Current treatment limitations in age-related macular degeneration and future approaches based on cell therapy and tissue engineering

Journal of Ophthalmology

Volumn 2014, Issue , 2014, Pages

  Fernandez Robredo P ^a   Sancho, A ^b   Johnen, S ^c   Recalde, S ^a   Gama, N ^d   Thumann, G ^d   Groll, J ^e   Garcia Layana A ^a,f  

^a UNIVERSITY OF NAVARRA   (Spain)

^b TECNUN UNIVERSITY OF NAVARRA   (Spain)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84893684999     PISSN: 2090004X     EISSN: 20900058     Source Type: Journal    
DOI: 10.1155/2014/510285     Document Type: Article

References (170)

1. Bird A. C., Retinal photoreceptor dystrophies Ll. Edward Jackson Memorial Lecture. American Journal of Ophthalmology 1995 119 5 543 562 2-s2.0-0029035306
2. Klein R., Klein B. E. K., Jemen S. C., Cruichshanks K. J., The relationship of ocular factors to the incidence and progression of age-related maculopathy. Archives of Ophthalmology 1998 116 4 506 513 2-s2.0-0031893363 (Pubitemid 28169753)
3. Banerjee A., Kumar S., Kulhara P., Gupta A., Prevalence of depression and its effect on disability in patients with age-related macular degeneration. Indian Journal of Ophthalmology 2008 56 6 469 474 2-s2.0-54349128140 10.4103/0301-4738.42643
4. Nowak J. Z., Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacological Reports 2006 58 3 353 363 2-s2.0-33746373850 (Pubitemid 44111070)
5. Jager R. D., Mieler W. F., Miller J. W., Age-related macular degeneration. The New England Journal of Medicine 2008 358 24 2544 2617 2-s2.0-45149098715 10.1056/NEJMra0801537 (Pubitemid 351831361)
6. Zarbin M. A., Current concepts in the pathogenesis of age-related macular degeneration. Archives of Ophthalmology 2004 122 4 598 614 2-s2.0-1842478123 10.1001/archopht.122.4.598 (Pubitemid 38456297)
7. Buschini E., Piras A., Nuzzi R., Vercelli A., Age related macular degeneration and drusen: neuroinflammation in the retina. Progress in Neurobiology 2011 95 1 14 25 2-s2.0-79960671469 10.1016/j.pneurobio.2011.05.011
8. del Priore L. V., Tezel T. H., Kaplan H. J., Maculoplasty for age-related macular degeneration: reengineering Bruch's membrane and the human macula. Progress in Retinal and Eye Research 2006 25 6 539 562 2-s2.0-33750523637 10.1016/j.preteyeres.2006.08.001 (Pubitemid 44666508)
9. Tezel T. H., del Priore L. V., Berger A. S., Kaplan H. J., Adult retinal pigment epithelial transplantation in exudative age-related macular degeneration. American Journal of Ophthalmology 2007 143 4 584 e2 2-s2.0-33947408058 10.1016/j.ajo.2006.12.007 (Pubitemid 46463938)
10. Hubschman J. P., Reddy S., Schwartz S. D., Age-related macular degeneration: current treatments. Clinical Ophthalmology 2009 3 1 155 166 2-s2.0-77953371996
11. Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the macular photocoagulation study. Macular Photocoagulation Study Group. Archives of Ophthalmology 1991 109 9 1242 1257 2-s2.0-0025776268
12. Laser photocoagulation of subfoveal neovascular lesions of age-related macular degeneration. Updated findings from two clinical trials. Macular Photocoagulation Study Group. Archives of Ophthalmology 1993 111 9 1200 1209 2-s2.0-0027237206
13. Persistent and recurrent neovascularization after laser photocoagulation for subfoveal choroidal neovascularization of age-related macular degeneration. Macular Photocoagulation Study Group. Archives of Ophthalmology 1994 112 4 489 499 2-s2.0-0028349664
14. Bressler N. M., Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-TAP report 2. Archives of Ophthalmology 2001 119 2 198 207 2-s2.0-0035124965 (Pubitemid 32147926)
15. Binder S., Stanzel B. V., Krebs I., Glittenberg C., Transplantation of the RPE in AMD. Progress in Retinal and Eye Research 2007 26 5 516 554 2-s2.0-34548124615 10.1016/j.preteyeres.2007.02.002 (Pubitemid 47302351)
16. Bressler N. M., Silva J. C., Bressler S. B., Fine S. L., Green W. R., Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina 1994 14 2 130 142 2-s2.0-0028233212 10.1097/00006982-199414020-00006 (Pubitemid 24195742)
17. Ferrara N., Gerber H.-P., LeCouter J., The biology of VEGF and its receptors. Nature Medicine 2003 9 6 669 676 2-s2.0-0037699954 10.1038/nm0603-669 (Pubitemid 36749215)
18. Kliffen M., Sharma H. S., Mooy C. M., Kerkvliet S., de Jong P. T. V. M., Increased expression of angiogenic growth factors in age-related maculopathy. British Journal of Ophthalmology 1997 81 2 154 162 2-s2.0-0031050126 (Pubitemid 27092496)
19. Lally D. R., Gerstenblith A. T., Regillo C. D., Preferred therapies for neovascular age-related macular degeneration. Current Opinion in Ophthalmology 2012 23 3 182 188 2-s2.0-84859706026 10.1097/ICU.0b013e328352411c
20. Rofagha S., Bhisitkul R. B., Boyer D. S., Sadda S. R., Zhang K., Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology 2013 120 11 2292 2299 10.1016/j.ophtha.2013.03.046
21. Schraermeyer U., Julien S., Effects of bevacizumab in retina and choroid after intravitreal injection into monkey eyes. Expert Opinion on Biological Therapy 2013 13 2 157 167
22. Chang T. S., Bressler N. M., Fine J. T., Dolan C. M., Ward J., Klesert T. R., Improved vision-related function after ranibizumab treatment of neovascular age-related macular degeneration: results of a randomized clinical trial. Archives of Ophthalmology 2007 125 11 1460 1469 2-s2.0-36148980784 10.1001/archopht.125.11.1460 (Pubitemid 350106676)
23. Haller J. A., Current anti-vascular endothelial growth factor dosing regimens: benefits and burden. Ophthalmology 2013 120 5, supplement S3 S7
24. Dixon J. A., Oliver S. C. N., Olson J. L., Mandava N., VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration. Expert Opinion on Investigational Drugs 2009 18 10 1573 1580 2-s2.0-70349330817 10.1517/13543780903201684
25. Kaiser P. K., Emerging therapies for neovascular age-related macular degeneration: drugs in the pipeline. Ophthalmology 2013 120 5, supplement S11 S15
26. Adams J. A., Paiva K. L., Munzenrider J. E., Miller J. W., Gragoudas E. S., Proton beam therapy for age-related macular degeneration: development of a standard plan. Medical Dosimetry 1999 24 4 233 238 2-s2.0-0032804142 10.1016/S0958-3947(99)00024-2
27. Finger P. T., Gelman Y. P., Berson A. M., Szechter A., Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study. British Journal of Ophthalmology 2003 87 12 1497 1503 2-s2.0-0347517735 10.1136/bjo.87.12.1497 (Pubitemid 38010556)
28. Sivagnanavel V., Evans J. R., Ockrim Z., Chong V., Radiotherapy for neovascular age-related macular degeneration. Cochrane Database of Systematic Reviews 2004 4 CD004004 2-s2.0-16644377677
29. Zambarakji H. J., Lane A. M., Ezra E., Gauthier D., Goitein M., Adams J. A., Munzenrider J. E., Miller J. W., Gragoudas E. S., Proton beam irradiation for neovascular age-related macular degeneration. Ophthalmology 2006 113 11 2012 2019 2-s2.0-33750304884 10.1016/j.ophtha.2006.05.036 (Pubitemid 44635705)
30. Ávila M. P., Farah M. E., Santos A., Duprat J. P., Woodward B. W., Nau J., Twelve-month short-term safety and visual-acuity results from a multicentre prospective study of epiretinal strontium-90 brachytherapy with bevacizumab for the treatment of subfoveal choroidal neovascularisation secondary to age-related macular degeneration. British Journal of Ophthalmology 2009 93 3 305 309 2-s2.0-61749100479 10.1136/bjo.2008.145912
31. Ávila M. P., Farah M. E., Santos A., Kapran Z., Duprat J. P., Woodward B. W., Nau J., Twelve-month safety and visual acuity results from a feasibility study of intraocular, epiretinal radiation therapy for the treatment of subfoveal CNV secondary to amd. Retina 2009 29 2 157 169 2-s2.0-63249111858 10.1097/IAE.0b013e3181985915
32. Gertner M., Chell E., Pan K.-H., Hansen S., Kaiser P. K., Moshfeghi D. M., Stereotactic targeting and dose verification for age-related macular degeneration. Medical Physics 2010 37 2 600 606 2-s2.0-75749128302 10.1118/1.3291648
33. Silva R. A., Moshfeghi A. A., Kaiser P. K., Singh R. P., Moshfeghi D. M., Radiation treatment for age-related macular degeneration. Seminars in Ophthalmology 2011 26 3 121 130 10.3109/08820538.2011.554486
34. Dugel P. U., Bebchuk J. D., Nau J., Reichel E., Singer M., Barak A., Binder S., Jackson T. L., Epimacular brachytherapy for neovascular age-related macular degeneration: a randomized, controlled trial (CABERNET). Ophthalmology 2013 120 2 317 327
35. Heier J. S., Antoszyk A. N., Pavan P. R., Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study. Ophthalmology 2006 113 4 633.e1 633.e4
36. Hernandez-Pastor L. J., Ortega A., Garcia-Layana A., Giraldez J., Ranibizumab for neovascular age-related macular degeneration. American Journal of Health-System Pharmacy 2008 65 19 1805 1814 2-s2.0-54749087545 10.2146/ajhp070342
37. Rosenfeld P. J., Brown D. M., Heier J. S., Boyer D. S., Kaiser P. K., Chung C. Y., Kim R. Y., Ranibizumab for neovascular age-related macular degeneration. The New England Journal of Medicine 2006 355 14 1419 1431 2-s2.0-33749445317 10.1056/NEJMoa054481 (Pubitemid 44511557)
38. Schmitz-Valckenberg S., Fleckenstein M., Helb H.-M., Issa P. C., Scholl H. P. N., Holz F. G., In vivo imaging of foveal sparing in geographic atrophy secondary to age-related macular degeneration. Investigative Ophthalmology and Visual Science 2009 50 8 3915 3921 2-s2.0-68349089202 10.1167/iovs.08-2484
39. Thumann G., Salz A. K., Walter P., Johnen S., Preservation of photoreceptors in dystrophic RCS rats following allo- and xenotransplantation of IPE cells. Graefe's Archive for Clinical and Experimental Ophthalmology 2009 247 3 363 369 2-s2.0-59749088122 10.1007/s00417-008-0998-x
40. Thumann G., Viethen A., Gaebler A., Walter P., Kaempf S., Johnen S., Salz A. K., The in vitro and in vivo behaviour of retinal pigment epithelial cells cultured on ultrathin collagen membranes. Biomaterials 2009 30 3 287 294 2-s2.0-55249091080 10.1016/j.biomaterials.2008.09.039
41. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Archives of Ophthalmology 2001 119 10 1439 1452
42. Klingel R., Fassbender C., Fischer I., Hattenbach L., Gümbel H., Pulido J., Koch F., Rheopheresis for age-related macular degeneration: a novel indication for therapeutic apheresis in ophthalmology. Therapeutic Apheresis 2002 6 4 271 281 2-s2.0-0036673481
43. Pulido J. S., Anderson W. B. Jr., Flynn J. T., Lichter P. R., Sanders D., Multicenter prospective, randomized, double-masked, placebo-controlled study of rheopheresis to treat nonexudative age-related macular degeneration: interim analysis. Transactions of the American Ophthalmological Society 2002 100 85 107 2-s2.0-0036988460 (Pubitemid 37039360)
44. Pulido J. S., Sanders D., Klingel R., Rheopheresis for age-related macular degeneration: clinical results and putative mechanism of action. Canadian Journal of Ophthalmology 2005 40 3 332 340 2-s2.0-21744436076 (Pubitemid 40942260)
45. Friberg T. R., Laser photocoagulation of eyes with drusen: will it help. Seminars in Ophthalmology 1999 14 1 45 50 2-s2.0-0032932136 (Pubitemid 29215310)
46. Friberg T. R., Musch D. C., Lim J. I., Morse L., Freeman W., Sinclair S., Prophylactic treatment of age-related macular degeneration report number 1: 810-nanometer laser to eyes with drusen. Unilaterally eligible patients. Ophthalmology 2006 113 4 612 622 2-s2.0-33645360621 10.1016/j.ophtha.2005.10.066
47. da Cruz L., Chen F. K., Ahmado A., Greenwood J., Coffey P., RPE transplantation and its role in retinal disease. Progress in Retinal and Eye Research 2007 26 6 598 635 2-s2.0-35348953619 10.1016/j.preteyeres.2007.07.001 (Pubitemid 47615562)
48. de Juan E. Jr., Loewenstein A., Bressler N. M., Alexander J., Translocation of the retina for management of subfoveal choroidal neovascularization II: a preliminary report in humans. American Journal of Ophthalmology 1998 125 5 635 646 2-s2.0-0032076996 10.1016/S0002-9394(98)00018-X (Pubitemid 28265512)
49. Lai J. C., Lapolice D. J., Stinnett S. S., Meyer C. H., Arieu L. M., Keller M. A., Toth C. A., Visual outcomes following macular translocation with 360°peripheral retinectomy. Archives of Ophthalmology 2002 120 10 1317 1324 2-s2.0-0036822821 (Pubitemid 36105437)
50. Machemer R., Steinhorst U. H., Retinal separation, retinotomy, and macular relocation: II. A surgical approach for age-related macular degeneration? Graefe's Archive for Clinical and Experimental Ophthalmology 1993 231 11 635 641 2-s2.0-0027426439 10.1007/BF00921957 (Pubitemid 23342235)
51. Gelisken F., Voelker M., Schwabe R., Besch D., Aisenbrey S., Szurman P., Grisanti S., Herzau V., Bartz-Schmidt K. U., Full macular translocation versus photodynamic therapy with verteporfin in the treatment of neovascular age-related macular degeneration: 1-year results of a prospective, controlled, randomised pilot trial (FMT-PDT). Graefe's Archive for Clinical and Experimental Ophthalmology 2007 245 8 1085 1095 2-s2.0-34447135409 10.1007/s00417-006-0524-y (Pubitemid 47034332)
52. Binder S., Krebs I., Hilgers R.-D., Abri A., Stolba U., Assadoulina A., Kellner L., Stanzel B. V., Jahn C., Feichtinger H., Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration: a prospective trial. Investigative Ophthalmology and Visual Science 2004 45 11 4151 4160 2-s2.0-6944253464 10.1167/iovs.04-0118 (Pubitemid 39411174)
53. Falkner-Radler C. I., Krebs I., Glittenberg C., Považay B., Drexler W., Graf A., Binder S., Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study. British Journal of Ophthalmology 2011 95 3 370 375 2-s2.0-79952025858 10.1136/bjo.2009.176305
54. Joussen A. M., How complete is successful? "Autologous retinal pigment epithelium and choriod translocation in patients with exsudative age-related macular degeneration: a short-term follow-up" by Jan van Meurs and P.R. van Biesen. Graefe's Archive for Clinical and Experimental Ophthalmology 2003 241 12 966 967 2-s2.0-0346969424 10.1007/s00417-003-0792-8 (Pubitemid 38028889)
55. Joussen A. M., Heussen F. M. A., Joeres S., Llacer H., Prinz B., Rohrschneider K., Maaijwee K. J. M., van Meurs J., Kirchhof B., Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration. American Journal of Ophthalmology 2006 142 1 17 30 2-s2.0-33745394637 10.1016/j.ajo.2006.01.090 (Pubitemid 43946784)
56. MacLaren R. E., Uppal G. S., Balaggan K. S., Tufail A., Munro P. M. G., Milliken A. B., Ali R. R., Rubin G. S., Aylward G. W., da Cruz L., Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration. Ophthalmology 2007 114 3 561 570 2-s2.0-33847102621 10.1016/j.ophtha.2006.06.049 (Pubitemid 46282940)
57. Peyman G. A., Blinder K. J., Paris C. L., Alturki W., Nelson N. C. Jr., Desai U., A technique for retinal pigment epithelium transplantation for age-related macular degeneration secondary to extensive subfoveal scarring. Ophthalmic Surgery 1991 22 2 102 108 2-s2.0-0025904308
58. Carr A. J., Smart M. J., Ramsden C. M., Powner M. B., da Cruz L., Coffey P. J., Development of human embryonic stem cell therapies for age-related macular degeneration. Trends in Neurosciences 2013 36 7 385 395 10.1016/j.tins.2013.03.006
59. Desai M., Pratt L. A., Lentzner H., Robinson K. N., Trends in vision and hearing among older Americans. Aging Trends 2001 2 1 8 2-s2.0-0035295978
60. Verma L., Das T., Binder S., Heriot W. J., Kirchhof B., Venkatesh P., Krebs I., Stolba U., Jahn C., Feichtinger H., Kellner L., Krugluger H., Pawelka I., Frohner U., Kruger A., Li W., Tewari H. K., New approaches in the management of choroidal neovascular membrane in age-related macular degeneration. Indian Journal of Ophthalmology 2000 48 4 263 278 2-s2.0-0034574727 (Pubitemid 33621461)
61. Dargent-Molina P., Favier F., Grandjean H., Baudoin C., Schott A. M., Hausherr E., Meunier P. J., Bréart G., Fall-related factors and risk of hip fracture: the EPIDOS prospective study. The Lancet 1996 348 9021 145 149 2-s2.0-0030594825 10.1016/S0140-6736(96)01440-7 (Pubitemid 26238096)
62. Ivers R. Q., Cumming R. G., Mitchell P., Attebo K., Visual impairment and falls in older adults: the blue mountains eye study. Journal of the American Geriatrics Society 1998 46 1 58 64 2-s2.0-0031985325 (Pubitemid 28037674)
63. Lee H. K. M., Scudds R. J., Comparison of balance in older people with and without visual impairment. Age and Ageing 2003 32 6 643 649 2-s2.0-0344465912 10.1093/ageing/afg110 (Pubitemid 37461573)
64. Cruess A. F., Zlateva G., Xu X., Soubrane G., Pauleikhoff D., Lotery A., Mones J., Buggage R., Schaefer C., Knight T., Goss T. F., Economic burden of bilateral neovascular age-related macular degeneration: multi-country observational study. PharmacoEconomics 2008 26 1 57 73 2-s2.0-37549039136
65. Williams R. A., Brody B. L., Thomas R. G., Kaplan R. M., Brown S. I., The psychosocial impact of macular degeneration. Archives of Ophthalmology 1998 116 4 514 520 2-s2.0-0031916591 (Pubitemid 28169754)
66. Laser photocoagulation of subfoveal recurrent neovascular lesions in age-related macular degeneration. Results of a randomized clinical trial. Macular Photocoagulation Study Group. Archives of Ophthalmology 1991 109 9 1232 1241 2-s2.0-0025887896
67. Brown G., Brown M. M., Let us wake the nation on the treatment for age-related macular degeneration. Current Opinion in Ophthalmology 2010 21 3 169 171 2-s2.0-77951278567 10.1097/ICU.0b013e3283388605
68. Brown M. M., Brown G. C., Stein J. D., Roth Z., Campanella J., Beauchamp G. R., Age-related macular degeneration: economic burden and value-based medicine analysis. Canadian Journal of Ophthalmology 2005 40 3 277 287 2-s2.0-21744445056 (Pubitemid 40942254)
69. Oishi A., Mandai M., Nishida A., Hata M., Matsuki T., Kurimoto Y., Remission and dropout rate of anti-VEGF therapy for age-related macular degeneration. European Journal of Ophthalmology 2011 21 6 777 782 10.5301/EJO.2011.7430
70. Tufail A., Patel P. J., Egan C., Hykin P., da Cruz L., Gregor Z., Dowler J., Majid M. A., Bailey C., Mohamed Q., Johnston R., Bunce C., Xing W., ABC Trial Investigators A. T. I., Bevacizumab for neovascular age related macular degeneration (ABC Trial): multicentre randomised double masked study. British Medical Journal 2010 340, article c2459 2-s2.0-77954470039 10.1136/bmj.c2459
71. Sharma S., Oliver-Fernandez A., Age-related macular degeneration and quality of life: how to interpret a research paper in health-related quality of life. Current Opinion in Ophthalmology 2004 15 3 227 231 2-s2.0-2442438990 10.1097/01.icu.0000124082.88389.cf (Pubitemid 38638868)
72. Bonastre J., le Pen C., Soubrane G., Quentel G., The burden of age-related macular degeneration: results of a cohort study in two french referral centres. PharmacoEconomics 2003 21 3 181 190 2-s2.0-0037218226 10.2165/00019053-200321030-00003 (Pubitemid 36286662)
73. Cruess A., Zlateva G., Xu X., Rochon S., Burden of illness of neovascular age-related macular degeneration in Canada. Canadian Journal of Ophthalmology 2007 42 6 836 843 2-s2.0-38149099226 10.3129/I07-153
74. Lopez R., Gouras P., Brittis M., Kjeldbye H., Transplantation of cultured rabbit retinal epithelium to rabbit retina using a closed-eye method. Investigative Ophthalmology and Visual Science 1987 28 7 1131 1137 2-s2.0-0023243353 (Pubitemid 17089951)
75. Arnhold S., Heiduschka P., Klein H., Absenger Y., Basnaoglu S., Kreppel F., Renke-Fahle S., Kochanek S., Bartz-Schmidt K.-U., Addicks K., Schraermeyer U., Adenovirally transduced bone marrow stromal cells differentiate into pigment epithelial cells and induce rescue effects in RCS rats. Investigative Ophthalmology and Visual Science 2006 47 9 4121 4129 2-s2.0-33749124542 10.1167/iovs.04-1501 (Pubitemid 46044331)
76. Coffey P. J., Girman S., Wang S. M., Hetherington L., Keegan D. J., Adamson P., Greenwood J., Lund R. D., Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Nature Neuroscience 2002 5 1 53 56 2-s2.0-0036138746 10.1038/nn782 (Pubitemid 34038783)
77. Gias C., Jones M., Keegan D., Adamson P., Greenwood J., Lund R., Martindale J., Johnston D., Berwick J., Mayhew J., Coffey P., Preservation of visual cortical function following retinal pigment epithelium transplantation in the RCS rat using optical imaging techniques. European Journal of Neuroscience 2007 25 7 1940 1948 2-s2.0-34147210524 10.1111/j.1460-9568.2007.05459.x (Pubitemid 46581735)
78. -/- mice. Investigative Ophthalmology and Visual Science 2002 43 10 3307 3311 2-s2.0-0036784952
79. Lu B., Malcuit C., Wang S., Girman S., Francis P., Lemieux L., Lanza R., Lund R., Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem Cells 2009 27 9 2126 2135 2-s2.0-70349873363 10.1002/stem.149
80. Lund R. D., Wang S., Klimanskaya I., Holmes T., Ramos-Kelsey R., Lu B., Girman S., Bischoff N., Sauvé Y., Lanza R., Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. Cloning and Stem Cells 2006 8 3 189 199 2-s2.0-33750732308 10.1089/clo.2006.8.189 (Pubitemid 44735173)
81. Semkova I., Kreppel F., Welsandt G., Luther T., Kozlowski J., Janicki H., Kochanek S., Schraermeyer U., Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye. Proceedings of the National Academy of Sciences of the United States of America 2002 99 20 13090 13095 2-s2.0-0036790941 10.1073/pnas.202486199
82. Wang S., Lu B., Girman S., Holmes T., Bischoff N., Lund R. D., Morphological and functional rescue in RCS rats after RPE cell line transplantation at a later stage of degeneration. Investigative Ophthalmology and Visual Science 2008 49 1 416 421 2-s2.0-39549118221 10.1167/iovs.07-0992
83. Algvere P. V., Berglin L., Gouras P., Sheng Y., Kopp E. D., Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy. Graefe's Archive for Clinical and Experimental Ophthalmology 1997 235 3 149 158 2-s2.0-0030998645 10.1007/BF00941722 (Pubitemid 27132396)
84. Ma Z., Han L., Wang C., Dou H., Hu Y., Feng X., Xu Y., Wang Z., Yin Z., Liu Y., Autologous transplantation of retinal pigment epithelium-Bruch's membrane complex for hemorrhagic age-related macular degeneration. Investigative Ophthalmology and Visual Science 2009 50 6 2975 2981 2-s2.0-66849103887 10.1167/iovs.08-2573
85. Abe T., Yoshida M., Tomita H., Kano T., Nakagawa Y., Sato M., Wada Y., Fuse N., Yamada T., Tamai M., Functional analysis after auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration. Tohoku Journal of Experimental Medicine 1999 189 4 295 305 2-s2.0-0033253283
86. Abe T., Yoshida M., Yoshioka Y., Wakusawa R., Tokita-Ishikawa Y., Seto H., Tamai M., Nishida K., Iris pigment epithelial cell transplantation for degenerative retinal diseases. Progress in Retinal and Eye Research 2007 26 3 302 321 2-s2.0-33947622660 10.1016/j.preteyeres.2007.01.003 (Pubitemid 46498799)
87. Aisenbrey S., Lafaut B. A., Szurman P., Hilgers R.-D., Esser P., Walter P., Bartz-Schmidt K. U., Thumann G., Iris pigment epithelial translocation in the treatment of exudative macular degeneration: a 3-year follow-up. Archives of Ophthalmology 2006 124 2 183 188 2-s2.0-32644470965 10.1001/archopht.124.2.183 (Pubitemid 43247067)
88. Schwartz S. D., Hubschman J.-P., Heilwell G., Franco-Cardenas V., Pan C. K., Ostrick R. M., Mickunas E., Gay R., Klimanskaya I., Lanza R., Embryonic stem cell trials for macular degeneration: a preliminary report. The Lancet 2012 379 9817 713 720 2-s2.0-84857643783 10.1016/S0140-6736(12)60028-2
89. Arnhold S., Semkova I., Andressen C., Lenartz D., Meissner G., Sturm V., Kochanek S., Addicks K., Schraermeyer U., Iris pigment epithelial cells: a possible cell source for the future treatment of neurodegenerative diseases. Experimental Neurology 2004 187 2 410 417 2-s2.0-2342604382 10.1016/j.expneurol. 2004.02.015 (Pubitemid 38610287)
90. Thumann G., Bartz-Schmidt K. U., Heimann K., Schraermeyer U., Phagocytosis of rod outer segments by human iris pigment epithelial cells in vitro. Graefe's Archive for Clinical and Experimental Ophthalmology 1998 236 10 753 757 2-s2.0-0031670583 10.1007/s004170050154 (Pubitemid 28458675)
91. Thumann G., Kociok N., Bartz-Schmidt K. U., Esser P., Schraermeyer U., Heimann K., Detection of mRNA for proteins involved in retinol metabolism in iris pigment epithelium. Graefe's Archive for Clinical and Experimental Ophthalmology 1999 237 12 1046 1051 2-s2.0-0033394622 10.1007/s004170050343 (Pubitemid 30021297)
92. Crafoord S., Geng L., Seregard S., Algvere P. V., Photoreceptor survival in transplantation of autologous iris pigment epithelial cells to the subretinal space. Acta Ophthalmologica Scandinavica 2002 80 4 387 394 2-s2.0-0036667903 10.1034/j.1600-0420.2002.800408.x
93. Thumann G., Bartz-Schmidt K. U., El Bakri H., Schraermeyer U., Spee C., Cui J. Z., Hinton D. R., Ryan S. J., Heimann K., Transplantation of autologous iris pigment epithelium to the subretinal space in rabbits. Transplantation 1999 68 2 195 201 2-s2.0-0033609523 10.1097/00007890-199907270-00006 (Pubitemid 29360276)
94. Bhutto I. A., McLeod D. S., Hasegawa T., Kim S. Y., Merges C., Tong P., Lutty G. A., Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Experimental Eye Research 2006 82 1 99 110 2-s2.0-30344447284 10.1016/j.exer.2005.05.007 (Pubitemid 43063401)
95. Tong J.-P., Chan W.-M., Liu D. T. L., Lai T. Y. Y., Choy K.-W., Pang C.-P., Lam D. S. C., Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. American Journal of Ophthalmology 2006 141 3 456 462 2-s2.0-33144456714 10.1016/j.ajo.2005.10.012 (Pubitemid 43265948)
96. Ferrara N., Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Seminars in Oncology 2002 29 6, supplement 16 10 14 2-s2.0-0036985699
97. Miller J. W., Le Couter J., Strauss E. C., Ferrara N., Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology 2013 120 1 106 114
98. Kwak N., Okamoto N., Wood J. M., Campochiaro P. A., VEGF is major stimulator in model of choroidal neovascularization. Investigative Ophthalmology and Visual Science 2000 41 10 3158 3164 2-s2.0-0033823756
99. Ohno-Matsui K., Molecular mechanism for choroidal neovascularization in age-related macular degeneration. Nippon Ganka Gakkai Zasshi 2003 107 11 657 673 2-s2.0-1542674453
100. Carwile M. E., Culbert R. B., Sturdivant R. L., Kraft T. W., Rod outer segment maintenance is enhanced in the presence of BFGF, CNTF and GDNF. Experimental Eye Research 1998 66 6 791 805 2-s2.0-0032098247 10.1006/exer.1998.0488 (Pubitemid 28446315)
101. LaVail M. M., Unoki K., Yasumura D., Matthes M. T., Yancopoulos G. D., Steinberg R. H., Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proceedings of the National Academy of Sciences of the United States of America 1992 89 23 11249 11253 2-s2.0-0026462896 10.1073/pnas.89.23.11249
102. Unoki K., LaVail M. M., Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Investigative Ophthalmology and Visual Science 1994 35 3 907 915 2-s2.0-0028198705 (Pubitemid 24079821)
103. Chong N. H. V., Alexander R. A., Waters L., Barnett K. C., Bird A. C., Luthert P. J., Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration. Investigative Ophthalmology and Visual Science 1999 40 6 1298 1305 2-s2.0-0032925488 (Pubitemid 29211474)
104. Barnstable C. J., Tombran-Tink J., Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Progress in Retinal and Eye Research 2004 23 5 561 577 2-s2.0-4043074205 10.1016/j.preteyeres.2004.05.002 (Pubitemid 39078362)
105. Dawson D. W., Volpert O. V., Gillis P., Crawford S. E., Xu H.-J., Benedict W., Bouck N. P., Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999 285 5425 245 248 2-s2.0-0033538517 10.1126/science.285.5425.245 (Pubitemid 29329995)
106. Kociok N., Joussen A. M., Varied expression of functionally important genes of RPE and choroid in the macula and in the periphery of normal human eyes. Graefe's Archive for Clinical and Experimental Ophthalmology 2007 245 1 101 113 2-s2.0-34248634582 10.1007/s00417-006-0266-x (Pubitemid 46766736)
107. Kozulin P., Natoli R., O'Brien K. M. B., Madigan M. C., Provis J. M., The cellular expression of antiangiogenic factors in fetal primate macula. Investigative Ophthalmology and Visual Science 2010 51 8 4298 4306 2-s2.0-77955903331 10.1167/iovs.09-4905
108. Bhutto I. A., Kim S. Y., McLeod D. S., Merges C., Fukai N., Olsen B. R., Lutty G. A., Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration. Investigative Ophthalmology and Visual Science 2004 45 5 1544 1552 2-s2.0-2442654323 10.1167/iovs.03-0862 (Pubitemid 38859336)
109. Bhutto I. A., Uno K., Merges C., Zhang L., McLeod D. S., Lutty G. A., Reduction of endogenous angiogenesis inhibitors in Bruch's membrane of the submacular region in eyes with age-related macular degeneration. Archives of Ophthalmology 2008 126 5 670 678 2-s2.0-43549093349 10.1001/archopht.126.5.670 (Pubitemid 351679563)
110. Holekamp N. M., Bouck N., Volpert O., Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. American Journal of Ophthalmology 2002 134 2 220 227 2-s2.0-0036329579 10.1016/S0002-9394(02)01549-0 (Pubitemid 34831826)
111. Ogata N., Wada M., Otsuji T., Jo N., Tombran-Tink J., Matsumura M., Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization. Investigative Ophthalmology and Visual Science 2002 43 4 1168 1175 2-s2.0-0036211549 (Pubitemid 34258289)
112. Spranger J., Osterhoff M., Reimann M., Möhlig M., Ristow M., Francis M. K., Cristofalo V., Hammes H.-P., Smith G., Boulton M., Pfeiffer A. F. H., Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes 2001 50 12 2641 2645 2-s2.0-0035654217 (Pubitemid 33733112)
113. Lee S., Song S. J., Yu H. G., Current smoking is associated with a poor visual acuity improvement after intravitreal ranibizumab therapy in patients with exudative age-related macular degeneration. Journal of Korean Medical Science 2013 28 5 769 774
114. Pons M., Marin-Castaño M. E., Nicotine increases the VEGF/PEDF ratio in retinal pigment epithelium: a possible mechanism for CNV in passive smokers with AMD. Investigative Ophthalmology & Visual Science 2011 52 6 3842 3853 2-s2.0-79957746980
115. Brown D. M., Michels M., Kaiser P. K., Heier J. S., Sy J. P., Ianchulev T., Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology 2009 116 1 57 65 2-s2.0-57949094834 10.1016/j.ophtha.2008.10.018
116. Martin D. F., Maguire M. G., Ying G.-S., Grunwald J. E., Fine S. L., Jaffe G. J., Ranibizumab and bevacizumab for neovascular age-related macular degeneration. The New England Journal of Medicine 2011 364 20 1897 1908 2-s2.0-79956218863 10.1056/NEJMoa1102673
117. Adelman R. A., Zheng Q., Mayer H. R., Persistent ocular hypertension following intravitreal bevacizumab and ranibizumab injections. Journal of Ocular Pharmacology and Therapeutics 2010 26 1 105 110 2-s2.0-77649324295 10.1089/jop.2009.0076
118. Krishnan R., Goverdhan S., Lochhead J., Submacular haemorrhage after intravitreal bevacizumab compared with intravitreal ranibizumab in large occult choroidal neovascularization. Clinical and Experimental Ophthalmology 2009 37 4 384 388 2-s2.0-67651180667 10.1111/j.1442-9071.2009.02043.x
119. Gullapalli V. K., Sugino I. K., van Patten Y., Shah S., Zarbin M. A., Impaired RPE survival on aged submacular human Bruch's membrane. Experimental Eye Research 2005 80 2 235 248 2-s2.0-12744265198 10.1016/j.exer.2004.09.006
120. Hussain A. A., Lee Y., Zhang J.-J., Marshall J., Disturbed matrix metalloproteinase activity of Bruch's membrane in age-related macular
121. Hussain A. A., Starita C., Hodgetts A., Marshall J., Macromolecular diffusion characteristics of ageing human Bruch's membrane: implications for age-related macular degeneration (AMD). Experimental Eye Research 2010 90 6 703 710 2-s2.0-77952787410 10.1016/j.exer.2010.02.013
122. Sugino I. K., Sun Q., Wang J., Nunes C. F., Cheewatrakoolpong N., Rapista A., Johnson A. C., Malcuit C., Klimanskaya I., Lanza R., Zarbin M. A., Comparison of FRPE and human embryonic stem cell-derived rpe behavior on aged human Bruch's membrane. Investigative Ophthalmology and Visual Science 2011 52 8 4979 4997 2-s2.0-79955372799 10.1167/iovs.10-5386
123. Yuan X., Gu X., Crabb J. S., Yue X., Shadrach K., Hollyfield J. G., Crabb J. W., Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes. Molecular and Cellular Proteomics 2010 9 6 1031 1046 2-s2.0-77953162265 10.1074/mcp.M900523-MCP200
124. Hynes S. R., Lavik E. B., A tissue-engineered approach towards retinal repair: scaffolds for cell transplantation to the subretinal space. Graefe's Archive for Clinical and Experimental Ophthalmology 2010 248 6 763 778 2-s2.0-77952089945 10.1007/s00417-009-1263-7
125. Stanzel B. V., Liu Z., Brinken R., Braun N., Holz F. G., Eter N., Subretinal delivery of ultrathin rigid-elastic cell carriers using a metallic shooter instrument and biodegradable hydrogel encapsulation. Investigative Ophthalmology & Visual Science 2012 53 1 490 500 2-s2.0-84858816449
126. Thomson H. A. J., Treharne A. J., Walker P., Grossel M. C., Lotery A. J., Optimisation of polymer scaffolds for retinal pigment epithelium (RPE) cell transplantation. British Journal of Ophthalmology 2011 95 4 563 568 2-s2.0-79952970513 10.1136/bjo.2009.166728
127. Bartsch U., Oriyakhel W., Kenna P. F., Linke S., Richard G., Petrowitz B., Humphries P., Farrar G. J., Ader M., Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice. Experimental Eye Research 2008 86 4 691 700 2-s2.0-41049110191 10.1016/j.exer.2008.01.018
128. del Cerro M., Notter M. F. D., del Cerro C., Wiegand S. J., Grover D. A., Lazar E., Intraretinal transplantation for rod-cell replacement in light-damaged retinas. Journal of Neural Transplantation 1989 1 1 1 10 2-s2.0-0024851127 (Pubitemid 20064443)
129. Kwan A. S. L., Wang S., Lund R. D., Photoreceptor layer reconstruction in a rodent model of retinal degeneration. Experimental Neurology 1999 159 1 21 33 2-s2.0-0032830443 10.1006/exnr.1999.7157 (Pubitemid 29444900)
130. Grabundzija I., Wang J., Sebe A., Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Research 2013 41 3 1829 1847
131. Jin Z. B., Okamoto S., Xiang P., Takahashi M., Integration-free induced pluripotent stem cells derived from retinitis pigmentosa patient for disease modeling. Stem Cells Translational Medicine 2012 1 6 503 509
132. Buchholz D. E., Pennington B. O., Croze R. H., Hinman C. R., Coffey P. J., Clegg D. O., Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Translational Medicine 2013 2 5 384 393 10.5966/sctm.2012-0163
133. Maruotti J., Wahlin K., Gorrell D., Bhutto I., Lutty G., Zack D. J., A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Translational Medicine 2013 2 5 341 354 10.5966/sctm.2012-0106
134. Melville H., Carpiniello M., Hollis K., Staffaroni A., Golestaneh N., Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration. Journal of Translational Medicine 2013 11, article 53 10.1186/1479-5876-11-53
135. Moviglia G. A., Moviglia G. A., Blasetti N., Zarate J. O., Pelayes D. E., In vitro differentiation of adult adipose mesenchymal stem cells into retinal progenitor cells. Ophthalmic Research 2012 48 supplement 1 1 5
136. Mekala S. R., Vauhini V., Nagarajan U., Maddileti S., Gaddipati S., Mariappan I., Derivation, characterization and retinal differentiation of induced pluripotent stem cells. Journal of Biosciences 2013 38 1 123 134
137. Lamba D. A., McUsic A., Hirata R. K., Wang P.-R., Russell D., Reh T. A., Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS ONE 2010 5 1 2-s2.0-77649329847 10.1371/journal.pone.0008763 e8763
138. MacLaren R. E., Pearson R. A., MacNeil A., Douglas R. H., Salt T. E., Akimoto M., Swaroop A., Sowden J. C., Ali R. R., Retinal repair by transplantation of photoreceptor precursors. Nature 2006 444 7116 203 207 2-s2.0-33750861299 10.1038/nature05161 (Pubitemid 44722060)
139. Geurts A. M., Hackett C. S., Bell J. B., Bergemann T. L., Collier L. S., Carlson C. M., Largaespada D. A., Hackett P. B., Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Research 2006 34 9 2803 2811 2-s2.0-33744827138 10.1093/nar/gkl301 (Pubitemid 43985641)
140. Ivics Z., Hackett P. B., Plasterk R. H., Izsvák Z., Molecular reconstruction of sleeping beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 1997 91 4 501 510 2-s2.0-0030662074 (Pubitemid 27508239)
141. Izsvák Z., Hackett P. B., Cooper L. J. N., Ivics Z., Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. BioEssays 2010 32 9 756 767 2-s2.0-77956668327 10.1002/bies.201000027
142. Mátés L., Chuah M. K. L., Belay E., Jerchow B., Manoj N., Acosta-Sanchez A., Grzela D. P., Schmitt A., Becker K., Matrai J., Ma L., Samara-Kuko E., Gysemans C., Pryputniewicz D., Miskey C., Fletcher B., Vandendriessche T., Ivics Z., Izsvák Z., Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nature Genetics 2009 41 6 753 761 2-s2.0-67349250885 10.1038/ng.343
143. Sheridan C., Williams R., Grierson I., Basement membranes and artificial substrates in cell transplantation. Graefe's Archive for Clinical and Experimental Ophthalmology 2004 242 1 68 75 2-s2.0-1142287449 10.1007/s00417-003-0800-z (Pubitemid 38208286)
144. Tezel T. H., Kaplan H. J., del Priore L. V., Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch's membrane. Investigative Ophthalmology and Visual Science 1999 40 2 467 476 2-s2.0-0032894965 (Pubitemid 29063845)
145. Castellarin A. A., Sugino I. K., Vargas J. A., Parolini B., Lui G. M., Zarbin M. A., In vitro transplantation of fetal human retinal pigment epithelial cells onto human cadaver Bruch's membrane. Experimental Eye Research 1998 66 1 49 67 2-s2.0-0031940980 10.1006/exer.1997.0404 (Pubitemid 28070338)
146. Thumann G., Schraermeyer U., Bartz-Schmidt K. U., Heimann K., Descemet's membrane as membranous support in RPE/IPE transplantation. Current Eye Research 1997 16 12 1236 1238 2-s2.0-0030721609 (Pubitemid 27515679)
147. Kiilgaard J. F., Wiencke A. K., Scherfig E., Prause J. U., La Cour M., Transplantation of allogenic anterior lens capsule to the subretinal space in pigs. Acta Ophthalmologica Scandinavica 2002 80 1 76 81 2-s2.0-0036249288 10.1034/j.1600-0420.2002.800115.x (Pubitemid 34506347)
148. Capeéans C., Piñeiro Ces A., Pardo M., Sueiro-López C., Blanco M. J., Domínguez F., Sánchez-Salorio M., Amniotic membrane as support for human retinal pigment epithelium (RPE) cell growth. Acta Ophthalmologica Scandinavica 2003 81 3 271 277 2-s2.0-0038081416 10.1034/j.1600-0420.2003.00076.x (Pubitemid 36806266)
149. Stanzel B. V., Espana E. M., Grueterich M., Kawakita T., Parel J.-M., Tseng S. C. G., Binder S., Amniotic membrane maintains the phenotype of rabbit retinal pigment epithelial cells in culture. Experimental Eye Research 2005 80 1 103 112 2-s2.0-12344312158 10.1016/j.exer.2004.06.032 (Pubitemid 40126518)
150. Fung A., Lee C. J., Leng T., Tissue engineered lens capsule as a substrate for IPE and RPE transplantation. Investigative Ophthalmology & Visual Science 2002 43 12. E-abstract 3452
151. Nadri S., Yazdani S., Arefian E., Gohari Z., Eslaminejad M. B., Kazemi B., Soleimani M., Mesenchymal stem cells from trabecular meshwork become photoreceptor-like cells on amniotic membrane. Neuroscience Letters 2013 541 43 48
152. Lavik E. B., Klassen H., Warfvinge K., Langer R., Young M. J., Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials 2005 26 16 3187 3196 2-s2.0-10644281300 10.1016/j.biomaterials.2004.08.022 (Pubitemid 39647253)
153. Yao J., Tao S. L., Young M. J., Synthetic polymer scaffolds for stem cell transplantation in retinal tissue engineering. Polymers 2011 3 2 899 914 2-s2.0-79960175928 10.3390/polym3020899
154. Neeley W. L., Redenti S., Klassen H., Tao S., Desai T., Young M. J., Langer R., A microfabricated scaffold for retinal progenitor cell grafting. Biomaterials 2008 29 4 418 426 2-s2.0-36049003639 10.1016/j.biomaterials.2007. 10.007 (Pubitemid 350100796)
155. Redenti S., Tao S., Yang J., Gu P., Klassen H., Saigal S., Desai T., Young M. J., Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. Journal of Ocular Biology, Diseases, and Informatics 2008 1 1 19 29 2-s2.0-43749091476 10.1007/s12177-008-9005-3
156. Tao S., Young C., Redenti S., Zhang Y., Klassen H., Desai T., Young M. J., Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab on a Chip 2007 7 6 695 701 2-s2.0-34249804151 10.1039/b618583e (Pubitemid 46848695)
157. Mano J. F., Silva G. A., Azevedo H. S., Malafaya P. B., Sousa R. A., Silva S. S., Boesel L. F., Oliveira J. M., Santos T. C., Marques A. P., Neves N. M., Reis R. L., Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends. Journal of the Royal Society Interface 2007 4 17 999 1030 2-s2.0-37349091115 10.1098/rsif.2007.0220 (Pubitemid 350303872)
158. Alamein M. A., Stephens S., Liu Q., Skabo S., Warnke P. H., Mass production of nanofibrous extracellular matrix with controlled 3D morphology for large-scale soft tissue regeneration. Tissue Engineering C 2013 19 6 458 472
159. Vaquette C., Cooper-White J. J., Increasing electrospun scaffold pore size with tailored collectors for improved cell penetration. Acta Biomaterialia 2011 7 6 2544 2557 2-s2.0-79955591893 10.1016/j.actbio.2011.02.036
160. Brown T. D., Dalton P. D., Hutmacher D. W., Direct writing by way of melt electrospinning. Advanced Materials 2011 23 47 5651 5657 2-s2.0-83455228407 10.1002/adma.201103482
161. Wei C., Dong J., Direct fabrication of high-resolution three-dimensional polymeric scaffolds using electrohydrodynamic hot jet plotting. Journal of Micromechanics and Microengineering 2013 23 2 025017
162. Steedman M. R., Tao S. L., Klassen H., Desai T. A., Enhanced differentiation of retinal progenitor cells using microfabricated topographical cues. Biomedical Microdevices 2010 12 3 363 369 2-s2.0-77952890022 10.1007/s10544-009-9392-7
163. McUsic A. C., Lamba D. A., Reh T. A., Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials 2012 33 5 1396 1405 2-s2.0-83355166270 10.1016/j.biomaterials.2011.10.083
164. Tezel T. H., del Priore L. V., Kaplan H. J., Reengineering of aged Bruch's membrane to enhance retinal pigment epithelium repopulation. Investigative Ophthalmology and Visual Science 2004 45 9 3337 3348 2-s2.0-4344600751 10.1167/iovs.04-0193 (Pubitemid 39121874)
165. Hersel U., Dahmen C., Kessler H., RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials 2003 24 24 4385 4415 2-s2.0-0041559949 10.1016/S0142-9612(03)00343-0 (Pubitemid 36960136)
166. Treharne A. J., Thomson H. A., Grossel M. C., Lotery A. J., Developing methacrylate-based copolymers as an artificial Bruch's membrane substitute. Journal of Biomedical Materials Research A 2012 100 9 2358 2364
167. Sistiabudi R., Paderi J., Panitch A., Ivanisevic A., Modification of native collagen with cell-adhesive peptide to promote RPE cell attachment on Bruch's membrane. Biotechnology and Bioengineering 2009 102 6 1723 1729 2-s2.0-65349096155 10.1002/bit.22215
168. Grafahrend D., Heffels K.-H., Beer M. V., Gasteier P., Möller M., Boehm G., Dalton P. D., Groll J., Degradable polyester scaffolds with controlled surface chemistry combining minimal protein adsorption with specific bioactivation. Nature Materials 2011 10 1 67 73 2-s2.0-78650272820 10.1038/nmat2904
169. Bartneck M., Heffels K.-H., Pan Y., Bovi M., Zwadlo-Klarwasser G., Groll J., Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres. Biomaterials 2012 33 16 4136 4146 2-s2.0-84858797742 10.1016/j.biomaterials.2012.02.050
170. Grafahrend D., Heffels K.-H., Möller M., Klee D., Groll J., Electrospun, biofunctionalized fibers as tailored in vitro substrates for keratinocyte cell culture. Macromolecular Bioscience 2010 10 9 1022 1027 2-s2.0-77956631332 10.1002/mabi.201000068