Intracellular pH response to anoxia in acutely dissociated adult rat hippocampal CA1 neurons

Journal of Neurophysiology

Volumn 87, Issue 5, 2002, Pages 2209-2224

  Sheldon, Claire ^a   Church, John ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2',7' BIS(2 CARBOXYETHYL) 5(6) CARBOXYFLUORESCEIN; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; BICARBONATE; CALCIUM ION; CARBON DIOXIDE; CARBOXYFLUORESCEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; LITHIUM ION; UNCLASSIFIED DRUG; ZINC ION;

ACIDIFICATION; ALKALINIZATION; ANIMAL CELL; ANOXIA; ARTICLE; CELL PH; CONTROLLED STUDY; ENZYME INHIBITION; HIPPOCAMPUS; MALE; NERVE CELL; NONHUMAN; PERFUSION; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; PROTON TRANSPORT; RAT; REGULATORY MECHANISM; SECOND MESSENGER; SIGNAL TRANSDUCTION; STEADY STATE;

EID: 0036083038     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2002.87.5.2209     Document Type: Article

References (89)

1. Characterization of acid extrusion mechanisms in cultured fetal rat hippocampal neurons
2. Effect of trace levels of nigericin on intracellular pH and acid-base transport in rat renal mesangial cells
3. Hypoxia stimulates acid extrusion and acid loading in cultured hippocampal astrocytes
4. pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats
5. Use of BCECF and propidium iodide to assess membrane integrity of acutely isolated CA1 neurons from rat hippocampus
6. Developmental changes in intracellular calcium regulation in rat cerebral cortex during hypoxia
7. Cyclic Amp concentrations in rat neocortex and hippocampus during and following incomplete ischemia: Effects of central noradrenergic neurons, prostaglandins, and adenosine
8. Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells
9. i
10. + channel in cultured rat hippocampal neurons
11. Voltage-activated hydrogen ion currents
12. + antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils
13. Common themes and problems of bioenergetics and voltage-gated proton channels
14. + conductance
15. 2+ concentration changes in cultured post-natal rat hippocampal neurons
16. + indicator SBFI
17. Protein serine/threonine kinases (PKA, PKC and CaMKII) involved in ischemic brain pathology
18. Sodium-hydrogen exchangers and sodium-bicarbonate co-transporters: Ontogeny of protein expression in the rat brain
19. Voltage-gated proton channels in microglia
20. Relations between intracellular ions and energy metabolism: A study with monensin in synaptosomes, neurons, and C6 glioma cells
21. Ions and energy in mammalian brain
22. The importance of sodium for anoxic transmission damage in rat hippocampal slices: Mechanisms of protection by lidocaine
23. +
24. Anoxia induces an increase in intracellular sodium in rat central neurons in vitro
25. Changes in intracellular pH of mouse hippocampal slices responding to hypoxia and/or glucose depletion
26. Inhibition of the red blood cell calcium pump by eosin and other fluorescein analogues
27. + exchanger
28. Effect of anoxia on ion distribution in the brain
29. 2+: An endogenous modulator of ligand- and voltage-gated ion channels
30. Changes in intracellular pH associated with glutamate excitotoxicity
31. Calcium and pH in anoxic and toxic injury
32. + exchange
33. N-methyl-d-aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons
34. Membrane dysfunction induced by in vitro ischemia in immature rat hippocampal CA1 neurons
35. i and changes in intracellular pH during chemical anoxia in mouse neocortical neurons in primary culture
36. Influence of sodium-hydrogen exchange on intracellular pH, sodium, and tension in sheep cardiac Purkinje fibers
37. + exchange. Structure, regulation, and its role in heart disease
38. Protection of hippocampal slices from young rats against anoxic transmission damage is due to better maintenance of ATP
39. Glutamate impairs neuronal calcium extrusion while reducing sodium gradient
40. Concentrations of energy metabolites and cyclic nucleotides during and after bilateral ischemia in the gerbil cerebral cortex
41. Characteristics of protective effects of NMDA antagonist and calcium channel antagonist on ischemic calcium accumulation in rat hippocampal CA1 region
42. + exchange inhibitor, in transient cerebral ischemia in rats
43. The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH
44. Noradrenaline-inducible cyclic-AMP accumulation in rat cerebral cortex: Changes during complete global ischemia
45. Ischemic cell death in brain neurons
46. Intracellular pH in the brain following transient ischemia
47. Tissue swelling and intracellular pH in the CA1 region of anoxic rat hippocampus
48. Fitting curves to data using nonlinear regression: A practical and nonmathematical review
49. 2+ mobilization in the CA1 area of hippocampal slices from immature and mature rats during ischemia or glucose deprivation
50. A rapid redistribution of hydrogen ions is associated with depolarization and repolarization subsequent to cerebral ischemia reperfusion
51. 2, interstitial pH, and potassium activity in the rat cerebral cortex during anoxia and the subsequent recovery period
52. Influence of acid-base changes on the intracellular calcium concentration of neurons in primary culture
53. + exchanger
54. i increase during oxidative stress
55. + exchange inhibitor, protects gerbil hippocampal neurons from ischemic injury
56. Recovery of intracellular pH in cortical brain slices following anoxia studied by nuclear magnetic resonance spectroscopy: Role of lactate removal, extracellular sodium and sodium/hydrogen exchange
57. 1H nuclear magnetic resonance spectroscopy: Role of extracellular bicarbonate and chloride
58. Experimental ischemia induces a persistent depolarization blocked by decreased calcium and NMDA antagonists
59. + exchanger
60. - exchange function differs in adult and fetal rat hippocampal neurons
61. + exchange in isolated type-1 cells of neonatal rat carotid body
62. Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla
63. The influence of age on pH regulation in hippocampal slices before, during, and after anoxia
64. Regulation of pH in rat brain synaptosomes. I. Role of sodium, bicarbonate, and potassium
65. - exchange
66. i) changes evoked by anoxia in isolated adult rat hippocampal CA1 neurons
67. Assessment of the role of adrenoceptor function in ischemia-induced impairment of 2-deoxyglucose uptake and CA1 field potential in rat hippocampal slices
68. Acidosis-related damage
69. 2+] in hypoxia and ischemia in rat brain in vivo
70. +] in the hippocampus during recovery from short-term, transient ischemia
71. Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation
72. Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
73. Effects of noradrenaline on intracellular pH in acutely dissociated adult rat hippocampal CA1 neurons
74. Membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 pyramidal neurons
75. Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro
76. + pump
77. + exchange in the sheep cardiac Purkinje fiber
78. Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture
79. + exchangers
80. 2+: A novel ionic mediator of neural injury in brain disease
81. An in vitro model of ischemia: Metabolic and electrical alterations in the hippocampal slice
82. Comparison of simultaneous pH measurements made with 8-hydroxypyrene-1,3,6-trisulphonic acid (HPTS) and pH-sensitive microelectrodes in snail neurons
83. 2+-ATPase in NMDA-induced intracellular acidification
84. + ions on Na-H exchange in sheep cardiac Purkinje fibers
85. 2 deprivation in mouse CA1 neurons
86. 1 adrenergic stimulation: A potential role for receptor-mediated activation of sarcolemmal sodium-hydrogen exchange
87. Gain control of NMDA-receptor currents by intracellular sodium
88. 2+-ATPase
89. 2+ release from mitochondria