메뉴 건너뛰기




Volumn 26, Issue 4, 2013, Pages 355-364

Somatic mutations and epigenetic abnormalities in myelodysplastic syndromes

Author keywords

epigenetics; genetics; histone; methylation; myelodysplastic syndromes

Indexed keywords

POLYCOMB REPRESSIVE COMPLEX 2;

EID: 84893721635     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2014.01.001     Document Type: Review
Times cited : (33)

References (67)
  • 1
    • 70350720044 scopus 로고    scopus 로고
    • MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
    • M.E. Figueroa, L. Skrabanek, and Y. Li et al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation Blood 114 16 2009 Oct 15 3448 3458
    • (2009) Blood , vol.114 , Issue.16 , pp. 3448-3458
    • Figueroa, M.E.1    Skrabanek, L.2    Li, Y.3
  • 2
    • 60849089645 scopus 로고    scopus 로고
    • Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
    • Y. Jiang, A. Dunbar, and L.P. Gondek et al. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML Blood 113 6 2009 Feb 5 1315 1325
    • (2009) Blood , vol.113 , Issue.6 , pp. 1315-1325
    • Jiang, Y.1    Dunbar, A.2    Gondek, L.P.3
  • 3
    • 84887322071 scopus 로고    scopus 로고
    • Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells
    • Y. Wei, R. Chen, and S. Dimicoli et al. Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells Leukemia 27 11 2013 Nov 2177 2186
    • (2013) Leukemia , vol.27 , Issue.11 , pp. 2177-2186
    • Wei, Y.1    Chen, R.2    Dimicoli, S.3
  • 4
    • 84875223910 scopus 로고    scopus 로고
    • Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes
    • M. del Rey, K. O'Hagan, and M. Dellett et al. Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes Leukemia 27 3 2013 Mar 610 618
    • (2013) Leukemia , vol.27 , Issue.3 , pp. 610-618
    • Del Rey, M.1    O'Hagan, K.2    Dellett, M.3
  • 5
    • 84875217558 scopus 로고    scopus 로고
    • Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms
    • V. Radulovic, G. de Haan, and K. Klauke Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms Leukemia 27 3 2013 Mar 523 533
    • (2013) Leukemia , vol.27 , Issue.3 , pp. 523-533
    • Radulovic, V.1    De Haan, G.2    Klauke, K.3
  • 6
    • 30144443995 scopus 로고    scopus 로고
    • Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis
    • K. Mihara, M. Chowdhury, and N. Nakaju et al. Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis Blood 107 1 2006 Jan 1 305 308
    • (2006) Blood , vol.107 , Issue.1 , pp. 305-308
    • Mihara, K.1    Chowdhury, M.2    Nakaju, N.3
  • 7
    • 84873568880 scopus 로고    scopus 로고
    • The ASXL-BAP1 axis: New factors in myelopoiesis, cancer and epigenetics
    • O. Abdel-Wahab, and A. Dey The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics Leukemia 27 1 2013 Jan 10 15
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 10-15
    • Abdel-Wahab, O.1    Dey, A.2
  • 8
    • 77952421834 scopus 로고    scopus 로고
    • Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
    • J. Boultwood, J. Perry, and A. Pellagatti et al. Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia Leukemia 24 5 2010 1062 1065
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 1062-1065
    • Boultwood, J.1    Perry, J.2    Pellagatti, A.3
  • 9
    • 84865152223 scopus 로고    scopus 로고
    • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    • O. Abdel-Wahab, M. Adli, and L.M. LaFave et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression Cancer Cell 22 2 2012 Aug 14 180 193
    • (2012) Cancer Cell , vol.22 , Issue.2 , pp. 180-193
    • Abdel-Wahab, O.1    Adli, M.2    Lafave, L.M.3
  • 10
    • 84856657348 scopus 로고    scopus 로고
    • TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia
    • C. Perez, N. Martinez-Calle, and J.I. Martin-Subero et al. TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia PLoS One 7 2 2012 e31605
    • (2012) PLoS One , vol.7 , Issue.2 , pp. 31605
    • Perez, C.1    Martinez-Calle, N.2    Martin-Subero, J.I.3
  • 11
    • 84857150890 scopus 로고    scopus 로고
    • Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
    • J. Yamazaki, R. Taby, and A. Vasanthakumar et al. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia Epigenetics 7 2 2012 Feb 201 207
    • (2012) Epigenetics , vol.7 , Issue.2 , pp. 201-207
    • Yamazaki, J.1    Taby, R.2    Vasanthakumar, A.3
  • 12
    • 84880571480 scopus 로고    scopus 로고
    • The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation
    • S.J. Song, K. Ito, and U. Ala et al. The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation Cell Stem Cell 13 1 2013 Jul 3 87 101
    • (2013) Cell Stem Cell , vol.13 , Issue.1 , pp. 87-101
    • Song, S.J.1    Ito, K.2    Ala, U.3
  • 13
    • 84885196364 scopus 로고    scopus 로고
    • Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma
    • F. Asmar, V. Punj, and J. Christensen et al. Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma Haematologica 98 12 2013 Dec 1912 1920
    • (2013) Haematologica , vol.98 , Issue.12 , pp. 1912-1920
    • Asmar, F.1    Punj, V.2    Christensen, J.3
  • 14
    • 84885848576 scopus 로고    scopus 로고
    • Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
    • P. Guilhamon, M. Eskandarpour, and D. Halai et al. Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2 Nat Commun 17 4 2013 Jul 2166
    • (2013) Nat Commun , vol.17 , Issue.4 , pp. 2166
    • Guilhamon, P.1    Eskandarpour, M.2    Halai, D.3
  • 15
    • 84864311315 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
    • M.T. Bocker, F. Tuorto, and G. Raddatz et al. Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster Nat Commun 3 2012 818
    • (2012) Nat Commun , vol.3 , pp. 818
    • Bocker, M.T.1    Tuorto, F.2    Raddatz, G.3
  • 16
    • 84872953223 scopus 로고    scopus 로고
    • TET2 promotes histone O-GlcNAcylation during gene transcription
    • Q. Chen, Y. Chen, and C. Bian et al. TET2 promotes histone O-GlcNAcylation during gene transcription Nature 493 7433 2013 Jan 24 561 564
    • (2013) Nature , vol.493 , Issue.7433 , pp. 561-564
    • Chen, Q.1    Chen, Y.2    Bian, C.3
  • 17
    • 84884139186 scopus 로고    scopus 로고
    • Activation of the transcriptional function of the NF-kappaB protein c-Rel by O-GlcNAc glycosylation
    • P. Ramakrishnan, P.M. Clark, and D.E. Mason et al. Activation of the transcriptional function of the NF-kappaB protein c-Rel by O-GlcNAc glycosylation Sci Signal 6 290 2013 ra75
    • (2013) Sci Signal , vol.6 , Issue.290 , pp. 75
    • Ramakrishnan, P.1    Clark, P.M.2    Mason, D.E.3
  • 18
    • 84885021313 scopus 로고    scopus 로고
    • Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
    • A. Kon, L.Y. Shih, and M. Minamino et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms Nat Genet 45 10 2013 Oct 1232 1237
    • (2013) Nat Genet , vol.45 , Issue.10 , pp. 1232-1237
    • Kon, A.1    Shih, L.Y.2    Minamino, M.3
  • 19
    • 84856709581 scopus 로고    scopus 로고
    • Deregulation of microRNAs in myelodysplastic syndrome
    • G.W. Rhyasen, and D.T. Starczynowski Deregulation of microRNAs in myelodysplastic syndrome Leukemia 26 1 2011 Jan 13 22
    • (2011) Leukemia , vol.26 , Issue.1 , pp. 13-22
    • Rhyasen, G.W.1    Starczynowski, D.T.2
  • 20
    • 67650588646 scopus 로고    scopus 로고
    • MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    • R. Garzon, S. Liu, and M. Fabbri et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1 Blood 113 25 2009 Jun 18 6411 6418
    • (2009) Blood , vol.113 , Issue.25 , pp. 6411-6418
    • Garzon, R.1    Liu, S.2    Fabbri, M.3
  • 21
    • 84864744041 scopus 로고    scopus 로고
    • Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients
    • C. Santamaria, S. Muntion, and B. Roson et al. Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients Haematologica 97 8 2012 Aug 1218 1224
    • (2012) Haematologica , vol.97 , Issue.8 , pp. 1218-1224
    • Santamaria, C.1    Muntion, S.2    Roson, B.3
  • 22
    • 77950862042 scopus 로고    scopus 로고
    • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
    • M.H. Raaijmakers, S. Mukherjee, and S. Guo et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia Nature 464 7290 2010 Apr 8 852 857
    • (2010) Nature , vol.464 , Issue.7290 , pp. 852-857
    • Raaijmakers, M.H.1    Mukherjee, S.2    Guo, S.3
  • 23
    • 84874053510 scopus 로고    scopus 로고
    • Xist RNA is a potent suppressor of hematologic cancer in mice
    • E. Yildirim, J.E. Kirby, and D.E. Brown et al. Xist RNA is a potent suppressor of hematologic cancer in mice Cell 152 4 2013 Feb 14 727 742
    • (2013) Cell , vol.152 , Issue.4 , pp. 727-742
    • Yildirim, E.1    Kirby, J.E.2    Brown, D.E.3
  • 24
    • 34250729138 scopus 로고    scopus 로고
    • Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    • J.L. Rinn, M. Kertesz, and J.K. Wang et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs Cell 129 7 2007 Jun 29 1311 1323
    • (2007) Cell , vol.129 , Issue.7 , pp. 1311-1323
    • Rinn, J.L.1    Kertesz, M.2    Wang, J.K.3
  • 25
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • W. Yu, D. Gius, and P. Onyango et al. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA Nature 451 7175 2008 Jan 10 202 206
    • (2008) Nature , vol.451 , Issue.7175 , pp. 202-206
    • Yu, W.1    Gius, D.2    Onyango, P.3
  • 26
    • 84871412366 scopus 로고    scopus 로고
    • Connections between chromatin signatures and splicing
    • L.I. Gomez Acuna, A. Fiszbein, and M. Allo et al. Connections between chromatin signatures and splicing Wiley Interdiscip Rev RNA 4 1 2013 Jan-Feb 77 91
    • (2013) Wiley Interdiscip Rev RNA , vol.4 , Issue.1 , pp. 77-91
    • Gomez Acuna, L.I.1    Fiszbein, A.2    Allo, M.3
  • 27
    • 84881086323 scopus 로고    scopus 로고
    • Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
    • W. Timp, and A.P. Feinberg Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host Nat Rev Cancer 13 7 2013 Jul 497 510
    • (2013) Nat Rev Cancer , vol.13 , Issue.7 , pp. 497-510
    • Timp, W.1    Feinberg, A.P.2
  • 28
    • 34548208677 scopus 로고    scopus 로고
    • Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
    • S.M. Chambers, C.A. Shaw, and C. Gatza et al. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation PLoS Biol 5 8 2007 Aug e201
    • (2007) PLoS Biol , vol.5 , Issue.8 , pp. 201
    • Chambers, S.M.1    Shaw, C.A.2    Gatza, C.3
  • 29
    • 79955970344 scopus 로고    scopus 로고
    • Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging
    • M.T. Bocker, I. Hellwig, and A. Breiling et al. Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging Blood 117 19 2011 May 12 e182 e189
    • (2011) Blood , vol.117 , Issue.19
    • Bocker, M.T.1    Hellwig, I.2    Breiling, A.3
  • 30
    • 84875965163 scopus 로고    scopus 로고
    • Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    • I. Beerman, C. Bock, and B.S. Garrison et al. Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging Cell Stem Cell 12 4 2013 Apr 4 413 425
    • (2013) Cell Stem Cell , vol.12 , Issue.4 , pp. 413-425
    • Beerman, I.1    Bock, C.2    Garrison, B.S.3
  • 31
    • 84875825778 scopus 로고    scopus 로고
    • Quantitative comparison of CDKN2B methylation in Pediatric and adult myelodysplastic syndromes
    • M. Kim, H. Kook, and H.J. Park et al. Quantitative comparison of CDKN2B methylation in Pediatric and adult myelodysplastic syndromes Acta Haematol 130 2013 115 121
    • (2013) Acta Haematol , vol.130 , pp. 115-121
    • Kim, M.1    Kook, H.2    Park, H.J.3
  • 32
    • 84859584516 scopus 로고    scopus 로고
    • Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: Is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?
    • H.C. Hasselbalch Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer? Blood 119 14 2012 Apr 5 3219 3225
    • (2012) Blood , vol.119 , Issue.14 , pp. 3219-3225
    • Hasselbalch, H.C.1
  • 33
    • 70350539558 scopus 로고    scopus 로고
    • Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies
    • Y. Ye, M.A. McDevitt, and M. Guo et al. Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies Cancer Res 69 21 2009 Nov 1 8482 8490
    • (2009) Cancer Res , vol.69 , Issue.21 , pp. 8482-8490
    • Ye, Y.1    McDevitt, M.A.2    Guo, M.3
  • 34
    • 84877153495 scopus 로고    scopus 로고
    • Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions
    • A. Aziz, E.J. Baxter, and C. Edwards et al. Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions J Clin Invest 123 5 2013 May 1 2169 2182
    • (2013) J Clin Invest , vol.123 , Issue.5 , pp. 2169-2182
    • Aziz, A.1    Baxter, E.J.2    Edwards, C.3
  • 35
    • 84881668166 scopus 로고    scopus 로고
    • Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence
    • A. Venkatraman, X.C. He, and J.L. Thorvaldsen et al. Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence Nature 500 7462 2013 Aug 15 345 349
    • (2013) Nature , vol.500 , Issue.7462 , pp. 345-349
    • Venkatraman, A.1    He, X.C.2    Thorvaldsen, J.L.3
  • 36
    • 84555207349 scopus 로고    scopus 로고
    • Dnmt3a is essential for hematopoietic stem cell differentiation
    • G.A. Challen, D. Sun, and M. Jeong et al. Dnmt3a is essential for hematopoietic stem cell differentiation Nat Genet 44 1 2012 Jan 23 31
    • (2012) Nat Genet , vol.44 , Issue.1 , pp. 23-31
    • Challen, G.A.1    Sun, D.2    Jeong, M.3
  • 37
    • 84856746717 scopus 로고    scopus 로고
    • Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
    • A. Herrera-Merchan, L. Arranz, and J.M. Ligos et al. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease Nat Commun 3 2012 623
    • (2012) Nat Commun , vol.3 , pp. 623
    • Herrera-Merchan, A.1    Arranz, L.2    Ligos, J.M.3
  • 38
    • 74949143986 scopus 로고    scopus 로고
    • Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
    • C.L. Fisher, N. Pineault, and C. Brookes et al. Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia Blood 115 1 2010 38 46
    • (2010) Blood , vol.115 , Issue.1 , pp. 38-46
    • Fisher, C.L.1    Pineault, N.2    Brookes, C.3
  • 39
    • 84893805760 scopus 로고    scopus 로고
    • Conditional deletion of Asxl1 results in myelodysplasia
    • 12021
    • O. Abdel-Wahab, J. Gao, and M. Adli et al. Conditional deletion of Asxl1 results in myelodysplasia ASH annual meeting abstracts 2012 vol. 120(21) November 16, 2012 308
    • (2012) ASH Annual Meeting Abstracts 2012 , vol.VOL. , pp. 308
    • Abdel-Wahab, O.1    Gao, J.2    Adli, M.3
  • 40
    • 79958097977 scopus 로고    scopus 로고
    • Gene expression profiling in MDS and AML: Potential and future avenues
    • K. Theilgaard-Monch, J. Boultwood, and S. Ferrari et al. Gene expression profiling in MDS and AML: potential and future avenues Leukemia 25 6 2011 Jun 909 920
    • (2011) Leukemia , vol.25 , Issue.6 , pp. 909-920
    • Theilgaard-Monch, K.1    Boultwood, J.2    Ferrari, S.3
  • 41
    • 77951728570 scopus 로고    scopus 로고
    • The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
    • S.W. Lane, S.M. Sykes, and F. Al-Shahrour et al. The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS Blood 115 17 2010 Apr 29 3489 3497
    • (2010) Blood , vol.115 , Issue.17 , pp. 3489-3497
    • Lane, S.W.1    Sykes, S.M.2    Al-Shahrour, F.3
  • 42
    • 84876907152 scopus 로고    scopus 로고
    • Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming
    • C.X. Song, K.E. Szulwach, and Q. Dai et al. Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming Cell 153 3 2013 Apr 25 678 691
    • (2013) Cell , vol.153 , Issue.3 , pp. 678-691
    • Song, C.X.1    Szulwach, K.E.2    Dai, Q.3
  • 43
    • 84863176405 scopus 로고    scopus 로고
    • Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
    • J.J. Trowbridge, A.U. Sinha, and N. Zhu et al. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains Genes Dev 26 4 2012 Feb 15 344 349
    • (2012) Genes Dev , vol.26 , Issue.4 , pp. 344-349
    • Trowbridge, J.J.1    Sinha, A.U.2    Zhu, N.3
  • 44
    • 84878945942 scopus 로고    scopus 로고
    • Genome-wide profiling reveals epigenetic inactivation of the PU.1 pathway by histone H3 lysine 27 trimethylation in cytogenetically normal myelodysplastic syndrome
    • J.X. Cheng, J. Anastasi, and K. Watanabe et al. Genome-wide profiling reveals epigenetic inactivation of the PU.1 pathway by histone H3 lysine 27 trimethylation in cytogenetically normal myelodysplastic syndrome Leukemia 27 6 2013 Jun 1291 1300
    • (2013) Leukemia , vol.27 , Issue.6 , pp. 1291-1300
    • Cheng, J.X.1    Anastasi, J.2    Watanabe, K.3
  • 45
    • 84874744945 scopus 로고    scopus 로고
    • Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34(+) progenitor cells
    • C. Davies, B.H. Yip, and M. Fernandez-Mercado et al. Silencing of ASXL1 impairs the granulomonocytic lineage potential of human CD34(+) progenitor cells Br J Haematol 160 6 2013 Mar 842 850
    • (2013) Br J Haematol , vol.160 , Issue.6 , pp. 842-850
    • Davies, C.1    Yip, B.H.2    Fernandez-Mercado, M.3
  • 46
    • 84855860977 scopus 로고    scopus 로고
    • Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis
    • O. Hopfer, F. Nolte, and M. Mossner et al. Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis Eur J Haematol 88 2 2012 Feb 144 153
    • (2012) Eur J Haematol , vol.88 , Issue.2 , pp. 144-153
    • Hopfer, O.1    Nolte, F.2    Mossner, M.3
  • 47
    • 84870767308 scopus 로고    scopus 로고
    • Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes
    • A. Raval, K.J. Sridhar, and S. Patel et al. Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes Blood 120 24 2012 Dec 6 4812 4818
    • (2012) Blood , vol.120 , Issue.24 , pp. 4812-4818
    • Raval, A.1    Sridhar, K.J.2    Patel, S.3
  • 48
    • 84881159187 scopus 로고    scopus 로고
    • Orchestrated intron retention regulates normal granulocyte differentiation
    • J.J. Wong, W. Ritchie, and O.A. Ebner et al. Orchestrated intron retention regulates normal granulocyte differentiation Cell 154 3 2013 Aug 1 583 595
    • (2013) Cell , vol.154 , Issue.3 , pp. 583-595
    • Wong, J.J.1    Ritchie, W.2    Ebner, O.A.3
  • 49
    • 84863337617 scopus 로고    scopus 로고
    • Clonal architecture of secondary acute myeloid leukemia
    • M.J. Walter, D. Shen, and L. Ding et al. Clonal architecture of secondary acute myeloid leukemia N Engl J Med 366 12 2012 Mar 22 1090 1098
    • (2012) N Engl J Med , vol.366 , Issue.12 , pp. 1090-1098
    • Walter, M.J.1    Shen, D.2    Ding, L.3
  • 50
    • 84883474570 scopus 로고    scopus 로고
    • Single-cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos
    • C. Lorthongpanich, L.F. Cheow, and S. Balu et al. Single-cell DNA-methylation analysis reveals epigenetic chimerism in preimplantation embryos Science 341 6150 2013 Sep 6 1110 1112
    • (2013) Science , vol.341 , Issue.6150 , pp. 1110-1112
    • Lorthongpanich, C.1    Cheow, L.F.2    Balu, S.3
  • 51
    • 84883742684 scopus 로고    scopus 로고
    • Epigenetics in clinical practice: The examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia
    • E.H. Estey Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia Leukemia 27 9 2013 Sep 1803 1812
    • (2013) Leukemia , vol.27 , Issue.9 , pp. 1803-1812
    • Estey, E.H.1
  • 52
    • 79960456078 scopus 로고    scopus 로고
    • Hypomethylating agents reactivate FOXO3A in acute myeloid leukemia
    • S. Thepot, E. Lainey, and T. Cluzeau et al. Hypomethylating agents reactivate FOXO3A in acute myeloid leukemia Cell Cycle 10 14 2011 Jul 15 2323 2330
    • (2011) Cell Cycle , vol.10 , Issue.14 , pp. 2323-2330
    • Thepot, S.1    Lainey, E.2    Cluzeau, T.3
  • 53
    • 84876444289 scopus 로고    scopus 로고
    • Genomic impact of transient low-dose decitabine treatment on primary AML cells
    • J.M. Klco, D.H. Spencer, and T.L. Lamprecht et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells Blood 121 9 2013 Feb 28 1633 1643
    • (2013) Blood , vol.121 , Issue.9 , pp. 1633-1643
    • Klco, J.M.1    Spencer, D.H.2    Lamprecht, T.L.3
  • 54
    • 84876585121 scopus 로고    scopus 로고
    • Functional DNA demethylation is accompanied by chromatin accessibility
    • K. Pandiyan, J.S. You, and X. Yang et al. Functional DNA demethylation is accompanied by chromatin accessibility Nucleic Acids Res 41 7 2013 Apr 3973 3985
    • (2013) Nucleic Acids Res , vol.41 , Issue.7 , pp. 3973-3985
    • Pandiyan, K.1    You, J.S.2    Yang, X.3
  • 55
    • 67349200930 scopus 로고    scopus 로고
    • The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    • C. Flotho, R. Claus, and C. Batz et al. The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells Leukemia 23 6 2009 Jun 1019 1028
    • (2009) Leukemia , vol.23 , Issue.6 , pp. 1019-1028
    • Flotho, C.1    Claus, R.2    Batz, C.3
  • 56
    • 84877350071 scopus 로고    scopus 로고
    • Identification of direct targets and modified bases of RNA cytosine methyltransferases
    • V. Khoddami, and B.R. Cairns Identification of direct targets and modified bases of RNA cytosine methyltransferases Nat Biotechnol 31 5 2013 May 458 464
    • (2013) Nat Biotechnol , vol.31 , Issue.5 , pp. 458-464
    • Khoddami, V.1    Cairns, B.R.2
  • 57
    • 84885021313 scopus 로고    scopus 로고
    • Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
    • A. Kon, L.Y. Shih, and M. Minamino et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms Nat Genet 45 10 2013 Oct 1232 1237
    • (2013) Nat Genet , vol.45 , Issue.10 , pp. 1232-1237
    • Kon, A.1    Shih, L.Y.2    Minamino, M.3
  • 58
    • 84880976662 scopus 로고    scopus 로고
    • Somatic SETBP1 mutations in myeloid malignancies
    • H. Makishima, K. Yoshida, and N. Nguyen et al. Somatic SETBP1 mutations in myeloid malignancies Nat Genet 45 8 2013 Aug 942 946
    • (2013) Nat Genet , vol.45 , Issue.8 , pp. 942-946
    • Makishima, H.1    Yoshida, K.2    Nguyen, N.3
  • 59
    • 84885571172 scopus 로고    scopus 로고
    • SETBP1 mutation analysis in 944 patients with MDS and AML
    • F. Thol, K.J. Suchanek, and C. Koenecke et al. SETBP1 mutation analysis in 944 patients with MDS and AML Leukemia 27 10 2013 Oct 2072 2075
    • (2013) Leukemia , vol.27 , Issue.10 , pp. 2072-2075
    • Thol, F.1    Suchanek, K.J.2    Koenecke, C.3
  • 60
    • 84878947680 scopus 로고    scopus 로고
    • SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias
    • F. Damm, R. Itzykson, and O. Kosmider et al. SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias Leukemia 27 6 2013 Jun 1401 1403
    • (2013) Leukemia , vol.27 , Issue.6 , pp. 1401-1403
    • Damm, F.1    Itzykson, R.2    Kosmider, O.3
  • 61
    • 84883744431 scopus 로고    scopus 로고
    • Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies
    • I. Gómez-Seguí, H. Makishima, and A. Jerez et al. Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies Leukemia 27 9 2013 Sep 1943 1946
    • (2013) Leukemia , vol.27 , Issue.9 , pp. 1943-1946
    • Gómez-Seguí, I.1    Makishima, H.2    Jerez, A.3
  • 62
    • 84888246901 scopus 로고    scopus 로고
    • BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders
    • F. Damm, V. Chesnais, and Y. Nagata et al. BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders Blood 122 18 2013 Oct 31 3169 3177
    • (2013) Blood , vol.122 , Issue.18 , pp. 3169-3177
    • Damm, F.1    Chesnais, V.2    Nagata, Y.3
  • 63
    • 84888219405 scopus 로고    scopus 로고
    • Clinical and biological implications of driver mutations in myelodysplastic syndromes
    • E. Papaemmanuil, M. Gerstung, and L. Malcovati et al. Clinical and biological implications of driver mutations in myelodysplastic syndromes Blood 122 22 2013 Nov 21 3616 3627
    • (2013) Blood , vol.122 , Issue.22 , pp. 3616-3627
    • Papaemmanuil, E.1    Gerstung, M.2    Malcovati, L.3
  • 65
    • 84878900540 scopus 로고    scopus 로고
    • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes
    • M.J. Walter, D. Shen, and J. Shao et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes Leukemia 27 6 2013 Jun 1275 1282
    • (2013) Leukemia , vol.27 , Issue.6 , pp. 1275-1282
    • Walter, M.J.1    Shen, D.2    Shao, J.3
  • 66
    • 84885657625 scopus 로고    scopus 로고
    • NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes
    • D.M. Murphy, R. Bejar, and K. Stevenson et al. NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes Leukemia 27 10 2013 Oct 2077 2081
    • (2013) Leukemia , vol.27 , Issue.10 , pp. 2077-2081
    • Murphy, D.M.1    Bejar, R.2    Stevenson, K.3
  • 67
    • 84886299367 scopus 로고    scopus 로고
    • Utility of peripheral blood for cytogenetic and mutation analysis in myelodysplastic syndrome
    • A.M. Mohamedali, H. Alkhatabi, and A. Kulasekararaj et al. Utility of peripheral blood for cytogenetic and mutation analysis in myelodysplastic syndrome Blood 122 4 2013 Jul 25 567 570
    • (2013) Blood , vol.122 , Issue.4 , pp. 567-570
    • Mohamedali, A.M.1    Alkhatabi, H.2    Kulasekararaj, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.