Interchenar retrotransfer of aureothin intermediates in an iterative polyketide synthase module

Journal of the American Chemical Society

Volumn 134, Issue 30, 2012, Pages 12382-12385

  Busch, Benjamin ^a,b   Ueberschaar, Nico ^a,b   Sugimoto, Yuki ^a,b   Hertweck, Christian ^a,b  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASSEMBLY LINE; HETERODIMERS; ITERATION PROCESS; MUTATIONAL ANALYSIS; POLYKETIDE SYNTHASES; POLYKETIDES;

CHEMISTRY; SYNTHESIS (CHEMICAL);

KETONES;

ACYL CARRIER PROTEIN; ACYLTRANSFERASE; ANTIFUNGAL AGENT; AUREOTHAN; HETERODIMER; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; MUTATIONAL ANALYSIS; SHUTTLE VECTOR;

CHROMONES; MUTATION; POLYKETIDE SYNTHASES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; STREPTOMYCES;

EID: 84864447607     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja304454r     Document Type: Article

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21. 0), in some cases traces of aureothin could be detected by HPLC-MS (SIM). This surprising non-zero aureothin production could be rationalized by an alternative ACP-loading, possibly by the AT of the fatty acid synthase complex; see: Wesener, S. R.; Potharla, V. Y.; Cheng, Y. Q. Appl. Environ. Microbiol. 2011, 77, 1501-1507