Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells

Fibrogenesis and Tissue Repair

Volumn 2, Issue 1, 2009, Pages

  Gentilini, Alessandra ^a   Lottini, Benedetta ^a   Brogi, Marco ^a   Caligiuri, Alessandra ^a   Cosmi, Lorenzo ^a   Marra, Fabio ^a   Pinzani, Massimo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 66149130096     PISSN: None     EISSN: 17551536     Source Type: Journal    
DOI: 10.1186/1755-1536-2-1     Document Type: Article

References (35)

1. Friedman SL. Liver fibrosis: from bench to bedside. J Hepatol 2003, 38:S38-S53. 10.1016/S0168-8278(02)00429-4, 12591185.
2. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005, 115:209-218. 546435, 15690074.
3. Benyon RC, Arthur MJP. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis 2001, 21:373-385. 10.1055/s-2001-17552, 11586466.
4. Schuppan D, Ruehl M, Somasundran R, Hahn EG. Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis 2001, 21:351-372. 10.1055/s-2001-17556, 11586465.
5. Pinzani M, Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 2001, 21:397-416. 10.1055/s-2001-17554, 11586468.
6. Pinzani M, Vizzutti F. Fibrosis and cirrhosis reversibility: clinical features and clinical implications. Clin Liver Dis 2008, 12:901-913. 10.1016/j.cld.2008.07.006, 18984473.
7. Issa R, Williams E, Trim N, Kendall T, Arthur MJ, Reichen J, Benyon RC, Iredale JP. Apoptosis of hepatic stellate cells: involvement in the resolution of of biliary fibrosis. Gut 2001, 48:548-557. 1728234, 11247901, 10.1136/gut.48.4.548.
8. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, Arthur MJ. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998, 102:538-549. 508915, 9691091, 10.1172/JCI1018.
9. Murphy FR, Issa R, Zhou X, Ratnarajah S, Nagase H, Arthur MJ, Benyon C, Iredale JP. Inhibition of apoptosis of activated hepatic stellate cells by TIMP-1 is mediated via effects on MMP-inhibition: implications for reversibility of liver fibrosis. J Biol Chem 2002, 277:11069-11076. 10.1074/jbc.M111490200, 11796725.
10. Iredale JP. Hepatic stellate cell behaviour during resolution of liver injury. Semin Liver Dis 2001, 21:427-436. 10.1055/s-2001-17557, 11586470.
11. Elsharkawy AM, Oakley F, Mann DA. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Review. Apoptosis 2005, 10:927-939. 10.1007/s10495-005-1055-4, 16151628.
12. Trim N, Morgan S, Evans M, Issa R, Fine D, Afford S, Wilkins B, Iredale J. Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. Am J Pathol 2000, 156:1235-1243. 1876895, 10751349.
13. Novo E, Marra F, Zamara E, Valfrè di Bonzo L, Monitillo L, Cannito S, Petrai I, Mazzocca A, Bonacchi A, De Franco RSM, Colombatto S, Autelli R, Pinzani M, Parola M. Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans. Gut 2006, 55:1174-1182. 10.1136/gut.2005.082701, 16423888.
14. Le Roith D, Werner H, Beitner-Johnson D, Roberts CT. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995, 2:143-163.
15. Caufriez A, Reding P, Urbain D, Golstein J, Copinschi G. Insulin-like growth factor I: a good indicator of functional hepatocellular capacity in alcoholic liver cirrhosis. J Endocrinol Invest 1991, 14:317-321.
16. Pinzani M, Knauss TC, Pierce GF, Hsieh P, Kenney W, Dubyak GR, Abboud HE. Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells. Am J Physiol 1991, 260:C485-C491.
17. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Review. Endocr Rev 1995, 16:3-34. 10.1210/er.16.1.3, 7758431.
18. Gentilini A, Marra F, Gentilini P, Pinzani M. Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic stellate cells. J Hepatol 2000, 32:227-234. 10.1016/S0168-8278(00)80067-7, 10707862.
19. Casini A, Pinzani M, Milani S, Grappone C, Galli G, Jezequel AM, Schuppan D, Rotella CM, Surrenti C. Regulation of extracellular matrix synthesis by transforming growth factor-beta1 in human fat-storing cells. Gastroenterology 1993, 105:245-253.
20. Cassiman D, Roskams T. Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research. J Hepatol 2002, 37:527-535. 10.1016/S0168-8278(02)00263-5, 12217608.
21. Cassiman D, Libbrecht L, Desmet V, Denef C, Roskams T. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 2002, 36:200-209. 10.1016/S0168-8278(01)00260-4, 11830331.
22. Sallie R, Cohen AT, Tibbs CJ, Portmann BC, Rayner A, O'Grady JG, Tan KC, Williams R. Recurrence of hepatitis C following orthotopic liver transplantation: a polymerase chain reaction and histological study. J Hepatol 1994, 21:536-542. 10.1016/S0168-8278(94)80098-7, 7814799.
23. Robino G, Parola M, Marra F, Caligiuri A, DeFranco RM, Zamara E, Bellomo G, Gentilini P, Pinzani M, Dianzani MU. Interaction between 4-hydroxy-2,3-alkenals and the platelet-derived growth factor-beta receptor. Reduced tyrosine phosphorylation and downstream signaling in hepatic stellate cells. Biol Chem 2000, 275:40561-40567.
24. Sastry KS, Karpova Y, Kulik G. Epidermal growth factor protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways. J Biol Chem 2006, 281:27367-27377. 10.1074/jbc.M511485200, 16847055.
25. Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004, 117:421-426. 10.1016/S0092-8674(04)00452-0, 15137936.
26. Mitsiades CS, Mitsiades N, Koutsilieris M. The Akt pathway: molecular targets for anticancer drug development. Curr Cancer Drug Targets 2004, 4:235-256. 10.2174/1568009043333032, 15134532.
27. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789. 10.1038/378785a0, 8524413.
28. Brunet A, Bonni A, Zigmond M, Lin M, Juo P, Hu L, Anderson M, Arden K, Blenis J, Greenberg M. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96:857-868. 10.1016/S0092-8674(00)80595-4, 10102273.
29. Pinzani M, Rombouts K, Colagrande S. Fibrosis in chronic liver diseases: diagnosis and management. J Hepatol 2005, 42(Suppl 1):S22-S36.
30. Friedman SL. Hepatic fibrosis-Overview. Toxicology 2008, 254:120-129. 10.1016/j.tox.2008.06.013, 18662740.
31. Kawada N. Human hepatic stellate cells are resistant to apoptosis: implications for human fibrogenic liver disease. Review. Gut 2006, 55:1073-1074. 10.1136/gut.2005.090449, 16849344.
32. Kooijman R. Regulation of apoptosis by insulin-like growth factor (IGF)-I. Review. Cytokine Growth Factor Rev 2006, 17:305-323. 10.1016/j.cytogfr.2006.02.002, 16621671.
33. Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 1998, 12:3499-3511. 317244, 9832503, 10.1101/gad.12.22.3499.
34. Kapoor M, Liu S, Shi-wen X, Huh K, McCann M, Denton CP, Woodgett JR, Abraham DJ, Leask A. GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest 2008, 118:3279-3290. 2542848, 18802478, 10.1172/JCI35381R1.
35. Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000, 404:782-787. 10.1038/35008115, 10783894.