Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity

Metabolomics

Volumn 8, Issue 6, 2012, Pages 997-1011

  Gonzalez, Esperanza ^a   van Liempd, Sebastiaan ^a   Conde Vancells, Javier ^a   Gutierrez de Juan, Virginia ^a   Perez Cormenzana, Miriam ^b   Mayo, Rebeca ^b   Berisa, Agustin ^c   Alonso, Cristina ^b   Marquez, Cesar A ^d   Barr, Jonathan ^b   Lu, Shelly C ^e   Mato, Jose M ^a   Falcon Perez, Juan M ^a,f  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b OWL Genomics   (Spain)

^c FAES FARMA SA   (Spain)

^d Bizkaia Technology Park   (Spain)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

Acute liver injury; Biomarkers; DILI; Galactosamine; Hepatotoxicity; Serum metabolic profiling; UPLC MS MS metabolomics

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINO ACID; AMINOTRANSFERASE; BIOLOGICAL MARKER; GALACTOSAMINE; GLUCOSE; MEMBRANE LIPID;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME ACTIVITY; ENZYME ASSAY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; LIVER CELL DAMAGE; LIVER HISTOLOGY; LIVER INJURY; LIVER TOXICITY; MALE; METABOLOMICS; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALIA; RATTUS;

EID: 84868367130     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-011-0329-9     Document Type: Article

References (50)

1. Arai, K., Lee, K., Berthiaume, F., Tompkins, R. G., & Yarmush, M. L. (2001). Intrahepatic amino acid and glucose metabolism in a d-galactosamine-induced rat liver failure model. Hepatology, 34, 360-371.
2. Barr, J., Vazquez-Chantada, M., Alonso, C., Perez-Cormenzana, M., Mayo, R., Galan, A., et al. (2010). Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. Journal of Proteome Research, 9, 4501-4512.
3. Boelsterli, U. A., & Lim, P. L. (2007). Mitochondrial abnormalities-a link to idiosyncratic drug hepatotoxicity? Toxicology and Applied Pharmacology, 220, 92-107.
4. Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W., et al. (2002). Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nature Medicine, 8, 1439-1444.
5. Cabrero, C., Duce, A. M., Ortiz, P., Alemany, S., & Mato, J. M. (1988). Specific loss of the high-molecular-weight form of S-adenosyl-l-methionine synthetase in human liver cirrhosis. Hepatology, 8, 1530-1534.
6. Chan, E. C., Yap, S. L., Lau, A. J., Leow, P. C., Toh, D. F., & Koh, H. L. (2007). Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rapid Communications in Mass Spectrometry, 21, 519-528.
7. Chen, C., Gonzalez, F. J., & Idle, J. R. (2007). LC-MS-based metabolomics in drug metabolism. Drug Metabolism Reviews, 39, 581-597.
8. Clarke, C. J., & Haselden, J. N. (2008). Metabolic profiling as a tool for understanding mechanisms of toxicity. Toxicologic Pathology, 36, 140-147.
9. Coen, M. (2010). A metabonomic approach for mechanistic exploration of pre-clinical toxicology. Toxicology, 278, 326-340.
10. Coen, M., Hong, Y. S., Clayton, T. A., Rohde, C. M., Pearce, J. T., Reily, M. D., et al. (2007). The mechanism of galactosamine toxicity revisited; a metabonomic study. Journal of Proteome Research, 6, 2711-2719.
11. Coen, M., Want, E. J., Clayton, T. A., Rhode, C. M., Hong, Y. S., Keun, H. C., et al. (2009). Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis. Journal of Proteome Research, 8, 5175-5187.
12. Dan, Y. Y., & Yeoh, G. C. (2008). Liver stem cells: A scientific and clinical perspective. Journal of Gastroenterology and Hepatology, 23, 687-698.
13. Decker, K., & Keppler, D. (1972). Galactosamine induced liver injury. Progress in Liver Diseases, 4, 183-199.
14. Duarte, I. F., Stanley, E. G., Holmes, E., Lindon, J. C., Gil, A. M., Tang, H., et al. (2005). Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning 1H NMR spectroscopy. Analytical Chemistry, 77, 5570-5578.
15. El-Mofty, S. K., Scrutton, M. C., Serroni, A., Nicolini, C., & Farber, J. L. (1975). Early, reversible plasma membrane injury in galactosamine-induced liver cell death. The American Journal of Pathology, 79, 579-596.
16. Feng, B., Wu, S., Lv, S., Liu, F., Chen, H., Yan, X., et al. (2007). Metabolic profiling analysis of a d-galactosamine/lipopolysaccharide-induced mouse model of fulminant hepatic failure. Journal of Proteome Research, 6, 2161-2167.
17. Fernie, A. R., Trethewey, R. N., Krotzky, A. J., & Willmitzer, L. (2004). Metabolite profiling: From diagnostics to systems biology. Nature Reviews Molecular Cell Biology, 5, 763-769.
18. Fox, L. M., Cox, D. G., Lockridge, J. L., Wang, X., Chen, X., Scharf, L., et al. (2009). Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biology, 7, e1000228.
19. Gomez-Lechon, M. J., Castell, J. V., & Donato, M. T. (2008). An update on metabolism studies using human hepatocytes in primary culture. Expert Opinion on Drug Metabolism, 4, 837-854.
20. Kaplowitz, N. (2001). Drug-induced liver disorders: Implications for drug development and regulation. Drug Safety, 24, 483-490.
21. Keppler, D., Lesch, R., Reutter, W., & Decker, K. (1968). Experimental hepatitis induced by d-galactosamine. Experimental and Molecular Pathology, 9, 279-290.
22. Kitazawa, T., Tsujimoto, T., Kawaratani, H., & Fukui, H. (2009). Therapeutic approach to regulate innate immune response by Toll-like receptor 4 antagonist E5564 in rats with D-galactosamine-induced acute severe liver injury. Journal of Gastroenterology and Hepatology, 24, 1089-1094.
23. Koff, R. S., Fitts, J. J., Sabesin, S. M., & Zimmerman, H. J. (1971). d-galactosamine hepatotoxicity II. Mechanism of fatty liver production. Proceedings of the Society for Experimental Biology and Medicine, 138, 89-92.
24. Komano, T., Egashira, Y., & Sanada, H. (2008). l-Gln and l-Ser suppress the d-galactosamine-induced IL-18 expression and hepatitis. Biochemical and Biophysical Research Communications, 372, 688-690.
25. Kushnir, M. M., Rockwood, A. L., Bergquist, J. (2009). Liquid chromatography-tandem mass spectrometry applications in endocrinology. Mass Spectrometry Reviews, 29, 480-502.
26. Lin, H. M., Barnett, M. P., Roy, N. C., Joyce, N. I., Zhu, S., Armstrong, K., et al. (2010). Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease. Journal of Proteome Research, 9, 1965-1975.
27. Lott, J. A., & Landesman, P. W. (1984). The enzymology of skeletal muscle disorders. Critical Reviews in Clinical Laboratory Sciences, 20, 153-190.
28. Lutz, U., Lutz, R. W., & Lutz, W. K. (2006). Metabolic profiling of glucuronides in human urine by LC-MS/MS and partial least-squares discriminant analysis for classification and prediction of gender. Analytical Chemistry, 78, 4564-4571.
29. Lv, S., Wei, L., Wang, J. H., Wang, J. Y., & Liu, F. (2007). Identification of novel molecular candidates for acute liver failure in plasma of BALB/c murine model. Journal of Proteome Research, 6, 2746-2752.
30. Maezono, K., Kajiwara, K., Mawatari, K., Shinkai, A., Torii, K., & Maki, T. (1996). Alanine protects liver from injury caused by F-galactosamine and CCl4. Hepatology, 24, 185-191.
31. Major, H. J., Williams, R., Wilson, A. J., & Wilson, I. D. (2006). A metabonomic analysis of plasma from Zucker rat strains using gas chromatography/mass spectrometry and pattern recognition. Rapid Communications in Mass Spectrometry, 20, 3295-3302.
32. Mato, J. M., Martinez-Chantar, M. L., & Lu, S. C. (2008). Methionine metabolism and liver disease. Annual Review of Nutrition, 28, 273-293.
33. Medline, A., Schaffner, F., & Popper, H. (1970). Ultrastructural features in galactosamine-induced hepatitis. Experimental and Molecular Pathology, 12, 201-211.
34. Miller, T. J., Knapton, A., Adeyemo, O., Noory, L., Weaver, J., & Hanig, J. P. (2008). Cytochrome c: A non-invasive biomarker of drug-induced liver injury. Journal of Applied Toxicology, 28, 815-828.
35. Miyahara, M., Enzan, H., Shiraishi, N., Kawase, M., Yamamoto, M., Hara, H., et al. (1982). Mitochondrial damage in galactosamine-induced liver intoxication in rats. Biochimica et Biophysica Acta, 714, 505-515.
36. Muller, P. Y., & Dieterle, F. (2009). Tissue-specific, non-invasive toxicity biomarkers: Translation from preclinical safety assessment to clinical safety monitoring. Expert Opinion on Drug Metabolism, 5, 1023-1038.
37. Newsome, P. N., Plevris, J. N., Nelson, L. J., & Hayes, P. C. (2000). Animal models of fulminant hepatic failure: A critical evaluation. Liver Transplantation, 6, 21-31.
38. Nicholls, A. W., Mortishire-Smith, R. J., & Nicholson, J. K. (2003). NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chemical Research in Toxicology, 16, 1395-1404.
39. Nicholson, J. K., & Wilson, I. D. (2003). Opinion: Understanding 'global' systems biology: Metabonomics and the continuum of metabolism. Nature Reviews Drug Discovery, 2, 668-676.
40. Nordstrom, A., O'Maille, G., Qin, C., & Siuzdak, G. (2006). Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: Quantitative analysis of endogenous and exogenous metabolites in human serum. Analytical Chemistry, 78, 3289-3295.
41. Novakova, L., Solichova, D., & Solich, P. (2006). Advantages of ultra performance liquid chromatography over high-performance liquid chromatography: Comparison of different analytical approaches during analysis of diclofenac gel. Journal of Separation Science, 29, 2433-2443.
42. Ozer, J., Ratner, M., Shaw, M., Bailey, W., & Schomaker, S. (2008). The current state of serum biomarkers of hepatotoxicity. Toxicology, 245, 194-205.
43. Petkova, D. H., Momchilova, A. B., Markovska, T. T., & Koumanov, K. S. (1987). d-galactosamine induced changes in rat liver plasma membranes lipid composition and some enzyme activities. The International Journal of Biochemistry, 19, 289-291.
44. Schauer, N., & Fernie, A. R. (2006). Plant metabolomics: Towards biological function and mechanism. Trends in Plant Science, 11, 508-516.
45. Stramentinoli, G., Gualano, M., & Ideo, G. (1978). Protective role of S-adenosyl-l-methionine on liver injury induced by d-galactosamine in rats. Biochemical Pharmacology, 27, 1431-1433.
46. Tosti, E., Dahl, L., Endresen, M. J., & Henriksen, T. (1999). Endothelial degradation of extracellular lyso-phosphatidylcholine. Scandinavian Journal of Clinical and Laboratory Investigation, 59, 249-257.
47. Tunon, M. J., Alvarez, M., Culebras, J. M., & Gonzalez-Gallego, J. (2009). An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World Journal of Gastroenterology, 15, 3086-3098.
48. Ulrich, R. G. (2007). Idiosyncratic toxicity: A convergence of risk factors. Annual Review of Medicine, 58, 17-34.
49. Yovchev, M. I., Grozdanov, P. N., Zhou, H., Racherla, H., Guha, C., & Dabeva, M. D. (2008). Identification of adult hepatic progenitor cells capable of repopulating injured rat liver. Hepatology, 47, 636-647.
50. Zhang, Q., Wang, G., Du, Y., Zhu, L., & Jiye, A. (2007). GC/MS analysis of the rat urine for metabonomic research. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 854, 20-25.