles in ocular tissues Journal of Microencapsulation 1991 8 4 497 504
69. De Campos A. M., Snchez A., Alonso M. J., Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A International Journal of Pharmaceutics 2001 224 1-2 159 168 (Pubitemid 32706495)
70. Felt O., Furrer P., Mayer J. M., Plazonnet B., Buri P., Gurny R., Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention International Journal of Pharmaceutics 1999 180 2 185 193 (Pubitemid 29238202)
71. Shen J., Deng Y., Jin X., Ping Q., Su Z., Li L., Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: improving in vivo ocular distribution International Journal of Pharmaceutics 2010 402 1-2 248 253
72. Reidy J. J., Gebhardt B. M., Kaufman H. E., The collagen shield: a new vehicle for delivery of cyclosporin A to the eye Cornea 1990 9 3 196 199 (Pubitemid 20298630)
73. Pleyer U., Elkins B., Ruckert D., Lutz S., Grammer J., Chou J., Schmidt K. H., Mondino B. J., Ocular absorption of cyclosporine A from liposomes incorporated into collagen shields Current Eye Research 1994 13 3 177 181 (Pubitemid 24088421)
74. Gebhardt B. M., Kaufman H. E., Collagen as a delivery system for hydrophobic drugs: studies with cyclosporine Journal of Ocular Pharmacology and Therapeutics 1995 11 3 319 327
75. Bourges J. L., Lallemand F., Agla E., Besseghir K., Dumont J. M., BenEzra D., Gurny R., Behar-Cohen F., Evaluation of a topical cyclosporine A prodrug on corneal graft rejection in rats Molecular Vision 2006 12 1461 1466 (Pubitemid 46117008)
76. Lallemand F., Furrer P., Felt-Baeyens O., Gex-Fabry M., Dumont J. M., Besseghir K., Gurny R., A novel water-soluble cyclosporine A prodrug: ocular tolerance and in vivo kinetics International Journal of Pharmaceutics 2005 295 1-2 7 14 (Pubitemid 40558784)
77. Meadows D., Nonaqueous fluorinated drug delivery vehicle suspensions. Patent US, 1992
78. Harper C. A. III, Khoobehi B., Peyman G. A., Gebhardt B. M., Dunlap W. A., Bioavailability of microsphere-entrapped cyclosporine A in the cornea and aqueous of rabbits International Ophthalmology 1993 17 6 337 340 (Pubitemid 24134940)
79. Alghadyan A. A., Peyman G. A., Khoobehi B., Milner S., Liu K. R., Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection International Ophthalmology 1988 12 2 101 104 (Pubitemid 19007718)
80. Apel A., Oh C., Chiu R., Saville B., Cheng Y. L., Rootman D., A subconjunctival degradable implant for cyclosporine delivery in corneal transplant therapy Current Eye Research 1995 14 8 659 667
81. Grisolano J. Jr., Peyman G. A., Retinal toxicity study of intravitreal cyclosporin Ophthalmic Surgery 1986 17 3 155 156 (Pubitemid 16126710)
82. Jaffe G. J., Yang C. S., Wang X. C., Cousins S. W., Gallemore R. P., Ashton P., Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis Ophthalmology 1998 105 1 46 56 (Pubitemid 28070601)
83. Nelson J. D., Helms H., Fiscella R., Southwell Y., Hirsch J. D., A new look at dry eye disease and its treatment Advances in Therapy 2000 17 2 84 93 (Pubitemid 30419037)
84. Brown M. M., Brown G. C., Brown H. C., Peet J., Roth Z., Value-based medicine, comparative effectiveness, and cost-effectiveness analysis of topical cyclosporine for the treatment of dry eye syndrome Archives of Ophthalmology 2009 127 2 146 152
85. Adriaens E., Dierckens K., Bauters T. G. M., Nelis H. J., Van Goethem F., Vanparys P., Remon J. P., The mucosal toxicity of different benzalkonium chloride analogues evaluated with an alternative test using slugs Pharmaceutical Research 2001 18 7 937 942 (Pubitemid 32799937)
86. Monti D., Chetoni P., Burgalassi S., Najarro M., Saettone M. F., Increased corneal hydration induced by potential ocular penetration enhancers: assessment by differential scanning calorimetry (DSC) and by desiccation International Journal of Pharmaceutics 2002 232 1-2 139 147 (Pubitemid 34076759)
87. Yavuz B., Bilensoy E., Vural I., umnu M., Alternative oral exemestane formulation: improved dissolution and permeation International Journal of Pharmaceutics 2010 398 1-2 137 145
88. Kanai A., Alba R. M., Takano T., Kobayashi C., Nakajima A., Kurihara K., Yokoyama T., Fukami M., The effect on the cornea of alpha cyclodextrin vehicle for cyclosporin eye drops Transplantation Proceedings 1989 21 1, part 3 3150 3152 (Pubitemid 19124695)
89. Mueller D. W., Improved extemporaneous formulation of cyclosporine ophthalmic drops American Journal of Hospital Pharmacy 1994 51 24 3080 3081
90. Rao S. N., Topical cyclosporine 0.05 for the prevention of dry eye disease progression Journal of Ocular Pharmacology and Therapeutics 2010 26 2 157 164
91. Solch S., Nadler P. I., Silverman M. H., Safety and tolerability of two percent cyclosporine (Sandimmune) ophthalmic ointment in normal volunteers Journal of Ocular Pharmacology 1991 7 4 301 312
92. Sansom J., Barnett K. C., Neumann W., Schulte-Neumann A., Clerc B., Jegou J. P., De Haas V., Weingarten A., Treatment of keratoconjunctivitis sicca in dogs with cyclosporine ophthalmic ointment: a European clinical field trial Veterinary Record 1995 137 20 504 507
93. Muchtar S., Almog S., Torracca M. T., Saettone M. F., Benita S., A submicron emulsion as ocular vehicle for delta-8-tetrahydrocannabinol: effect on intraocular pressure in rabbits Ophthalmic Research 1992 24 3 142 149
94. Naveh N., Muchtar S., Benita S., Pilocarpine incorporated into a submicron emulsion vehicle causes an unexpectedly prolonged ocular hypotensive effect in rabbits Journal of Ocular Pharmacology 1994 10 3 509 520 (Pubitemid 24321149)
95. Lallemand F., Felt-Baeyens O., Besseghir K., Behar-Cohen F., Gurny R., Cyclosporine A delivery to the eye: a pharmaceutical challenge European Journal of Pharmaceutics and Biopharmaceutics 2003 56 3 307 318 (Pubitemid 37346503)
96. Law S. L., Huang K. J., Chiang C. H., Acyclovir-containing liposomes for potential ocular delivery: corneal penetration and absorption Journal of Controlled Release 2000 63 1-2 135 140 (Pubitemid 30046949)
97. Lee S. S., Kim H., Wang N. S., Bungay P. M., Gilger B. C., Yuan P., Kim J., Csaky K. G., Robinson M. R., A pharmacokinetic and safety evaluation of an episcleral cyclosporine implant for potential use in high-risk keratoplasty rejection Investigative Ophthalmology Visual Science 2007 48 5 2023 2029 (Pubitemid 351261270)
98. Bozdag S., Dillen K., Vandervoort J., Ludwig A., The effect of freeze-drying with different cryoprotectants and gamma-irradiation sterilization on the characteristics of ciprofloxacin HCl-loaded poly(D,L-lactide-glycolide) nanoparticles Journal of Pharmacy and Pharmacology 2005 57 6 699 707 (Pubitemid 40694877)
99. Dillen K., Bozdag S., Vandervoort J., Ludwig A., Evaluation of the physicochemical characteristics and activity of various kinds of ciprofloxacin HCl-loaded cationic nanoparticles Journal of Drug Delivery Science and Technology 2007 17 1 49 56 (Pubitemid 46347815)
100. Calvo B., Sanchez A., Martinez J., Lopez M. I., Calonge M., Pastor J. C., Alonso M. J., Polyester nanocapsules as new topical ocular delivery systems for cyclosporin A Pharmaceutical Research 1996 13 2 311 315 (Pubitemid 26074197)
101. Calvo P., Thomas C., Alonso M. J., Vila-Jato J. L., Robinson J. R., Study of the mechanism of interaction of poly( -caprolactone) nanocapsules with the cornea by confocal laser scanning microscopy International Journal of Pharmaceutics 1994 103 3 283 291
102. Le Bourlais C. A., Chevanne F., Turlin B., Acar L., Zia H., Sado P. A., Needham T. E., Leverge R., Effect of cyclosporine A formulations on bovine corneal absorption: ex-vivo study Journal of Microencapsulation 1997 14 4 457 467 (Pubitemid 27313368)
103. de Rojas Silva M. V., Rodrguez-Ares M. T., Snchez-Salorio M., Lamas Daz M. J., Cuevas Alvarez J., Vila Jato J. L., Capeans Tomé C., Efficacy of subconjunctival cyclosporin-containing microspheres on keratoplasty rejection in the rabbit Graefe's Archive for Clinical and Experimental Ophthalmology 1999 237 10 840 847 (Pubitemid 29438466)
104. Cavanak T., Sucker H., Cyclosporin. Formulation of dosage forms Progress in Allergy 1986 38 65 72
105. Besarab A., Jarrell B. E., Hirsch S., Use of the isolated perfused kidney model to assess the acute pharmacologic effects of cyclosporine and its vehicle, cremophor EL Transplantation 1987 44 2 195 201 (Pubitemid 17148072)
106. Freise C. E., Liu T., Hong K., Osorio R. W., Papahadjopoulos D., Ferrell L., Ascher N. L., Roberts J. P., The increased efficacy and decreased nephrotoxicity of a cyclosporine liposome Transplantation 1994 57 6 928 932 (Pubitemid 24114689)