Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells

Liver International

Volumn 29, Issue 4, 2009, Pages 567-574

  Ma, Junji ^a   Li, Fangfang ^a   Liu, Li ^a   Cui, Donglai ^a   Wu, Xiaohui ^a   Jiang, Xiaoyu ^a   Jiang, Huiqing ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

ERK; HSCs; Locostatin; Migration; Proliferation; RKIP

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; RAF PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL ASSAY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; LIVER CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; STELLATE CELL; UPREGULATION; WOUND CLOSURE;

ANIMALS; APOPTOSIS; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SEPARATION; DOWN-REGULATION; DRUG COMBINATIONS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPATIC STELLATE CELLS; MALE; OXAZOLIDINONES; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION;

EID: 62749124854     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.01981.x     Document Type: Article

References (40)

1. Thirunavukkarasu C, Watkins SC, Gandhi CR. Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: Role of p38 MAPK. Hepatology 2006; 44: 389-98.
2. Uyama N, Zhao L, Van Rossen E, et al. Hepatic stellate cells express synemin, a protein bridging intermediate filaments to focal adhesions. Gut 2006; 55: 1276-89.
3. Milliano MT, Luxon BA. Rat hepatic stellate cells become retinoid unresponsive during activation. Hepatol Res 2005; 33: 225-33.
4. Yang C, Zeisberg M, Mosterman B, et al. Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology 2003; 124: 147-59.
5. Reeves HL, Friedman SL. Activation of hepatic stellate cells - a key issue in liver fibrosis. Front Biosci 2002; 7: D808-26.
6. Hwang YH, Choi JY, Kim S, et al. Over-expression of c-raf-1 proto-oncogene in liver cirrhosis and hepatocellular carcinoma. Hepatol Res 2004; 29: 113-21.
7. Jiang MD, Zheng SM, Xu H, et al. An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis. Hepatobiliary Pancreat Dis Int 2008; 7: 51-7.
8. Reimann T, Hempel U, Krautwald S, et al. Transforming growth factor-beta1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett 1997; 403: 57-60.
9. Benitez-Rajal J, Lorite MJ, Burt AD, Day CP, Thompson MG. Phospholipase D and extracellular signal-regulated kinase in hepatic stellate cells: effects of platelet-derived growth factor and extracellular nucleotides. Am J Physiol Gastrointest Liver Physiol 2006; 291: G977-86.
10. Svegliati-Baroni G, Ridolfi F, Hannivoort R, et al. Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor. Gastroenterology 2005; 128: 1042-55.
11. Antoine M, Wirz W, Taq CG, et al. Expression and function of fibroblast growth factor (FGF) 9 in hepatic stellate cells and its role in toxic liver injury. Biochem Biophys Res Commun 2007; 361: 335-41.
12. Yeung K, Seitz T, Li S, et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 1999; 401: 173-7.
13. Park S, Rath O, Beach S, et al. Regulation of RKIP binding to the N-region of the Raf-1 kinase. FEBS Lett 2006; 580: 6405-12.
14. Kroslak T, Koch T, Kahl E, Höllt V. Human phosphatidylethanolamine-binding protein facilitates heterotrimeric G protein-dependent signaling. J Biol Chem 2001; 276: 39772-8.
15. Lorenz K, Lohse MJ, Quitterer U. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature 2003; 426: 574-9.
16. Corbit KC, Trakul N, Eves EM, et al. Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem 2003; 278: 13061-8.
17. Klysik J, Theroux SJ, Sedivy JM, Moffit JS, Boekelheide K. Signaling crossroads: The function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal 2008; 20: 1-9.
18. Fu Z, Smith PC, Zhang L, et al. Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst 2003; 95: 878-89.
19. Park S, Yeung ML, Beach S, Shields JM, Yeung KC. RKIP downregulates B-Raf kinase activity in melanoma cancer cells. Oncogene 2005; 24: 3535-40.
20. Hagan S, Al-Mulla F, Mallon E, et al. Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis. Clin Cancer Res 2005; 11: 7392-7.
21. Zhang L, Fu Z, Binkley C, et al. Raf kinase inhibitory protein inhibits beta-cell proliferation. Surgery 2004; 136: 708-15.
22. Al-Mulla F, Hagan S, Behbehani AI, et al. Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin Oncol 2006; 24: 5672-9.
23. Minoo P, Zlobec I, Baker K, et al. Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer. Am J Clin Pathol 2007; 127: 820-7.
24. Lee HC, Tian B, Sedivy JM, Wands JR, Kim M. Loss of raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology 2006; 131: 1208-17.
25. Schuierer MM, Btaille F, Weiss TS, Hellerbrand C, Bosserhoff AK. Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma. Oncol Rep 2006; 16: 451-6.
26. Mc Henry KT, Ankala SV, Ghosh AK, Fenteany G. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem 2002; 3: 1105-11.
27. Zhu S, Mc Henry KT, Lane WS, Fenteany G. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem Biol 2005; 12: 981-91.
28. Mc Henry KT, Montesano R, Zhu S, et al. Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion. J Cell Biochem 2008; 103: 972-85.
29. Hagens WI, Mattos A, Greupink R, et al. Targeting 15d-prostaglandin J2 to hepatic stellate cells: Two options evaluated. Pharm Res 2007; 24: 566-74.
30. Aprigliano I, Dudas J, Ramadori G, Saile B. Atorvastatin induces apoptosis by a caspase-9-dependent pathway: An in vitro study on activated rat hepatic stellate cells. Liver Int 2008; 28: 546-57.
31. Leung TH, Ching YP, Yam JW, et al. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci USA 2005; 102: 15207-12.
32. Friedman SL. Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008; 88: 125-72.
33. Wang XM, Yu DM, McCaughan GW, Gorrell MD. Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology 2005; 42: 935-45.
34. Meurer SK, Tihaa L, Lahme B, Gressner AM, Weiskirchen R. Identification of endoglin in rat hepatic stellate cells: New insights into transforming growth factor beta receptor signaling. J Biol Chem 2005; 280: 3078-87.
35. Shafiei MS, Rockey DC. The role of integrin-linked kinase in liver wound healing. J Biol Chem 2006; 281: 24863-72.
36. Kobayashi Y, Bridle KR, Ramm GA, et al. Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells. Liver Int 2007; 27: 1066-75.
37. Zhang Y, Ikegami T, Honda A, et al. Involvement of integrin-linked kinase in carbon tetrachloride-induced hepatic fibrosis in rats. Hepatology 2006; 44: 612-22.
38. De Minicis S, Candelaresi C, Marzioni M, et al. Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo. Gut 2008; 57: 352-64.
39. Kolch W. Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000; 351 (Part 2): 289-305.
40. Borkham-Kamphorst E, Herrmann J, Stoll D, et al. Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Lab Invest 2004; 84: 766-77.