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Volumn 13, Issue 5, 2011, Pages

Cellular and molecular pathogenesis of systemic lupus erythematosus: Lessons from animal models

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6;

EID: 80053607514     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3465     Document Type: Review
Times cited : (51)

References (90)
  • 1
    • 2542505506 scopus 로고    scopus 로고
    • The role of complement in the development of systemic lupus erythematosus
    • 10.1146/annurev.immunol.22.012703.104549, 15032584
    • Manderson AP, Botto M, Walport MJ. The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 2004, 22:431-456. 10.1146/annurev.immunol.22.012703.104549, 15032584.
    • (2004) Annu Rev Immunol , vol.22 , pp. 431-456
    • Manderson, A.P.1    Botto, M.2    Walport, M.J.3
  • 2
    • 0014259755 scopus 로고
    • Pathogenesis of the glomerulonephritis of NZB/W mice
    • 10.1084/jem.127.3.507, 2138462, 4169964
    • Lambert PH, Dixon FJ. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med 1968, 127:507-522. 10.1084/jem.127.3.507, 2138462, 4169964.
    • (1968) J Exp Med , vol.127 , pp. 507-522
    • Lambert, P.H.1    Dixon, F.J.2
  • 3
    • 0034966564 scopus 로고    scopus 로고
    • Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolyssacharide administration
    • 10.1002/1529-0131(200106)44:6<1320::AID-ART224>3.0.CO;2-X, 11407691
    • Licht R, van Bruggen MC, Oppers-Walgreen B, Rijke TP, Berden JH. Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolyssacharide administration. Arthritis Rheum 2001, 44:1320-1330. 10.1002/1529-0131(200106)44:6<1320::AID-ART224>3.0.CO;2-X, 11407691.
    • (2001) Arthritis Rheum , vol.44 , pp. 1320-1330
    • Licht, R.1    van Bruggen, M.C.2    Oppers-Walgreen, B.3    Rijke, T.P.4    Berden, J.H.5
  • 4
    • 0031825552 scopus 로고    scopus 로고
    • Systemic exposure to irradiated apoptotic cells induces autoantibody production
    • 10.1084/jem.188.2.387, 2212450, 9670050
    • Mevorach D, Zhou JL, Song X, Elkon KB. Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med 1998, 188:387-392. 10.1084/jem.188.2.387, 2212450, 9670050.
    • (1998) J Exp Med , vol.188 , pp. 387-392
    • Mevorach, D.1    Zhou, J.L.2    Song, X.3    Elkon, K.B.4
  • 5
    • 0034041159 scopus 로고    scopus 로고
    • Lupus, DNase and defective disposal of cellular debris
    • 10.1038/75963, 10835621
    • Walport MJ. Lupus, DNase and defective disposal of cellular debris. Nat Genet 2000, 25:135-136. 10.1038/75963, 10835621.
    • (2000) Nat Genet , vol.25 , pp. 135-136
    • Walport, M.J.1
  • 6
    • 0036645294 scopus 로고    scopus 로고
    • Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase
    • 10.1084/jem.20012094, 2194017, 12093878
    • Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, Earp HS, Matsushima G, Reap EA. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 2002, 196:135-140. 10.1084/jem.20012094, 2194017, 12093878.
    • (2002) J Exp Med , vol.196 , pp. 135-140
    • Cohen, P.L.1    Caricchio, R.2    Abraham, V.3    Camenisch, T.D.4    Jennette, J.C.5    Roubey, R.A.6    Earp, H.S.7    Matsushima, G.8    Reap, E.A.9
  • 7
    • 0033961425 scopus 로고    scopus 로고
    • Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM
    • 10.1073/pnas.97.3.1184, 15562, 10655505
    • Boes M, Schmidt T, Linkemann K, Beaudette BC, Marshak-Rothstein A, Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc Natl Acad Sci USA 2000, 97:1184-1189. 10.1073/pnas.97.3.1184, 15562, 10655505.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1184-1189
    • Boes, M.1    Schmidt, T.2    Linkemann, K.3    Beaudette, B.C.4    Marshak-Rothstein, A.5    Chen, J.6
  • 10
    • 0000675914 scopus 로고    scopus 로고
    • Abnormalities in B cell activity and the immunoglobulin repertoire in human systemic lupus erythematosus
    • Grammer AC, Dorner T, Lipsky PE. Abnormalities in B cell activity and the immunoglobulin repertoire in human systemic lupus erythematosus. Mol Pathol Autoimmune Dis 2001, 2:282-318.
    • (2001) Mol Pathol Autoimmune Dis , vol.2 , pp. 282-318
    • Grammer, A.C.1    Dorner, T.2    Lipsky, P.E.3
  • 11
    • 0027983579 scopus 로고
    • The role of B cells in lpr/lpr-induced autoimmunity
    • 10.1084/jem.180.4.1295, 2191708, 7931063
    • Shlomchik MJ, Madaio MP, Ni D, Trounstein M, Huszar D. The role of B cells in lpr/lpr-induced autoimmunity. J Exp Med 1994, 180:1295-1306. 10.1084/jem.180.4.1295, 2191708, 7931063.
    • (1994) J Exp Med , vol.180 , pp. 1295-1306
    • Shlomchik, M.J.1    Madaio, M.P.2    Ni, D.3    Trounstein, M.4    Huszar, D.5
  • 12
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • 10.1084/jem.189.10.1639, 2193634, 10330443
    • Chan OT, Hannum LG, Haberman AM, Madaio MP, Shlomchik MJ. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999, 189:1639-1648. 10.1084/jem.189.10.1639, 2193634, 10330443.
    • (1999) J Exp Med , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 13
    • 0034651766 scopus 로고    scopus 로고
    • Cutting edge: B cells promote CD8+ T cell activation in MRL-Fas(lpr) mice independently of MHC class I antigen presentation
    • Chan OT, Sh lomchik MJ. Cutting edge: B cells promote CD8+ T cell activation in MRL-Fas(lpr) mice independently of MHC class I antigen presentation. J Immunol 2000, 164:1658-1662.
    • (2000) J Immunol , vol.164 , pp. 1658-1662
    • Chan, O.T.1    Sh lomchik, M.J.2
  • 14
    • 0030456897 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
    • 10.1084/jem.184.6.2271, 2196394, 8976182
    • Wolf SD, Dittel BN, Hardardottir F, Janeway CA. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 1996, 184:2271-2278. 10.1084/jem.184.6.2271, 2196394, 8976182.
    • (1996) J Exp Med , vol.184 , pp. 2271-2278
    • Wolf, S.D.1    Dittel, B.N.2    Hardardottir, F.3    Janeway, C.A.4
  • 16
    • 77954505663 scopus 로고    scopus 로고
    • Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity
    • 10.4049/jimmunol.0902385, 20368271
    • Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol 2010, 184:4801-4809. 10.4049/jimmunol.0902385, 20368271.
    • (2010) J Immunol , vol.184 , pp. 4801-4809
    • Watanabe, R.1    Ishiura, N.2    Nakashima, H.3    Kuwano, Y.4    Okochi, H.5    Tamaki, K.6    Sato, S.7    Tedder, T.F.8    Fujimoto, M.9
  • 19
    • 0030764557 scopus 로고    scopus 로고
    • Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency
    • 10.1016/S0167-7799(97)01060-3, 9263478
    • Shultz LD, Rajan TV, Greiner DL. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol 1997, 15:302-307. 10.1016/S0167-7799(97)01060-3, 9263478.
    • (1997) Trends Biotechnol , vol.15 , pp. 302-307
    • Shultz, L.D.1    Rajan, T.V.2    Greiner, D.L.3
  • 20
    • 0028784215 scopus 로고
    • Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
    • 10.1016/0092-8674(95)90171-X, 7585947
    • Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 1995, 83:301-311. 10.1016/0092-8674(95)90171-X, 7585947.
    • (1995) Cell , vol.83 , pp. 301-311
    • Hibbs, M.L.1    Tarlinton, D.M.2    Armes, J.3    Grail, D.4    Hodgson, G.5    Maglitto, R.6    Stacker, S.A.7    Dunn, A.R.8
  • 21
    • 0033695963 scopus 로고    scopus 로고
    • Spontaneous autoimmune disease in Fc(gamma) RIIB-deficient mice results from strain-specific epistasis
    • 10.1016/S1074-7613(00)00027-3, 10981970
    • Bolland S, Ravetch JV. Spontaneous autoimmune disease in Fc(gamma) RIIB-deficient mice results from strain-specific epistasis. Immunity 2000, 13:277-285. 10.1016/S1074-7613(00)00027-3, 10981970.
    • (2000) Immunity , vol.13 , pp. 277-285
    • Bolland, S.1    Ravetch, J.V.2
  • 22
    • 33644943621 scopus 로고    scopus 로고
    • Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19
    • 10.1016/j.molimm.2005.11.003, 16430962
    • Taylor DK, Ito E, Thorn M, Sundar K, Tedder T, Spatz LA. Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19. Mol Immunol 2006, 43:1776-1790. 10.1016/j.molimm.2005.11.003, 16430962.
    • (2006) Mol Immunol , vol.43 , pp. 1776-1790
    • Taylor, D.K.1    Ito, E.2    Thorn, M.3    Sundar, K.4    Tedder, T.5    Spatz, L.A.6
  • 24
    • 0345306152 scopus 로고    scopus 로고
    • Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB × NZWF1 mice
    • 10.1191/0961203303lu483oa, 14667100
    • Hasegawa K, Hayashi T. Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB × NZWF1 mice. Lupus 2003, 12:838-845. 10.1191/0961203303lu483oa, 14667100.
    • (2003) Lupus , vol.12 , pp. 838-845
    • Hasegawa, K.1    Hayashi, T.2
  • 25
    • 22944490869 scopus 로고    scopus 로고
    • Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    • 10.1084/jem.20050338, 2212997, 16027240
    • Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 2005, 202:321-331. 10.1084/jem.20050338, 2212997, 16027240.
    • (2005) J Exp Med , vol.202 , pp. 321-331
    • Christensen, S.R.1    Kashgarian, M.2    Alexopoulou, L.3    Flavell, R.A.4    Akira, S.5    Shlomchik, M.J.6
  • 26
    • 35748964708 scopus 로고    scopus 로고
    • Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity
    • 10.1111/j.1600-065X.2007.00572.x, 17979852
    • Krieg AM, Vollmer J. Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity. Immunol Rev 2007, 220:251-269. 10.1111/j.1600-065X.2007.00572.x, 17979852.
    • (2007) Immunol Rev , vol.220 , pp. 251-269
    • Krieg, A.M.1    Vollmer, J.2
  • 27
    • 33745168605 scopus 로고    scopus 로고
    • Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    • 10.1126/science.1124978, 16709748
    • Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB, Bolland S. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006, 312:1669-1672. 10.1126/science.1124978, 16709748.
    • (2006) Science , vol.312 , pp. 1669-1672
    • Pisitkun, P.1    Deane, J.A.2    Difilippantonio, M.J.3    Tarasenko, T.4    Satterthwaite, A.B.5    Bolland, S.6
  • 28
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • 10.1084/jem.190.11.1697, 2195729, 10587360
    • Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider P, Tschopp J, Browning JL. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999, 190:1697-1710. 10.1084/jem.190.11.1697, 2195729, 10587360.
    • (1999) J Exp Med , vol.190 , pp. 1697-1710
    • Mackay, F.1    Woodcock, S.A.2    Lawton, P.3    Ambrose, C.4    Baetscher, M.5    Schneider, P.6    Tschopp, J.7    Browning, J.L.8
  • 30
    • 0030425799 scopus 로고    scopus 로고
    • T cells in murine lupus: propagation and regulation of disease
    • 10.1007/BF00351176, 9112236
    • Peng SL, Craft J. T cells in murine lupus: propagation and regulation of disease. Mol Biol Rep 1996, 23:247-251. 10.1007/BF00351176, 9112236.
    • (1996) Mol Biol Rep , vol.23 , pp. 247-251
    • Peng, S.L.1    Craft, J.2
  • 31
    • 0030702821 scopus 로고    scopus 로고
    • Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis
    • 10.1084/jem.186.9.1451, 2199116, 9348302
    • Seery JP, Carroll JM, Cattell V, Watt FM. Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis. J Exp Med 1997, 186:1451-1459. 10.1084/jem.186.9.1451, 2199116, 9348302.
    • (1997) J Exp Med , vol.186 , pp. 1451-1459
    • Seery, J.P.1    Carroll, J.M.2    Cattell, V.3    Watt, F.M.4
  • 32
    • 0030953632 scopus 로고    scopus 로고
    • Roles of interferon-gamma and interleukin-4 in murine lupus
    • 10.1172/JCI119361, 508018, 9109438
    • Peng SL, Moslehi J, Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest 1997, 99:1936-1946. 10.1172/JCI119361, 508018, 9109438.
    • (1997) J Clin Invest , vol.99 , pp. 1936-1946
    • Peng, S.L.1    Moslehi, J.2    Craft, J.3
  • 33
    • 0031155269 scopus 로고    scopus 로고
    • IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice
    • Haas C, Ryffel B, Le Hir M. IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice. J Immunol 1997, 158:5484-5491.
    • (1997) J Immunol , vol.158 , pp. 5484-5491
    • Haas, C.1    Ryffel, B.2    Le Hir, M.3
  • 34
    • 0023571873 scopus 로고
    • In vivo treatment of (NZB × NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon
    • 10.1084/jem.166.3.798, 2188698, 3114409
    • Jacob CO, van der Meide PH, McDevitt HO. In vivo treatment of (NZB × NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med 1987, 166:798-803. 10.1084/jem.166.3.798, 2188698, 3114409.
    • (1987) J Exp Med , vol.166 , pp. 798-803
    • Jacob, C.O.1    van der Meide, P.H.2    McDevitt, H.O.3
  • 35
    • 0028576993 scopus 로고
    • Soluble interferon-gamma receptor: a therapeutically useful drug for systemic lupus erythematosus
    • 10.1089/jir.1994.14.283, 7861031
    • Ozmen L, Roman D, Fountoulakis M, Schmid G, Ryffel B, Garotta G. Soluble interferon-gamma receptor: a therapeutically useful drug for systemic lupus erythematosus. J Interferon Res 1994, 14:283-284. 10.1089/jir.1994.14.283, 7861031.
    • (1994) J Interferon Res , vol.14 , pp. 283-284
    • Ozmen, L.1    Roman, D.2    Fountoulakis, M.3    Schmid, G.4    Ryffel, B.5    Garotta, G.6
  • 36
    • 34250162775 scopus 로고    scopus 로고
    • Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells
    • Kang HK, Liu M, Datta SK. Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol 2007, 178:7849-7858.
    • (2007) J Immunol , vol.178 , pp. 7849-7858
    • Kang, H.K.1    Liu, M.2    Datta, S.K.3
  • 37
    • 38849094491 scopus 로고    scopus 로고
    • Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling
    • 10.1016/j.cyto.2007.09.015, 18061473
    • Li X. Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling. Cytokine 2008, 41:105-113. 10.1016/j.cyto.2007.09.015, 18061473.
    • (2008) Cytokine , vol.41 , pp. 105-113
    • Li, X.1
  • 38
    • 55249119291 scopus 로고    scopus 로고
    • IL-17 and the Th17 lineage in systemic lupus erythematosus
    • 10.1097/BOR.0b013e328304b6b5, 18698171
    • Garrett-Sinha LA, John S, Gaffen SL. IL-17 and the Th17 lineage in systemic lupus erythematosus. Curr Opin Rheumatol 2008, 20:519-525. 10.1097/BOR.0b013e328304b6b5, 18698171.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 519-525
    • Garrett-Sinha, L.A.1    John, S.2    Gaffen, S.L.3
  • 39
    • 6044259760 scopus 로고    scopus 로고
    • T cells in the pathogenesis of systemic lupus erythematosus
    • 10.1016/j.clim.2004.05.001, 15380523
    • Hoffman RW. T cells in the pathogenesis of systemic lupus erythematosus. Clin Immunol 2004, 113:4-13. 10.1016/j.clim.2004.05.001, 15380523.
    • (2004) Clin Immunol , vol.113 , pp. 4-13
    • Hoffman, R.W.1
  • 40
    • 0031838606 scopus 로고    scopus 로고
    • Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus
    • 10.1002/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H, 9663482
    • Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998, 41:1241-1250. 10.1002/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H, 9663482.
    • (1998) Arthritis Rheum , vol.41 , pp. 1241-1250
    • Herrmann, M.1    Voll, R.E.2    Zoller, O.M.3    Hagenhofer, M.4    Ponner, B.B.5    Kalden, J.R.6
  • 41
    • 0019503417 scopus 로고
    • Decreased numbers of monocytes in inflamatory exudates in systemic lupus erythematosus
    • Passero FC, Myers AR. Decreased numbers of monocytes in inflamatory exudates in systemic lupus erythematosus. J Rheumatol 1981, 8:62-68.
    • (1981) J Rheumatol , vol.8 , pp. 62-68
    • Passero, F.C.1    Myers, A.R.2
  • 42
    • 33750991860 scopus 로고    scopus 로고
    • Innate immunity and systemic lupus erythematosus
    • Jin O, Sun L, Kavikondala S, Lau C. Innate immunity and systemic lupus erythematosus. APLAR J Rheumatol 2006, 9:359-364.
    • (2006) APLAR J Rheumatol , vol.9 , pp. 359-364
    • Jin, O.1    Sun, L.2    Kavikondala, S.3    Lau, C.4
  • 44
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • 10.1126/science.1061663, 11452127
    • Lu Q, Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 2001, 293:306-311. 10.1126/science.1061663, 11452127.
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 45
    • 22144457050 scopus 로고    scopus 로고
    • T cell hyperactivity in lupus as a consequence of hyperstimulatory antigenpresenting cells
    • 10.1172/JCI23049, 1143586, 15951839
    • Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, Wakeland EK, Mohan C. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigenpresenting cells. J Clin Invest 2005, 115:1869-1878. 10.1172/JCI23049, 1143586, 15951839.
    • (2005) J Clin Invest , vol.115 , pp. 1869-1878
    • Zhu, J.1    Liu, X.2    Xie, C.3    Yan, M.4    Yu, Y.5    Sobel, E.S.6    Wakeland, E.K.7    Mohan, C.8
  • 46
    • 34548839875 scopus 로고    scopus 로고
    • Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6
    • 10.1182/blood-2006-12-061648, 1952615, 17712049
    • Kilmon MA, Wagner NJ, Garland AL, Lin L, Aviszus K, Wysocki LJ, Vilen BJ. Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6. Blood 2007, 110:1595-1602. 10.1182/blood-2006-12-061648, 1952615, 17712049.
    • (2007) Blood , vol.110 , pp. 1595-1602
    • Kilmon, M.A.1    Wagner, N.J.2    Garland, A.L.3    Lin, L.4    Aviszus, K.5    Wysocki, L.J.6    Vilen, B.J.7
  • 47
    • 0037451167 scopus 로고    scopus 로고
    • Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    • 10.1084/jem.20021553, 2193846, 12642603
    • Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, Pascual V. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003, 197:711-723. 10.1084/jem.20021553, 2193846, 12642603.
    • (2003) J Exp Med , vol.197 , pp. 711-723
    • Bennett, L.1    Palucka, A.K.2    Arce, E.3    Cantrell, V.4    Borvak, J.5    Banchereau, J.6    Pascual, V.7
  • 49
    • 12344309921 scopus 로고    scopus 로고
    • Mature dendritic cells readily break tolerance in normal mice but do not lead to disease expression
    • 10.1002/art.20759, 15641101
    • Georgiev M, Agle LM, Chu JL, Elkon KB, Ashany D. Mature dendritic cells readily break tolerance in normal mice but do not lead to disease expression. Arthritis Rheum 2005, 52:225-238. 10.1002/art.20759, 15641101.
    • (2005) Arthritis Rheum , vol.52 , pp. 225-238
    • Georgiev, M.1    Agle, L.M.2    Chu, J.L.3    Elkon, K.B.4    Ashany, D.5
  • 50
    • 33644502594 scopus 로고    scopus 로고
    • Dendritic cell apoptosis in the maintenance of immune tolerance
    • 10.1126/science.1122545, 16497935
    • Chen M, Wang YH, Wang Y, Huang L, Sandoval H, Liu YJ, Wang J. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 2006, 311:1160-1164. 10.1126/science.1122545, 16497935.
    • (2006) Science , vol.311 , pp. 1160-1164
    • Chen, M.1    Wang, Y.H.2    Wang, Y.3    Huang, L.4    Sandoval, H.5    Liu, Y.J.6    Wang, J.7
  • 51
    • 34447099218 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease
    • Fairhurst AM, Wandstrat AE, Wakeland EK. Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. Adv Immunol 2006, 92:1-69.
    • (2006) Adv Immunol , vol.92 , pp. 1-69
    • Fairhurst, A.M.1    Wandstrat, A.E.2    Wakeland, E.K.3
  • 52
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • 10.1084/jem.20050914, 2213213, 16230478
    • Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005, 202:1131-1139. 10.1084/jem.20050914, 2213213, 16230478.
    • (2005) J Exp Med , vol.202 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6    Chang, B.7    Duramad, O.8    Coffman, R.L.9
  • 53
    • 85047693371 scopus 로고    scopus 로고
    • Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    • 544604, 15668740
    • Means TK, Latz E, Hayashi F, Murali MR, Golenbock DT, Luster AD. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 2005, 115:407-417. 544604, 15668740.
    • (2005) J Clin Invest , vol.115 , pp. 407-417
    • Means, T.K.1    Latz, E.2    Hayashi, F.3    Murali, M.R.4    Golenbock, D.T.5    Luster, A.D.6
  • 54
    • 32044460431 scopus 로고    scopus 로고
    • Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN
    • Le Bon A, Thompson C, Kamphuis E, Durand V, Rossmann C, Kalinke U, Tough DF. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 2006, 176:2074-2078.
    • (2006) J Immunol , vol.176 , pp. 2074-2078
    • Le Bon, A.1    Thompson, C.2    Kamphuis, E.3    Durand, V.4    Rossmann, C.5    Kalinke, U.6    Tough, D.F.7
  • 56
    • 0000373624 scopus 로고
    • A DNA-reacting f actor in serum of a patient with lupus erythematosus diffusus
    • Ceppellini R, Polli E, Celada F. A DNA-reacting f actor in serum of a patient with lupus erythematosus diffusus. Proc Soc Exp Biol Med 1957, 96:572-574.
    • (1957) Proc Soc Exp Biol Med , vol.96 , pp. 572-574
    • Ceppellini, R.1    Polli, E.2    Celada, F.3
  • 57
    • 1342300520 scopus 로고    scopus 로고
    • Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice
    • 10.1084/jem.20030132, 2211797, 14757744
    • Liang Z, Xie C, Chen C, Kreska D, Hsu K, Li L, Zhou XJ, Mohan C. Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice. J Exp Med 2004, 199:381-398. 10.1084/jem.20030132, 2211797, 14757744.
    • (2004) J Exp Med , vol.199 , pp. 381-398
    • Liang, Z.1    Xie, C.2    Chen, C.3    Kreska, D.4    Hsu, K.5    Li, L.6    Zhou, X.J.7    Mohan, C.8
  • 59
    • 39549111438 scopus 로고    scopus 로고
    • Anti-DNA antibodies in the pathogenesis of lupus nephritis--the emerging mechanisms
    • 10.1016/j.autrev.2007.12.001, 18295737
    • Yung S, Chan TM. Anti-DNA antibodies in the pathogenesis of lupus nephritis--the emerging mechanisms. Autoimmun Rev 2008, 7:317-321. 10.1016/j.autrev.2007.12.001, 18295737.
    • (2008) Autoimmun Rev , vol.7 , pp. 317-321
    • Yung, S.1    Chan, T.M.2
  • 60
    • 1542619237 scopus 로고    scopus 로고
    • Enrichment of anti-glomerular antigen antibody-producing cells in the kidneys of MRL/MpJ-Fas(lpr) mice
    • Sekine H, Watanabe H, Gilkeson GS. Enrichment of anti-glomerular antigen antibody-producing cells in the kidneys of MRL/MpJ-Fas(lpr) mice. J Immunol 2004, 172:3913-3921.
    • (2004) J Immunol , vol.172 , pp. 3913-3921
    • Sekine, H.1    Watanabe, H.2    Gilkeson, G.S.3
  • 61
    • 1642540587 scopus 로고    scopus 로고
    • Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis
    • 10.1084/jem.20031519, 2211766, 14718514
    • Waters ST, McDuffie M, Bagavant H, Deshmukh US, Gaskin F, Jiang C, Tung KS, Fu SM. Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J Exp Med 2004, 199:255-264. 10.1084/jem.20031519, 2211766, 14718514.
    • (2004) J Exp Med , vol.199 , pp. 255-264
    • Waters, S.T.1    McDuffie, M.2    Bagavant, H.3    Deshmukh, U.S.4    Gaskin, F.5    Jiang, C.6    Tung, K.S.7    Fu, S.M.8
  • 63
    • 0037829136 scopus 로고    scopus 로고
    • Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus
    • Mannik M, Merrill CE, Stamps LD, Wener MH. Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus. J Rheumatol 2003, 30:1495-1504.
    • (2003) J Rheumatol , vol.30 , pp. 1495-1504
    • Mannik, M.1    Merrill, C.E.2    Stamps, L.D.3    Wener, M.H.4
  • 64
    • 31044440224 scopus 로고    scopus 로고
    • Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays
    • 10.1172/JCI23587, 1297234, 16322790
    • Li QZ, Xie C, Wu T, Mackay M, Aranow C, Putterman C, Mohan C. Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest 2005, 115:3428-3439. 10.1172/JCI23587, 1297234, 16322790.
    • (2005) J Clin Invest , vol.115 , pp. 3428-3439
    • Li, Q.Z.1    Xie, C.2    Wu, T.3    Mackay, M.4    Aranow, C.5    Putterman, C.6    Mohan, C.7
  • 65
    • 0037868032 scopus 로고    scopus 로고
    • Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition
    • Schiffer L, Sinha J, Wang X, Huang W, von Gersdorff G, Schiffer M, Madaio MP, Davidson A. Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition. J Immunol 2003, 171:489-497.
    • (2003) J Immunol , vol.171 , pp. 489-497
    • Schiffer, L.1    Sinha, J.2    Wang, X.3    Huang, W.4    von Gersdorff, G.5    Schiffer, M.6    Madaio, M.P.7    Davidson, A.8
  • 67
    • 33751554877 scopus 로고    scopus 로고
    • Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes
    • Bagavant H, Deshmukh US, Wang H, Ly T, Fu SM. Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes. J Immunol 2006, 177:8258-8265.
    • (2006) J Immunol , vol.177 , pp. 8258-8265
    • Bagavant, H.1    Deshmukh, U.S.2    Wang, H.3    Ly, T.4    Fu, S.M.5
  • 69
    • 0033830014 scopus 로고    scopus 로고
    • Interleukin-4 transgenic mice develop glomerulosclerosis independent of immunoglobulin deposition
    • 10.1002/1521-4141(200009)30:9<2698::AID-IMMU2698>3.0.CO;2-1, 11009105
    • Ruger BM, Erb KJ, He Y, Lane JM, Davis PF, Hasan Q. Interleukin-4 transgenic mice develop glomerulosclerosis independent of immunoglobulin deposition. Eur J Immunol 2000, 30:2698-2703. 10.1002/1521-4141(200009)30:9<2698::AID-IMMU2698>3.0.CO;2-1, 11009105.
    • (2000) Eur J Immunol , vol.30 , pp. 2698-2703
    • Ruger, B.M.1    Erb, K.J.2    He, Y.3    Lane, J.M.4    Davis, P.F.5    Hasan, Q.6
  • 70
    • 0042062277 scopus 로고    scopus 로고
    • IL-4 and many roads to lupuslike autoimmunity
    • 10.1016/S1521-6616(03)00145-1, 12921752
    • Singh RR. IL-4 and many roads to lupuslike autoimmunity. Clin Immunol 2003, 108:73-79. 10.1016/S1521-6616(03)00145-1, 12921752.
    • (2003) Clin Immunol , vol.108 , pp. 73-79
    • Singh, R.R.1
  • 71
    • 10744220446 scopus 로고    scopus 로고
    • Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis
    • 10.1097/01.ASN.0000114553.36258.91, 14978163
    • Krüger T, Benke D, Eitner F, Lang A, Wirtz M, Hamilton-Williams EE, Engel D, Giese B, Müller-Newen G, Floege J, Kurts C. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol 2004, 15:613-621. 10.1097/01.ASN.0000114553.36258.91, 14978163.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 613-621
    • Krüger, T.1    Benke, D.2    Eitner, F.3    Lang, A.4    Wirtz, M.5    Hamilton-Williams, E.E.6    Engel, D.7    Giese, B.8    Müller-Newen, G.9    Floege, J.10    Kurts, C.11
  • 73
    • 34548335243 scopus 로고    scopus 로고
    • Dendritic cells and the immunopa thogenesis of systemic lupus erythematosus
    • 10.1007/BF02685895, 17695248
    • Monrad S, Kaplan MJ. Dendritic cells and the immunopa thogenesis of systemic lupus erythematosus. Immunol Res 2007, 37:135-145. 10.1007/BF02685895, 17695248.
    • (2007) Immunol Res , vol.37 , pp. 135-145
    • Monrad, S.1    Kaplan, M.J.2
  • 74
    • 0023156194 scopus 로고
    • Leukocyte analysis using monoclonal antibodies in human glomerulonephritis
    • 10.1038/ki.1987.93, 3495689
    • Hooke DH, Gee DC, Atkins RC. Leukocyte analysis using monoclonal antibodies in human glomerulonephritis. Kidney Int 1987, 31:964-972. 10.1038/ki.1987.93, 3495689.
    • (1987) Kidney Int , vol.31 , pp. 964-972
    • Hooke, D.H.1    Gee, D.C.2    Atkins, R.C.3
  • 77
    • 34447315527 scopus 로고    scopus 로고
    • Experimental anti-GBM disease as a tool for studying spontaneous lupus nephritis
    • 10.1016/j.clim.2007.05.007, 17640604
    • Fu Y, Du Y, Mohan C. Experimental anti-GBM disease as a tool for studying spontaneous lupus nephritis. Clin Immunol 2007, 124:109-118. 10.1016/j.clim.2007.05.007, 17640604.
    • (2007) Clin Immunol , vol.124 , pp. 109-118
    • Fu, Y.1    Du, Y.2    Mohan, C.3
  • 78
    • 0019371079 scopus 로고
    • Abrogation of macrophage-dependent injury in experimental glomerulonephritis in the rabbit. Use of an antimacrophage serum
    • 10.1172/JCI110304, 370850, 7276168
    • Holdsworth SR, Neale TJ, Wilson CB. Abrogation of macrophage-dependent injury in experimental glomerulonephritis in the rabbit. Use of an antimacrophage serum. J Clin Invest 1981, 68:686-698. 10.1172/JCI110304, 370850, 7276168.
    • (1981) J Clin Invest , vol.68 , pp. 686-698
    • Holdsworth, S.R.1    Neale, T.J.2    Wilson, C.B.3
  • 79
    • 0037213079 scopus 로고    scopus 로고
    • Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation
    • Ikezumi Y, Hurst LA, Masaki T, Atkins RC, Nikolic-Paterson DJ. Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation. Kidney Int 2003, 63:83-95.
    • (2003) Kidney Int , vol.63 , pp. 83-95
    • Ikezumi, Y.1    Hurst, L.A.2    Masaki, T.3    Atkins, R.C.4    Nikolic-Paterson, D.J.5
  • 80
    • 0029893876 scopus 로고    scopus 로고
    • TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease
    • Moore KJ, Yeh K, Naito T, Kelley VR. TNF-alpha enhances colony-stimulating factor-1-induced macrophage accumulation in autoimmune renal disease. J Immunol 1996, 157:427-432.
    • (1996) J Immunol , vol.157 , pp. 427-432
    • Moore, K.J.1    Yeh, K.2    Naito, T.3    Kelley, V.R.4
  • 81
    • 0015403094 scopus 로고
    • Pathologic mechanisms in neutrophil-mediated injury
    • 2032754, 4262347
    • Henson PM. Pathologic mechanisms in neutrophil-mediated injury. Am J Pathol 1972, 68:593-612. 2032754, 4262347.
    • (1972) Am J Pathol , vol.68 , pp. 593-612
    • Henson, P.M.1
  • 82
    • 19944428744 scopus 로고    scopus 로고
    • Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases
    • 10.1182/blood-2004-02-0564, 15358625
    • Scapini P, Carletto A, Nardelli B, Calzetti F, Roschke V, Merigo F, Tamassia N, Pieropan S, Biasi D, Sbarbati A, Sozzani S, Bambara L, Cassatella MA. Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases. Blood 2005, 105:830-837. 10.1182/blood-2004-02-0564, 15358625.
    • (2005) Blood , vol.105 , pp. 830-837
    • Scapini, P.1    Carletto, A.2    Nardelli, B.3    Calzetti, F.4    Roschke, V.5    Merigo, F.6    Tamassia, N.7    Pieropan, S.8    Biasi, D.9    Sbarbati, A.10    Sozzani, S.11    Bambara, L.12    Cassatella, M.A.13
  • 83
    • 0028153954 scopus 로고
    • Role of oxidants and proteases in glomerular injury
    • 10.1038/ki.1994.45, 8164419
    • Johnson RJ, Lovett D, Lehrer RI, Couser WG, Klebanoff SJ. Role of oxidants and proteases in glomerular injury. Kidney Int 1994, 45:352-359. 10.1038/ki.1994.45, 8164419.
    • (1994) Kidney Int , vol.45 , pp. 352-359
    • Johnson, R.J.1    Lovett, D.2    Lehrer, R.I.3    Couser, W.G.4    Klebanoff, S.J.5
  • 85
    • 0028135036 scopus 로고
    • Podocyte expression of MHC class I and II and intercellular adhesion molecule-1 (ICAM-1) in experimental pauci-immune crescentic glomerulonephritis
    • 1534396, 7955534
    • Coers W, Brouwer E, Vos JT, Chand A, Huitema S, Heeringa P, Kallenberg CG, Weening JJ. Podocyte expression of MHC class I and II and intercellular adhesion molecule-1 (ICAM-1) in experimental pauci-immune crescentic glomerulonephritis. Clin Exp Immunol 1994, 98:279-286. 1534396, 7955534.
    • (1994) Clin Exp Immunol , vol.98 , pp. 279-286
    • Coers, W.1    Brouwer, E.2    Vos, J.T.3    Chand, A.4    Huitema, S.5    Heeringa, P.6    Kallenberg, C.G.7    Weening, J.J.8
  • 86
    • 0027935085 scopus 로고
    • B7(+)-transfectant tubular epithelial cells induce T cell anergy, ignorance or proliferation
    • 10.1038/ki.1994.147, 8007580
    • Yokoyama H, Zheng X, Strom TB, Kelley VR. B7(+)-transfectant tubular epithelial cells induce T cell anergy, ignorance or proliferation. Kidney Int 1994, 45:1105-1112. 10.1038/ki.1994.147, 8007580.
    • (1994) Kidney Int , vol.45 , pp. 1105-1112
    • Yokoyama, H.1    Zheng, X.2    Strom, T.B.3    Kelley, V.R.4
  • 87
    • 34249101942 scopus 로고    scopus 로고
    • Cytokines in glomeruloneph ritis
    • 10.1016/j.semnephrol.2007.02.002, 17533006
    • Tipping PG, Holdsworth SR. Cytokines in glomeruloneph ritis. Semin Nephrol 2007, 27:275-285. 10.1016/j.semnephrol.2007.02.002, 17533006.
    • (2007) Semin Nephrol , vol.27 , pp. 275-285
    • Tipping, P.G.1    Holdsworth, S.R.2
  • 88
    • 0032479962 scopus 로고    scopus 로고
    • Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis
    • 10.1084/jem.188.3.597, 2212465, 9687536
    • Li S, Kurts C, Kontgen F, Holdsworth SR, Tipping PG. Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis. J Exp Med 1998, 188:597-602. 10.1084/jem.188.3.597, 2212465, 9687536.
    • (1998) J Exp Med , vol.188 , pp. 597-602
    • Li, S.1    Kurts, C.2    Kontgen, F.3    Holdsworth, S.R.4    Tipping, P.G.5
  • 89
    • 68149180876 scopus 로고    scopus 로고
    • TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis
    • 10.1016/j.imlet.2009.06.010, 19573558
    • Molano A, Lakhani P, Aran A, Burkly LC, Michaelson JS, Putterman C. TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis. Immunol Lett 2009, 125:119-128. 10.1016/j.imlet.2009.06.010, 19573558.
    • (2009) Immunol Lett , vol.125 , pp. 119-128
    • Molano, A.1    Lakhani, P.2    Aran, A.3    Burkly, L.C.4    Michaelson, J.S.5    Putterman, C.6
  • 90
    • 0038205934 scopus 로고    scopus 로고
    • Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis
    • 10.1097/01.ASN.0000073902.38428.33, 12819238
    • Timoshanko JR, Sedgwick JD, Holdsworth SR, Tipping PG. Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. J Am Soc Nephrol 2003, 14:1785-1793. 10.1097/01.ASN.0000073902.38428.33, 12819238.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1785-1793
    • Timoshanko, J.R.1    Sedgwick, J.D.2    Holdsworth, S.R.3    Tipping, P.G.4


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