-
1
-
-
44449177930
-
The serine protease TMPRSS6 is required to sense iron deficiency
-
DOI 10.1126/science.1157121
-
Du X, She E, Gelbart T, Truksa J, Lee P, et al. (2008) The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088-1092. (Pubitemid 351929552)
-
(2008)
Science
, vol.320
, Issue.5879
, pp. 1088-1092
-
-
Du, X.1
She, E.2
Gelbart, T.3
Truksa, J.4
Lee, P.5
Xia, Y.6
Khovananth, K.7
Mudd, S.8
Mann, N.9
Moresco, E.M.Y.10
Beutler, E.11
Beutler, B.12
-
2
-
-
42649118442
-
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
-
DOI 10.1038/ng.130, PII NG130
-
Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, et al. (2008) Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet 40: 569-571. (Pubitemid 351601217)
-
(2008)
Nature Genetics
, vol.40
, Issue.5
, pp. 569-571
-
-
Finberg, K.E.1
Heeney, M.M.2
Campagna, D.R.3
Aydinok, Y.4
Pearson, H.A.5
Hartman, K.R.6
Mayo, M.M.7
Samuel, S.M.8
Strouse, J.J.9
Markianos, K.10
Andrews, N.C.11
Fleming, M.D.12
-
3
-
-
70350628958
-
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
-
Benyamin B, Ferreira MA, Willemsen G, Gordon S, Middelberg RP, et al. (2009) Common variants in TMPRSS6 are associated with iron status and erythrocyte volume. Nat Genet 41: 1173-1175.
-
(2009)
Nat Genet
, vol.41
, pp. 1173-1175
-
-
Benyamin, B.1
Ferreira, M.A.2
Willemsen, G.3
Gordon, S.4
Middelberg, R.P.5
-
4
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
DOI 10.1126/science.1104742
-
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093. (Pubitemid 40007660)
-
(2004)
Science
, vol.306
, Issue.5704
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.D.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
5
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 41: 478-481.
-
(2009)
Nat Genet
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
Canonne-Hergaux, F.4
Coppin, H.5
-
6
-
-
56449096622
-
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
-
Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, et al. (2008) The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab 8: 502-511.
-
(2008)
Cell Metab
, vol.8
, pp. 502-511
-
-
Silvestri, L.1
Pagani, A.2
Nai, A.3
De Domenico, I.4
Kaplan, J.5
-
7
-
-
84893474718
-
Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matripatase-2 protein
-
Zhang AS, Anderson SA, Wang J, Yang F, Demaster K, et al. (2010) Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matripatase-2 protein. Blood.
-
(2010)
Blood
-
-
Zhang, A.S.1
Anderson, S.A.2
Wang, J.3
Yang, F.4
Demaster, K.5
-
8
-
-
84861380376
-
Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: Identification of a hypoxia-responsive element in the TMPRSS6 promoter region
-
Maurer E, Gutschow M, Stirnberg M (2012) Matriptase-2 (TMPRSS6) is directly up-regulated by hypoxia inducible factor-1: identification of a hypoxia-responsive element in the TMPRSS6 promoter region. Biol Chem 393: 535-540.
-
(2012)
Biol Chem
, vol.393
, pp. 535-540
-
-
Maurer, E.1
Gutschow, M.2
Stirnberg, M.3
-
9
-
-
77956822859
-
EPO-mediated reduction in Hamp expression in vivo corrects iron deficiency anaemia in TMPRSS6 deficiency
-
Peng H, Truksa J, Lee P (2010) EPO-mediated reduction in Hamp expression in vivo corrects iron deficiency anaemia in TMPRSS6 deficiency. Br J Haematol 151: 106-109.
-
(2010)
Br J Haematol
, vol.151
, pp. 106-109
-
-
Peng, H.1
Truksa, J.2
Lee, P.3
-
10
-
-
79960674973
-
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
-
Meynard D, Vaja V, Sun CC, Corradini E, Chen S, et al. (2011) Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood 118: 747-756.
-
(2011)
Blood
, vol.118
, pp. 747-756
-
-
Meynard, D.1
Vaja, V.2
Sun, C.C.3
Corradini, E.4
Chen, S.5
-
11
-
-
77955005442
-
Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
-
De Domenico I, Zhang TY, Koening CL, Branch RW, London N, et al. (2010) Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest 120: 2395-2405.
-
(2010)
J Clin Invest
, vol.120
, pp. 2395-2405
-
-
De Domenico, I.1
Zhang, T.Y.2
Koening, C.L.3
Branch, R.W.4
London, N.5
-
12
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
DOI 10.1172/JCI200420945
-
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, et al. (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113: 1271-1276. (Pubitemid 39069926)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.9
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
Keller, C.4
Taudorf, S.5
Pedersen, B.K.6
Ganz, T.7
-
13
-
-
33845985236
-
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
-
DOI 10.1182/blood-2006-07-033969
-
Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, et al. (2007) STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109: 353-358. (Pubitemid 46053077)
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 353-358
-
-
Verga, F.M.V.1
Spasic, M.V.2
Kessler, R.3
Stolte, J.4
Hentze, M.W.5
Muckenthaler, M.U.6
-
14
-
-
67349204418
-
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD
-
Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU (2009) Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl) 87: 471-480.
-
(2009)
J Mol Med (Berl)
, vol.87
, pp. 471-480
-
-
Casanovas, G.1
Mleczko-Sanecka, K.2
Altamura, S.3
Hentze, M.W.4
Muckenthaler, M.U.5
-
15
-
-
84864053080
-
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling
-
Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, et al. (2012) Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood 120: 431-439.
-
(2012)
Blood
, vol.120
, pp. 431-439
-
-
Besson-Fournier, C.1
Latour, C.2
Kautz, L.3
Bertrand, J.4
Ganz, T.5
-
16
-
-
0034820507
-
Bacterial lipopolysaccharides and innate immunity
-
DOI 10.1179/096805101101532675
-
Alexander C, Rietschel ET (2001) Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 7: 167-202. (Pubitemid 32894573)
-
(2001)
Journal of Endotoxin Research
, vol.7
, Issue.3
, pp. 167-202
-
-
Alexander, C.1
Rietschel, E.Th.2
-
17
-
-
84876539389
-
Role of hepcidin in the setting of hypoferremia during acute inflammation
-
Deschemin JC, Vaulont S (2013) Role of hepcidin in the setting of hypoferremia during acute inflammation. PLoS One 8: e61050.
-
(2013)
PLoS One
, vol.8
-
-
Deschemin, J.C.1
Vaulont, S.2
-
18
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531-539.
-
(2006)
Nat Genet
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
-
19
-
-
0035794217
-
DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites
-
Ehret GB, Reichenbach P, Schindler U, Horvath CM, Fritz S, et al. (2001) DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J Biol Chem 276: 6675-6688.
-
(2001)
J Biol Chem
, vol.276
, pp. 6675-6688
-
-
Ehret, G.B.1
Reichenbach, P.2
Schindler, U.3
Horvath, C.M.4
Fritz, S.5
-
20
-
-
0036288973
-
Opposite nuclear level and binding activity of STAT5B and STAT3 proteins with rat haptoglobin gene under normal and turpentine induced acute phase conditions
-
DOI 10.1023/A:1015749109119
-
Grigorov I, Lazic T, Cvetkovic I, Milosavljevic T, Petrovic M (2001) Opposite nuclear level and binding activity of STAT5B and STAT3 proteins with rat haptoglobin gene under normal and turpentine induced acute phase conditions. Mol Biol Rep 28: 217-222. (Pubitemid 34718395)
-
(2002)
Molecular Biology Reports
, vol.28
, Issue.4
, pp. 217-222
-
-
Grigorov, I.1
Lazic, T.2
Cvetkovic, I.3
Milosavljevic, T.4
Petrovic, M.5
-
21
-
-
55749096751
-
Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1
-
Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, et al. (2008) Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood 112: 3878-3888.
-
(2008)
Blood
, vol.112
, pp. 3878-3888
-
-
Kerenyi, M.A.1
Grebien, F.2
Gehart, H.3
Schifrer, M.4
Artaker, M.5
-
22
-
-
0037071409
-
JAKs, STATs and Src kinases in hematopoiesis
-
DOI 10.1038/sj.onc.1205398
-
Rane SG, Reddy EP (2002) JAKs, STATs and Src kinases in hematopoiesis. Oncogene 21: 3334-3358. (Pubitemid 34587707)
-
(2002)
Oncogene
, vol.21
, Issue.21 REV. ISS. 2
, pp. 3334-3358
-
-
Rane, S.G.1
Reddy, E.P.2
-
23
-
-
84875253909
-
Erythropoietin stimulation decreases hepcidin expression through hematopoietic activity on bone marrow cells in mice
-
Sasaki Y, Noguchi-Sasaki M, Yasuno H, Yorozu K, Shimonaka Y (2012) Erythropoietin stimulation decreases hepcidin expression through hematopoietic activity on bone marrow cells in mice. Int J Hematol 96: 692-700.
-
(2012)
Int J Hematol
, vol.96
, pp. 692-700
-
-
Sasaki, Y.1
Noguchi-Sasaki, M.2
Yasuno, H.3
Yorozu, K.4
Shimonaka, Y.5
-
24
-
-
84861525631
-
Deletion of Tmprss6 attenuates the phenotype in a mouse model of beta-thalassemia
-
Nai A, Pagani A, Mandelli G, Lidonnici MR, Silvestri L, et al. (2012) Deletion of Tmprss6 attenuates the phenotype in a mouse model of beta-thalassemia. Blood.
-
(2012)
Blood
-
-
Nai, A.1
Pagani, A.2
Mandelli, G.3
Lidonnici, M.R.4
Silvestri, L.5
-
25
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
DOI 10.1073/pnas.072632499
-
Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, et al. (2002) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A 99: 4596-4601. (Pubitemid 34286030)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.7
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
Mativet, S.4
Beaumont, C.5
Grandchamp, B.6
Sirito, M.7
Sawadogo, M.8
Kahn, A.9
Vaulont, S.10
-
26
-
-
14744278436
-
Anemia of chronic disease
-
Weiss G, Goodnough LT (2005) Anemia of chronic disease. N Engl J Med 352: 1011-1023.
-
(2005)
N Engl J Med
, vol.352
, pp. 1011-1023
-
-
Weiss, G.1
Goodnough, L.T.2
-
27
-
-
84862792124
-
Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
-
Sun CC, Vaja V, Babitt JL, Lin HY (2012) Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol 87: 392-400.
-
(2012)
Am J Hematol
, vol.87
, pp. 392-400
-
-
Sun, C.C.1
Vaja, V.2
Babitt, J.L.3
Lin, H.Y.4
|