The NA+/H+ exchanger SM-20220 attenuates ischemic injury in in vitro and in vivo models

Pharmacology

Volumn 63, Issue 2, 2001, Pages 76-81

  Horikawa, Naotsugu ^a,b   Nishioka, Mizue ^a   Itoh, Natsuko ^a   Kuribayashi, Yoshikazu ^a   Matsui, Kazuki ^a   Ohashi, Naohito ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b NONE   (Japan)

Author keywords

5 (N ethyl N isopropyl) amiloride; Glia; Hypoxia; Na+ H+ exchange inhibitor; Neuron; SM 20220

Indexed keywords

ANTIPORTER; LACTATE DEHYDROGENASE; N (AMINOIMINOMETHYL) 1 METHYL 1H INDOLE 2 CARBOXAMIDE METHANESULFONATE; SM 20220; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME RELEASE; GLIA; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; REOXYGENATION;

AMIDES; AMILORIDE; ANIMALS; BRAIN ISCHEMIA; CELL HYPOXIA; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDOLES; INFARCTION, MIDDLE CEREBRAL ARTERY; L-LACTATE DEHYDROGENASE; MALE; NEUROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; PREGNANCY; RATS; RATS, WISTAR; SODIUM-HYDROGEN ANTIPORTER;

EID: 0034900475     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056116     Document Type: Article

References (27)

1. Pathophysiology and treatment of focal cerebral ischemia. Part I
2. Pathophysiology of acute ischemic stroke
3. + exchangers of mammalian cells
4. 2+ overload
5. Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibition
6. 5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death
7. + antiportor, and is fully reversed by amiloride
8. + exchange inhibitor, in transient cerebral ischemia in rats
9. + exchange inhibitor SM-20220 reduces infarct size in both transient and permanent middle cerebral artery occlusion in rats
10. Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuron injury when combined with glutamate receptor antagonists
11. An enzyme-release assay for natural cytotoxicity
12. Reversible middle cerebral artery occlusion without craniectomy in rats
13. Membrane events leading to glial swelling and brain edema. Brain edema
14. The multiple causes of ischemic brain damage: A speculative synthesis
15. 2+ exchanger: Physiology and pharmacology
16. 2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytes
17. Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture
18. Amiloride and its analogs as tools in the study of ion transport
19. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
20. Activity and isozyme pattern of lactate dehydrogenase in neurons and astroblasts cultured from brains of chick embryos
21. Cell death in primary cultures of mouse neurons and astrocytes during exposure to and recovery from hypoxia, substrate deprivation and simulated ischemia
22. Calcium-mediated neurotoxicity. Relationship to specific channel types and role in ischemic damage
23. Calcium flux, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis
24. Reperfusion paradox: A novel mode of glial cell injury
25. The early events of oxygen and glucose deprivation: Setting the scene for neuronal death?
26. Extracellular calcium is a mediator of astroglial injury during combined glucose-oxygen deprivation
27. Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats