Inhibition of Na+/H+ exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury

Brain Research

Volumn 913, Issue 2, 2001, Pages 156-158

  Pilitsis, J G ^a   Diaz, F G ^a   O'Regan, M H ^b   Phillis, J W ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF DETROIT MERCY   (United States)

Author keywords

Cerebral ischemia; Cerebroprotection; Free fatty acid; Na+ H+ exchange; Phospholipase; SM 20220

Indexed keywords

ARACHIDONIC ACID DERIVATIVE; DOCOSAHEXAENOIC ACID; FATTY ACID; LINOLEIC ACID; MYRISTIC ACID; N (AMINOIMINOMETHYL) 1 METHYL 1H INDOLE 2 CARBOXAMIDE METHANESULFONATE; PALMITIC ACID; PROTON; PROTON PUMP INHIBITOR; SM 20220; SODIUM ION; UNCLASSIFIED DRUG;

ACIDOSIS; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; DRUG EFFECT; DRUG MECHANISM; EFFUSION; ION EXCHANGE; LIPID BRAIN LEVEL; NEUROPROTECTION; NONHUMAN; PH; PRIORITY JOURNAL; REPERFUSION INJURY;

ACIDOSIS; AMIDES; ANIMALS; BRAIN ISCHEMIA; CELL MEMBRANE; CEREBRAL CORTEX; DOWN-REGULATION; FATTY ACIDS, NONESTERIFIED; INDOLES; INTRACELLULAR FLUID; ION TRANSPORT; NEUROPROTECTIVE AGENTS; PHOSPHOLIPASES; RATS; REPERFUSION INJURY; SODIUM; SODIUM-HYDROGEN ANTIPORTER;

EID: 0035929513     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02760-3     Document Type: Article

References (20)

1. + exchanger (NHE5) highly expressed in brain
2. Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes
3. 2 and its role in brain tissue
4. + exchange inhibitor on cerebral ischemia
5. + exchange in cardiac physiology and pathophysiology: Mediation of myocardial reperfusion injury by the pH paradox
6. Glial swelling during extracellular acidosis in vitro
7. + exchange inhibitor, in transient cerebral ischemia in rats
8. + exchange inhibitor, improves consciousness recovery and neurological outcome following transient cerebral ischemia in gerbils
9. ++, and pH in ischemic newborn myocardium
10. ++ exchangers: Physiology and pharmacology
11. Acid induced death in neurons and glia
12. + exchangers of mammalian cells
13. + exchange inhibitor protects gerbil hippocampal neurons from ischemic injury
14. + exchange by 5-(N-ethyl-N-isopropyl) amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex
15. Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology
16. ++ overload and prolonged acidosis on reperfusion
17. 2 activation in human platelets
18. Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation
19. Protective effects of extracellular acidosis and blockade of sodium/hydrogen ion exchange during recovery from metabolic inhibition in neuronal tissue culture
20. + exchange isoform 1 mutant mice