Pirfenidone restricts Th2 differentiation in vitro and limits Th2 response in experimental liver fibrosis

European Journal of Pharmacology

Volumn 678, Issue 1-3, 2012, Pages 71-77

  Navarro Partida, Jose ^a   Martinez Rizo, Abril Bernardette ^a   Gonzalez Cuevas, Jaime ^a   Arrevillaga Boni, Gerardo ^b   Ortiz Navarrete, Vianney ^b   Armendariz Borunda, Juan ^a,c  

^a UNIVERSITY OF GUADALAJARA   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c HOSPITAL CIVIL DE GUADALAJARA FRAY ANTONIO ALCALDE   (Mexico)

Author keywords

Immunomodulation; Liver fibrosis; Pirfenidone; T helper response

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PIRFENIDONE; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CIRRHOSIS; LIVER FIBROSIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH1 GENE; TH2 CELL; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; DNA; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION; INTERFERON-GAMMA; INTERLEUKIN-4; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDONES; RATS; RATS, WISTAR; T-BOX DOMAIN PROTEINS; TH1 CELLS; TH2 CELLS;

EID: 84857058986     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.12.025     Document Type: Article

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