7-Chloroquinolinotriazoles: Synthesis by the azide-alkyne cycloaddition click chemistry, antimalarial activity, cytotoxicity and SAR studies

European Journal of Medicinal Chemistry

Volumn 73, Issue , 2014, Pages 295-309

  Pereira, Guilherme R ^a   Brandão, Geraldo Célio ^b   Arantes, Lucas M ^a   De Oliveira Jr , Háliton A ^a   De Paula, Renata Cristina ^a   Do Nascimento, Maria Fernanda A ^a   Dos Santos, Fábio M ^a   Da Rocha, Ramon K ^a   Lopes, Júlio César D ^a   De Oliveira, Alaíde Braga ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

Author keywords

7 Chloroquinolinotriazoles; Antimalarial activity; Click chemistry; Cytotoxicity in HepG2; Plasmodium falciparum; Quinolines; Triazoles

Indexed keywords

1 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL] N,N DIMETHYLMETHANAMINE; 1 [[1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]PIPERIDIN 4 OL; 1,2,3 TRIAZOLE DERIVATIVE; 2 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PROPAN 2 OL; 3 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PROPAN 1 OL; 3 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PROPYL 4 ETHYLBENZOATE; 3 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PROPYL 4 METHOXY BENZOATE; 3 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PROPYL 4 TERT BUTYL BENZOATE; 3 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL)PROPYL 4 TRIFLUOROMETOXY BENZOATE; 4 [1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL) N,N DIMETHYLANILINE; 4 [[1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]MORPHOLINE; 7 CHLORO 4 (4 CYCLOHEXYL 1H 1,2,3 TRIAZOL 1 YL)QUINOLINE; 7 CHLORO 4 (4 P TOLYL 1H 1,2,3 TRIAZOL 1 YL)QUINOLINE; 7 CHLORO 4 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)QUINOLINE; 7 CHLORO 4 [4 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 1 YL)QUINOLINE; 7 CHLORO 4 [4 (6 METHOXYNAPHTHALEN 2 YL) 1H 1,2,3 TRIAZOL 1 YL]QUINOLINE; 7 CHLORO 4 [[4 (PIPERIDIN 1 YL)METHYL] 1H 1,2,3 TRIAZOL 1 YL)QUINOLINE; 7 CHLOROQUINOLINOTRIAZOLE DERIVATIVE; ALKYNE; ANTIMALARIAL AGENT; AZIDE; CHLOROQUINE; N [[1 (7 CHLOROQUINOLIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] N ETHYLETHANAMINE; QUINOLINE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CLICK CHEMISTRY; CONTROLLED STUDY; CYCLOADDITION; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION;

7-CHLOROQUINOLINOTRIAZOLES; ANTIMALARIAL ACTIVITY; CLICK CHEMISTRY; CYTOTOXICITY IN HEPG2; PLASMODIUM FALCIPARUM; QUINOLINES; TRIAZOLES;

ALKYNES; ANTIMALARIALS; AZIDES; CELL SURVIVAL; CLICK CHEMISTRY; CYCLOADDITION REACTION; DRUG RESISTANCE; HEP G2 CELLS; HUMANS; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84893184589     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.022     Document Type: Article

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