Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria

Science

Volumn 340, Issue 6138, 2013, Pages 1330-1333

  Ibrahim, Mohamed X ^a   Sayin, Volkan I ^a   Akula, Murali K ^a   Liu, Meng ^a   Fong, Loren G ^b   Young, Stephen G ^b   Bergo, Martin O ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; INITIATION FACTOR 4E; LAMIN A; LAMIN C; MAMMALIAN TARGET OF RAPAMYCIN; PRELAMIN A; PROTEIN; PROTEIN KINASE B; PROTEIN P21; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

CYTOLOGY; METHYLATION; RODENT; SENESCENCE; SIGNALING;

ALLELE; ARTICLE; BODY WEIGHT; CELL AGING; CELL NUCLEUS; CELL PROLIFERATION; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; FRACTURE; GRIP STRENGTH; HUMAN; IMMUNOPRECIPITATION; METHYLATION; MOUSE; NONHUMAN; OSSIFICATION; PHENOTYPE; PRIORITY JOURNAL; PROGERIA; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

MAMMALIA; MUS;

EID: 84878940945     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1238880     Document Type: Article

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