Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in Biofluids: Application to experimental toxicology studies

Analytical Chemistry

Volumn 82, Issue 12, 2010, Pages 5282-5289

  Want, Elizabeth J ^a   Coen, Muireann ^a   Masson, Perrine ^a   Keun, Hector C ^a   Pearce, Jake T M ^a   Reily, Michael D ^b   Robertson, Donald G ^b   Rohde, Cynthia M ^c   Holmes, Elaine ^a   Lindon, John C ^a   Plumb, Robert S ^d   Nicholson, Jeremy K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b BRISTOL MYERS SQUIBB   (United States)

^c PFIZER INC   (United States)

^d WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUITY; BILE ACID; BIOFLUIDS; BIOLOGICAL FLUIDS; CLINICAL STUDY; CONTROL LEVEL; GALACTOSAMINE; GRADIENT ELUTION; HEPATIC DAMAGE; HEPATOTOXICITY; HIGHLY-CORRELATED; LIVER DAMAGE; TOF MASS SPECTROMETER; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETONITRILE; ACIDS; BODY FLUIDS; DAMAGE DETECTION; LIQUIDS; LIVER; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; ORGANIC POLYMERS; TOXICITY;

LIQUID CHROMATOGRAPHY;

BILE ACID; GALACTOSAMINE; GLYCINE;

ANIMAL; ARTICLE; BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; MALE; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PATHOLOGY; RAT; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; VALIDATION STUDY; PROCEDURES;

ANIMALS; BILE ACIDS AND SALTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GALACTOSAMINE; GLYCINE; LINEAR MODELS; LIVER; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 77953595299     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac1007078     Document Type: Article

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