The protective effects of Hibiscus sabdariffa extract on CCl 4-induced liver fibrosis in rats

Food and Chemical Toxicology

Volumn 44, Issue 3, 2006, Pages 336-343

  Liu, Jer Yuh ^a   Chen, Chang Che ^a   Wang, Wen Hong ^a   Hsu, Jeng Dong ^b   Yang, Mon Yuan ^a   Wang, Chau Jong ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Hibiscus sabdariffa extract; Liver fibrosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GLUTATHIONE; HIBISCUS SABDARIFFA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME BLOOD LEVEL; FATTY LIVER; HIBISCUS; LIPID PEROXIDATION; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; MALE; NONHUMAN; RAT; STELLATE CELL;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HIBISCUS; LIPID PEROXIDATION; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SEVERITY OF ILLNESS INDEX; SILYMARIN;

ANIMALIA; HIBISCUS; HIBISCUS SABDARIFFA; RATTUS NORVEGICUS;

EID: 28844451168     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.08.003     Document Type: Article

References (33)

1. B.H. Ali, H.M. Mousa, and S. El-Mougy The effect of a water extract and anthocyanins of Hibiscus sabdariffa L. on paracetamol-induced hepatoxicity in rats Phytother. Res. 17 1 2003 56 59
2. H.U. Bergmeyer, M. Horder, and R. Rej International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase (l-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2) J. Clin. Chem. Clin. Biochem. 24 7 1986 481 495
3. H.U. Bergmeyer, M. Horder, and R. Rej International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase (l-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1) J. Clin. Chem. Clin. Biochem. 24 7 1986 497 510
4. C.C. Chen, J.D. Hsu, S.F. Wang, H.C. Chiang, M.Y. Yang, E.S. Kao, Y.C. Ho, and C.J. Wang Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits J. Agric. Food Chem. 51 18 2003 5472 5477
5. T. Chewonarin, T. Kinouchi, K. Kataoka, H. Arimochi, T. Kuwahara, U. Vinitketkumnuen, and Y. Ohnishi Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in F344 rats Food Chem. Toxicol. 37 6 1999 591 601
6. A.A. Dafallah, and Z. al-Mustafa Investigation of the antiinflammatory activity of Acacia nilotica and Hibiscus sabdariffa Am. J. Chin. Med. 24 1 1996 263 269
7. A.M. de Leeuw, S.P. McCarthy, A. Geerts, and D.L. Knook Purified rat liver fat-storing cells in culture divide and contain collagen Hepatology 4 3 1984 392 403
8. C.G. Fraga, B.E. Leibovitz, and A.L. Tappel Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes Free Radic. Biol. Med. 4 3 1988 155 161
9. M. Haji Faraji, and A. Haji Tarkhani The effect of sour tea (Hibiscus sabdariffa) on essential hypertension J. Ethnopharmacol. 65 3 1999 231 236
10. 4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats Hepatology 34 4 Part 1 2001 677 687
11. M. Junnila, T. Rahko, A. Sukura, and L.A. Lindberg Reduction of carbon tetrachloride-induced hepatotoxic effects by oral administration of betaine in male Han-Wistar rats: a morphometric histological study Vet. Pathol. 37 3 2000 231 238
12. D. Kershenobich Stalnikowitz, and A.B. Weissbrod Liver fibrosis and inflammation. A review Ann. Hepatol. 2 4 2003 159 163
13. M.S. Kim, J.K. Kim, H.J. Kim, S.R. Moon, B.C. Shin, K.W. Park, H.O. Yang, S.M. Kim, and R. Park Hibiscus extract inhibits the lipid droplet accumulation and adipogenic transcription factors expression of 3T3-L1 preadipocytes J. Altern. Complement. Med. 9 4 2003 499 504
14. P. Kumaravelu, D.P. Dakshinamoorthy, S. Subramaniam, H. Devaraj, and N.S. Devaraj Effect of eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver Biochem. Pharmacol. 49 11 1995 1703 1707
15. C.C. Lin, and P.C. Huang Antioxidant and hepatoprotective effects of Acathopanax senticosus Phytother. Res. 14 17 2000 489 494
16. C.L. Liu, J.M. Wang, C.Y. Chu, M.T. Cheng, and T.H. Tseng In vivo protective effect of protocatechuic acid on tert-butyl hydroperoxide induced rat hepatotoxicity Food Chem. Toxicol. 40 5 2002 635 641
17. 4 liver damage J. Appl. Toxicol. 10 4 1990 275 279
18. P. Muriel, T. Garciapina, V. Perez-Alvarez, and M. Mourelle Silymarin protects against paracetamol-induced lipid peroxidation and liver damage J. Appl. Toxicol. 12 6 1992 439 442
19. 4 administration inducing liver cytolysis and fibrosis in rat Br. J. Exp. Pathol. 68 1 1987 7 13
20. N.N. Nissen, and P. Martin Hepatocellular carcinoma: the high-risk patient J. Clin. Gastroenterol. 35 5 Suppl. 2 2002 S79 S85
21. K. Okita, I. Sakaida, and K. Hino Current strategies for chemoprevention of hepatocellular carcinoma Oncology 62 Suppl. 1 2002 24 28
22. P.C. Onyenekwe, E.O. Ajani, D.A. Ameh, and K.S. Gamaniel Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats Cell Biochem. Funct. 17 3 1999 199 206
23. G. Poli, E. Albano, and M.U. Dianzani The role of lipid peroxidation in liver damage Chem. Phys. Lipids 45 2-4 1987 117 142
24. R.O. Recknagel, E.A. Glende Jr., J.A. Dolak, and R.L. Waller Mechanisms of carbon tetrachloride toxicity Pharmacol. Ther. 43 1 1989 139 154
25. S. Schafer, O. Zerbe, and A.M. Gressner The synthesis of proteoglycans in fat-storing cells of rat liver Hepatology 7 4 1987 680 687
26. A.P. Senft, T.P. Dalton, and H.G. Shertzer Determining glutathione and glutathione disulfide using the fluorescence probe o-phthalaldehyde Anal. Biochem. 280 1 2000 80 86
27. S.A. Sheweita, M. Abd El-Gabar, and M. Bastawy Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants Toxicology 165 2-3 2001 217 224
28. S.A. Sheweita, M. El-Gabar, and M. Bastawy Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants Toxicology 169 2 2001 83 92
29. J.C. Shyu, Y.S. Hsieh, C.L. Chang, C.C. Tsai, C.K. Cheng, and J.Y. Liu Change in protein kinase C activity on day 5 of decidualization in pseudopregnant rats Chin. J. Physiol. 40 2 1997 107 112
30. Y.O. Teselkin, I.V. Babenkova, V.K. Kolhir, A.I. Baginskaya, N.A. Tjukavkina, Y.A. Kolesnik, I.A. Selivanova, and A.A. Eichholz Dihydroquercetin as a means of antioxidative defence in rats with tetrachloromethane hepatitis Phytother. Res. 14 3 2000 160 162
31. T.H. Tseng, C.J. Wang, E.S. Kao, and H.Y. Chu Hibiscus protocatechuic acid protects against oxidative damage induced by tert-butylhydroperoxide in rat primary hepatocytes Chem. Biol. Interact. 101 2 1996 137 148
32. C.J. Wang, J.M. Wang, W.L. Lin, C.Y. Chu, F.P. Chou, and T.H. Tseng Protective effect of Hibiscus anthocyanins against tert-butyl hydroperoxide-induced hepatic toxicity in rats Food Chem. Toxicol. 38 5 2000 411 416
33. H.E. Wasmuth, F. Lammert, and S. Matern Genetic risk factors for hepatic fibrosis in chronic liver diseases Med. Klin. (Munich) 98 12 2003 754 762