On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 304-312

  Da Silva Jr , Eufrânio N ^a   De Melo, Isadora M M ^a   Diogo, Emilay B T ^a   Costa, Verenice A ^a   De Souza Filho, José D ^a   Valença, Wagner O ^b   Camara, Celso A ^b   De Oliveira, Ronaldo N ^b   De Araujo, Alexandre S ^c   Emery, Flávio S ^d   Dos Santos, Marcelo R ^e   De Simone, Carlos A ^d   Menna Barreto, Rubem F S ^f   De Castro, Solange L ^f  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e UNIVERSITY OF BRASILIA   (Brazil)

^f INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Chagas disease; Chemotherapy; Lapachol; Naphthoquinones; Trypanosoma cruzi

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 2 [4 (4 BROMOPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 1,4 NAPHTHOQUINONE; 2 [4 (4 NITROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 1,4 NAPHTHOQUINONE; 2 [4 (4 TOLYL) 1H 1,2,3 TRIAZOL 1 YL] 1,4 NAPHTHOQUINONE; 2 AZIDO 3 (3 METHYLBUT 2 ENYL)NAPHTHALENE 1,4 DIONE; 2 CHLORO 3 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL) 1,4 NAPHTHOQUINONE; 2,2 DIMETHYL 3 [4 (4 NITROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2,3 DIHYDRONAPHTHO[1,2 B]FURAN 4,5 DIONE; 2,2 DIMETHYL 3 [4 (4 TOLYL) 1H 1,2,3 TRIAZOL 1 YL] 2,3 DIHYDRONAPHTHOL[1,2 B]FURAN 4,5 DIONE; 3 (3 METHYLBUT 2 EN 1 YL) 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL 4 METHYLBENZENESULFONATE; 3 (3 METHYLBUT 2 ENYL) 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL METHANESULFONATE; 3 (3 METHYLBUT 2 ENYL)NAPHTHALENE 1,4 DIONE; 3 [4 (4 BROMOPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2,2 DIMETHYL 2,3 DIHYDRONAPHTHOL[1,2 B]FURAN 4,5 DIONE; 3 [4 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2,2 DIMETHYL 2,3 DIHYDRONAPHTHOL[1,2 B]FURAN 4,5 DIONE; 3 [4 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2,2 DIMETHYL 2,3 DIHDYRONAPHTHOL[1,2 B]FURAN 4,5 DIONE; ANTIPARASITIC AGENT; BENZNIDAZOLE; LAPACHOL; NAPHTHOQUINONE; UNCLASSIFIED DRUG;

ARTICLE; CHAGAS DISEASE; CLICK CHEMISTRY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; NONHUMAN; TRYPANOSOMA CRUZI;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; CLICK CHEMISTRY; DRUG DISCOVERY; MICE; NAPHTHOQUINONES; TRIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 84860335912     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.039     Document Type: Article

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