Role of Hepcidin in the Setting of Hypoferremia during Acute Inflammation

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Deschemin, Jean Christophe ^a,b,c   Vaulont, Sophie ^a,b,c  

^a INSERM   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN; HEPCIDIN; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; OXIDOREDUCTASE; PROTEIN DCYTB; UNCLASSIFIED DRUG; CATION TRANSPORT PROTEIN; IRON; LIPOPOLYSACCHARIDE; METAL TRANSPORTING PROTEIN 1;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DUODENUM; GENE EXPRESSION; HEPCIDIN GENE; HETEROZYGOTE; HYPOFERREMIA; INFLAMMATION; IRON BLOOD LEVEL; IRON DEFICIENCY; MOUSE; NONHUMAN; SPLEEN; TISSUE LEVEL; ANIMAL; ANTIBODY SPECIFICITY; BLOOD; C57BL MOUSE; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; LIVER; MALE; METABOLISM;

MUS;

ACUTE DISEASE; ANIMALS; CATION TRANSPORT PROTEINS; DUODENUM; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; HEPCIDINS; INFLAMMATION; IRON; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; ORGAN SPECIFICITY;

EID: 84876539389     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061050     Document Type: Article

References (31)

1. Lu YC, Yeh WC, Ohashi PS, (2008) LPS/TLR4 signal transduction pathway. Cytokine 42: 145-151.
2. Weiss G, (2009) Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta 1790: 682-693.
3. Ganz T, Nemeth E, (2012) Hepcidin and iron homeostasis. Biochim Biophys Acta 1823: 1434-1443.
4. Badial PR, Oliveira-Filho JP, Cunha PH, Araujo JP, Peiro JR, et al. (2011) Influence of experimental inflammatory response on hepatic hepcidin gene expression and plasma iron concentration in sheep. Vet Immunol Immunopathol 141: 157-161.
5. Lou DQ, Lesbordes JC, Nicolas G, Viatte L, Bennoun M, et al. (2005) Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. Hepatology 41: 1056-1064.
6. Kemna EH, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D, (2005) Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106: 51864-51866.
7. Lesbordes-Brion JC, Viatte L, Bennoun M, Lou DQ, Ramey G, et al. (2006) Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 108: 1402-1405.
8. Ramey G, Deschemin JC, Durel B, Canonne-Hergaux F, Nicolas G, et al. (2010) Hepcidin targets ferroportin for degradation in hepatocytes. Haematologica 95: 501-504.
9. Viatte L, Lesbordes-Brion JC, Lou DQ, Bennoun M, Nicolas G, et al. (2005) Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice. Blood 105: 4861-4864.
10. Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P, (1999) Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93: 4406-4417.
11. Canonne-Hergaux F, Donovan A, Delaby C, Wang HJ, Gros P, (2006) Comparative studies of duodenal and macrophage ferroportin proteins. Am J Physiol Gastrointest Liver Physiol 290: G156-163.
12. Besson-Fournier C, Latour C, Kautz L, Bertrand J, Ganz T, et al. (2012) Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood 120: 431-439.
13. Yang F, Liu XB, Quinones M, Melby PC, Ghio A, et al. (2002) Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem 277: 39786-39791.
14. Yeh KY, Yeh M, Glass J, (2004) Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Am J Physiol Gastrointest Liver Physiol 286: G385-394.
15. Zhang DL, Hughes RM, Ollivierre-Wilson H, Ghosh MC, Rouault TA, (2009) A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab 9: 461-473.
16. Layoun A, Huang H, Calve A, Santos MM, (2012) Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice. Am J Pathol 180: 2340-2350.
17. Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, et al. (2012) Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol 189: 1911-1919.
18. Anderson GJ, Frazer DM, Wilkins SJ, Becker EM, Millard KN, et al. (2002) Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. Biochem Soc Trans 30: 724-726.
19. Krijt J, Vokurka M, Sefc L, Duricova D, Necas E, (2006) Effect of lipopolysaccharide and bleeding on the expression of intestinal proteins involved in iron and haem transport. Folia Biol 52: 1-5.
20. Rodrigues PN, Gomes SS, Neves JV, Gomes-Pereira S, Correia-Neves M, et al. (2011) Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin. Immunobiology 216: 1127-1134.
21. Laftah AH, Sharma N, Brookes MJ, McKie AT, Simpson RJ, et al. (2006) Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice. Biochem J 397: 61-67.
22. Schubert TE, Bosserhoff AK, Peyssonaux C, Echtenacher B, Knutson M, et al. (2012) Hypoferraemia during the early inflammatory response is dependent on tumour necrosis factor activity in a murine model of protracted peritonitis. Mol Med Report 6: 838-842.
23. Villarroel P, Le Blanc S, Arredondo M (2012) Interleukin-6 and Lipopolysaccharide Modulate Hepcidin mRNA Expression by Hepg2 Cells. Biol Trace Elem Res.
24. Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, et al. (2011) Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood 118: 736-746.
25. Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112: 1503-1509.
26. Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 41: 478-481.
27. Krijt J, Vokurka M, Chang KT, Necas E, (2004) Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood 104: 4308-4310.
28. Niederkofler V, Rishard S, Arber S, (2005) Hemojuvelin is essential for dietary iron-sensing and its mutation leads to severe iron overload. J Clin Invest 115: 2180-2186.
29. Constante M, Wang D, Raymond VA, Bilodeau M, Santos MM, (2007) Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170: 497-504.
30. Salama MF, Bayele HK, Srai SS, (2012) Tumour necrosis factor alpha downregulates human hemojuvelin expression via a novel response element within its promoter. J Biomed Sci 19: 83.
31. Lawless MW, Greene CM, (2012) Toll-like receptor signalling in liver disease: ER stress the missing link? Cytokine 59: 195-202.