메뉴 건너뛰기




Volumn 5, Issue 1, 2014, Pages 79-98

Na+/H+ Exchangers and Intracellular pH in Perinatal Brain Injury

Author keywords

Birth asphxyia; Brain alkalosis; Hypoxia ischemia; Neonatal encephalopathy; Neuroprotection; NHE blockade

Indexed keywords

SODIUM PROTON EXCHANGE PROTEIN;

EID: 84893764201     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-013-0322-x     Document Type: Article
Times cited : (49)

References (160)
  • 1
    • 77954315863 scopus 로고    scopus 로고
    • Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy
    • doi:10.1016/j.earlhumdev.2010.05.010
    • Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010;86(6): 329-38. doi: 10. 1016/j. earlhumdev. 2010. 05. 010.
    • (2010) Early Hum Dev , vol.86 , Issue.6 , pp. 329-338
    • Kurinczuk, J.J.1    White-Koning, M.2    Badawi, N.3
  • 2
    • 77149149663 scopus 로고    scopus 로고
    • Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data
    • Edwards AD, Brocklehurst P, Gunn AJ, Halliday H, Juszczak E, Levene M, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ. 2010;340: c363.
    • (2010) Bmj , vol.340
    • Edwards, A.D.1    Brocklehurst, P.2    Gunn, A.J.3    Halliday, H.4    Juszczak, E.5    Levene, M.6
  • 3
    • 0028079731 scopus 로고
    • Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy
    • Lorek A, Takei Y, Cady EB, Wyatt JS, Penrice J, Edwards AD, et al. Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1994;36(6): 699-706.
    • (1994) Pediatr Res , vol.36 , Issue.6 , pp. 699-706
    • Lorek, A.1    Takei, Y.2    Cady, E.B.3    Wyatt, J.S.4    Penrice, J.5    Edwards, A.D.6
  • 4
    • 0032797461 scopus 로고    scopus 로고
    • Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy
    • doi:10.1203/00006450-199909000-00007
    • Robertson NJ, Cox IJ, Cowan FM, Counsell SJ, Azzopardi D, Edwards AD. Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res. 1999;46(3): 287-96. doi: 10. 1203/00006450-199909000-00007.
    • (1999) Pediatr Res , vol.46 , Issue.3 , pp. 287-296
    • Robertson, N.J.1    Cox, I.J.2    Cowan, F.M.3    Counsell, S.J.4    Azzopardi, D.5    Edwards, A.D.6
  • 5
    • 0036895240 scopus 로고    scopus 로고
    • Brain alkaline intracellular pH after neonatal encephalopathy
    • doi:10.1002/ana.10365
    • Robertson NJ, Cowan FM, Cox IJ, Edwards AD. Brain alkaline intracellular pH after neonatal encephalopathy. Ann Neurol. 2002;52(6): 732-42. doi: 10. 1002/ana. 10365.
    • (2002) Ann Neurol , vol.52 , Issue.6 , pp. 732-742
    • Robertson, N.J.1    Cowan, F.M.2    Cox, I.J.3    Edwards, A.D.4
  • 6
    • 33745905923 scopus 로고    scopus 로고
    • Follow-up of the term infant after hypoxic-ischemic encephalopathy
    • Robertson CM, Perlman M. Follow-up of the term infant after hypoxic-ischemic encephalopathy. Paediatr child Health. 2006;11(5): 278-82.
    • (2006) Paediatr Child Health , vol.11 , Issue.5 , pp. 278-282
    • Robertson, C.M.1    Perlman, M.2
  • 7
    • 0031801912 scopus 로고    scopus 로고
    • Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short- and long-term outcome
    • doi:10.1203/00006450-199806000-00005
    • Bona E, Hagberg H, Loberg EM, Bagenholm R, Thoresen M. Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short- and long-term outcome. Pediatr Res. 1998;43(6): 738-45. doi: 10. 1203/00006450-199806000-00005.
    • (1998) Pediatr Res , vol.43 , Issue.6 , pp. 738-745
    • Bona, E.1    Hagberg, H.2    Loberg, E.M.3    Bagenholm, R.4    Thoresen, M.5
  • 8
    • 0028910724 scopus 로고
    • Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet
    • doi:10.1203/00006450-199505000-00019
    • Thoresen M, Penrice J, Lorek A, Cady EB, Wylezinska M, Kirkbride V, et al. Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res. 1995;37(5): 667-70. doi: 10. 1203/00006450-199505000-00019.
    • (1995) Pediatr Res , vol.37 , Issue.5 , pp. 667-670
    • Thoresen, M.1    Penrice, J.2    Lorek, A.3    Cady, E.B.4    Wylezinska, M.5    Kirkbride, V.6
  • 9
    • 84893721906 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence. Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury. 2010 Accessed 26 May 2010
    • National Institute for Health and Clinical Excellence. Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury. 2010. http://guidance. nice. org. uk/IPG347/Guidance/pdf/English. Accessed 26 May 2010.
  • 11
    • 13844321255 scopus 로고    scopus 로고
    • Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
    • doi:10.1016/s0140-6736(05)17946-x
    • Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365(9460): 663-70. doi: 10. 1016/s0140-6736(05)17946-x.
    • (2005) Lancet , vol.365 , Issue.9460 , pp. 663-670
    • Gluckman, P.D.1    Wyatt, J.S.2    Azzopardi, D.3    Ballard, R.4    Edwards, A.D.5    Ferriero, D.M.6
  • 12
    • 26444452073 scopus 로고    scopus 로고
    • Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
    • doi:10.1056/NEJMcps050929
    • Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353(15): 1574-84. doi: 10. 1056/NEJMcps050929.
    • (2005) N Engl J Med , vol.353 , Issue.15 , pp. 1574-1584
    • Shankaran, S.1    Laptook, A.R.2    Ehrenkranz, R.A.3    Tyson, J.E.4    McDonald, S.A.5    Donovan, E.F.6
  • 13
    • 70349611684 scopus 로고    scopus 로고
    • Moderate hypothermia to treat perinatal asphyxial encephalopathy
    • doi:10.1056/NEJMoa0900854
    • Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361(14): 1349-58. doi: 10. 1056/NEJMoa0900854.
    • (2009) N Engl J Med , vol.361 , Issue.14 , pp. 1349-1358
    • Azzopardi, D.V.1    Strohm, B.2    Edwards, A.D.3    Dyet, L.4    Halliday, H.L.5    Juszczak, E.6
  • 14
    • 84855910493 scopus 로고    scopus 로고
    • Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy
    • doi:10.1038/pr.2011.30
    • Guillet R, Edwards AD, Thoresen M, Ferriero DM, Gluckman PD, Whitelaw A, et al. Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy. Pediatr Res. 2012;71(2): 205-9. doi: 10. 1038/pr. 2011. 30.
    • (2012) Pediatr Res , vol.71 , Issue.2 , pp. 205-209
    • Guillet, R.1    Edwards, A.D.2    Thoresen, M.3    Ferriero, D.M.4    Gluckman, P.D.5    Whitelaw, A.6
  • 15
    • 77954311938 scopus 로고    scopus 로고
    • Experimental treatments for hypoxic ischaemic encephalopathy
    • doi:10.1016/j.earlhumdev.2010.05.011
    • Kelen D, Robertson NJ. Experimental treatments for hypoxic ischaemic encephalopathy. Early Hum Dev. 2010;86(6): 369-77. doi: 10. 1016/j. earlhumdev. 2010. 05. 011.
    • (2010) Early Hum Dev , vol.86 , Issue.6 , pp. 369-377
    • Kelen, D.1    Robertson, N.J.2
  • 16
    • 33745679668 scopus 로고    scopus 로고
    • MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy
    • Barkovich AJ, Miller SP, Bartha A, Newton N, Hamrick SE, Mukherjee P, et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol. 2006;27(3): 533-47.
    • (2006) AJNR Am J Neuroradiol , vol.27 , Issue.3 , pp. 533-547
    • Barkovich, A.J.1    Miller, S.P.2    Bartha, A.3    Newton, N.4    Hamrick, S.E.5    Mukherjee, P.6
  • 17
    • 0037333201 scopus 로고    scopus 로고
    • Origin and timing of brain lesions in term infants with neonatal encephalopathy
    • doi:10.1016/s0140-6736(03)12658-x
    • Cowan F, Rutherford M, Groenendaal F, Eken P, Mercuri E, Bydder GM, et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet. 2003;361(9359): 736-42. doi: 10. 1016/s0140-6736(03)12658-x.
    • (2003) Lancet , vol.361 , Issue.9359 , pp. 736-742
    • Cowan, F.1    Rutherford, M.2    Groenendaal, F.3    Eken, P.4    Mercuri, E.5    Bydder, G.M.6
  • 18
    • 0001454788 scopus 로고
    • Brain damage in the monkey, Macaca mulatta, by asphyxia neonatorum
    • Ranck Jr JB, Windle WF. Brain damage in the monkey, Macaca mulatta, by asphyxia neonatorum. Exp Neurol. 1959;1(2): 130-54.
    • (1959) Exp Neurol , vol.1 , Issue.2 , pp. 130-154
    • Ranck Jr., J.B.1    Windle, W.F.2
  • 19
    • 0016630108 scopus 로고
    • Central nervous system findings in the newborn monkey following severe in utero partial asphyxia
    • Brann Jr AW, Myers RE. Central nervous system findings in the newborn monkey following severe in utero partial asphyxia. Neurology. 1975;25(4): 327-38.
    • (1975) Neurology , vol.25 , Issue.4 , pp. 327-338
    • Brann Jr., A.W.1    Myers, R.E.2
  • 20
    • 0015507001 scopus 로고
    • Two patterns of perinatal brain damage and their conditions of occurrence
    • Myers RE. Two patterns of perinatal brain damage and their conditions of occurrence. Am J Obstet Gynecol. 1972;112(2): 246-76.
    • (1972) Am J Obstet Gynecol , vol.112 , Issue.2 , pp. 246-276
    • Myers, R.E.1
  • 21
    • 44449092142 scopus 로고    scopus 로고
    • Patterns of brain injury in neonates exposed to perinatal sentinel events
    • doi:10.1542/peds.2007-0770
    • Okereafor A, Allsop J, Counsell SJ, Fitzpatrick J, Azzopardi D, Rutherford MA, et al. Patterns of brain injury in neonates exposed to perinatal sentinel events. Pediatrics. 2008;121(5): 906-14. doi: 10. 1542/peds. 2007-0770.
    • (2008) Pediatrics , vol.121 , Issue.5 , pp. 906-914
    • Okereafor, A.1    Allsop, J.2    Counsell, S.J.3    Fitzpatrick, J.4    Azzopardi, D.5    Rutherford, M.A.6
  • 22
    • 0028037046 scopus 로고
    • Effect of neonatal hypoxia-ischemia on nigro-striatal dopamine receptors and on striatal neuropeptide Y, dynorphin A and substance P concentrations in rats
    • Johnson M, Hanson GR, Gibb JW, Adair J, Filloux F. Effect of neonatal hypoxia-ischemia on nigro-striatal dopamine receptors and on striatal neuropeptide Y, dynorphin A and substance P concentrations in rats. Brain Res Dev Brain Res. 1994;83(1): 109-18.
    • (1994) Brain Res Dev Brain Res , vol.83 , Issue.1 , pp. 109-118
    • Johnson, M.1    Hanson, G.R.2    Gibb, J.W.3    Adair, J.4    Filloux, F.5
  • 23
    • 78049241508 scopus 로고    scopus 로고
    • Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy
    • doi:10.1016/j.earlhumdev.2010.08.013
    • Martinez-Biarge M, Diez-Sebastian J, Rutherford MA, Cowan FM. Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010;86(11): 675-82. doi: 10. 1016/j. earlhumdev. 2010. 08. 013.
    • (2010) Early Hum Dev , vol.86 , Issue.11 , pp. 675-682
    • Martinez-Biarge, M.1    Diez-Sebastian, J.2    Rutherford, M.A.3    Cowan, F.M.4
  • 24
    • 27644499032 scopus 로고    scopus 로고
    • Watershed infarcts in the full term neonatal brain
    • doi:10.1136/adc.2005.073544
    • Groenendaal F, de Vries LS. Watershed infarcts in the full term neonatal brain. Arch Dis Child Fetal Neonatal Ed. 2005;90(6): F488. doi: 10. 1136/adc. 2005. 073544.
    • (2005) Arch Dis Child Fetal Neonatal Ed , vol.90 , Issue.6
    • Groenendaal, F.1    de Vries, L.S.2
  • 25
    • 59449090050 scopus 로고    scopus 로고
    • Comparison of computer tomography and magnetic resonance imaging scans on the third day of life in term newborns with neonatal encephalopathy
    • doi:10.1542/peds.2008-0283
    • Chau V, Poskitt KJ, Sargent MA, Lupton BA, Hill A, Roland E, et al. Comparison of computer tomography and magnetic resonance imaging scans on the third day of life in term newborns with neonatal encephalopathy. Pediatrics. 2009;123(1): 319-26. doi: 10. 1542/peds. 2008-0283.
    • (2009) Pediatrics , vol.123 , Issue.1 , pp. 319-326
    • Chau, V.1    Poskitt, K.J.2    Sargent, M.A.3    Lupton, B.A.4    Hill, A.5    Roland, E.6
  • 26
    • 0030278250 scopus 로고    scopus 로고
    • Hypoxic-ischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome
    • Rutherford M, Pennock J, Schwieso J, Cowan F, Dubowitz L. Hypoxic-ischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome. Arch Dis Child Fetal Neonatal Ed. 1996;75(3): F145-51.
    • (1996) Arch Dis Child Fetal Neonatal Ed , vol.75 , Issue.3
    • Rutherford, M.1    Pennock, J.2    Schwieso, J.3    Cowan, F.4    Dubowitz, L.5
  • 27
    • 48249153830 scopus 로고    scopus 로고
    • Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia
    • doi:10.1542/peds.2007-2822
    • Burns CM, Rutherford MA, Boardman JP, Cowan FM. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia. Pediatrics. 2008;122(1): 65-74. doi: 10. 1542/peds. 2007-2822.
    • (2008) Pediatrics , vol.122 , Issue.1 , pp. 65-74
    • Burns, C.M.1    Rutherford, M.A.2    Boardman, J.P.3    Cowan, F.M.4
  • 28
    • 0036086421 scopus 로고    scopus 로고
    • Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors
    • doi:10.1203/00006450-200207000-00014
    • Miller SP, Newton N, Ferriero DM, Partridge JC, Glidden DV, Barnwell A, et al. Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors. Pediatr Res. 2002;52(1): 71-7. doi: 10. 1203/00006450-200207000-00014.
    • (2002) Pediatr Res , vol.52 , Issue.1 , pp. 71-77
    • Miller, S.P.1    Newton, N.2    Ferriero, D.M.3    Partridge, J.C.4    Glidden, D.V.5    Barnwell, A.6
  • 29
    • 24044548649 scopus 로고    scopus 로고
    • Neuropsychological and educational problems at school age associated with neonatal encephalopathy
    • doi:10.1136/adc.2004.067520
    • Marlow N, Rose AS, Rands CE, Draper ES. Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2005;90(5): F380-7. doi: 10. 1136/adc. 2004. 067520.
    • (2005) Arch Dis Child Fetal Neonatal Ed , vol.90 , Issue.5
    • Marlow, N.1    Rose, A.S.2    Rands, C.E.3    Draper, E.S.4
  • 30
    • 0036823090 scopus 로고    scopus 로고
    • Neurological and perceptual-motor outcome at 5-6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI
    • doi:10.1055/s-2002-36737
    • Barnett A, Mercuri E, Rutherford M, Haataja L, Frisone MF, Henderson S, et al. Neurological and perceptual-motor outcome at 5-6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI. Neuropediatrics. 2002;33(5): 242-8. doi: 10. 1055/s-2002-36737.
    • (2002) Neuropediatrics , vol.33 , Issue.5 , pp. 242-248
    • Barnett, A.1    Mercuri, E.2    Rutherford, M.3    Haataja, L.4    Frisone, M.F.5    Henderson, S.6
  • 31
    • 33750741104 scopus 로고    scopus 로고
    • Does perinatal asphyxia impair cognitive function without cerebral palsy?
    • doi:10.1136/adc.2005.092445
    • Gonzalez FF, Miller SP. Does perinatal asphyxia impair cognitive function without cerebral palsy? Arch Dis Child Fetal Neonatal Ed. 2006;91(6): F454-9. doi: 10. 1136/adc. 2005. 092445.
    • (2006) Arch Dis Child Fetal Neonatal Ed , vol.91 , Issue.6
    • Gonzalez, F.F.1    Miller, S.P.2
  • 33
    • 0024521338 scopus 로고
    • Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy
    • doi:10.1203/00006450-198905000-00004
    • Azzopardi D, Wyatt JS, Cady EB, Delpy DT, Baudin J, Stewart AL, et al. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1989;25(5): 445-51. doi: 10. 1203/00006450-198905000-00004.
    • (1989) Pediatr Res , vol.25 , Issue.5 , pp. 445-451
    • Azzopardi, D.1    Wyatt, J.S.2    Cady, E.B.3    Delpy, D.T.4    Baudin, J.5    Stewart, A.L.6
  • 34
    • 0031026883 scopus 로고    scopus 로고
    • Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain
    • Blumberg RM, Cady EB, Wigglesworth JS, McKenzie JE, Edwards AD. Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain. Exp Brain Res Exp Hirnforsch Exp Cereb. 1997;113(1): 130-7.
    • (1997) Exp Brain Res Exp Hirnforsch Exp Cereb , vol.113 , Issue.1 , pp. 130-137
    • Blumberg, R.M.1    Cady, E.B.2    Wigglesworth, J.S.3    McKenzie, J.E.4    Edwards, A.D.5
  • 35
    • 34249859347 scopus 로고    scopus 로고
    • Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets
    • doi:10.1016/j.brainres.2007.03.083
    • Iwata O, Iwata S, Thornton JS, De Vita E, Bainbridge A, Herbert L, et al. "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res. 2007;1154: 173-80. doi: 10. 1016/j. brainres. 2007. 03. 083.
    • (2007) Brain Res , vol.1154 , pp. 173-180
    • Iwata, O.1    Iwata, S.2    Thornton, J.S.3    De Vita, E.4    Bainbridge, A.5    Herbert, L.6
  • 36
    • 0021165604 scopus 로고
    • Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants
    • Hope PL, Costello AM, Cady EB, Delpy DT, Tofts PS, Chu A, et al. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet. 1984;2(8399): 366-70.
    • (1984) Lancet , vol.2 , Issue.8399 , pp. 366-370
    • Hope, P.L.1    Costello, A.M.2    Cady, E.B.3    Delpy, D.T.4    Tofts, P.S.5    Chu, A.6
  • 37
    • 0030872009 scopus 로고    scopus 로고
    • Early cerebral-metabolite quantification in perinatal hypoxic-ischaemic encephalopathy by proton and phosphorus magnetic resonance spectroscopy
    • Cady EB, Amess P, Penrice J, Wylezinska M, Sams V, Wyatt JS. Early cerebral-metabolite quantification in perinatal hypoxic-ischaemic encephalopathy by proton and phosphorus magnetic resonance spectroscopy. Magn Reson Imaging. 1997;15(5): 605-11.
    • (1997) Magn Reson Imaging , vol.15 , Issue.5 , pp. 605-611
    • Cady, E.B.1    Amess, P.2    Penrice, J.3    Wylezinska, M.4    Sams, V.5    Wyatt, J.S.6
  • 38
    • 0029907291 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of cerebral 31P magnetic resonance spectroscopy in neonates with perinatal asphyxia
    • doi:10.1203/00006450-199611000-00015
    • Martin E, Buchli R, Ritter S, Schmid R, Largo RH, Boltshauser E, et al. Diagnostic and prognostic value of cerebral 31P magnetic resonance spectroscopy in neonates with perinatal asphyxia. Pediatr Res. 1996;40(5): 749-58. doi: 10. 1203/00006450-199611000-00015.
    • (1996) Pediatr Res , vol.40 , Issue.5 , pp. 749-758
    • Martin, E.1    Buchli, R.2    Ritter, S.3    Schmid, R.4    Largo, R.H.5    Boltshauser, E.6
  • 39
    • 0026633564 scopus 로고
    • Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro
    • Urenjak J, Williams SR, Gadian DG, Noble M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem. 1992;59(1): 55-61.
    • (1992) J Neurochem , vol.59 , Issue.1 , pp. 55-61
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 40
    • 76049118074 scopus 로고    scopus 로고
    • Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis
    • doi:10.1542/peds.2009-1046
    • Thayyil S, Chandrasekaran M, Taylor A, Bainbridge A, Cady EB, Chong WK, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics. 2010;125(2): e382-95. doi: 10. 1542/peds. 2009-1046.
    • (2010) Pediatrics , vol.125 , Issue.2
    • Thayyil, S.1    Chandrasekaran, M.2    Taylor, A.3    Bainbridge, A.4    Cady, E.B.5    Chong, W.K.6
  • 41
    • 0015868782 scopus 로고
    • Determination of intracellular pH by 31P magnetic resonance
    • Moon RB, Richards JH. Determination of intracellular pH by 31P magnetic resonance. J Biol Chem. 1973;248(20): 7276-8.
    • (1973) J Biol Chem , vol.248 , Issue.20 , pp. 7276-7278
    • Moon, R.B.1    Richards, J.H.2
  • 43
    • 0023627411 scopus 로고
    • The use of the chemical shift of the phosphomonoester P-31 magnetic resonance peak for the determination of intracellular pH in the brains of neonates
    • Corbett RJ, Laptook AR, Nunnally RL. The use of the chemical shift of the phosphomonoester P-31 magnetic resonance peak for the determination of intracellular pH in the brains of neonates. Neurology. 1987;37(11): 1771-9.
    • (1987) Neurology , vol.37 , Issue.11 , pp. 1771-1779
    • Corbett, R.J.1    Laptook, A.R.2    Nunnally, R.L.3
  • 44
    • 0029058065 scopus 로고
    • Application of the accurate assessment of intracellular magnesium and pH from the 31P shifts of ATP to cerebral hypoxia-ischemia in neonatal rat
    • Williams GD, Smith MB. Application of the accurate assessment of intracellular magnesium and pH from the 31P shifts of ATP to cerebral hypoxia-ischemia in neonatal rat. Magn Reson Med: off J Soc Magn Reson Med/Soc Magn Reson Med. 1995;33(6): 853-7.
    • (1995) Magn Reson Med: Off J Soc Magn Reson Med/Soc Magn Reson Med , vol.33 , Issue.6 , pp. 853-857
    • Williams, G.D.1    Smith, M.B.2
  • 45
    • 72949121897 scopus 로고    scopus 로고
    • Sensors and regulators of intracellular pH
    • doi:10.1038/nrm2820
    • Casey JR, Grinstein S, Orlowski J. Sensors and regulators of intracellular pH. Nat Rev Mol Cell Biol. 2010;11(1): 50-61. doi: 10. 1038/nrm2820.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , Issue.1 , pp. 50-61
    • Casey, J.R.1    Grinstein, S.2    Orlowski, J.3
  • 46
    • 0029834439 scopus 로고    scopus 로고
    • Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture
    • Vornov JJ, Thomas AG, Jo D. Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture. J Neurochem. 1996;67(6): 2379-89.
    • (1996) J Neurochem , vol.67 , Issue.6 , pp. 2379-2389
    • Vornov, J.J.1    Thomas, A.G.2    Jo, D.3
  • 47
    • 0026063083 scopus 로고
    • Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes
    • Bond JM, Herman B, Lemasters JJ. Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes. Biochem Biophys Res Commun. 1991;179(2): 798-803.
    • (1991) Biochem Biophys Res Commun , vol.179 , Issue.2 , pp. 798-803
    • Bond, J.M.1    Herman, B.2    Lemasters, J.J.3
  • 48
    • 0027259172 scopus 로고
    • 2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes
    • 2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes. Am J Physiol. 1993;265(1 Pt 1): C129-37.
    • (1993) Am J Physiol , vol.265 , Issue.1 Pt 1
    • Bond, J.M.1    Chacon, E.2    Herman, B.3    Lemasters, J.J.4
  • 49
    • 0030868479 scopus 로고    scopus 로고
    • The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury
    • Lemasters JJ, Nieminen AL, Qian T, Trost LC, Herman B. The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury. Mol Cell Biochem. 1997;174(1-2): 159-65.
    • (1997) Mol Cell Biochem , vol.174 , Issue.1-2 , pp. 159-165
    • Lemasters, J.J.1    Nieminen, A.L.2    Qian, T.3    Trost, L.C.4    Herman, B.5
  • 50
    • 0025350861 scopus 로고
    • Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
    • doi:10.1038/345347a0
    • Traynelis SF, Cull-Candy SG. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature. 1990;345(6273): 347-50. doi: 10. 1038/345347a0.
    • (1990) Nature , vol.345 , Issue.6273 , pp. 347-350
    • Traynelis, S.F.1    Cull-Candy, S.G.2
  • 51
    • 0026440558 scopus 로고
    • Extracellular alkalinity exacerbates injury of cultured cortical neurons
    • Giffard RG, Weiss JH, Choi DW. Extracellular alkalinity exacerbates injury of cultured cortical neurons. Stroke: J Cereb Circ. 1992;23(12): 1817-21.
    • (1992) Stroke: J Cereb Circ , vol.23 , Issue.12 , pp. 1817-1821
    • Giffard, R.G.1    Weiss, J.H.2    Choi, D.W.3
  • 52
    • 0038121757 scopus 로고    scopus 로고
    • An overview of inhibitors of Na(+)/H(+) exchanger
    • Masereel B, Pochet L, Laeckmann D. An overview of inhibitors of Na(+)/H(+) exchanger. Eur J Med Chem. 2003;38(6): 547-54.
    • (2003) Eur J Med Chem , vol.38 , Issue.6 , pp. 547-554
    • Masereel, B.1    Pochet, L.2    Laeckmann, D.3
  • 54
    • 34249806031 scopus 로고    scopus 로고
    • Role of membrane ion transport proteins in cerebral ischemic damage
    • Kintner DB, Wang Y, Sun D. Role of membrane ion transport proteins in cerebral ischemic damage. Front Biosci: J Virtual Libr. 2007;12: 762-70.
    • (2007) Front Biosci: J Virtual Libr , vol.12 , pp. 762-770
    • Kintner, D.B.1    Wang, Y.2    Sun, D.3
  • 55
    • 40949103035 scopus 로고    scopus 로고
    • + exchanger family, regulates osteoclast differentiation and survival [corrected]
    • doi:10.1016/j.bbrc.2008.01.168
    • + exchanger family, regulates osteoclast differentiation and survival [corrected]. Biochem Biophys Res Commun. 2008;369(2): 320-6. doi: 10. 1016/j. bbrc. 2008. 01. 168.
    • (2008) Biochem Biophys Res Commun , vol.369 , Issue.2 , pp. 320-326
    • Lee, S.H.1    Kim, T.2    Park, E.S.3    Yang, S.4    Jeong, D.5    Choi, Y.6
  • 56
    • 0036083415 scopus 로고    scopus 로고
    • Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria
    • doi:10.1152/ajpcell.00420.2001
    • Brett CL, Wei Y, Donowitz M, Rao R. Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Am J Physiol Cell Physiol. 2002;282(5): C1031-41. doi: 10. 1152/ajpcell. 00420. 2001.
    • (2002) Am J Physiol Cell Physiol , vol.282 , Issue.5
    • Brett, C.L.1    Wei, Y.2    Donowitz, M.3    Rao, R.4
  • 57
    • 1242272754 scopus 로고    scopus 로고
    • Diversity of the mammalian sodium/proton exchanger SLC9 gene family
    • doi:10.1007/s00424-003-1110-3
    • Orlowski J, Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch. 2004;447(5): 549-65. doi: 10. 1007/s00424-003-1110-3.
    • (2004) Pflugers Arch , vol.447 , Issue.5 , pp. 549-565
    • Orlowski, J.1    Grinstein, S.2
  • 58
    • 0031009070 scopus 로고    scopus 로고
    • + exchangers in rat central nervous system
    • + exchangers in rat central nervous system. Neuroscience. 1997;79(2): 591-603.
    • (1997) Neuroscience , vol.79 , Issue.2 , pp. 591-603
    • Ma, E.1    Haddad, G.G.2
  • 59
    • 0035793026 scopus 로고    scopus 로고
    • Sodium-hydrogen exchangers and sodium-bicarbonate co-transporters: ontogeny of protein expression in the rat brain
    • Douglas RM, Schmitt BM, Xia Y, Bevensee MO, Biemesderfer D, Boron WF, et al. Sodium-hydrogen exchangers and sodium-bicarbonate co-transporters: ontogeny of protein expression in the rat brain. Neuroscience. 2001;102(1): 217-28.
    • (2001) Neuroscience , vol.102 , Issue.1 , pp. 217-228
    • Douglas, R.M.1    Schmitt, B.M.2    Xia, Y.3    Bevensee, M.O.4    Biemesderfer, D.5    Boron, W.F.6
  • 60
    • 0024814758 scopus 로고
    • + exchange-deficient mutants
    • + exchange-deficient mutants. Am J Physiol. 1989;257(6 Pt 1): C1158-65.
    • (1989) Am J Physiol. , vol.257 , Issue.6 Pt 1
    • Rotin, D.1    Grinstein, S.2
  • 61
    • 0021894461 scopus 로고
    • + exchanger
    • doi:10.1146/annurev.ph.47.030185.002553
    • + exchanger. Annu Rev Physiol. 1985;47: 545-60. doi: 10. 1146/annurev. ph. 47. 030185. 002553.
    • (1985) Annu Rev Physiol , vol.47 , pp. 545-560
    • Aronson, P.S.1
  • 63
    • 36448993314 scopus 로고    scopus 로고
    • Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A
    • doi:10.1016/j.yjmcc.2007.09.013
    • Haworth RS, Roberts NA, Cuello F, Avkiran M. Regulation of protein kinase D activity in adult myocardium: novel counter-regulatory roles for protein kinase Cepsilon and protein kinase A. J Mol Cell Cardiol. 2007;43(6): 686-95. doi: 10. 1016/j. yjmcc. 2007. 09. 013.
    • (2007) J Mol Cell Cardiol , vol.43 , Issue.6 , pp. 686-695
    • Haworth, R.S.1    Roberts, N.A.2    Cuello, F.3    Avkiran, M.4
  • 64
    • 0034780077 scopus 로고    scopus 로고
    • Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization
    • doi:10.1128/mcb.21.22.7545-7557.2001
    • Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, et al. Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol Cell Biol. 2001;21(22): 7545-57. doi: 10. 1128/mcb. 21. 22. 7545-7557. 2001.
    • (2001) Mol Cell Biol , vol.21 , Issue.22 , pp. 7545-7557
    • Khaled, A.R.1    Moor, A.N.2    Li, A.3    Kim, K.4    Ferris, D.K.5    Muegge, K.6
  • 65
    • 34250378750 scopus 로고    scopus 로고
    • + exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771
    • doi:10.1074/jbc.M611073200
    • + exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771. J Biol Chem. 2007;282(9): 6292-9. doi: 10. 1074/jbc. M611073200.
    • (2007) J Biol Chem , vol.282 , Issue.9 , pp. 6292-6299
    • Malo, M.E.1    Li, L.2    Fliegel, L.3
  • 66
    • 0032541338 scopus 로고    scopus 로고
    • p160ROCK mediates RhoA activation of Na-H exchange
    • doi:10.1093/emboj/17.16.4712
    • Tominaga T, Ishizaki T, Narumiya S, Barber DL. p160ROCK mediates RhoA activation of Na-H exchange. EMBO J. 1998;17(16): 4712-22. doi: 10. 1093/emboj/17. 16. 4712.
    • (1998) EMBO J , vol.17 , Issue.16 , pp. 4712-4722
    • Tominaga, T.1    Ishizaki, T.2    Narumiya, S.3    Barber, D.L.4
  • 67
    • 0035903087 scopus 로고    scopus 로고
    • + exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor
    • doi:10.1074/jbc.M102679200
    • + exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. J Biol Chem. 2001;276(33): 31349-56. doi: 10. 1074/jbc. M102679200.
    • (2001) J Biol Chem , vol.276 , Issue.33 , pp. 31349-31356
    • Yan, W.1    Nehrke, K.2    Choi, J.3    Barber, D.L.4
  • 68
    • 0034834554 scopus 로고    scopus 로고
    • COUP-TFI and COUP-TFII regulate expression of the NHE through a nuclear hormone responsive element with enhancer activity
    • Fernandez-Rachubinski F, Fliegel L. COUP-TFI and COUP-TFII regulate expression of the NHE through a nuclear hormone responsive element with enhancer activity. Eur J Biochem. 2001;268(3): 620-34.
    • (2001) Eur J Biochem , vol.268 , Issue.3 , pp. 620-634
    • Fernandez-Rachubinski, F.1    Fliegel, L.2
  • 69
    • 4143065633 scopus 로고    scopus 로고
    • + exchanger by thyroid hormone
    • doi:10.1016/s0083-6729(04)69009-1
    • + exchanger by thyroid hormone. Vitam Horm. 2004;69: 249-69. doi: 10. 1016/s0083-6729(04)69009-1.
    • (2004) Vitam Horm , vol.69 , pp. 249-269
    • Slepkov, E.1    Fliegel, L.2
  • 70
    • 0034503095 scopus 로고    scopus 로고
    • Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation
    • Denker SP, Huang DC, Orlowski J, Furthmayr H, Barber DL. Direct binding of the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. Mol Cell. 2000;6(6): 1425-36.
    • (2000) Mol Cell , vol.6 , Issue.6 , pp. 1425-1436
    • Denker, S.P.1    Huang, D.C.2    Orlowski, J.3    Furthmayr, H.4    Barber, D.L.5
  • 71
    • 34250683573 scopus 로고    scopus 로고
    • Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1
    • doi:10.1097/MNH.0b013e3281bd888d
    • Meima ME, Mackley JR, Barber DL. Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1. Curr Opin Nephrol Hypertens. 2007;16(4): 365-72. doi: 10. 1097/MNH. 0b013e3281bd888d.
    • (2007) Curr Opin Nephrol Hypertens , vol.16 , Issue.4 , pp. 365-372
    • Meima, M.E.1    Mackley, J.R.2    Barber, D.L.3
  • 72
    • 0037164808 scopus 로고    scopus 로고
    • Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
    • doi:10.1083/jcb.200208050
    • Denker SP, Barber DL. Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol. 2002;159(6): 1087-96. doi: 10. 1083/jcb. 200208050.
    • (2002) J Cell Biol , vol.159 , Issue.6 , pp. 1087-1096
    • Denker, S.P.1    Barber, D.L.2
  • 73
    • 33744832157 scopus 로고    scopus 로고
    • Role of the Na/H exchanger NHE1 in cell migration
    • doi:10.1111/j.1748-1716.2006.01543.x
    • Stock C, Schwab A. Role of the Na/H exchanger NHE1 in cell migration. Acta Physiol (Oxf). 2006;187(1-2): 149-57. doi: 10. 1111/j. 1748-1716. 2006. 01543. x.
    • (2006) Acta Physiol (Oxf) , vol.187 , Issue.1-2 , pp. 149-157
    • Stock, C.1    Schwab, A.2
  • 75
    • 18544363096 scopus 로고    scopus 로고
    • A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis
    • doi:10.1083/jcb.200412145
    • Patel H, Barber DL. A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis. J Cell Biol. 2005;169(2): 321-9. doi: 10. 1083/jcb. 200412145.
    • (2005) J Cell Biol , vol.169 , Issue.2 , pp. 321-329
    • Patel, H.1    Barber, D.L.2
  • 76
    • 0028100685 scopus 로고
    • + exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation
    • + exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation. J Biol Chem. 1994;269(38): 23544-52.
    • (1994) J Biol Chem , vol.269 , Issue.38 , pp. 23544-23552
    • Kapus, A.1    Grinstein, S.2    Wasan, S.3    Kandasamy, R.4    Orlowski, J.5
  • 77
    • 0026587013 scopus 로고
    • Transmembrane receptors and intracellular pathways that control cell proliferation
    • doi:10.1146/annurev.ph.54.030192.001211
    • Pouyssegur J, Seuwen K. Transmembrane receptors and intracellular pathways that control cell proliferation. Annu Rev Physiol. 1992;54: 195-210. doi: 10. 1146/annurev. ph. 54. 030192. 001211.
    • (1992) Annu Rev Physiol , vol.54 , pp. 195-210
    • Pouyssegur, J.1    Seuwen, K.2
  • 78
    • 0242582266 scopus 로고    scopus 로고
    • Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition
    • doi:10.1074/jbc.M308099200
    • Putney LK, Barber DL. Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J Biol Chem. 2003;278(45): 44645-9. doi: 10. 1074/jbc. M308099200.
    • (2003) J Biol Chem , vol.278 , Issue.45 , pp. 44645-44649
    • Putney, L.K.1    Barber, D.L.2
  • 79
    • 0022626884 scopus 로고
    • Calcium and ischemic injury
    • doi:10.1056/nejm198606263142604
    • Cheung JY, Bonventre JV, Malis CD, Leaf A. Calcium and ischemic injury. N Engl J Med. 1986;314(26): 1670-6. doi: 10. 1056/nejm198606263142604.
    • (1986) N Engl J Med , vol.314 , Issue.26 , pp. 1670-1676
    • Cheung, J.Y.1    Bonventre, J.V.2    Malis, C.D.3    Leaf, A.4
  • 80
    • 0026777223 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology
    • doi:10.3171/jns.1992.77.2.0169
    • Siesjo BK. Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg. 1992;77(2): 169-84. doi: 10. 3171/jns. 1992. 77. 2. 0169.
    • (1992) J Neurosurg , vol.77 , Issue.2 , pp. 169-184
    • Siesjo, B.K.1
  • 82
    • 40949088992 scopus 로고    scopus 로고
    • Regulation of pH in the mammalian central nervous system under normal and pathological conditions: facts and hypotheses
    • doi:10.1016/j.neuint.2007.10.015
    • Obara M, Szeliga M, Albrecht J. Regulation of pH in the mammalian central nervous system under normal and pathological conditions: facts and hypotheses. Neurochem Int. 2008;52(6): 905-19. doi: 10. 1016/j. neuint. 2007. 10. 015.
    • (2008) Neurochem Int , vol.52 , Issue.6 , pp. 905-919
    • Obara, M.1    Szeliga, M.2    Albrecht, J.3
  • 83
    • 0036083038 scopus 로고    scopus 로고
    • Intracellular pH response to anoxia in acutely dissociated adult rat hippocampal CA1 neurons
    • Sheldon C, Church J. Intracellular pH response to anoxia in acutely dissociated adult rat hippocampal CA1 neurons. J Neurophys. 2002;87(5): 2209-24.
    • (2002) J Neurophys , vol.87 , Issue.5 , pp. 2209-2224
    • Sheldon, C.1    Church, J.2
  • 84
    • 47349123481 scopus 로고    scopus 로고
    • + exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia
    • doi:10.1016/j.expneurol.2008.04.007
    • + exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia. Exp Neurol. 2008;212(2): 314-23. doi: 10. 1016/j. expneurol. 2008. 04. 007.
    • (2008) Exp Neurol , vol.212 , Issue.2 , pp. 314-323
    • Hwang, I.K.1    Yoo, K.Y.2    An, S.J.3    Li, H.4    Lee, C.H.5    Choi, J.H.6
  • 85
    • 70449638079 scopus 로고    scopus 로고
    • pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats
    • doi:10.1152/ajpregu.91038.2008
    • Kersh AE, Hartzler LK, Havlin K, Hubbell BB, Nanagas V, Kalra A, et al. pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats. Am J Physiol Regul Integr Comp Physiol. 2009;297(5): R1409-20. doi: 10. 1152/ajpregu. 91038. 2008.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297 , Issue.5
    • Kersh, A.E.1    Hartzler, L.K.2    Havlin, K.3    Hubbell, B.B.4    Nanagas, V.5    Kalra, A.6
  • 86
    • 0032751764 scopus 로고    scopus 로고
    • The course of circulatory and cerebral recovery after circulatory arrest: influence of pre-arrest, arrest and post-arrest factors
    • Jorgensen EO, Holm S. The course of circulatory and cerebral recovery after circulatory arrest: influence of pre-arrest, arrest and post-arrest factors. Resuscitation. 1999;42(3): 173-82.
    • (1999) Resuscitation , vol.42 , Issue.3 , pp. 173-182
    • Jorgensen, E.O.1    Holm, S.2
  • 87
    • 30544436513 scopus 로고    scopus 로고
    • + exchanger isoform 1-null mice after in vitro and in vivo ischemia
    • doi:10.1523/jneurosci.3271-05.2005
    • + exchanger isoform 1-null mice after in vitro and in vivo ischemia. J Neurosci. 2005;25(49): 11256-68. doi: 10. 1523/jneurosci. 3271-05. 2005.
    • (2005) J Neurosci , vol.25 , Issue.49 , pp. 11256-11268
    • Luo, J.1    Chen, H.2    Kintner, D.B.3    Shull, G.E.4    Sun, D.5
  • 88
    • 0346095481 scopus 로고    scopus 로고
    • + exchanger inhibitor, SM-20220, is protective against excitotoxicity in cultured cortical neurons
    • doi:10.1161/01.str.0000106910.42815.c2
    • + exchanger inhibitor, SM-20220, is protective against excitotoxicity in cultured cortical neurons. Stroke: J Cereb Circ. 2004;35(1): 185-90. doi: 10. 1161/01. str. 0000106910. 42815. c2.
    • (2004) Stroke: J Cereb Circ , vol.35 , Issue.1 , pp. 185-190
    • Matsumoto, Y.1    Yamamoto, S.2    Suzuki, Y.3    Tsuboi, T.4    Terakawa, S.5    Ohashi, N.6
  • 89
    • 23244450438 scopus 로고    scopus 로고
    • Hypothermia and amiloride preserve energetics in a neonatal brain slice model
    • doi:10.1203/01.pdr.0000170899.90479.1e
    • Robertson NJ, Bhakoo K, Puri BK, Edwards AD, Cox IJ. Hypothermia and amiloride preserve energetics in a neonatal brain slice model. Pediatr Res. 2005;58(2): 288-96. doi: 10. 1203/01. pdr. 0000170899. 90479. 1e.
    • (2005) Pediatr Res , vol.58 , Issue.2 , pp. 288-296
    • Robertson, N.J.1    Bhakoo, K.2    Puri, B.K.3    Edwards, A.D.4    Cox, I.J.5
  • 91
    • 0034785768 scopus 로고    scopus 로고
    • Role of Na(+)/H(+) exchanger during O(2) deprivation in mouse CA1 neurons
    • Yao H, Gu XQ, Douglas RM, Haddad GG. Role of Na(+)/H(+) exchanger during O(2) deprivation in mouse CA1 neurons. Am J Physiol Cell Physiol. 2001;281(4): C1205-10.
    • (2001) Am J Physiol Cell Physiol , vol.281 , Issue.4
    • Yao, H.1    Gu, X.Q.2    Douglas, R.M.3    Haddad, G.G.4
  • 92
    • 25444486418 scopus 로고    scopus 로고
    • + exchange activity in response to in vitro ischemia depends in part on activation of ERK1/2
    • doi:10.1152/ajpcell.00092.2005
    • + exchange activity in response to in vitro ischemia depends in part on activation of ERK1/2. Am J Physiol Cell Physiol. 2005;289(4): C934-45. doi: 10. 1152/ajpcell. 00092. 2005.
    • (2005) Am J Physiol Cell Physiol , vol.289 , Issue.4
    • Kintner, D.B.1    Look, A.2    Shull, G.E.3    Sun, D.4
  • 93
    • 33646679415 scopus 로고    scopus 로고
    • N-methyl-isobutyl-amiloride ameliorates brain injury when commenced before hypoxia ischemia in neonatal mice
    • doi:10.1203/01.pdr.0000196805.68082.22
    • Kendall GS, Robertson NJ, Iwata O, Peebles D, Raivich G. N-methyl-isobutyl-amiloride ameliorates brain injury when commenced before hypoxia ischemia in neonatal mice. Pediatr Res. 2006;59(2): 227-31. doi: 10. 1203/01. pdr. 0000196805. 68082. 22.
    • (2006) Pediatr Res , vol.59 , Issue.2 , pp. 227-231
    • Kendall, G.S.1    Robertson, N.J.2    Iwata, O.3    Peebles, D.4    Raivich, G.5
  • 94
    • 0032714556 scopus 로고    scopus 로고
    • Cerebroprotective properties of SM-20220, a potent Na(+)/H(+) exchange inhibitor, in transient cerebral ischemia in rats
    • Kuribayashi Y, Itoh N, Kitano M, Ohashi N. Cerebroprotective properties of SM-20220, a potent Na(+)/H(+) exchange inhibitor, in transient cerebral ischemia in rats. Eur J Pharmacol. 1999;383(2): 163-8.
    • (1999) Eur J Pharmacol , vol.383 , Issue.2 , pp. 163-168
    • Kuribayashi, Y.1    Itoh, N.2    Kitano, M.3    Ohashi, N.4
  • 96
    • 0037449475 scopus 로고    scopus 로고
    • Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects
    • Touret N, Tanneur V, Godart H, Seidler R, Taki N, Burger E, et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 2003;459(2-3): 151-8.
    • (2003) Eur J Pharmacol , vol.459 , Issue.2-3 , pp. 151-158
    • Touret, N.1    Tanneur, V.2    Godart, H.3    Seidler, R.4    Taki, N.5    Burger, E.6
  • 97
    • 27444435312 scopus 로고    scopus 로고
    • + exchanger inhibitor, on neuronal cell death and brain ischemia
    • doi:10.1016/j.brainres.2005.09.002
    • + exchanger inhibitor, on neuronal cell death and brain ischemia. Brain Res. 2005;1061(1): 67-71. doi: 10. 1016/j. brainres. 2005. 09. 002.
    • (2005) Brain Res , vol.1061 , Issue.1 , pp. 67-71
    • Park, H.S.1    Lee, B.K.2    Park, S.3    Kim, S.U.4    Lee, S.H.5    Baik, E.J.6
  • 98
    • 0037008460 scopus 로고    scopus 로고
    • SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model
    • Suzuki Y, Matsumoto Y, Ikeda Y, Kondo K, Ohashi N, Umemura K. SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res. 2002;945(2): 242-8.
    • (2002) Brain Res , vol.945 , Issue.2 , pp. 242-248
    • Suzuki, Y.1    Matsumoto, Y.2    Ikeda, Y.3    Kondo, K.4    Ohashi, N.5    Umemura, K.6
  • 99
    • 0034900475 scopus 로고    scopus 로고
    • The Na(+)/H(+) exchanger SM-20220 attenuates ischemic injury in in vitro and in vivo models
    • Horikawa N, Nishioka M, Itoh N, Kuribayashi Y, Matsui K, Ohashi N. The Na(+)/H(+) exchanger SM-20220 attenuates ischemic injury in in vitro and in vivo models. Pharmacology. 2001;63(2): 76-81.
    • (2001) Pharmacology , vol.63 , Issue.2 , pp. 76-81
    • Horikawa, N.1    Nishioka, M.2    Itoh, N.3    Kuribayashi, Y.4    Matsui, K.5    Ohashi, N.6
  • 101
    • 80052647286 scopus 로고    scopus 로고
    • Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains
    • doi:10.1111/j.1471-4159.2011.07403.x
    • Shi Y, Chanana V, Watters JJ, Ferrazzano P, Sun D. Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains. J Neurochem. 2011;119(1): 124-35. doi: 10. 1111/j. 1471-4159. 2011. 07403. x.
    • (2011) J Neurochem , vol.119 , Issue.1 , pp. 124-135
    • Shi, Y.1    Chanana, V.2    Watters, J.J.3    Ferrazzano, P.4    Sun, D.5
  • 103
    • 0035870524 scopus 로고    scopus 로고
    • Rapid astrocyte death induced by transient hypoxia, acidosis, and extracellular ion shifts
    • Bondarenko A, Chesler M. Rapid astrocyte death induced by transient hypoxia, acidosis, and extracellular ion shifts. Glia. 2001;34(2): 134-42.
    • (2001) Glia , vol.34 , Issue.2 , pp. 134-142
    • Bondarenko, A.1    Chesler, M.2
  • 104
    • 11144298043 scopus 로고    scopus 로고
    • 2+ exchange in hypoxia-related acute astrocyte death
    • doi:10.1002/glia.20107
    • 2+ exchange in hypoxia-related acute astrocyte death. Glia. 2005;49(1): 143-52. doi: 10. 1002/glia. 20107.
    • (2005) Glia , vol.49 , Issue.1 , pp. 143-152
    • Bondarenko, A.1    Svichar, N.2    Chesler, M.3
  • 105
    • 0027090461 scopus 로고
    • The regulation of intracellular pH in cultured astrocytes and neuroblastoma cells, and its dependence on extracellular pH in a HCO3-free solution
    • Mellergard PE, Ouyang YB, Siesjo BK. The regulation of intracellular pH in cultured astrocytes and neuroblastoma cells, and its dependence on extracellular pH in a HCO3-free solution. Can J Physiol Pharmacol. 1992;70(Suppl): S293-300.
    • (1992) Can J Physiol Pharmacol , vol.70 , Issue.SUPPL.
    • Mellergard, P.E.1    Ouyang, Y.B.2    Siesjo, B.K.3
  • 106
    • 13244296850 scopus 로고    scopus 로고
    • + exchange inhibition prior to 90 minutes of hypothermic circulatory arrest
    • discussion -54, doi:10.1016/j.athoracsur.2004.07.007
    • + exchange inhibition prior to 90 minutes of hypothermic circulatory arrest. Ann Thorac Surg. 2005;79(2): 646-54. doi: 10. 1016/j. athoracsur. 2004. 07. 007. discussion -54.
    • (2005) Ann Thorac Surg , vol.79 , Issue.2 , pp. 646-654
    • Castella, M.1    Buckberg, G.D.2    Tan, Z.3
  • 107
    • 0034711584 scopus 로고    scopus 로고
    • Inhibition of Na(+)/H(+) exchange by 5-(N-ethyl-N-isopropyl)-amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex
    • Phillis JW, Ren J, O'Regan MH. Inhibition of Na(+)/H(+) exchange by 5-(N-ethyl-N-isopropyl)-amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex. Brain Res. 2000;884(1-2): 155-62.
    • (2000) Brain Res , vol.884 , Issue.1-2 , pp. 155-162
    • Phillis, J.W.1    Ren, J.2    O'Regan, M.H.3
  • 108
    • 0023785022 scopus 로고
    • Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus
    • 28
    • Gerhardt SC, Boast CA. Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus. Behav Neurosci. 1988;102(2): 301-3. 28.
    • (1988) Behav Neurosci , vol.102 , Issue.2 , pp. 301-303
    • Gerhardt, S.C.1    Boast, C.A.2
  • 109
    • 0034004176 scopus 로고    scopus 로고
    • + exchange inhibitor, improves consciousness recovery and neurological outcome following transient cerebral ischaemia in gerbils
    • + exchange inhibitor, improves consciousness recovery and neurological outcome following transient cerebral ischaemia in gerbils. J Pharm Pharmacol. 2000;52(4): 441-4.
    • (2000) J Pharm Pharmacol , vol.52 , Issue.4 , pp. 441-444
    • Kuribayashi, Y.1    Itoh, N.2    Horikawa, N.3    Ohashi, N.4
  • 110
    • 0035929513 scopus 로고    scopus 로고
    • Inhibition of Na(+)/H(+) exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury
    • Pilitsis JG, Diaz FG, O'Regan MH, Phillis JW. Inhibition of Na(+)/H(+) exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Brain Res. 2001;913(2): 156-8.
    • (2001) Brain Res , vol.913 , Issue.2 , pp. 156-158
    • Pilitsis, J.G.1    Diaz, F.G.2    O'Regan, M.H.3    Phillis, J.W.4
  • 111
    • 84874108321 scopus 로고    scopus 로고
    • Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model
    • doi:10.1111/jnc.12097
    • Robertson NJ, Kato T, Bainbridge A, Chandrasekaran M, Iwata O, Kapetanakis A, et al. Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. J Neurochem. 2013;124(5): 645-57. doi: 10. 1111/jnc. 12097.
    • (2013) J Neurochem , vol.124 , Issue.5 , pp. 645-657
    • Robertson, N.J.1    Kato, T.2    Bainbridge, A.3    Chandrasekaran, M.4    Iwata, O.5    Kapetanakis, A.6
  • 112
    • 76049118313 scopus 로고    scopus 로고
    • Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial
    • doi:10.1542/peds.2009-0136
    • van Rooij LG, Toet MC, van Huffelen AC, Groenendaal F, Laan W, Zecic A, et al. Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial. Pediatrics. 2010;125(2): e358-66. doi: 10. 1542/peds. 2009-0136.
    • (2010) Pediatrics , vol.125 , Issue.2
    • van Rooij, L.G.1    Toet, M.C.2    van Huffelen, A.C.3    Groenendaal, F.4    Laan, W.5    Zecic, A.6
  • 113
    • 0033841360 scopus 로고    scopus 로고
    • Electrographic seizures in neonates correlate with poor neurodevelopmental outcome
    • McBride MC, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology. 2000;55(4): 506-13.
    • (2000) Neurology , vol.55 , Issue.4 , pp. 506-513
    • McBride, M.C.1    Laroia, N.2    Guillet, R.3
  • 114
    • 0037453267 scopus 로고    scopus 로고
    • Cerebral impedance and neurological outcome following a mild or severe hypoxic/ischemic episode in neonatal piglets
    • Lingwood BE, Dunster KR, Healy GN, Ward LC, Colditz PB. Cerebral impedance and neurological outcome following a mild or severe hypoxic/ischemic episode in neonatal piglets. Brain Res. 2003;969(1-2): 160-7.
    • (2003) Brain Res , vol.969 , Issue.1-2 , pp. 160-167
    • Lingwood, B.E.1    Dunster, K.R.2    Healy, G.N.3    Ward, L.C.4    Colditz, P.B.5
  • 115
    • 23844485506 scopus 로고    scopus 로고
    • Oxidative and nitrative injury in periventricular leukomalacia: a review
    • Zurich, Switzerland
    • Haynes RL, Baud O, Li J, Kinney HC, Volpe JJ, Folkerth DR. Oxidative and nitrative injury in periventricular leukomalacia: a review. Brain Pathol. 2005;15(3): 225-33. Zurich, Switzerland.
    • (2005) Brain Pathol , vol.15 , Issue.3 , pp. 225-233
    • Haynes, R.L.1    Baud, O.2    Li, J.3    Kinney, H.C.4    Volpe, J.J.5    Folkerth, D.R.6
  • 116
    • 35148821932 scopus 로고    scopus 로고
    • Neonatal seizures
    • doi:10.1002/ana.21167
    • Silverstein FS, Jensen FE. Neonatal seizures. Ann Neurol. 2007;62(2): 112-20. doi: 10. 1002/ana. 21167.
    • (2007) Ann Neurol , vol.62 , Issue.2 , pp. 112-120
    • Silverstein, F.S.1    Jensen, F.E.2
  • 117
    • 43049117128 scopus 로고    scopus 로고
    • Moderate neonatal encephalopathy: pre- and perinatal risk factors and long-term outcome
    • doi:10.1080/00016340801996622
    • Lindstrom K, Hallberg B, Blennow M, Wolff K, Fernell E, Westgren M. Moderate neonatal encephalopathy: pre- and perinatal risk factors and long-term outcome. Acta Obstet Gynecol Scand. 2008;87(5): 503-9. doi: 10. 1080/00016340801996622.
    • (2008) Acta Obstet Gynecol Scand , vol.87 , Issue.5 , pp. 503-509
    • Lindstrom, K.1    Hallberg, B.2    Blennow, M.3    Wolff, K.4    Fernell, E.5    Westgren, M.6
  • 118
    • 74449093727 scopus 로고    scopus 로고
    • Seizures are associated with brain injury severity in a neonatal model of hypoxia-ischemia
    • doi:10.1016/j.neuroscience.2009.11.067
    • Bjorkman ST, Miller SM, Rose SE, Burke C, Colditz PB. Seizures are associated with brain injury severity in a neonatal model of hypoxia-ischemia. Neuroscience. 2010;166(1): 157-67. doi: 10. 1016/j. neuroscience. 2009. 11. 067.
    • (2010) Neuroscience , vol.166 , Issue.1 , pp. 157-167
    • Bjorkman, S.T.1    Miller, S.M.2    Rose, S.E.3    Burke, C.4    Colditz, P.B.5
  • 119
    • 84870175374 scopus 로고    scopus 로고
    • The long and the short of it: gene and environment interactions during early cortical development and consequences for long-term neurological disease
    • doi:10.3389/fpsyt.2012.00050
    • Stolp H, Neuhaus A, Sundramoorthi R, Molnar Z. The long and the short of it: gene and environment interactions during early cortical development and consequences for long-term neurological disease. Front Psychiatry. 2012;3: 50. doi: 10. 3389/fpsyt. 2012. 00050.
    • (2012) Front Psychiatry , vol.3 , pp. 50
    • Stolp, H.1    Neuhaus, A.2    Sundramoorthi, R.3    Molnar, Z.4
  • 120
    • 84880646653 scopus 로고    scopus 로고
    • Outcome following neonatal seizures
    • doi:10.1016/j.siny.2013.01.002
    • Uria-Avellanal C, Marlow N, Rennie JM. Outcome following neonatal seizures. Semin Fetal Neonatal Med. 2013;18(4): 224-32. doi: 10. 1016/j. siny. 2013. 01. 002.
    • (2013) Semin Fetal Neonatal Med , vol.18 , Issue.4 , pp. 224-232
    • Uria-Avellanal, C.1    Marlow, N.2    Rennie, J.M.3
  • 121
    • 0037396871 scopus 로고    scopus 로고
    • Neonatal seizures and their treatment
    • doi:10.1097/01.wco.0000063768.15877.23
    • Rennie JM, Boylan GB. Neonatal seizures and their treatment. Curr Opin Neurol. 2003;16(2): 177-81. doi: 10. 1097/01. wco. 0000063768. 15877. 23.
    • (2003) Curr Opin Neurol , vol.16 , Issue.2 , pp. 177-181
    • Rennie, J.M.1    Boylan, G.B.2
  • 122
    • 43649089599 scopus 로고    scopus 로고
    • Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia
    • CD001240, doi:10.1002/14651858.CD001240.pub2
    • Evans DJ, Levene MI, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane database Syst Rev. 2007;3, CD001240. doi: 10. 1002/14651858. CD001240. pub2.
    • (2007) Cochrane Database Syst Rev , vol.3
    • Evans, D.J.1    Levene, M.I.2    Tsakmakis, M.3
  • 123
    • 33947241483 scopus 로고    scopus 로고
    • Treatment of neonatal seizures
    • doi:10.1136/adc.2004.068551
    • Rennie J, Boylan G. Treatment of neonatal seizures. Arch Dis Child Fetal Neonatal Ed. 2007;92(2): F148-50. doi: 10. 1136/adc. 2004. 068551.
    • (2007) Arch Dis Child Fetal Neonatal Ed , vol.92 , Issue.2
    • Rennie, J.1    Boylan, G.2
  • 126
    • 69249216499 scopus 로고    scopus 로고
    • Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury
    • doi:10.1016/j.jpeds.2009.03.040
    • Glass HC, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM, Miller SP. Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury. J Pediatr. 2009;155(3): 318-23. doi: 10. 1016/j. jpeds. 2009. 03. 040.
    • (2009) J Pediatr , vol.155 , Issue.3 , pp. 318-323
    • Glass, H.C.1    Glidden, D.2    Jeremy, R.J.3    Barkovich, A.J.4    Ferriero, D.M.5    Miller, S.P.6
  • 127
    • 79952637126 scopus 로고    scopus 로고
    • Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial
    • doi:10.1177/0883073810380915
    • Kwon JM, Guillet R, Shankaran S, Laptook AR, McDonald SA, Ehrenkranz RA, et al. Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial. J Child Neurol. 2011;26(3): 322-8. doi: 10. 1177/0883073810380915.
    • (2011) J Child Neurol , vol.26 , Issue.3 , pp. 322-328
    • Kwon, J.M.1    Guillet, R.2    Shankaran, S.3    Laptook, A.R.4    McDonald, S.A.5    Ehrenkranz, R.A.6
  • 128
    • 84870190971 scopus 로고    scopus 로고
    • Relationship between perinatal factors and neurologic outcome
    • American Academy of PediatricsAmerican College of Obstetricians and Gynecologists, R. Poland and R. Freeman (Eds.), Elk Grove Village: American Academy of Pediatrics
    • Poland R, Freeman R, American Academy of Pediatrics, American College of Obstetricians and Gynecologists. Relationship between perinatal factors and neurologic outcome. In: Poland R, Freeman R, editors. Guidelines for perinatal care. Elk Grove Village: American Academy of Pediatrics; 2002.
    • (2002) Guidelines for Perinatal Care
    • Poland, R.1    Freeman, R.2
  • 129
    • 3442899906 scopus 로고    scopus 로고
    • Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia
    • Salhab WA, Wyckoff MH, Laptook AR, Perlman JM. Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia. Pediatrics. 2004;114(2): 361-6.
    • (2004) Pediatrics , vol.114 , Issue.2 , pp. 361-366
    • Salhab, W.A.1    Wyckoff, M.H.2    Laptook, A.R.3    Perlman, J.M.4
  • 130
    • 6944239041 scopus 로고    scopus 로고
    • Hypoxic-ischemic brain injury in the term infant-current concepts
    • doi:10.1016/j.earlhumdev.2004.06.003
    • Shalak L, Perlman JM. Hypoxic-ischemic brain injury in the term infant-current concepts. Early Hum Dev. 2004;80(2): 125-41. doi: 10. 1016/j. earlhumdev. 2004. 06. 003.
    • (2004) Early Hum Dev , vol.80 , Issue.2 , pp. 125-141
    • Shalak, L.1    Perlman, J.M.2
  • 131
    • 0019842691 scopus 로고
    • Cell damage in the brain: a speculative synthesis
    • doi:10.1038/jcbfm.1981.18
    • Siesjo BK. Cell damage in the brain: a speculative synthesis. J Cereb Blood Flow Metab. 1981;1(2): 155-85. doi: 10. 1038/jcbfm. 1981. 18.
    • (1981) J Cereb Blood Flow Metab , vol.1 , Issue.2 , pp. 155-185
    • Siesjo, B.K.1
  • 132
    • 0025320647 scopus 로고
    • The regulation and modulation of pH in the nervous system
    • Chesler M. The regulation and modulation of pH in the nervous system. Prog Neurobiol. 1990;34(5): 401-27.
    • (1990) Prog Neurobiol , vol.34 , Issue.5 , pp. 401-427
    • Chesler, M.1
  • 133
    • 0028173658 scopus 로고
    • Ionic basis of GABAA receptor channel function in the nervous system
    • Kaila K. Ionic basis of GABAA receptor channel function in the nervous system. Prog Neurobiol. 1994;42(4): 489-537.
    • (1994) Prog Neurobiol , vol.42 , Issue.4 , pp. 489-537
    • Kaila, K.1
  • 134
    • 0030055563 scopus 로고    scopus 로고
    • 2+ currents in isolated rat CA1 neurons
    • 2+ currents in isolated rat CA1 neurons. J Physiol. 1996;493(Pt 3): 719-32.
    • (1996) J Physiol , vol.493 , Issue.Pt 3 , pp. 719-732
    • Tombaugh, G.C.1    Somjen, G.G.2
  • 135
    • 0028818539 scopus 로고
    • The effect of pH on glycolysis and phosphofructokinase activity in cultured cells and synaptosomes
    • Erecinska M, Deas J, Silver IA. The effect of pH on glycolysis and phosphofructokinase activity in cultured cells and synaptosomes. J Neurochem. 1995;65(6): 2765-72.
    • (1995) J Neurochem , vol.65 , Issue.6 , pp. 2765-2772
    • Erecinska, M.1    Deas, J.2    Silver, I.A.3
  • 136
    • 0019256564 scopus 로고
    • Excessive cellular acidosis: an important mechanism of neuronal damage in the brain?
    • doi:10.1111/j.1748-1716.1980.tb06692.x
    • Rehncrona S, Rosen I, Siesjo BK. Excessive cellular acidosis: an important mechanism of neuronal damage in the brain? Acta Physiol Scand. 1980;110(4): 435-7. doi: 10. 1111/j. 1748-1716. 1980. tb06692. x.
    • (1980) Acta Physiol Scand , vol.110 , Issue.4 , pp. 435-437
    • Rehncrona, S.1    Rosen, I.2    Siesjo, B.K.3
  • 137
    • 78449251558 scopus 로고    scopus 로고
    • Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism
    • doi:10.1523/jneurosci.3355-10.2010
    • Ruusuvuori E, Kirilkin I, Pandya N, Kaila K. Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism. J Neurosci. 2010;30(46): 15638-42. doi: 10. 1523/jneurosci. 3355-10. 2010.
    • (2010) J Neurosci , vol.30 , Issue.46 , pp. 15638-15642
    • Ruusuvuori, E.1    Kirilkin, I.2    Pandya, N.3    Kaila, K.4
  • 138
    • 79953291955 scopus 로고    scopus 로고
    • Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy
    • doi:10.1002/ana.22223
    • Helmy MM, Tolner EA, Vanhatalo S, Voipio J, Kaila K. Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy. Ann Neurol. 2011;69(3): 493-500. doi: 10. 1002/ana. 22223.
    • (2011) Ann Neurol , vol.69 , Issue.3 , pp. 493-500
    • Helmy, M.M.1    Tolner, E.A.2    Vanhatalo, S.3    Voipio, J.4    Kaila, K.5
  • 140
    • 0031037685 scopus 로고    scopus 로고
    • 2+ currents in isolated rat CA1 neurons
    • 2+ currents in isolated rat CA1 neurons. J Neurophys. 1997;77(2): 639-53.
    • (1997) J Neurophys , vol.77 , Issue.2 , pp. 639-653
    • Tombaugh, G.C.1    Somjen, G.G.2
  • 141
    • 0030799957 scopus 로고    scopus 로고
    • Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study
    • Towfighi J, Mauger D, Vannucci RC, Vannucci SJ. Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. Brain Res Dev Brain Res. 1997;100(2): 149-60.
    • (1997) Brain Res Dev Brain Res , vol.100 , Issue.2 , pp. 149-160
    • Towfighi, J.1    Mauger, D.2    Vannucci, R.C.3    Vannucci, S.J.4
  • 142
    • 0027742942 scopus 로고
    • Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury
    • Simon RP, Niro M, Gwinn R. Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury. J Pharmacol Exp Ther. 1993;267(3): 1428-31.
    • (1993) J Pharmacol Exp Ther , vol.267 , Issue.3 , pp. 1428-1431
    • Simon, R.P.1    Niro, M.2    Gwinn, R.3
  • 143
    • 0034988173 scopus 로고    scopus 로고
    • Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat
    • doi:10.1203/00006450-200106000-00015
    • Vannucci RC, Towfighi J, Brucklacher RM, Vannucci SJ. Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat. Pediatr Res. 2001;49(6): 799-803. doi: 10. 1203/00006450-200106000-00015.
    • (2001) Pediatr Res , vol.49 , Issue.6 , pp. 799-803
    • Vannucci, R.C.1    Towfighi, J.2    Brucklacher, R.M.3    Vannucci, S.J.4
  • 144
    • 33745903391 scopus 로고    scopus 로고
    • Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis
    • doi:10.1038/nm1422
    • Schuchmann S, Schmitz D, Rivera C, Vanhatalo S, Salmen B, Mackie K, et al. Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nat Med. 2006;12(7): 817-23. doi: 10. 1038/nm1422.
    • (2006) Nat Med , vol.12 , Issue.7 , pp. 817-823
    • Schuchmann, S.1    Schmitz, D.2    Rivera, C.3    Vanhatalo, S.4    Salmen, B.5    Mackie, K.6
  • 145
    • 84870177177 scopus 로고    scopus 로고
    • Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia
    • doi:10.1093/brain/aws257
    • Helmy MM, Ruusuvuori E, Watkins PV, Voipio J, Kanold PO, Kaila K. Acid extrusion via blood-brain barrier causes brain alkalosis and seizures after neonatal asphyxia. Brain. 2012;135(Pt 11): 3311-9. doi: 10. 1093/brain/aws257.
    • (2012) Brain , vol.135 , Issue.Pt 11 , pp. 3311-3319
    • Helmy, M.M.1    Ruusuvuori, E.2    Watkins, P.V.3    Voipio, J.4    Kanold, P.O.5    Kaila, K.6
  • 146
    • 80054732942 scopus 로고    scopus 로고
    • Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop
    • doi:10.1016/j.jpeds.2011.08.004
    • Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, et al. Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr. 2011;159(5): 851. e1-8. e1. doi: 10. 1016/j. jpeds. 2011. 08. 004.
    • (2011) J Pediatr , vol.159 , Issue.5 , pp. 1-8
    • Higgins, R.D.1    Raju, T.2    Edwards, A.D.3    Azzopardi, D.V.4    Bose, C.L.5    Clark, R.H.6
  • 147
    • 0024546153 scopus 로고
    • Differential effects of cooling in hibernator and nonhibernator cells: Na permeation
    • Zhou ZQ, Willis JS. Differential effects of cooling in hibernator and nonhibernator cells: Na permeation. Am J Physiol. 1989;256(1 Pt 2): R49-55.
    • (1989) Am J Physiol , vol.256 , Issue.1 Pt 2
    • Zhou, Z.Q.1    Willis, J.S.2
  • 149
    • 0035210322 scopus 로고    scopus 로고
    • Effects of moderate hypothermia on sarcolemmal Na(+)/H(+) exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes
    • doi:10.1038/sj.bjp.0704405
    • Hoshino K, Avkiran M. Effects of moderate hypothermia on sarcolemmal Na(+)/H(+) exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes. Br J Pharmacol. 2001;134(7): 1587-95. doi: 10. 1038/sj. bjp. 0704405.
    • (2001) Br J Pharmacol , vol.134 , Issue.7 , pp. 1587-1595
    • Hoshino, K.1    Avkiran, M.2
  • 151
    • 0022591059 scopus 로고
    • Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities
    • Hamilton PA, Hope PL, Cady EB, Delpy DT, Wyatt JS, Reynolds EO. Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities. Lancet. 1986;1(8492): 1242-6.
    • (1986) Lancet , vol.1 , Issue.8492 , pp. 1242-1246
    • Hamilton, P.A.1    Hope, P.L.2    Cady, E.B.3    Delpy, D.T.4    Wyatt, J.S.5    Reynolds, E.O.6
  • 152
    • 0024323839 scopus 로고
    • Variations in the in vivo P-31 MR spectra of the developing human brain during postnatal life. Work in progress
    • Boesch C, Gruetter R, Martin E, Duc G, Wuthrich K. Variations in the in vivo P-31 MR spectra of the developing human brain during postnatal life. Work in progress. Radiology. 1989;172(1): 197-9.
    • (1989) Radiology , vol.172 , Issue.1 , pp. 197-199
    • Boesch, C.1    Gruetter, R.2    Martin, E.3    Duc, G.4    Wuthrich, K.5
  • 153
    • 0024536219 scopus 로고
    • Phosphorus metabolites and intracellular pH in the brains of normal and small for gestational age infants investigated by magnetic resonance spectroscopy
    • doi:10.1203/00006450-198905000-00003
    • Azzopardi D, Wyatt JS, Hamilton PA, Cady EB, Delpy DT, Hope PL, et al. Phosphorus metabolites and intracellular pH in the brains of normal and small for gestational age infants investigated by magnetic resonance spectroscopy. Pediatr Res. 1989;25(5): 440-4. doi: 10. 1203/00006450-198905000-00003.
    • (1989) Pediatr Res , vol.25 , Issue.5 , pp. 440-444
    • Azzopardi, D.1    Wyatt, J.S.2    Hamilton, P.A.3    Cady, E.B.4    Delpy, D.T.5    Hope, P.L.6
  • 154
    • 0024478438 scopus 로고
    • Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia
    • Laptook AR, Corbett RJ, Uauy R, Mize C, Mendelsohn D, Nunnally RL. Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia. Neurology. 1989;39(5): 709-12.
    • (1989) Neurology , vol.39 , Issue.5 , pp. 709-712
    • Laptook, A.R.1    Corbett, R.J.2    Uauy, R.3    Mize, C.4    Mendelsohn, D.5    Nunnally, R.L.6
  • 156
    • 0028353555 scopus 로고
    • Developmental changes of phosphorus metabolite concentrations in the human brain: a 31P magnetic resonance spectroscopy study in vivo
    • Buchli R, Martin E, Boesiger P, Rumpel H. Developmental changes of phosphorus metabolite concentrations in the human brain: a 31P magnetic resonance spectroscopy study in vivo. Pediatr Res. 1994;35(4 Pt 1): 431-5.
    • (1994) Pediatr Res , vol.35 , Issue.4 Pt 1 , pp. 431-435
    • Buchli, R.1    Martin, E.2    Boesiger, P.3    Rumpel, H.4
  • 157
    • 0020585794 scopus 로고
    • Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy
    • Cady EB, Costello AM, Dawson MJ, Delpy DT, Hope PL, Reynolds EO, et al. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet. 1983;1(8333): 1059-62.
    • (1983) Lancet , vol.1 , Issue.8333 , pp. 1059-1062
    • Cady, E.B.1    Costello, A.M.2    Dawson, M.J.3    Delpy, D.T.4    Hope, P.L.5    Reynolds, E.O.6
  • 158
    • 0029016544 scopus 로고
    • Methyl isobutyl amiloride delays normalization of brain intracellular pH after cardiac arrest in rats
    • Ferimer HN, Kutina KL, LaManna JC. Methyl isobutyl amiloride delays normalization of brain intracellular pH after cardiac arrest in rats. Crit Care Med. 1995;23(6): 1106-11.
    • (1995) Crit Care Med , vol.23 , Issue.6 , pp. 1106-1111
    • Ferimer, H.N.1    Kutina, K.L.2    LaManna, J.C.3
  • 159
    • 45249111182 scopus 로고    scopus 로고
    • Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions
    • doi:10.1111/j.1471-4159.2008.05355.x
    • Rocha MA, Crockett DP, Wong LY, Richardson JR, Sonsalla PK. Na(+)/H(+) exchanger inhibition modifies dopamine neurotransmission during normal and metabolic stress conditions. J Neurochem. 2008;106(1): 231-43. doi: 10. 1111/j. 1471-4159. 2008. 05355. x.
    • (2008) J Neurochem , vol.106 , Issue.1 , pp. 231-243
    • Rocha, M.A.1    Crockett, D.P.2    Wong, L.Y.3    Richardson, J.R.4    Sonsalla, P.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.