Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice

Hepatology

Volumn 53, Issue 4, 2011, Pages 1282-1293

  Matsubara, Tsutomu ^a   Tanaka, Naoki ^a   Patterson, Andrew D ^a   Cho, Joo Youn ^a,b   Krausz, Kristopher W ^a   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACYLGLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE; CERAMIDE; CHOLINE; FARNESOID X RECEPTOR; LINOLEOYL COENZYME A DESATURASE; LITHOCHOLIC ACID; LYSOPHOSPHATIDYLCHOLINE; MESSENGER RNA; OLEOYL COENZYME A; PALMITOYL COENZYME A; PHOSPHOLIPID; SMAD3 PROTEIN; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; STEAROYL COENZYME A; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE INDUCTION; HOMEOSTASIS; INTRAHEPATIC CHOLESTASIS; LIPID COMPOSITION; LIVER CELL; METABOLOME; MOUSE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-ACYLGLYCEROPHOSPHOCHOLINE O-ACYLTRANSFERASE; ANIMALS; CERAMIDES; CHOLESTASIS; FEMALE; HOMEOSTASIS; LITHOCHOLIC ACID; LYSOPHOSPHATIDYLCHOLINES; METABOLOME; MICE; MICE, INBRED C57BL; PHOSPHOLIPIDS; RNA, MESSENGER; SPHINGOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 79953764496     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24193     Document Type: Article

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