UPLC-MS-based serum metabonomics for identifying acute liver injury biomarkers in Chinese miniature pigs

Toxicology Letters

Volumn 225, Issue 3, 2014, Pages 358-366

  Ma, Jing ^a   Yu, Jiong ^b   Su, Xiaoru ^a   Zhu, Chengxing ^a   Yang, Xiao ^a   Sun, Huawang ^a   Chen, Deying ^b   Wang, Ying ^a   Cao, Hongcui ^a,b   Lu, Jianxin ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Acute liver injury; Biomarker; Metabonomics; UPLC MS

Indexed keywords

AMIDE; BILE ACID CONJUGATE; BIOLOGICAL MARKER; FATTY ACID AMIDE; GALACTOSAMINE; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG; BILE ACID; FATTY ACID;

ACUTE DISEASE; ACUTE LIVER INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMICS; BLOOD SAMPLING; CHINESE; CONTROLLED STUDY; LIPID BLOOD LEVEL; LIPID METABOLISM; LIVER INJURY; MALE; METABOLIC DISORDER; METABONOMICS; MINIPIG; NONHUMAN; PORCINE MODEL; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METABOLOMICS; MULTIVARIATE ANALYSIS; PROCEDURES; RANDOMIZATION; SWINE; TOXIC HEPATITIS;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG-INDUCED LIVER INJURY; FATTY ACIDS; LYSOPHOSPHATIDYLCHOLINES; MALE; METABOLOMICS; MULTIVARIATE ANALYSIS; PHOSPHATIDYLCHOLINES; RANDOM ALLOCATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SWINE; SWINE, MINIATURE; TANDEM MASS SPECTROMETRY;

EID: 84893661727     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.01.008     Document Type: Article

References (47)

1. Bando K., Kunimatsu T., Sakai J., Kimura J., Funabashi H., Seki T., Bamba T., Fukusaki E. GC-MS-based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats. J. Appl. Toxicol. 2011, 31:524-535.
2. Benz C., Angermüller S., Töx U., Klöters-Plachky P., Riedel H.-D., Sauer P., Stremmel W., Stiehl A. Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes. J. Hepatol. 1998, 28:99-106.
3. Boelsterli U.A., Lim P.L. Mitochondrial abnormalities- a link to idiosyncratic drug hepatotoxicity?. Toxicol. Appl. Pharm. 2007, 220:92-107.
4. Brindle J.T., Antti H., Holmes E., Tranter G., Nicholson J.K., Bethell H.W., Clarke S., Schofield P.M., McKilligin E., Mosedale D.E., Grainger D.J. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat. Med. 2002, 8:1439-1444.
5. Burke J.E., Dennis E.A. Phospholipase A2 structure/function, mechanism, and signaling. J. Lipid Res. 2009, 50:S237-S242.
6. Cao H., Yang J., Yu J., Pan Q., Li J., Zhou P., Li Y., Pan X., Wang Y., Li L. Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure. BMC Med. 2012, 10:56.
7. Clemmesen J.O., Høy C.-E., Jeppesen P.B., Ott P. Plasma phospholipid fatty acid pattern in severe liver disease. J. Hepatol. 2000, 32:481-487.
8. Coen M. A metabonomic approach for mechanistic exploration of pre-clinical toxicology. Toxicology 2010, 278:326-340.
9. Coen M., Hong Y.S., Clayton T.A., Rohde C.M., Pearce J.T., Reily M.D., Robertson D.G., Holmes E., Lindon J.C., Nicholson J.K. The mechanism of galactosamine toxicity revisited; a metabonomic study. J. Proteome Res. 2007, 6:2711-2719.
10. Coen M., Want E.J., Clayton T.A., Rhode C.M., Hong Y.S., Keun H.C., Cantor G.H., Metz A.L., Robertson D.G., Reily M.D., Holmes E., Lindon J.C., Nicholson J.K. Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis. J. Proteome Res. 2009, 8:5175-5187.
11. Cortes M., Pareja E., Castell J.V., Moya A., Mir J., Lahoz A. Exploring mass spectrometry suitability to examine human liver graft metabonomic profiles. Transplant. Proc. 2010, 42:2953-2958.
12. Cravatt B.F., Lichtman A.H. The endogenous cannabinoid system and its role in nociceptive behavior. J. Neurobiol. 2004, 61:149-160.
13. Cui Z., Houweling M. Phosphatidylcholine and cell death. BBA-Mol. Cell. Biol. Lipids 2002, 1585:87-96.
14. Fang Z.-Z., Krausz K.W., Tanaka N., Li F., Qu A., Idle J.R., Gonzalez F.J. Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Arch. Toxicol. 2013, 1-13.
15. Fella K., Gluckmann M., Hellmann J., Karas M., Kramer P.J., Kroger M. Use of two-dimensional gel electrophoresis in predictive toxicology: identification of potential early protein biomarkers in chemically induced hepatocarcinogenesis. Proteomics 2005, 5:1914-1927.
16. Feng B., Wu S., Lv S., Liu F., Chen H., Yan X., Li Y., Dong F., Wei L. Metabolic profiling analysis of a d-galactosamine/lipopolysaccharide-induced mouse model of fulminant hepatic failure. J. Proteome Res. 2007, 6:2161-2167.
17. Ganti S., Taylor S.L., Abu Aboud O., Yang J., Evans C., Osier M.V., Alexander D.C., Kim K., Weiss R.H. Kidney tumor biomarkers revealed by simultaneous multiple matrix metabolomics analysis. Cancer Res. 2012, 72:3471-3479.
18. Garcia-Canaveras J.C., Donato M.T., Castell J.V., Lahoz A. A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations. J. Proteome Res. 2011, 10:4825-4834.
19. Gonzalez E., van Liempd S., Conde-Vancells J., Gutierrez-de Juan V., Perez-Cormenzana M., Mayo R., Berisa A., Alonso C., Marquez C.A., Barr J. Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity. Metabolomics 2012, 8:997-1011.
20. Griffin J.L., Nicholls A.W. Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders. Pharmacogenomics 2006, 7:1095-1107.
21. Hao S., Xin J., Lian J., Xie Q., Chen D., Guo Y., Lu Y., Sheng G., Xu W., Huang J. Establishing a metabolomic model for the prognosis of hepatitis B virus-induced acute-on-chronic liver failure treated with different liver support systems. Metabolomics 2011, 7:400-412.
22. Hofmann A.F. The continuing importance of bile acids in liver and intestinal disease. Arch. Intern. Med. 1999, 159:2647.
23. Hunt C.M., Papay J.I., Edwards R.I., Theodore D., Alpers D.H., Dollery C., Debruin T.W., Adkison K.K., Stirnadel H.A., Gibbs T.G. Monitoring liver safety in drug development: the GSK experience. Regul. Toxicol. Pharmacol. 2007, 49:90-100.
24. Jia L., Chen J., Yin P., Lu X., Xu G. Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry. Metabolomics 2008, 4:183-189.
25. Kuliszkiewicz-Janus M., Janus W., Baczyński S. Application of 31P NMR spectroscopy in clinical analysis of changes of serum phospholipids in leukemia, lymphoma and some other non-haematological cancers. Anticancer Res. 1995, 16:1587-1594.
26. Lee J.W., Yamamoto T., Uchikata T., Matsubara A., Fukusaki E., Bamba T. Development of a polar lipid profiling method by supercritical fluid chromatography/mass spectrometry. J. Sep. Sci. 2011, 34:3553-3560.
27. Li F., Patterson A.D., Krausz K.W., Tanaka N., Gonzalez F.J. Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis. J. Lipid Res. 2012, 53:1625-1635.
28. Li M., Wang B., Zhang M., Rantalainen M., Wang S., Zhou H., Zhang Y., Shen J., Pang X., Wei H., Chen Y., Lu H., Zuo J., Su M., Qiu Y., Jia W., Xiao C., Smith L.M., Yang S., Holmes E., Tang H., Zhao G., Nicholson J.K., Li L., Zhao L. Symbiotic gut microbes modulate human metabolic phenotypes. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:2117-2122.
29. Li N.-j., Liu W.-t., Li W., Li S.-q., Chen X.-h., Bi K.-s., He P. Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/mass spectrometry. Clin. Biochem. 2010, 43:992-997.
30. Liu L., Wang M., Yang X., Bin M., Na L., Niu Y., Li Y., Sun C. Fasting serum lipid and dehydroepiandrosterone sulfate as important metabolites for detecting isolated postchallenge diabetes: serum metabolomics via ultra-high-performance liquid chromatography/mass spectrometry. Clin. Chem. 2013, 59:1338-1348.
31. Malhi H., Gores G.J., Lemasters J.J. Apoptosis and necrosis in the liver: a tale of two deaths?. Hepatology 2006, 43:S31-S44.
32. Matsubara T., Tanaka N., Patterson A.D., Cho J., Krausz K.W., Gonzalez F.J. Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice. Hepatology 2011, 53:1282-1293.
33. McKinney M.K., Cravatt B.F. Structure and function of fatty acid amide hydrolase. Annu. Rev. Biochem. 2005, 74:411-432.
34. Nicholson J.K., Lindon J.C., Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
35. Ozer J., Ratner M., Shaw M., Bailey W., Schomaker S. The current state of serum biomarkers of hepatotoxicity. Toxicology 2008, 245:194-205.
36. Patterson A.D., Li H., Eichler G.S., Krausz K.W., Weinstein J.N., Fornace A.J., Gonzalez F.J., Idle J.R. UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal. Chem. 2008, 80:665-674.
37. Pynn C.J., Henderson N.G., Clark H., Koster G., Bernhard W., Postle A.D. Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo. J. Lipid Res. 2011, 52:399-407.
38. Schoemaker M.H., Conde de la Rosa L., Buist-Homan M., Vrenken T.E., Havinga R., Poelstra K., Haisma H.J., Jansen P.L., Moshage H. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology 2004, 39:1563-1573.
39. Shi Q., Hong H., Senior J., Tong W. Biomarkers for drug-induced liver injury. Expert Rev. Gastroenterol. Hepatol. 2010, 4:225-234.
40. Smets F., Najimi M., Sokal E.M. Cell transplantation in the treatment of liver diseases. Pediatr. Transplant. 2008, 12:6-13.
41. Sreekumar A., Poisson L.M., Rajendiran T.M., Khan A.P., Cao Q., Yu J., Laxman B., Mehra R., Lonigro R.J., Li Y., Nyati M.K., Ahsan A., Kalyana-Sundaram S., Han B., Cao X., Byun J., Omenn G.S., Ghosh D., Pennathur S., Alexander D.C., Berger A., Shuster J.R., Wei J.T., Varambally S., Beecher C., Chinnaiyan A.M. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 2009, 457:910-914.
42. Tanaka N., Matsubara T., Krausz K.W., Patterson A.D., Gonzalez F.J. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology 2012, 56:118-129.
43. Taylor L.A., Arends J., Hodina A.K., Unger C., Massing U. Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status. Lipids Health Dis. 2007, 6:1-8.
44. Want E.J., Coen M., Masson P., Keun H.C., Pearce J.T., Reily M.D., Robertson D.G., Rohde C.M., Holmes E., Lindon J.C., Plumb R.S., Nicholson J.K. Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies. Anal. Chem. 2010, 82:5282-5289.
45. Yang J., Zhao X., Liu X., Wang C., Gao P., Wang J., Li L., Gu J., Yang S., Xu G. High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B. J. Proteome Res. 2006, 5:554-561.
46. Yang L., Xiong A., He Y., Wang Z., Wang C., Li W., Hu Z. Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry. Chem. Res. Toxicol. 2008, 21:2280-2288.
47. Zhou P., Li J., Shao L., Lv G., Zhao L., Huang H., Zhang A., Pan X., Liu W., Xie Q. Dynamic patterns of serum metabolites in fulminant hepatic failure pigs. Metabolomics 2012, 8:869-879.