SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias

Leukemia

Volumn 27, Issue 6, 2013, Pages 1401-1403

  Damm, F ^a,b,c   Itzykson, R ^a,b,d   Kosmider, O ^e,f,g   Droin, N ^a,b,d   Renneville, A ^h   Chesnais, V ^e,f,g   Gelsi Boyer, V ^i,j,k   De Botton, S ^a,b,c   Vey, N ^i,k   Preudhomme, C ^c,h,l   Clavert, A ^m   Delabesse, E ⁿ   Park, S ^o   Birnbaum, D ^i,j,k   Fontenay, M ^e,f,g   Bernard, O A ^a,b,c   Solary, E ^a,b,d,i  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c INSERM   (France)

^d Universite Paris Sud   (France)

^e INSTITUT COCHIN   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g HÔTEL DIEU   (France)

^h LILLE UNIVERSITY HOSPITAL   (France)

ⁱ INSTITUT PAOLI CALMETTES   (France)

^j AIX MARSEILLE UNIVERSITY   (France)

^k AIX MARSEILLE UNIVERSITY   (France)

^l UNIV LILLE   (France)

^m ANGERS UNIVERSITY HOSPITAL   (France)

ⁿ CHU PURPAN   (France)

^o Cancer Research Institute of Lille ^*  (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; SETBP 1 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; CELL PROLIFERATION; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CHRONIC MYELOMONOCYTIC LEUKEMIA; GENE OVEREXPRESSION; HUMAN; LETTER; MYELODYSPLASTIC SYNDROME; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING;

CARRIER PROTEINS; HUMANS; LEUKEMIA, MYELOID, ACUTE; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MUTATION; MYELODYSPLASTIC SYNDROMES; NUCLEAR PROTEINS;

EID: 84878947680     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.35     Document Type: Letter

References (12)

1. Piazza R, Valletta S, Winkelmann N, Redaelli S, Spinelli R, Pirola A et al. Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet 2012; 45: 18-24.
2. Hoischen A, van Bon BW, Gilissen C, Arts P, van Lier B, Steehouwer M et al. De novo mutations of SETBP1 cause Schinzel-Giedion syndrome. Nat Genet 2010; 42: 483-485.
3. Panagopoulos I, Kerndrup G, Carlsen N, Strombeck B, Isaksson M, Johansson B. Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12). Br J Haematol 2007; 136: 294-296. (Pubitemid 46020757)
4. Cristobal I, Blanco FJ, Garcia-Orti L, Marcotegui N, Vicente C, Rifon J et al. SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia. Blood 2010; 115: 615-625.
5. Oakley K, Han Y, Vishwakarma BA, Chu S, Bhatia R, Gudmundsson KO et al. Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. Blood 2012; 119: 6099-6108.
6. Kosmider O, Delabesse E, Mas VM, Cornillet-Lefebvre P, Blanchet O, Delmer A et al. TET2 mutations in secondary acute myeloid leukemias: a French retrospective study. Haematologica 2011; 96: 1059-1063.
7. Damm F, Kosmider O, Gelsi-Boyer V, Renneville A, Carbuccia N, Hidalgo-Curtis C et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood 2012; 119: 3211-3218.
8. Itzykson R, Kosmider O, Renneville A, Gelsi-Boyer V. A prognostic score including gene mutations in chronic myelomonocytic leukemia. J Clin Oncol 2013 (in press).
9. Itzykson R, Kosmider O, Renneville A, Morabito M, Preudhomme C, Berthon C et al. Clonal architecture of chronic myelomonocytic leukemias. Blood 2013; e-pub ahead of print 14 January 2013.
10. Dohner H, Estey EH, Amadori S, Appelbaum FR, Buchner T, Burnett AK et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115: 453-474.
11. Damm F, Fontenay M, Bernard OA. Point mutations in myelodysplastic syndromes. N Engl J Med 2011; 365: 1154-1155.
12. Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K et al. Clonal architecture of secondary acute myeloid leukemia. N Engl J Med 2012; 366: 1090-1098.