Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells

Circulation Research

Volumn 112, Issue 10, 2013, Pages

  Liu, Yiwen ^a   Drozdov, Ignat ^a   Shroff, Rukshana ^b   Beltran, Leilani E ^a   Shanahan, Catherine M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Aging; Calcification; DNA damage; Lamin A C; Osteogenesis; Senescence; Vascular smooth muscle cells

Indexed keywords

ALKALINE PHOSPHATASE; ATM PROTEIN; ATR PROTEIN; BONE MORPHOGENETIC PROTEIN 2; INTERLEUKIN 6; LAMIN A; OSTEOPROTEGERIN; PRELAMIN A; PROTEIN P16; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CYTOKINE; NUCLEAR PROTEIN; P16 PROTEIN, HUMAN; PROTEIN PRECURSOR; TUMOR PROTEIN;

ARTICLE; BLOOD VESSEL CALCIFICATION; CELL AGING; CELL DIFFERENTIATION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; MINERALIZATION; NUCLEAR LAMINA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ADULT; AGING; BONE DEVELOPMENT; CALCIFICATION; CELL CULTURE; CELL PROLIFERATION; FEMALE; GENETIC TRANSFECTION; GENETICS; IN VITRO STUDY; LAMIN A/C; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SENESCENCE; VASCULAR SMOOTH MUSCLE CELLS;

AGING; CALCIFICATION; DNA DAMAGE; LAMIN A/C; OSTEOGENESIS; SENESCENCE; VASCULAR SMOOTH MUSCLE CELLS;

ADULT; AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DNA DAMAGE; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN PRECURSORS; SIGNAL TRANSDUCTION; TRANSFECTION; VASCULAR CALCIFICATION;

MLCS; MLOWN;

EID: 84879808450     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.300543     Document Type: Article

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