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Volumn 29, Issue 4, 2013, Pages 229-234

Anti-cancer effect and underlying mechanism(s) of Kaempferol, a phytoestrogen, on the regulation of apoptosis in diverse cancer cell models

Author keywords

Apoptosis; Cancer models; Estrogen receptors; Kaempferol; Phytoestrogen

Indexed keywords


EID: 84893720574     PISSN: 19768257     EISSN: 22342753     Source Type: Journal    
DOI: 10.5487/TR.2013.29.4.229     Document Type: Review
Times cited : (157)

References (69)
  • 1
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: critical control points
    • Danial, N.N. and Korsmeyer, S.J. (2004) Cell death: critical control points. Cell, 116, 205-219.
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 2
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan, M.B. and Bartek, J. (2004) Cell-cycle checkpoints and cancer. Nature, 432, 316-323.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 3
    • 0016904759 scopus 로고
    • Tumor progression and homeostasis
    • Prehn, R.T. (1976) Tumor progression and homeostasis. Adv. Cancer Res., 23, 203-236.
    • (1976) Adv. Cancer Res. , vol.23 , pp. 203-236
    • Prehn, R.T.1
  • 4
    • 20544469985 scopus 로고    scopus 로고
    • Health effects of phytoestrogens
    • Branca, F. and Lorenzetti, S. (2005) Health effects of phytoestrogens. Forum Nutr., 100-111.
    • (2005) Forum Nutr. , pp. 100-111
    • Branca, F.1    Lorenzetti, S.2
  • 6
    • 84905111487 scopus 로고    scopus 로고
    • Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective
    • In press.
    • Poluzzi, E., Piccinni, C., Raschi, E., Rampa, A., Recanatini, M. and De Ponti, F. (2013) Phytoestrogens in postmenopause: the state of the art from a chemical, pharmacological and regulatory perspective. Curr. Med. Chem. In press.
    • (2013) Curr. Med. Chem
    • Poluzzi, E.1    Piccinni, C.2    Raschi, E.3    Rampa, A.4    Recanatini, M.5    De Ponti, F.6
  • 7
    • 0032116898 scopus 로고    scopus 로고
    • Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence
    • Tham, D.M., Gardner, C.D. and Haskell, W.L. (1998) Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J. Clin. Endocrinol. Metab., 83, 2223-2235.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 2223-2235
    • Tham, D.M.1    Gardner, C.D.2    Haskell, W.L.3
  • 9
    • 84873636347 scopus 로고    scopus 로고
    • Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17beta-estradiol or bisphenol A via the inhibition of cell cycle progression
    • Hwang, K.A., Kang, N.H., Yi, B.R., Lee, H.R., Park, M.A. and Choi, K.C. (2013) Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17beta-estradiol or bisphenol A via the inhibition of cell cycle progression. Int. J. Oncol., 42, 733-740.
    • (2013) Int. J. Oncol. , vol.42 , pp. 733-740
    • Hwang, K.A.1    Kang, N.H.2    Yi, B.R.3    Lee, H.R.4    Park, M.A.5    Choi, K.C.6
  • 10
    • 84884724080 scopus 로고    scopus 로고
    • Anticancer effect of genistein on BG-1 ovarian cancer growth induced by 17 betaestradiol or bisphenol A via the suppression of the crosstalk between estrogen receptor alpha and insulin-like growth factor-1 receptor signaling pathways
    • Hwang, K.A., Park, M.A., Kang, N.H., Yi, B.R., Hyun, S.H., Jeung, E.B. and Choi, K.C. (2013) Anticancer effect of genistein on BG-1 ovarian cancer growth induced by 17 betaestradiol or bisphenol A via the suppression of the crosstalk between estrogen receptor alpha and insulin-like growth factor-1 receptor signaling pathways. Toxicol. Appl. Pharmacol., 272, 637-646.
    • (2013) Toxicol. Appl. Pharmacol. , vol.272 , pp. 637-646
    • Hwang, K.A.1    Park, M.A.2    Kang, N.H.3    Yi, B.R.4    Hyun, S.H.5    Jeung, E.B.6    Choi, K.C.7
  • 11
    • 0035004114 scopus 로고    scopus 로고
    • Flavonoid antioxidants
    • Rice-Evans, C. (2001) Flavonoid antioxidants. Curr. Med. Chem., 8, 797-807.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 797-807
    • Rice-Evans, C.1
  • 12
    • 84862887611 scopus 로고    scopus 로고
    • Simultaneous analysis of six major compounds in Osterici Radix and Notopterygii Rhizoma et Radix by HPLC and discrimination of their origins from chemical fingerprint analysis
    • Kim, S., Kim, K.Y., Han, C.S., Ki, K.S., Min, K.J., Zhang, X. and Whang, W.K. (2012) Simultaneous analysis of six major compounds in Osterici Radix and Notopterygii Rhizoma et Radix by HPLC and discrimination of their origins from chemical fingerprint analysis. Arch. Pharmacal Res., 35, 691-699.
    • (2012) Arch. Pharmacal Res. , vol.35 , pp. 691-699
    • Kim, S.1    Kim, K.Y.2    Han, C.S.3    Ki, K.S.4    Min, K.J.5    Zhang, X.6    Whang, W.K.7
  • 13
    • 33646536345 scopus 로고    scopus 로고
    • Enzymatic preparation of kaempferol from green tea seed and its antioxidant activity
    • Park, J.S., Rho, H.S., Kim, D.H. and Chang, I.S. (2006) Enzymatic preparation of kaempferol from green tea seed and its antioxidant activity. J. Agric. Food Chem., 54, 2951-2956.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 2951-2956
    • Park, J.S.1    Rho, H.S.2    Kim, D.H.3    Chang, I.S.4
  • 14
    • 0033302430 scopus 로고    scopus 로고
    • Ginkgo biloba leaf extract: review of biological actions and clinical applications
    • Yoshikawa, T., Naito, Y. and Kondo, M. (1999) Ginkgo biloba leaf extract: review of biological actions and clinical applications. Antioxid. Redox Signaling, 1, 469-480.
    • (1999) Antioxid. Redox Signaling , vol.1 , pp. 469-480
    • Yoshikawa, T.1    Naito, Y.2    Kondo, M.3
  • 15
    • 22744459004 scopus 로고    scopus 로고
    • Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages
    • Kowalski, J., Samojedny, A., Paul, M., Pietsz, G. and Wilczok, T. (2005) Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol. Rep., 57, 390-394.
    • (2005) Pharmacol. Rep. , vol.57 , pp. 390-394
    • Kowalski, J.1    Samojedny, A.2    Paul, M.3    Pietsz, G.4    Wilczok, T.5
  • 16
    • 84877141820 scopus 로고    scopus 로고
    • [Kaempferol-induced apoptosis of human esophageal squamous carcinoma Eca-109 cells and the mechanism]
    • Li, R.J., Mei, J.Z. and Liu, G.J. (2011) [Kaempferol-induced apoptosis of human esophageal squamous carcinoma Eca-109 cells and the mechanism]. Nanfang Yike Daxue Xuebao, 31, 1440-1442.
    • (2011) Nanfang Yike Daxue Xuebao , vol.31 , pp. 1440-1442
    • Li, R.J.1    Mei, J.Z.2    Liu, G.J.3
  • 17
    • 62649152321 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction
    • Marfe, G., Tafani, M., Indelicato, M., Sinibaldi-Salimei, P., Reali, V., Pucci, B., Fini, M. and Russo, M.A. (2009) Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. J. Cell. Biochem., 106, 643-650.
    • (2009) J. Cell. Biochem. , vol.106 , pp. 643-650
    • Marfe, G.1    Tafani, M.2    Indelicato, M.3    Sinibaldi-Salimei, P.4    Reali, V.5    Pucci, B.6    Fini, M.7    Russo, M.A.8
  • 18
    • 84886508466 scopus 로고    scopus 로고
    • Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN
    • Xie, F., Su, M., Qiu, W., Zhang, M., Guo, Z., Su, B., Liu, J., Li, X. and Zhou, L. (2013) Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. Int. J. Mol. Sci., 14, 21215-21226.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 21215-21226
    • Xie, F.1    Su, M.2    Qiu, W.3    Zhang, M.4    Guo, Z.5    Su, B.6    Liu, J.7    Li, X.8    Zhou, L.9
  • 19
    • 0002684311 scopus 로고
    • A specific breeding problem of sheep on subterranean clover pastures in Western Australia
    • Bennetts, H.W., Underwood, E.J. and Shier, F.L. (1946) A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust. Vet. J., 22, 2-12.
    • (1946) Aust. Vet. J. , vol.22 , pp. 2-12
    • Bennetts, H.W.1    Underwood, E.J.2    Shier, F.L.3
  • 20
    • 0025181114 scopus 로고
    • Western diet and Western diseases: some hormonal and biochemical mechanisms and associations
    • Adlercreutz, H. (1990) Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand. J. Clin. Lab. Invest. Suppl., 201, 3-23.
    • (1990) Scand. J. Clin. Lab. Invest. Suppl. , vol.201 , pp. 3-23
    • Adlercreutz, H.1
  • 21
    • 0028941361 scopus 로고
    • Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat
    • Murkies, A.L., Lombard, C., Strauss, B.J., Wilcox, G., Burger, H.G. and Morton, M.S. (1995) Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat. Maturitas, 21, 189-195.
    • (1995) Maturitas , vol.21 , pp. 189-195
    • Murkies, A.L.1    Lombard, C.2    Strauss, B.J.3    Wilcox, G.4    Burger, H.G.5    Morton, M.S.6
  • 22
    • 0034213042 scopus 로고    scopus 로고
    • Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women
    • Simons, L.A., von Konigsmark, M., Simons, J. and Celermajer, D.S. (2000) Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am. J. Cardiol., 85, 1297-1301.
    • (2000) Am. J. Cardiol. , vol.85 , pp. 1297-1301
    • Simons, L.A.1    von Konigsmark, M.2    Simons, J.3    Celermajer, D.S.4
  • 23
    • 1342328575 scopus 로고    scopus 로고
    • The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial
    • Atkinson, C., Compston, J.E., Day, N.E., Dowsett, M. and Bingham, S.A. (2004) The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am. J. Clin. Nutr., 79, 326-333.
    • (2004) Am. J. Clin. Nutr. , vol.79 , pp. 326-333
    • Atkinson, C.1    Compston, J.E.2    Day, N.E.3    Dowsett, M.4    Bingham, S.A.5
  • 24
    • 0030880014 scopus 로고    scopus 로고
    • Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells
    • Wang, C. and Kurzer, M.S. (1997) Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells. Nutr. Cancer, 28, 236-247.
    • (1997) Nutr. Cancer , vol.28 , pp. 236-247
    • Wang, C.1    Kurzer, M.S.2
  • 25
    • 33744922639 scopus 로고    scopus 로고
    • Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells
    • Oh, S.M., Kim, Y.P. and Chung, K.H. (2006) Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells. Arch. Pharmacal Res., 29, 354-362.
    • (2006) Arch. Pharmacal Res. , vol.29 , pp. 354-362
    • Oh, S.M.1    Kim, Y.P.2    Chung, K.H.3
  • 27
    • 0031915796 scopus 로고    scopus 로고
    • Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study
    • Kao, Y.C., Zhou, C., Sherman, M., Laughton, C.A. and Chen, S. (1998) Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ. Health Perspect., 106, 85-92.
    • (1998) Environ. Health Perspect. , vol.106 , pp. 85-92
    • Kao, Y.C.1    Zhou, C.2    Sherman, M.3    Laughton, C.A.4    Chen, S.5
  • 28
    • 84880376674 scopus 로고    scopus 로고
    • Resveratrol regulates the cell viability promoted by 17beta-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor alpha and insulin growth factor-1 receptor in BG-1 ovarian cancer cells
    • Kang, N.H., Hwang, K.A., Lee, H.R., Choi, D.W. and Choi, K.C. (2013) Resveratrol regulates the cell viability promoted by 17beta-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor alpha and insulin growth factor-1 receptor in BG-1 ovarian cancer cells. Food Chem. Toxicol., 59, 373-379.
    • (2013) Food Chem. Toxicol. , vol.59 , pp. 373-379
    • Kang, N.H.1    Hwang, K.A.2    Lee, H.R.3    Choi, D.W.4    Choi, K.C.5
  • 30
    • 77952868913 scopus 로고    scopus 로고
    • Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells
    • Choi, E.J. and Ahn, W.S. (2008) Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutr. Res. Pract., 2, 322-325.
    • (2008) Nutr. Res. Pract. , vol.2 , pp. 322-325
    • Choi, E.J.1    Ahn, W.S.2
  • 31
    • 0036849077 scopus 로고    scopus 로고
    • The biochemistry and medical significance of the flavonoids
    • Havsteen, B.H. (2002) The biochemistry and medical significance of the flavonoids. Pharmacol. Ther., 96, 67-202.
    • (2002) Pharmacol. Ther. , vol.96 , pp. 67-202
    • Havsteen, B.H.1
  • 32
    • 19544384386 scopus 로고    scopus 로고
    • Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer
    • Touillaud, M.S., Pillow, P.C., Jakovljevic, J., Bondy, M.L., Singletary, S.E., Li, D. and Chang, S. (2005) Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer. Nutr. Cancer, 51, 162-169.
    • (2005) Nutr. Cancer , vol.51 , pp. 162-169
    • Touillaud, M.S.1    Pillow, P.C.2    Jakovljevic, J.3    Bondy, M.L.4    Singletary, S.E.5    Li, D.6    Chang, S.7
  • 33
    • 70449643130 scopus 로고    scopus 로고
    • Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells
    • Luo, H., Rankin, G.O., Liu, L., Daddysman, M.K., Jiang, B.H. and Chen, Y.C. (2009) Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr. Cancer, 61, 554-563.
    • (2009) Nutr. Cancer , vol.61 , pp. 554-563
    • Luo, H.1    Rankin, G.O.2    Liu, L.3    Daddysman, M.K.4    Jiang, B.H.5    Chen, Y.C.6
  • 34
    • 80052263870 scopus 로고    scopus 로고
    • Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFkappaB-cMyc-p21 pathway
    • Luo, H., Rankin, G.O., Juliano, N., Jiang, B.H. and Chen, Y.C. (2012) Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFkappaB-cMyc-p21 pathway. Food Chem., 130, 321-328.
    • (2012) Food Chem. , vol.130 , pp. 321-328
    • Luo, H.1    Rankin, G.O.2    Juliano, N.3    Jiang, B.H.4    Chen, Y.C.5
  • 35
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B. and Kinzler, K.W. (2004) Cancer genes and the pathways they control. Nat. Med., 10, 789-799.
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 37
    • 42749084654 scopus 로고    scopus 로고
    • Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner
    • Xu, W., Liu, J., Li, C., Wu, H.Z. and Liu, Y.W. (2008) Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett., 264, 229-240.
    • (2008) Cancer Lett. , vol.264 , pp. 229-240
    • Xu, W.1    Liu, J.2    Li, C.3    Wu, H.Z.4    Liu, Y.W.5
  • 38
    • 84879657942 scopus 로고    scopus 로고
    • Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells
    • Chen, H.J., Lin, C.M., Lee, C.Y., Shih, N.C., Peng, S.F., Tsuzuki, M., Amagaya, S., Huang, W.W. and Yang, J.S. (2013) Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. Oncol. Rep., 30, 925-932.
    • (2013) Oncol. Rep. , vol.30 , pp. 925-932
    • Chen, H.J.1    Lin, C.M.2    Lee, C.Y.3    Shih, N.C.4    Peng, S.F.5    Tsuzuki, M.6    Amagaya, S.7    Huang, W.W.8    Yang, J.S.9
  • 39
    • 84861372938 scopus 로고    scopus 로고
    • A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres
    • Martina, M., Clerici, M., Baldo, V., Bonetti, D., Lucchini, G. and Longhese, M.P. (2012) A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres. Mol. Cell Biol., 32, 1604-1617.
    • (2012) Mol. Cell Biol. , vol.32 , pp. 1604-1617
    • Martina, M.1    Clerici, M.2    Baldo, V.3    Bonetti, D.4    Lucchini, G.5    Longhese, M.P.6
  • 40
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis. An overview of cell death
    • Majno, G. and Joris, I. (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol., 146, 3-15.
    • (1995) Am. J. Pathol. , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 41
    • 7744235672 scopus 로고    scopus 로고
    • Death by design: apoptosis, necrosis and autophagy
    • Edinger, A.L. and Thompson, C.B. (2004) Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol., 16, 663-669.
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 663-669
    • Edinger, A.L.1    Thompson, C.B.2
  • 42
    • 0026508561 scopus 로고
    • Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
    • Fadok, V.A., Voelker, D.R., Campbell, P.A., Cohen, J.J., Bratton, D.L. and Henson, P.M. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol., 148, 2207-2216.
    • (1992) J. Immunol. , vol.148 , pp. 2207-2216
    • Fadok, V.A.1    Voelker, D.R.2    Campbell, P.A.3    Cohen, J.J.4    Bratton, D.L.5    Henson, P.M.6
  • 43
    • 0015117787 scopus 로고
    • Shrinkage necrosis: a distinct mode of cellular death
    • Kerr, J.F. (1971) Shrinkage necrosis: a distinct mode of cellular death. J. Pathol., 105, 13-20.
    • (1971) J. Pathol. , vol.105 , pp. 13-20
    • Kerr, J.F.1
  • 44
    • 0028329172 scopus 로고
    • Apoptosis. Its significance in cancer and cancer therapy
    • Kerr, J.F., Winterford, C.M. and Harmon, B.V. (1994) Apoptosis. Its significance in cancer and cancer therapy. Cancer, 73, 2013-2026.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.1    Winterford, C.M.2    Harmon, B.V.3
  • 45
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F., Wyllie, A.H. and Currie, A.R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 46
    • 0034630349 scopus 로고    scopus 로고
    • A simple method for accurate estimation of apoptotic cells
    • Singh, N.P. (2000) A simple method for accurate estimation of apoptotic cells. Exp. Cell Res., 256, 328-337.
    • (2000) Exp. Cell Res. , vol.256 , pp. 328-337
    • Singh, N.P.1
  • 47
    • 0037405816 scopus 로고    scopus 로고
    • A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis
    • Kelly, K.J., Sandoval, R.M., Dunn, K.W., Molitoris, B.A. and Dagher, P.C. (2003) A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis. Am. J. Physiol. Cell Physiol., 284, C1309-1318.
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284
    • Kelly, K.J.1    Sandoval, R.M.2    Dunn, K.W.3    Molitoris, B.A.4    Dagher, P.C.5
  • 48
    • 34347215518 scopus 로고    scopus 로고
    • Analysis of apoptosis by propidium iodide staining and flow cytometry
    • Riccardi, C. and Nicoletti, I. (2006) Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat. Protoc., 1, 1458-1461.
    • (2006) Nat. Protoc. , vol.1 , pp. 1458-1461
    • Riccardi, C.1    Nicoletti, I.2
  • 49
  • 50
    • 0242656497 scopus 로고    scopus 로고
    • Death receptor-induced cell killing
    • Thorburn, A. (2004) Death receptor-induced cell killing. Cell. Signalling, 16, 139-144.
    • (2004) Cell. Signalling , vol.16 , pp. 139-144
    • Thorburn, A.1
  • 51
    • 34447332785 scopus 로고    scopus 로고
    • Down-regulation of iNOS and TNFalpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues
    • Kim, H.K., Park, H.R., Lee, J.S., Chung, T.S., Chung, H.Y. and Chung, J. (2007) Down-regulation of iNOS and TNFalpha expression by kaempferol via NF-kappaB inactivation in aged rat gingival tissues. Biogerontology, 8, 399-408.
    • (2007) Biogerontology , vol.8 , pp. 399-408
    • Kim, H.K.1    Park, H.R.2    Lee, J.S.3    Chung, T.S.4    Chung, H.Y.5    Chung, J.6
  • 52
    • 32144442544 scopus 로고    scopus 로고
    • Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells
    • Pang, J.L., Ricupero, D.A., Huang, S., Fatma, N., Singh, D.P., Romero, J.R. and Chattopadhyay, N. (2006) Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells. Biochem. Pharmacol., 71, 818-826.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 818-826
    • Pang, J.L.1    Ricupero, D.A.2    Huang, S.3    Fatma, N.4    Singh, D.P.5    Romero, J.R.6    Chattopadhyay, N.7
  • 53
    • 4143115887 scopus 로고    scopus 로고
    • Deficient tumor necrosis factor-related apoptosisinducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis
    • Jin, Z., McDonald, E.R. 3rd, Dicker, D.T. and El-Deiry, W.S. (2004) Deficient tumor necrosis factor-related apoptosisinducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J. Biol. Chem., 279, 35829-35839.
    • (2004) J. Biol. Chem. , vol.279 , pp. 35829-35839
    • Jin, Z.1    McDonald III, E.R.2    Dicker, D.T.3    El-Deiry, W.S.4
  • 55
    • 56249131797 scopus 로고    scopus 로고
    • The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin
    • Siegelin, M.D., Reuss, D.E., Habel, A., Herold-Mende, C. and von Deimling, A. (2008) The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin. Mol. Cancer Ther., 7, 3566-3574.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3566-3574
    • Siegelin, M.D.1    Reuss, D.E.2    Habel, A.3    Herold-Mende, C.4    von Deimling, A.5
  • 56
    • 77953292595 scopus 로고    scopus 로고
    • Post-translational modifications in signal integration
    • Deribe, Y.L., Pawson, T. and Dikic, I. (2010) Post-translational modifications in signal integration. Nat. Struct. Mol. Biol., 17, 666-672.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 666-672
    • Deribe, Y.L.1    Pawson, T.2    Dikic, I.3
  • 57
    • 78650707134 scopus 로고    scopus 로고
    • Swords of cell death: caspase activation and regulation
    • Alenzi, F.Q., Lotfy, M. and Wyse, R. (2010) Swords of cell death: caspase activation and regulation. Asian Pac. J. Cancer Prev., 11, 271-280.
    • (2010) Asian Pac. J. Cancer Prev. , vol.11 , pp. 271-280
    • Alenzi, F.Q.1    Lotfy, M.2    Wyse, R.3
  • 58
    • 35148894128 scopus 로고    scopus 로고
    • Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations
    • Bestwick, C.S., Milne, L. and Duthie, S.J. (2007) Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations. Chem. Biol. Interact., 170, 76-85.
    • (2007) Chem. Biol. Interact. , vol.170 , pp. 76-85
    • Bestwick, C.S.1    Milne, L.2    Duthie, S.J.3
  • 59
    • 76749107731 scopus 로고    scopus 로고
    • Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis?
    • Engel, T. and Henshall, D.C. (2009) Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? Int. J. Physiol. Pathophysiol. Pharmacol., 1, 97-115.
    • (2009) Int. J. Physiol. Pathophysiol. Pharmacol. , vol.1 , pp. 97-115
    • Engel, T.1    Henshall, D.C.2
  • 60
    • 79955591914 scopus 로고    scopus 로고
    • Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
    • Indran, I.R., Tufo, G., Pervaiz, S. and Brenner, C. (2011) Recent advances in apoptosis, mitochondria and drug resistance in cancer cells. Biochim. Biophys. Acta, 1807, 735-745.
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 735-745
    • Indran, I.R.1    Tufo, G.2    Pervaiz, S.3    Brenner, C.4
  • 62
    • 0030662226 scopus 로고    scopus 로고
    • Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
    • Kim, Y.M., Talanian, R.V. and Billiar, T.R. (1997) Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem., 272, 31138-31148.
    • (1997) J. Biol. Chem. , vol.272 , pp. 31138-31148
    • Kim, Y.M.1    Talanian, R.V.2    Billiar, T.R.3
  • 63
    • 0036162636 scopus 로고    scopus 로고
    • Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector?
    • Cooper, C.E. (2002) Nitric oxide and cytochrome oxidase: substrate, inhibitor or effector? Trends Biochem. Sci., 27, 33-39.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 33-39
    • Cooper, C.E.1
  • 65
    • 17044420097 scopus 로고    scopus 로고
    • Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock
    • Reade, M.C., Millo, J.L., Young, J.D. and Boyd, C.A. (2005) Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock. Br. J. Anaesth., 94, 468-473.
    • (2005) Br. J. Anaesth. , vol.94 , pp. 468-473
    • Reade, M.C.1    Millo, J.L.2    Young, J.D.3    Boyd, C.A.4
  • 66
    • 33846582444 scopus 로고    scopus 로고
    • The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells
    • García-Mediavilla, V., Crespo, I., Collado, P.S., Esteller, A., Sánchez-Campos, S., Tuñón, M.J. and González-Gallego, J. (2007) The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur. J. Pharmacol., 557, 221-229.
    • (2007) Eur. J. Pharmacol. , vol.557 , pp. 221-229
    • García-Mediavilla, V.1    Crespo, I.2    Collado, P.S.3    Esteller, A.4    Sánchez-Campos, S.5    Tuñón, M.J.6    González-Gallego, J.7
  • 67
    • 84881344192 scopus 로고    scopus 로고
    • Real-time electrical detection of nitric oxide in biological systems with sub-nanomolar sensitivity
    • Jiang, S., Cheng, R., Wang, X., Xue, T., Liu, Y., Nel, A., Huang, Y. and Duan, X. (2013) Real-time electrical detection of nitric oxide in biological systems with sub-nanomolar sensitivity. Nat. Commun., 4, 2225.
    • (2013) Nat. Commun. , vol.4 , pp. 2225
    • Jiang, S.1    Cheng, R.2    Wang, X.3    Xue, T.4    Liu, Y.5    Nel, A.6    Huang, Y.7    Duan, X.8


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