Impaired glucose tolerance plus hyperlipidaemia induced by diet promotes retina microaneurysms in New Zealand rabbits

International Journal of Experimental Pathology

Volumn 92, Issue 1, 2011, Pages 40-49

  Helfenstein, Tatiana ^a   Fonseca, Francisco A ^a   Ihara, Sílvia S ^a   Bottós, Juliana M ^a   Moreira, Flávio T ^a   Pott Jr, Henrique ^b   Farah, Michel E ^a   Martins, Maria C ^a   Izar, Maria C ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b PONTIFÍCIA UNIVERSIDADE CATÓLICA DE CAMPINAS   (Brazil)

Author keywords

Animal models; Diet; Impaired glucose tolerance; Insulin resistance; Retinopathy

Indexed keywords

FRUCTOSAMINE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DIABETIC RETINOPATHY; DIET; FLUORESCENCE ANGIOGRAPHY; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; MALE; MICROANEURYSM; NONHUMAN; OPHTHALMOSCOPY; PRIORITY JOURNAL; RABBIT; WEIGHT GAIN;

ANEURYSM; ANIMALS; AORTA; ATHEROSCLEROSIS; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; DIET; FATTY LIVER; GLUCOSE INTOLERANCE; HYPERLIPIDEMIAS; IMMUNOHISTOCHEMISTRY; MALE; RABBITS; RETINA;

EID: 79251583728     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2010.00753.x     Document Type: Article

References (35)

1. Abdul-Ghani M.A., Jenkinson C.P., Richardson D.K., Tripathy D., DeFronzo R.A. (2006) Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes 55, 1430-1435.
2. American Diabetes Association. (2010) Standards of medical care in diabetes-2010. Diabetes Care 33, S11-S61.
3. Antonetti D.A., Barber A.J., Bronson S.K. et al. (2006) Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes 55, 2401-2411.
4. Barber A.J., Nakamura M., Wolpert E.B. et al. (2001) Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J. Biol. Chem. 276, 32814-32821.
5. Bulut H.E., Onarlioglu B., Kaloglu C., Ozdemir O., Ayan S. (2001) Effects of experimental diabetes and insulin treatment on rabbit renal morphology: a quantitative and qualitative study. Turk. J. Med. Sci. 31, 209-216.
6. Chatzigeorgiou A., Halapas A., Kalafatakis K., Kamper E. (2009) The use of animal models in the study of diabetes mellitus. In Vivo 23, 245-258.
7. Cowie C.C., Rust K.F., Ford E.S. et al. (2009) Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care 32, 287-294.
8. Davies M.J., Raymond N.T., Day J.L., Hales C.N., Burden A.C. (2000) Impaired glucose tolerance and fasting hyperglycaemia have different characteristics. Diabet. Med. 17, 433-440.
9. Griesmacher A., Kindhauser M., Andert S.E. et al. (1995) Enhanced serum levels of thiobarbituric-acid-reactive substances in diabetes mellitus. Am. J. Med. 98, 469-475.
10. Haddad A., Salazar J.J., Laicine E.M., Ramírez A.I., Ramírez J.M., Triviño A. (2003) A direct contact between astrocyte and vitreous body is possible in the rabbit eye due to discontinuities in the basement membrane of the retinal inner limiting membrane. Braz. J. Med. Biol. Res. 36, 207-211.
11. Hanley A.J., Wagenknecht L.E., Norris J.M. et al. (2009) Insulin resistance, beta cell dysfunction and visceral adiposity as predictors of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Family study. Diabetologia 52, 2079-2086.
12. Hudacko R.M., Sciancalepore J.P., Fyfe B.S. (2009) Diabetic microangiopathy in the liver: an autopsy study of incidence and association with other diabetic complications. Am. J. Clin. Pathol. 132, 494-499.
13. Ijubimov A.V., Burgeson R.E., Butkowski R.J. et al. (1996) Basement membrane abnormalities in human eyes with diabetic retinopathy. J. Histochem. Cytochem. 44, 1469-1479.
14. Kern T.S. & Engerman R.L. (1995) Galactose-induced retinal microangiopathy in rats. Invest. Ophthalmol. Vis. Sci. 36, 490-496.
15. Kern T.S. & Engerman R.L. (1996) A mouse model of diabetic retinopathy. Arch. Ophthalmol. 114, 986-990.
16. King H., Aubert R.E., Herman W.H. (1998) Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21, 1414-1431.
17. Kvanta A. (2006) Ocular angiogenesis: the role of growth factors. Acta Ophthalmol. Scand. 84, 282-288.
18. Lenzen S. (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51, 216-226.
19. Lewko B. & Stepinski J. (2009) Hyperglycemia and mechanical stress: targeting the renal podocyte. J. Cell. Physiol. 221, 288-295.
20. Mir S.H. & Darzi M.M. (2009) Histopathological abnormalities of prolonged alloxan-induced diabetes mellitus in rabbits. Int. J. Exp. Pathol. 90, 66-73.
21. Pomaro D.R., Ihara S.S., Pinto L.E. et al. (2005) High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits. J. Cardiovasc. Pharmacol. 45, 295-300.
22. Rees D.A. & Alcolado J.C. (2005) Animal models of diabetes mellitus. Diabet. Med. 22, 359-370.
23. Relvas W.G., Izar M.C., Segreto H.R. et al. (2010) Resident peritoneal inflammatory cells are pivotal in the development of experimental atherosclerosis. J. Atheroscler. Thromb. 17, 378-385.
24. Roy S., Maiello M., Lorenzi M. (1994) Increased expression of basement membrane collagen in human diabetic retinopathy. J. Clin. Invest. 93, 438-442.
25. Silva E.P., Fonseca F.A., Ihara S.S. et al. (2002) Early benefits of pravastatin to experimentally induced atherosclerosis. J. Cardiovasc. Pharmacol. 39, 389-395.
26. Sochor M., Baquer N.Z., McLean P. (1979) Glucose overutilization in diabetes: evidence from studies on the changes in hexokinase, the pentose phosphate pathway and glucuronate-xylulose pathway in rat kidney cortex in diabetes. Biochem. Biophys. Res. Commun. 86, 32-39.
27. Song Y., Manson J.E., Tinker L. et al. (2007) Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study. Diabetes Care 30, 1747-1752.
28. Srinivasan K. & Ramarao P. (2007) Animal models in type 2 diabetes research: an overview. Indian J. Med. Res. 125, 451-472.
29. Stirban A.O. & Tschoepe D. (2008) Cardiovascular complications in diabetes: targets and interventions. Diabetes Care 31, S215-S221.
30. Szkudelski T. (2001) The mechanism of alloxan and streptozotocin action in β cells of the rat pancreas. Physiol. Res. 50, 537-546.
31. Turner R.C., Millns H., Neil H.A. et al. (1998) Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ 316, 823-828.
32. Vogel W.M. & Apstein C.S. (1988) Effects of alloxan-induced diabetes on ischemia-reperfusion injury in rabbit hearts. Circ. Res. 62, 975-982.
33. Wagner J.E., Kavanagh K., Ward G.M., Auerbach B.J., Harwood Jr H.J., Kaplan J.R. (2006) Old world nonhuman primate models of type 2 diabetes mellitus. ILAR J. 47, 259-271.
34. Xi S., Yin W., Wang Z. et al. (2004) A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis. Int. J. Exp. Pathol. 85, 223-231.
35. Yin W., Yuan Z., Wang Z., Yang B., Yang Y. (2002) A diet high in saturated fat and sucrose alters glucoregulation and induces aortic fatty streaks in New Zealand white rabbits. Int. J. Exp. Diabetes Res. 3, 179-184.