A comprehensive untargeted metabonomic analysis of human steatotic liver tissue by RP and HILIC chromatography coupled to mass spectrometry reveals important metabolic alterations

Journal of Proteome Research

Volumn 10, Issue 10, 2011, Pages 4825-4834

  García Cañaveras, Juan C ^a,b   Donato, M Teresa ^a,b,c   Castell, José V ^a,b,c   Lahoz, Agustín ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

HILIC; mass spectrometry; metabonomics; NAFLD; steatosis; ULPC MS

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILE ACID; BIOLOGICAL MARKER; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMIC ACID; GLUTAMINE; HYPOXANTHINE; PHOSPHOLIPID; TRIACYLGLYCEROL;

ADULT; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY METABOLISM; FATTY LIVER; FEMALE; HOMEOSTASIS; HUMAN; HUMAN TISSUE; HYDROPHILIC INTERACTION CHROMATOGRAPHY; LIPID DEGRADATION; LIPID STORAGE; LIVER INJURY; LIVER METABOLISM; MALE; MASS SPECTROMETRY; METABOLIC DISORDER; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY;

ADULT; AGED; ANTIOXIDANTS; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; FATTY LIVER; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; LIVER; MALE; MASS SPECTROMETRY; METABOLOMICS; MIDDLE AGED; MITOCHONDRIA; PHOSPHOLIPIDS; SOLVENTS;

EID: 80053926087     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200629p     Document Type: Article

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