-
1
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
-
doi:10.1016/S0092-8674(00)81663-3
-
Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 99:323-34. doi:10.1016/S0092-8674(00)81663-3
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.O.1
Yang, H.2
Georgescu, M.M.3
Di Cristofano, A.4
Maehama, T.5
Shi, Y.6
-
2
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
doi:10.1074/jbc.273.22.13375
-
Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 273:13375-8. doi:10.1074/jbc.273.22.13375
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
3
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
doi:10.1200/JCO.2004.02.141
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol (2004) 22:2954-63. doi:10.1200/JCO.2004.02.141
-
(2004)
J Clin Oncol
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
4
-
-
77956236877
-
PI(3)king apart PTEN's role in cancer
-
doi:10.1158/1078-0432.CCR-09-2990
-
Zhang S, Yu D. PI(3)king apart PTEN's role in cancer. Clin Cancer Res (2010) 16:4325-30. doi:10.1158/1078-0432.CCR-09-2990
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4325-4330
-
-
Zhang, S.1
Yu, D.2
-
5
-
-
84860217431
-
The functions and regulation of the PTEN tumour suppressor
-
doi:10.1038/nrm3330
-
Song MS, Salmena L, PandolfiPP. The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol (2012) 13:283-96. doi:10.1038/nrm3330
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 283-296
-
-
Song, M.S.1
Salmena, L.2
Pandolfi, P.P.3
-
6
-
-
4344684649
-
PTEN function: how normal cells control it and tumour cells lose it
-
doi:10.1042/BJ20040825
-
Leslie NR, Downes CP. PTEN function: how normal cells control it and tumour cells lose it. Biochem J (2004) 382:1-11. doi:10.1042/BJ20040825
-
(2004)
Biochem J
, vol.382
, pp. 1-11
-
-
Leslie, N.R.1
Downes, C.P.2
-
7
-
-
51849167782
-
Understanding PTEN regulation: PIP2, polarity and protein stability
-
doi:10.1038/onc.2008.243
-
Leslie NR, Batty IH, Maccario H, Davidson L, Downes CP. Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene (2008) 27:5464-76. doi:10.1038/onc.2008.243
-
(2008)
Oncogene
, vol.27
, pp. 5464-5476
-
-
Leslie, N.R.1
Batty, I.H.2
Maccario, H.3
Davidson, L.4
Downes, C.P.5
-
8
-
-
66149141021
-
PTEN and the PI3-kinase pathway in cancer
-
doi:10.1146/annurev.pathol.4.110807.092311
-
Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol (2009) 4:127-50. doi:10.1146/annurev.pathol.4.110807.092311
-
(2009)
Annu Rev Pathol
, vol.4
, pp. 127-150
-
-
Chalhoub, N.1
Baker, S.J.2
-
9
-
-
0033809990
-
Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells
-
doi:10.1016/S0002-9440(10)64624-X
-
Perren A, Komminoth P, Saremaslani P, Matter C, Feurer S, Lees JA, et al. Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. Am J Pathol (2000) 157:1097-103. doi:10.1016/S0002-9440(10)64624-X
-
(2000)
Am J Pathol
, vol.157
, pp. 1097-1103
-
-
Perren, A.1
Komminoth, P.2
Saremaslani, P.3
Matter, C.4
Feurer, S.5
Lees, J.A.6
-
10
-
-
53649106156
-
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
-
doi:10.1038/nature07290
-
Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, et al. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature (2008) 455:813-7. doi:10.1038/nature07290
-
(2008)
Nature
, vol.455
, pp. 813-817
-
-
Song, M.S.1
Salmena, L.2
Carracedo, A.3
Egia, A.4
Lo-Coco, F.5
Teruya-Feldstein, J.6
-
11
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
doi:10.1073/pnas.95.23.13513
-
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A (1998) 95:13513-8. doi:10.1073/pnas.95.23.13513
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
Van der Kaay, J.4
Stolarov, J.P.5
Hemmings, B.A.6
-
12
-
-
33745888913
-
PTEN function in normal and neoplastic growth
-
doi:10.1016/j.canlet.2005.11.042
-
Chow LM, Baker SJ. PTEN function in normal and neoplastic growth. Cancer Lett (2006) 241:184-96. doi:10.1016/j.canlet.2005.11.042
-
(2006)
Cancer Lett
, vol.241
, pp. 184-196
-
-
Chow, L.M.1
Baker, S.J.2
-
13
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
doi:10.1038/nrg1879
-
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet (2006) 7(8):606-19. doi:10.1038/nrg1879
-
(2006)
Nat Rev Genet
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
14
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
doi:10.1038/ng0597-64
-
Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet (1997) 16:64-7. doi:10.1038/ng0597-64
-
(1997)
Nat Genet
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.4
Wang, S.I.5
Zheng, Z.6
-
15
-
-
0036206130
-
Protean PTEN: form and function
-
doi:10.1086/340026
-
Waite KA, Eng C. Protean PTEN: form and function. Am J Hum Genet (2002) 70:829-44. doi:10.1086/340026
-
(2002)
Am J Hum Genet
, vol.70
, pp. 829-844
-
-
Waite, K.A.1
Eng, C.2
-
16
-
-
0032100506
-
Alterations of the MMAC1/PTEN gene in lymphoid malignancies
-
Grønbaek K, Zeuthen J, Guldberg P, Ralfkiaer E, Hou-Jensen K. Alterations of the MMAC1/PTEN gene in lymphoid malignancies. Blood (1998) 91:4388-90.
-
(1998)
Blood
, vol.91
, pp. 4388-4390
-
-
Grønbaek, K.1
Zeuthen, J.2
Guldberg, P.3
Ralfkiaer, E.4
Hou-Jensen, K.5
-
17
-
-
0034802755
-
PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas
-
Minaguchi T, Yoshikawa H, Oda K, Ishino T, Yasugi T, Onda T, et al. PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas. Clin Cancer Res (2001) 7:2636-42.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2636-2642
-
-
Minaguchi, T.1
Yoshikawa, H.2
Oda, K.3
Ishino, T.4
Yasugi, T.5
Onda, T.6
-
18
-
-
4243110417
-
Pten dose dictates cancer progression in the prostate
-
doi:10.1371/journal.pbio.0000059
-
Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A, et al. Pten dose dictates cancer progression in the prostate. PloS Biol (2003) 1:E59. doi:10.1371/journal.pbio.0000059
-
(2003)
PloS Biol
, vol.1
-
-
Trotman, L.C.1
Niki, M.2
Dotan, Z.A.3
Koutcher, J.A.4
Di Cristofano, A.5
Xiao, A.6
-
19
-
-
0034978311
-
Pten, a protean tumor suppressor
-
doi:10.1016/S0002-9440(10)64656-1
-
Mutter GL. Pten, a protean tumor suppressor. Am J Pathol (2001) 158:1895-8. doi:10.1016/S0002-9440(10)64656-1
-
(2001)
Am J Pathol
, vol.158
, pp. 1895-1898
-
-
Mutter, G.L.1
-
20
-
-
33745325973
-
Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma
-
doi:10.1097/01.sla.0000220040.66012.a9
-
Rychahou PG, Jackson LN, Silva SR, Rajaraman S, Evers BM. Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Ann Surg (2006) 243:833-42. doi:10.1097/01.sla.0000220040.66012.a9
-
(2006)
Ann Surg
, vol.243
, pp. 833-842
-
-
Rychahou, P.G.1
Jackson, L.N.2
Silva, S.R.3
Rajaraman, S.4
Evers, B.M.5
-
21
-
-
44349111717
-
Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence?
-
doi:10.1016/j.amjsurg.2007.05.061
-
Colakoglu T, Yildirim S, Kayaselcuk F, Nursal TZ, Ezer A, Noyan T, et al. Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms: is PTEN loss predictor of local recurrence? Am J Surg (2008) 195:719-25. doi:10.1016/j.amjsurg.2007.05.061
-
(2008)
Am J Surg
, vol.195
, pp. 719-725
-
-
Colakoglu, T.1
Yildirim, S.2
Kayaselcuk, F.3
Nursal, T.Z.4
Ezer, A.5
Noyan, T.6
-
22
-
-
84879471604
-
PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer
-
doi:10.1158/1078-0432.CCR-12-3614
-
Day FL, Jorissen RN, Lipton L, Mouradov D, Sakthianandeswaren A, Christie M, et al. PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer. Clin Cancer Res (2013) 19:3285-96. doi:10.1158/1078-0432.CCR-12-3614
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3285-3296
-
-
Day, F.L.1
Jorissen, R.N.2
Lipton, L.3
Mouradov, D.4
Sakthianandeswaren, A.5
Christie, M.6
-
23
-
-
0033984095
-
Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis
-
doi:10.1093/hmg/9.2.283
-
Guanti G, Resta N, Simone C, Cariola F, Demma I, Fiorente P, et al. Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis. Hum Mol Genet (2000) 9:283-7. doi:10.1093/hmg/9.2.283
-
(2000)
Hum Mol Genet
, vol.9
, pp. 283-287
-
-
Guanti, G.1
Resta, N.2
Simone, C.3
Cariola, F.4
Demma, I.5
Fiorente, P.6
-
24
-
-
0035965935
-
PTEN gene mutations in colorectal cancers displaying microsatellite instability
-
doi:10.1016/S0304-3835(01)00691-7
-
Shin KH, Park YJ, Park JG. PTEN gene mutations in colorectal cancers displaying microsatellite instability. Cancer Lett (2001) 174:189-94. doi:10.1016/S0304-3835(01)00691-7
-
(2001)
Cancer Lett
, vol.174
, pp. 189-194
-
-
Shin, K.H.1
Park, Y.J.2
Park, J.G.3
-
25
-
-
0036968713
-
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers
-
doi:10.1016/S0002-9440(10)64200-9
-
Zhou XP, Loukola A, Salovaara R, Nystrom-Lahti M, Peltomäki P, de la Chapelle A, et al. PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol (2002) 161:439-47. doi:10.1016/S0002-9440(10)64200-9
-
(2002)
Am J Pathol
, vol.161
, pp. 439-447
-
-
Zhou, X.P.1
Loukola, A.2
Salovaara, R.3
Nystrom-Lahti, M.4
Peltomäki, P.5
de la Chapelle, A.6
-
26
-
-
2342504508
-
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers
-
doi:10.1158/0008-5472.CAN-2401-2
-
Goel A, Arnold CN, Niedzwiecki D, Carethers JM, Dowell JM, Wasserman L, et al. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res (2004) 64:3014-21. doi:10.1158/0008-5472.CAN-2401-2
-
(2004)
Cancer Res
, vol.64
, pp. 3014-3021
-
-
Goel, A.1
Arnold, C.N.2
Niedzwiecki, D.3
Carethers, J.M.4
Dowell, J.M.5
Wasserman, L.6
-
27
-
-
55549090038
-
Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation-status
-
doi:10.1002/humu.20860
-
Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, et al. Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation-status. Hum Mutat (2008) 29:E252-62. doi:10.1002/humu.20860
-
(2008)
Hum Mutat
, vol.29
-
-
Danielsen, S.A.1
Lind, G.E.2
Bjørnslett, M.3
Meling, G.I.4
Rognum, T.O.5
Heim, S.6
-
28
-
-
20144387695
-
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
-
doi:10.1158/0008-5472-CAN-04-3913
-
Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res (2005) 65:2554-9. doi:10.1158/0008-5472-CAN-04-3913
-
(2005)
Cancer Res
, vol.65
, pp. 2554-2559
-
-
Saal, L.H.1
Holm, K.2
Maurer, M.3
Memeo, L.4
Su, T.5
Wang, X.6
-
29
-
-
28244484956
-
Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer
-
doi:10.1158/0008-5472.CAN-05-2780
-
Frattini M, Signoroni S, Pilotti S, Bertario L, Benvenuti S, Zanon C, et al. Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer. Cancer Res (2005) 65:11227. doi:10.1158/0008-5472.CAN-05-2780
-
(2005)
Cancer Res
, vol.65
, pp. 11227
-
-
Frattini, M.1
Signoroni, S.2
Pilotti, S.3
Bertario, L.4
Benvenuti, S.5
Zanon, C.6
-
30
-
-
28244490997
-
High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
-
doi:10.1158/0008-5472.CAN-05-2620
-
Oda K, Stokoe D, Taketani Y, McCormick F. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res (2005) 65:10669-73. doi:10.1158/0008-5472.CAN-05-2620
-
(2005)
Cancer Res
, vol.65
, pp. 10669-10673
-
-
Oda, K.1
Stokoe, D.2
Taketani, Y.3
McCormick, F.4
-
31
-
-
84870812342
-
Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations
-
doi:10.1016/j.critrevonc.2012.05.001
-
Custodio A, Feliu J. Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations. Crit Rev Oncol Hematol (2013) 85:45-81. doi:10.1016/j.critrevonc.2012.05.001
-
(2013)
Crit Rev Oncol Hematol
, vol.85
, pp. 45-81
-
-
Custodio, A.1
Feliu, J.2
-
32
-
-
0035670906
-
Colorectal carcinomas and PTEN/MMAC1 gene mutations
-
Dicuonzo G, Angeletti S, Garcia-Foncillas J, Brugarolas A, Okrouzhnov Y, Santini D, et al. Colorectal carcinomas and PTEN/MMAC1 gene mutations. Clin Cancer Res (2001) 7:4049-53.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 4049-4053
-
-
Dicuonzo, G.1
Angeletti, S.2
Garcia-Foncillas, J.3
Brugarolas, A.4
Okrouzhnov, Y.5
Santini, D.6
-
33
-
-
0842308265
-
PTEN mutations are common in sporadic microsatellite stable colorectal cancer
-
doi:10.1038/sj.onc.1207059
-
Nassif NT, Lobo GP, Wu X, Henderson CJ, Morrison CD, Eng C, et al. PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene (2004) 23:617-28. doi:10.1038/sj.onc.1207059
-
(2004)
Oncogene
, vol.23
, pp. 617-628
-
-
Nassif, N.T.1
Lobo, G.P.2
Wu, X.3
Henderson, C.J.4
Morrison, C.D.5
Eng, C.6
-
34
-
-
58149354425
-
Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival
-
doi:10.1186/1471-230X-8-56
-
Sawai H, Yasuda A, Ochi N, Ma J, Matsuo Y, Wakasugi T, et al. Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. BMC Gastroenterol (2008) 8:56. doi:10.1186/1471-230X-8-56
-
(2008)
BMC Gastroenterol
, vol.8
, pp. 56
-
-
Sawai, H.1
Yasuda, A.2
Ochi, N.3
Ma, J.4
Matsuo, Y.5
Wakasugi, T.6
-
35
-
-
80052740350
-
Expression of PPAR? and PTEN in human colorectal cancer: an immunohistochemical study using tissue microarray methodology
-
Lin MS, Huang JX, Chen WC, Zhang BF, Fang J, Zhou Q, et al. Expression of PPAR? and PTEN in human colorectal cancer: an immunohistochemical study using tissue microarray methodology. Oncol Lett (2011) 2:1219-24.
-
(2011)
Oncol Lett
, vol.2
, pp. 1219-1224
-
-
Lin, M.S.1
Huang, J.X.2
Chen, W.C.3
Zhang, B.F.4
Fang, J.5
Zhou, Q.6
-
36
-
-
70350362333
-
PTEN expression and mutation in colorectal carcinomas
-
Li XH, Zheng HC, Takahashi H, Masuda S, Yang XH, Takano Y. PTEN expression and mutation in colorectal carcinomas. Oncol Rep (2009) 22:757-64.
-
(2009)
Oncol Rep
, vol.22
, pp. 757-764
-
-
Li, X.H.1
Zheng, H.C.2
Takahashi, H.3
Masuda, S.4
Yang, X.H.5
Takano, Y.6
-
37
-
-
73449138781
-
Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma
-
doi:10.1111/j.1365-2559.2009.03468.x
-
Jang KS, Song YS, Jang SH, Min KW, Na W, Jang SM, et al. Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma. Histopathology (2010) 56:229-39. doi:10.1111/j.1365-2559.2009.03468.x
-
(2010)
Histopathology
, vol.56
, pp. 229-239
-
-
Jang, K.S.1
Song, Y.S.2
Jang, S.H.3
Min, K.W.4
Na, W.5
Jang, S.M.6
-
38
-
-
84865396632
-
Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer
-
Jin C, Wang A, Chen J, Liu X, Wang G. Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer. Exp Ther Med (2012) 4:633-9.
-
(2012)
Exp Ther Med
, vol.4
, pp. 633-639
-
-
Jin, C.1
Wang, A.2
Chen, J.3
Liu, X.4
Wang, G.5
-
39
-
-
84893694180
-
PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival
-
doi:10.1002/cam4.97
-
Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, et al. PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Med (2013) 2:496-506. doi:10.1002/cam4.97
-
(2013)
Cancer Med
, vol.2
, pp. 496-506
-
-
Atreya, C.E.1
Sangale, Z.2
Xu, N.3
Matli, M.R.4
Tikishvili, E.5
Welbourn, W.6
-
40
-
-
84880325080
-
Altered PTEN function caused by deletion or gene disruption is associated with poor prognosis in rectal but not in colon cancer
-
doi:10.1016/j.humpath.2012.12.006
-
Bohn BA, Mina S, Krohn A, Simon R, Kluth M, Harasimowicz S, et al. Altered PTEN function caused by deletion or gene disruption is associated with poor prognosis in rectal but not in colon cancer. Hum Pathol (2013) 44:1524-33. doi:10.1016/j.humpath.2012.12.006
-
(2013)
Hum Pathol
, vol.44
, pp. 1524-1533
-
-
Bohn, B.A.1
Mina, S.2
Krohn, A.3
Simon, R.4
Kluth, M.5
Harasimowicz, S.6
-
41
-
-
84878558999
-
The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer
-
doi:10.1038/bjc.2013.212
-
Eklöf V, Wikberg ML, Edin S, Dahlin AM, Jonsson BA, Öberg Å, et al. The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer. Br J Cancer (2013) 108:2153-63. doi:10.1038/bjc.2013.212
-
(2013)
Br J Cancer
, vol.108
, pp. 2153-2163
-
-
Eklöf, V.1
Wikberg, M.L.2
Edin, S.3
Dahlin, A.M.4
Jonsson, B.A.5
Öberg, Å.6
-
42
-
-
84893693383
-
Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab
-
doi:10.1002/cam4.75
-
Price TJ, Hardingham JE, Lee CK, Townsend AR, Wrin JW, Wilson K, et al. Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab. Cancer Med (2013) 2:277-85. doi:10.1002/cam4.75
-
(2013)
Cancer Med
, vol.2
, pp. 277-285
-
-
Price, T.J.1
Hardingham, J.E.2
Lee, C.K.3
Townsend, A.R.4
Wrin, J.W.5
Wilson, K.6
-
43
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
doi:10.1016/j.ccr.2007.08.030
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell (2007) 12:395-402. doi:10.1016/j.ccr.2007.08.030
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
-
44
-
-
35348908314
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
-
doi:10.1038/sj.bjc.6604009
-
Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, Ghisletta M, et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer (2007) 97:1139-45. doi:10.1038/sj.bjc.6604009
-
(2007)
Br J Cancer
, vol.97
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
Martin, V.4
Molinari, F.5
Ghisletta, M.6
-
45
-
-
51849111556
-
PI3K pathway alterations in cancer: variations on a theme
-
doi:10.1038/onc.2008.245
-
Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene (2008) 27:5497-510. doi:10.1038/onc.2008.245
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
46
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
-
doi:10.1158/0008-5472.CAN-08-2466
-
Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res (2009) 69:1851-7. doi:10.1158/0008-5472.CAN-08-2466
-
(2009)
Cancer Res
, vol.69
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
Veronese, S.4
Nichelatti, M.5
Artale, S.6
-
47
-
-
59049089201
-
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
-
doi:10.1093/annonc/mdn541
-
Perrone F, Lampis A, Orsenigo M, Di Bartolomeo M, Gevorgyan A, Losa M, et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol (2009) 20:84-90. doi:10.1093/annonc/mdn541
-
(2009)
Ann Oncol
, vol.20
, pp. 84-90
-
-
Perrone, F.1
Lampis, A.2
Orsenigo, M.3
Di Bartolomeo, M.4
Gevorgyan, A.5
Losa, M.6
-
48
-
-
51249089269
-
Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study
-
doi:10.1186/1471-2407-8-234
-
Razis E, Briasoulis E, Vrettou E, Skarlos DV, Papamichael D, Kostopoulos I, et al. Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study. BMC Cancer (2008) 8:234. doi:10.1186/1471-2407-8-234
-
(2008)
BMC Cancer
, vol.8
, pp. 234
-
-
Razis, E.1
Briasoulis, E.2
Vrettou, E.3
Skarlos, D.V.4
Papamichael, D.5
Kostopoulos, I.6
-
49
-
-
66849140563
-
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
-
doi:10.1200/JCO.2008.20.2796
-
Loupakis F, Pollina L, Stasi I, Ruzzo A, Scartozzi M, Santini D, et al. PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J Clin Oncol (2009) 27:2622-9. doi:10.1200/JCO.2008.20.2796
-
(2009)
J Clin Oncol
, vol.27
, pp. 2622-2629
-
-
Loupakis, F.1
Pollina, L.2
Stasi, I.3
Ruzzo, A.4
Scartozzi, M.5
Santini, D.6
-
50
-
-
74249093155
-
PTEN status in advanced colorectal cancer treated with cetuximab
-
doi:10.1038/sj.bjc.6605471
-
Negri FV, Bozzetti C, Lagrasta CA, Crafa P, Bonasoni MP, Camisa R, et al. PTEN status in advanced colorectal cancer treated with cetuximab. Br J Cancer (2010) 102:162-4. doi:10.1038/sj.bjc.6605471
-
(2010)
Br J Cancer
, vol.102
, pp. 162-164
-
-
Negri, F.V.1
Bozzetti, C.2
Lagrasta, C.A.3
Crafa, P.4
Bonasoni, M.P.5
Camisa, R.6
-
51
-
-
77954215850
-
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
-
doi:10.1016/j.ejca.2010.03.036
-
Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, Vink-Börger ME, et al. Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer (2010) 46:1997-2009. doi:10.1016/j.ejca.2010.03.036
-
(2010)
Eur J Cancer
, vol.46
, pp. 1997-2009
-
-
Tol, J.1
Dijkstra, J.R.2
Klomp, M.3
Teerenstra, S.4
Dommerholt, M.5
Vink-Börger, M.E.6
-
52
-
-
84860628947
-
Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: a single center study
-
doi:10.1186/1479-5876-10-87
-
Ulivi P, Capelli L, Valgiusti M, Zoli W, Scarpi E, Chiadini E, et al. Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: a single center study. J Transl Med (2012) 10:87. doi:10.1186/1479-5876-10-87
-
(2012)
J Transl Med
, vol.10
, pp. 87
-
-
Ulivi, P.1
Capelli, L.2
Valgiusti, M.3
Zoli, W.4
Scarpi, E.5
Chiadini, E.6
-
53
-
-
73349094741
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
-
doi:10.1200/JCO.2008.21.6796
-
Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol (2009) 27:5924-30. doi:10.1200/JCO.2008.21.6796
-
(2009)
J Clin Oncol
, vol.27
, pp. 5924-5930
-
-
Laurent-Puig, P.1
Cayre, A.2
Manceau, G.3
Buc, E.4
Bachet, J.B.5
Lecomte, T.6
-
54
-
-
63949084084
-
Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant
-
doi:10.1038/sj.bjc.6604848
-
Molinari F, Martin V, Saletti P, De Dosso S, Spitale A, Camponovo A, et al. Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. Br J Cancer (2009) 100:1087-94. doi:10.1038/sj.bjc.6604848
-
(2009)
Br J Cancer
, vol.100
, pp. 1087-1094
-
-
Molinari, F.1
Martin, V.2
Saletti, P.3
De Dosso, S.4
Spitale, A.5
Camponovo, A.6
-
55
-
-
80053198693
-
Concordance of predictive markers for EGFR inhibitors in primary tumors and metastases in colorectal cancer: a review
-
doi:10.1634/theoncologist.2011-0024
-
Baas JM, Krens LL, Guchelaar HJ, Morreau H, Gelderblom H. Concordance of predictive markers for EGFR inhibitors in primary tumors and metastases in colorectal cancer: a review. Oncologist (2011) 16:1239-49. doi:10.1634/theoncologist.2011-0024
-
(2011)
Oncologist
, vol.16
, pp. 1239-1249
-
-
Baas, J.M.1
Krens, L.L.2
Guchelaar, H.J.3
Morreau, H.4
Gelderblom, H.5
-
56
-
-
84856452707
-
Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients:implications for cancer therapy
-
doi:10.2174/156800912799095162
-
Cejas P, López-Gómez M, Aguayo C, Madero R, Moreno-Rubio J, de Castro Carpeño J, et al. Analysis of the concordance in the EGFR pathway status between primary tumors and related metastases of colorectal cancer patients:implications for cancer therapy. Curr Cancer Drug Targets (2012) 12:124-31. doi:10.2174/156800912799095162
-
(2012)
Curr Cancer Drug Targets
, vol.12
, pp. 124-131
-
-
Cejas, P.1
López-Gómez, M.2
Aguayo, C.3
Madero, R.4
Moreno-Rubio, J.5
de Castro Carpeño, J.6
-
57
-
-
79951958340
-
A robust immunohistochemical assay for detecting PTEN expression in human tumors
-
doi:10.1097/PAI.0b013e3181f1da13
-
Sangale Z, Prass C, Carlson A, Tikishvili E, Degrado J, Lanchbury J, et al. A robust immunohistochemical assay for detecting PTEN expression in human tumors. Appl Immunohistochem Mol Morphol (2011) 19:173-83. doi:10.1097/PAI.0b013e3181f1da13
-
(2011)
Appl Immunohistochem Mol Morphol
, vol.19
, pp. 173-183
-
-
Sangale, Z.1
Prass, C.2
Carlson, A.3
Tikishvili, E.4
Degrado, J.5
Lanchbury, J.6
-
58
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
doi:10.1016/j.cell.2006.11.042
-
Shen WH, Balajee AS, Wang J, Wu H, Eng C, PandolfiPP, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell (2007) 128:157-70. doi:10.1016/j.cell.2006.11.042
-
(2007)
Cell
, vol.128
, pp. 157-170
-
-
Shen, W.H.1
Balajee, A.S.2
Wang, J.3
Wu, H.4
Eng, C.5
Pandolfi, P.P.6
-
59
-
-
84993915355
-
Tumour suppressors: role of nuclear PTEN revealed
-
doi:10.1038/nrc3028
-
Wrighton KH. Tumour suppressors: role of nuclear PTEN revealed. Nat Rev Cancer (2011) 11:154. doi:10.1038/nrc3028
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 154
-
-
Wrighton, K.H.1
-
60
-
-
24944568790
-
Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis
-
doi:10.1158/0008-5472.CAN-05-1888
-
Chung JH, Eng C. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res (2005) 65:8096-100. doi:10.1158/0008-5472.CAN-05-1888
-
(2005)
Cancer Res
, vol.65
, pp. 8096-8100
-
-
Chung, J.H.1
Eng, C.2
-
61
-
-
84857366043
-
Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study
-
doi:10.1136/jclinpath-2011-200353
-
Sartore-Bianchi A, Fieuws S, Veronese S, Moroni M, Personeni N, Frattini M, et al. Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study. J Clin Pathol (2012) 65:218-23. doi:10.1136/jclinpath-2011-200353
-
(2012)
J Clin Pathol
, vol.65
, pp. 218-223
-
-
Sartore-Bianchi, A.1
Fieuws, S.2
Veronese, S.3
Moroni, M.4
Personeni, N.5
Frattini, M.6
|