메뉴 건너뛰기




Volumn 30, Issue 4, 2013, Pages 411-426

Food for thought: Immunotoxicology: Challenges in the 21st century and in vitro opportunities

Author keywords

Alternative methods; Immune system; Toxicity testing; Toxicology for the 21st century; Xenobiotics

Indexed keywords

ENVIRONMENTAL CHEMICAL; PYROGEN; SUPERANTIGEN; IMMUNOTOXIN;

EID: 84893129066     PISSN: 1868596X     EISSN: 18688551     Source Type: Journal    
DOI: 10.14573/altex.2013.4.411     Document Type: Article
Times cited : (52)

References (89)
  • 1
    • 79956348442 scopus 로고    scopus 로고
    • Alternative (non-animal) methods for cosmetics testing: Current status and future prospects-2010
    • Adler, S., Basketter, D., Creton, S., et al. (2011). Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol 85, 367-485.
    • (2011) Arch Toxicol , vol.85 , pp. 367-485
    • Adler, S.1    Basketter, D.2    Creton, S.3
  • 2
    • 84861744139 scopus 로고    scopus 로고
    • A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - T4 report
    • Basketter, D. A., Clewell, H., Kimber, I., et al. (2012). A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report. ALTEX 29, 3-91.
    • (2012) ALTEX , vol.29 , pp. 3-91
    • Basketter, D.A.1    Clewell, H.2    Kimber, I.3
  • 5
    • 34249879680 scopus 로고    scopus 로고
    • The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes
    • Bremer, S., Pellizzer, C., Hoffmann, S., Seidle, T., and Hartung, T. (2007). The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes. Curr Pharm Des 13, 3047-3058.
    • (2007) Curr Pharm des , vol.13 , pp. 3047-3058
    • Bremer, S.1    Pellizzer, C.2    Hoffmann, S.3    Seidle, T.4    Hartung, T.5
  • 6
    • 42049095775 scopus 로고    scopus 로고
    • What's so special about the developing immune system?
    • Burns-Naas, L. A., Hastings, K. L., Ladics, G. S., et al. (2008). What's so special about the developing immune system? Int J Toxicol 27, 223-524.
    • (2008) Int J Toxicol , vol.27 , pp. 223-524
    • Burns-Naas, L.A.1    Hastings, K.L.2    Ladics, G.S.3
  • 7
    • 33845347862 scopus 로고    scopus 로고
    • In vitro tests to evaluate immunotoxicity: A preliminary study
    • Carfì, M., Gennari, A., Malerba, I., et al. (2007). In vitro tests to evaluate immunotoxicity: A preliminary study. Toxicology 229, 11-22.
    • (2007) Toxicology , vol.229 , pp. 11-22
    • Carfì, M.1    Gennari, A.2    Malerba, I.3
  • 8
    • 20144389652 scopus 로고    scopus 로고
    • Dendritic cells as a tool for the predictive identification of skin sensitisation hazard
    • Casati, S., Aeby, P., Basketter, D. A., et al. (2005). Dendritic cells as a tool for the predictive identification of skin sensitisation hazard. Altern Lab Anim 33, 47-62.
    • (2005) Altern Lab Anim , vol.33 , pp. 47-62
    • Casati, S.1    Aeby, P.2    Basketter, D.A.3
  • 9
    • 84861053918 scopus 로고    scopus 로고
    • Developmental immunotoxicity (dit) testing of pharmaceuticals: Current practices, state of the science, knowledge gaps, and recommendations
    • Collinge, M., Burns-Naas, L. A., Chellman, G. J., et al. (2012). Developmental immunotoxicity (DIT) testing of pharmaceuticals: current practices, state of the science, knowledge gaps, and recommendations. J Immunotoxicol 9, 210-230.
    • (2012) J Immunotoxicol , vol.9 , pp. 210-230
    • Collinge, M.1    Burns-Naas, L.A.2    Chellman, G.J.3
  • 10
    • 24644487872 scopus 로고    scopus 로고
    • Low level exposure to chemicals and immune system
    • Colosio, C., Birindelli, S., Corsini, E., et al. (2005). Low level exposure to chemicals and immune system. Toxicol Appl Pharmacol 207, 320-328.
    • (2005) Toxicol Appl Pharmacol , vol.207 , pp. 320-328
    • Colosio, C.1    Birindelli, S.2    Corsini, E.3
  • 11
    • 25444506363 scopus 로고    scopus 로고
    • Immunomodulatory effects of ebdtcs on agricultural workers occupationally exposed to the fungicide mancozeb
    • Corsini, E., Birindelli, S., Fustinoni, S., et al. (2005). Immunomodulatory effects of EBDTCs on agricultural workers occupationally exposed to the fungicide mancozeb. Toxicol Appl Pharmacol 208, 178-185.
    • (2005) Toxicol Appl Pharmacol , vol.208 , pp. 178-185
    • Corsini, E.1    Birindelli, S.2    Fustinoni, S.3
  • 12
    • 84893142651 scopus 로고    scopus 로고
    • Human immunotoxicology: Consequences and mechanisms
    • Corsini, E. (2006). Human immunotoxicology: Consequences and mechanisms. Toxicol Lett 164, S313.
    • (2006) Toxicol Lett , vol.164
    • Corsini, E.1
  • 13
    • 34447639088 scopus 로고    scopus 로고
    • Immunomodulatory effects of the herbicide propanil on cytokine production in humans: In vivo and in vitro exposure
    • Corsini, E., Codecà, I., Mangiaratti, S., et al. (2007). Immunomodulatory effects of the herbicide propanil on cytokine production in humans: In vivo and in vitro exposure. Toxicol Appl Pharmacol 222, 202-210
    • (2007) Toxicol Appl Pharmacol , vol.222 , pp. 202-210
    • Corsini, E.1    Codecà, I.2    Mangiaratti, S.3
  • 14
    • 70449579357 scopus 로고    scopus 로고
    • Immunotoxicology: Opportunities for non-animal test development
    • Corsini, E. and Roggen, E. L. (2009). Immunotoxicology: opportunities for non-animal test development. Altern Lab Anim 37, 387-397.
    • (2009) Altern Lab Anim , vol.37 , pp. 387-397
    • Corsini, E.1    Roggen, E.L.2
  • 15
    • 80455150597 scopus 로고    scopus 로고
    • Alterations in regulatory t-cells: Rediscovered pathways in immunotoxicology
    • Corsini, E., Oukka, M., Pieters, R., et al. (2011). Alterations in regulatory T-cells: rediscovered pathways in immunotoxicology. J Immunotoxicol 8, 251-257.
    • (2011) J Immunotoxicol , vol.8 , pp. 251-257
    • Corsini, E.1    Oukka, M.2    Pieters, R.3
  • 16
    • 84880059218 scopus 로고    scopus 로고
    • Pesticide induced immunotoxicity in humans: A comprehensive review of the existing evidence
    • Corsini, E., Sokooti, M., Galli, C. L., et al. (2013). Pesticide induced immunotoxicity in humans: a comprehensive review of the existing evidence. Toxicology 307, 123-135.
    • (2013) Toxicology , vol.307 , pp. 123-135
    • Corsini, E.1    Sokooti, M.2    Galli, C.L.3
  • 17
    • 0342905089 scopus 로고    scopus 로고
    • Modulation of the activity of human monocyte-derived dendritic cells by chemical haptens, a metal allergen, and a staphylococcal superantigen
    • Coutant, K. D. K., de Fraissinette, A. B. A., Cordier, A. A., and Ulrich, P. P. (1999). Modulation of the activity of human monocyte-derived dendritic cells by chemical haptens, a metal allergen, and a staphylococcal superantigen. Toxicol Sci 52,189-198.
    • (1999) Toxicol Sci , vol.52 , pp. 189-198
    • Coutant, K.D.K.1    De Fraissinette, A.B.A.2    Cordier, A.A.3    Ulrich, P.P.4
  • 18
    • 0028215199 scopus 로고
    • Lipopolysaccharide-neutralizing antibody reduces hepatocyte injury from acute hepatotoxin administration
    • Czaja, M. J., Xu, J., Ju, Y., et al. (1994). Lipopolysaccharide- neutralizing antibody reduces hepatocyte injury from acute hepatotoxin administration. Hepatology 19, 1282-1289.
    • (1994) Hepatology , vol.19 , pp. 1282-1289
    • Czaja, M.J.1    Xu, J.2    Ju, Y.3
  • 19
    • 74949109725 scopus 로고    scopus 로고
    • Assessment of pyrogenic contaminations with validated human whole-blood assay
    • Daneshian, M., von Aulock, S., and Hartung, T. (2009). Assessment of pyrogenic contaminations with validated human whole-blood assay. Nature Protoc 4, 1709-1721.
    • (2009) Nature Protoc , vol.4 , pp. 1709-1721
    • Daneshian, M.1    Von Aulock, S.2    Hartung, T.3
  • 21
    • 84893147622 scopus 로고    scopus 로고
    • Immunotoxicology: Effects of and response to drugs and chemicals
    • A. W. Hayes (ed.), 5th edition. Philadelphia, USA: Taylor & Francis
    • Dean, J. H., House, R. V., and Luster, M. (2007). Immunotoxicology: Effects of and response to drugs and chemicals. In A. W. Hayes (ed.), Principles and Methods of Toxicology (1755-1796). 5th edition. Philadelphia, USA: Taylor & Francis.
    • (2007) Principles and Methods of Toxicology , pp. 1755-1796
    • Dean, J.H.1    House, R.V.2    Luster, M.3
  • 23
    • 84893112645 scopus 로고    scopus 로고
    • Role of natural killer cells in immunotoxicity: An update
    • Descotes, J. and Ravel, G. (2005). Role of natural killer cells in immunotoxicity: an update. Expert Rev Clin Immunol 1, 603-608.
    • (2005) Expert Rev Clin Immunol , vol.1 , pp. 603-608
    • Descotes, J.1    Ravel, G.2
  • 24
    • 33847762337 scopus 로고    scopus 로고
    • Methods of evaluating immunotoxicity
    • Descotes, J. (2006). Methods of evaluating immunotoxicity. Expert Opin Drug Metab Toxicol 2, 249-259.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 249-259
    • Descotes, J.1
  • 25
    • 84858781810 scopus 로고    scopus 로고
    • Current status of developmental immunotoxicity: Early-life patterns and testing
    • DeWitt, J. C., Peden-Adams, M. M., Keil, D. E., and Dietert, R. R. (2012). Current status of developmental immunotoxicity: early-life patterns and testing. Toxicologic Pathology 40, 230-236.
    • (2012) Toxicologic Pathology , vol.40 , pp. 230-236
    • Dewitt, J.C.1    Peden-Adams, M.M.2    Keil, D.E.3    Dietert, R.R.4
  • 26
    • 10444249026 scopus 로고    scopus 로고
    • 3D-mednes: An alternative "in silico" technique for chemical research in toxicology. 1. Prediction of chemically induced agranulocytosis
    • Díaz, H. G., Marrero, Y., Hernández, I., et al. (2003). 3D-MEDNEs: an alternative "in silico" technique for chemical research in toxicology. 1. prediction of chemically induced agranulocytosis. Chem Res Toxicol 16, 1318-1327.
    • (2003) Chem Res Toxicol , vol.16 , pp. 1318-1327
    • Díaz, H.G.1    Marrero, Y.2    Hernández, I.3
  • 27
    • 57749115541 scopus 로고    scopus 로고
    • Developmental immunotoxicology (dit): Windows of vulnerability, immune dysfunction and safety assessment
    • Dietert, R. R. (2008). Developmental immunotoxicology (DIT): windows of vulnerability, immune dysfunction and safety assessment. J Immunotoxicol 5, 401-412.
    • (2008) J Immunotoxicol , vol.5 , pp. 401-412
    • Dietert, R.R.1
  • 29
    • 84937092509 scopus 로고
    • Wound healing: The role of the macrophage and other immune cells
    • DiPietro, L. A. (1995). Wound healing: the role of the macrophage and other immune cells. Shock 4, 233-240.
    • (1995) Shock , vol.4 , pp. 233-240
    • Dipietro, L.A.1
  • 30
    • 0014126359 scopus 로고
    • Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique
    • Dutton, R. W. R. and Mishell, R. I. R. (1967). Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique. J Exp Med 126, 443-454.
    • (1967) J Exp Med , vol.126 , pp. 443-454
    • Dutton, R.W.R.1    Mishell, R.I.R.2
  • 31
    • 0005034664 scopus 로고    scopus 로고
    • Environmental Defense Fund
    • Environmental Defense Fund (1997). Toxic ignorance. 1-65. http://bit.ly/17URkLP
    • (1997) Toxic Ignorance , pp. 1-65
  • 32
    • 0027170433 scopus 로고
    • Cytokine production in whole blood cell cultures of patients undergoing therapy with biological response modifiers or 5-fluorouracil
    • Elsässer-Beile, U., Kleist von, S., Lindenthal, A., et al. (1993). Cytokine production in whole blood cell cultures of patients undergoing therapy with biological response modifiers or 5-fluorouracil. Cancer Immunol Immunother 37, 169-174.
    • (1993) Cancer Immunol Immunother , vol.37 , pp. 169-174
    • Elsässer-Beile, U.1    Von, K.S.2    Lindenthal, A.3
  • 33
    • 77956074266 scopus 로고    scopus 로고
    • A niche for infectious disease in environmental health: Rethinking the toxicological paradigm
    • Feingold, B. J., Vegosen, L., Davis, M., et al. (2010). A niche for infectious disease in environmental health: Rethinking the toxicological paradigm. Environ Health Perspect 118, 1165-1172.
    • (2010) Environ Health Perspect , vol.118 , pp. 1165-1172
    • Feingold, B.J.1    Vegosen, L.2    Davis, M.3
  • 34
    • 84860828525 scopus 로고    scopus 로고
    • Analysis of the proposed eu regulation concerning biocide products and its opportunities for alternative approaches and a toxicology for the 21st century (t4 report)
    • Ferrario, D. and Rabbit, R. R. (2012). Analysis of the proposed EU regulation concerning biocide products and its opportunities for alternative approaches and a toxicology for the 21st century (t4 report). ALTEX 29, 157-172.
    • (2012) ALTEX , vol.29 , pp. 157-172
    • Ferrario, D.1    Rabbit, R.R.2
  • 35
    • 84893084903 scopus 로고
    • Use of whole blood methods in assessment of immune pa provement of human dendritic cell culture for immunotoxicological investigations
    • Fletcher, M. A., Baron, G. C., Ashman, M. R., et al. (1987). Use of whole blood methods in assessment of immune pa provement of human dendritic cell culture for immunotoxicological investigations. Cell Biol Toxicol 22, 243-255.
    • (1987) Cell Biol Toxicol , vol.22 , pp. 243-255
    • Fletcher, M.A.1    Baron, G.C.2    Ashman, M.R.3
  • 36
    • 34250197857 scopus 로고    scopus 로고
    • Interactions among infections, nutrients and xenobiotics
    • Ilbäck, N. G. and Friman, G. (2007). Interactions among infections, nutrients and xenobiotics. Crit Rev Food Sci Nutr 47, 499-519.
    • (2007) Crit Rev Food Sci Nutr , vol.47 , pp. 499-519
    • Ilbäck, N.G.1    Friman, G.2
  • 37
    • 0031749957 scopus 로고    scopus 로고
    • Extension of the protocol of oecd guideline 407 (28-day repeated dose oral toxicity test in the rat) to detect potential immunotoxicity of chemicals
    • Institóris, L., Siroki, O., Dési, I., et al. (1998). Extension of the protocol of OECD guideline 407 (28-day repeated dose oral toxicity test in the rat) to detect potential immunotoxicity of chemicals. Human Exp Toxicol 17, 206-211.
    • (1998) Human Exp Toxicol , vol.17 , pp. 206-211
    • Institóris, L.1    Siroki, O.2    Dési, I.3
  • 38
    • 80053511161 scopus 로고    scopus 로고
    • Integrating non-animal test information into an adaptive testing strategy - Skin sensitization proof of concept case
    • Jaworska, J., Harol, A., Kern, P. S., et al. (2011). Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case. ALTEX 28, 211-225.
    • (2011) ALTEX , vol.28 , pp. 211-225
    • Jaworska, J.1    Harol, A.2    Kern, P.S.3
  • 39
    • 65749087491 scopus 로고    scopus 로고
    • In vitro assessments of nanomaterial toxicity
    • Jones, C. F. and Grainger, D. W. (2009). In vitro assessments of nanomaterial toxicity. Adv Drug Delivery Rev 61, 438-456.
    • (2009) Adv Drug Delivery Rev , vol.61 , pp. 438-456
    • Jones, C.F.1    Grainger, D.W.2
  • 40
    • 77953460148 scopus 로고    scopus 로고
    • Small molecules as friends and foes of the immune system
    • Kadow, S., Jux, B., Chmill, S., and Esser, C. (2009). Small molecules as friends and foes of the immune system. Future Med Chem 1, 1583-1591.
    • (2009) Future Med Chem , vol.1 , pp. 1583-1591
    • Kadow, S.1    Jux, B.2    Chmill, S.3    Esser, C.4
  • 41
    • 77955918326 scopus 로고    scopus 로고
    • Toxic responses of the immune system
    • C. D. Klaassen (ed.), 7th edition. New York, USA: McGraw Hill Professional
    • Kaminski, N. E., Faubert Kaplan, B. E., and Holsapple, M. P. (2007). Toxic responses of the immune system. In C. D. Klaassen (ed.), Casarett and Doull's Toxicology (485-555). 7th edition. New York, USA: McGraw Hill Professional.
    • (2007) Casarett and Doull's Toxicology , pp. 485-555
    • Kaminski, N.E.1    Faubert Kaplan, B.E.2    Holsapple, M.P.3
  • 42
    • 0004182315 scopus 로고
    • Chemical-induced autoimmunity
    • J. H. Dean, M. I. Luster, A. E. Munson, and I. Kimber (eds.), 2nd edition. New York, USA: Raven Press
    • Kilburn, K. H. and Warshaw, R. H. (1994). Chemical-induced autoimmunity. In J. H. Dean, M. I. Luster, A. E. Munson, and I. Kimber (eds.), Immunotoxicology and Immunopharmacology (523-538). 2nd edition. New York, USA: Raven Press.
    • (1994) Immunotoxicology and Immunopharmacology , pp. 523-538
    • Kilburn, K.H.1    Warshaw, R.H.2
  • 43
    • 34547769251 scopus 로고    scopus 로고
    • A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: Comparisons to a 4 h 51cr-release assay
    • Kim, G. G. G., Donnenberg, V. S. V., Donnenberg, A. D. A., et al. (2007). A novel multiparametric flow cytometry-based cytotoxicity assay simultaneously immunophenotypes effector cells: Comparisons to a 4 h 51Cr-release assay. J Immunol Methods 325, 6-16.
    • (2007) J Immunol Methods , vol.325 , pp. 6-16
    • Kim, G.G.G.1    Donnenberg, V.S.V.2    Donnenberg, A.D.A.3
  • 44
    • 38949145803 scopus 로고    scopus 로고
    • A systematic look at an old problem
    • Kirkwood, T. B. L. (2008). A systematic look at an old problem. Nature 451, 644-647.
    • (2008) Nature , vol.451 , pp. 644-647
    • Kirkwood, T.B.L.1
  • 45
    • 0018184706 scopus 로고
    • Chemically induced agranulocytosis. 2 cases of bone marrow disorder after exposure to paint, sealing-wax and glue
    • Knutsen, B. B. (1978). Chemically induced agranulocytosis. 2 cases of bone marrow disorder after exposure to paint, sealing-wax and glue. Tidsskr Nor Laegeforen 98, 888-890.
    • (1978) Tidsskr Nor Laegeforen , vol.98 , pp. 888-890
    • Knutsen, B.B.1
  • 46
    • 58149178558 scopus 로고    scopus 로고
    • Functional assays are mandatory for correct prediction of immunotoxic properties of compounds in vitro
    • Koeper, L. M. and Vohr, H. W. (2009). Functional assays are mandatory for correct prediction of immunotoxic properties of compounds in vitro. Food Chem Toxicol 47, 110-118.
    • (2009) Food Chem Toxicol , vol.47 , pp. 110-118
    • Koeper, L.M.1    Vohr, H.W.2
  • 47
    • 0002232996 scopus 로고    scopus 로고
    • Chemical-induced autoimmunity
    • R. R. Smialowicz and M. P. Holsapple (eds.), Boca Raton, FL, USA: CRC Press
    • Kosuda, L. L. and Bigazzi, E. P. (1996). Chemical-induced autoimmunity. In R. R. Smialowicz and M. P. Holsapple (eds.), Experimental Immunotoxicology (419-468). Boca Raton, FL, USA: CRC Press.
    • (1996) Experimental Immunotoxicology , pp. 419-468
    • Kosuda, L.L.1    Bigazzi, E.P.2
  • 48
    • 0036448375 scopus 로고    scopus 로고
    • Animal models of endocrine/organ-specific autoimmune diseases: Do they really help us to understand human autoimmunity?
    • Lam-Tse, W. K. W., Lernmark, A. A., and Drexhage, H. A. H. (2002). Animal models of endocrine/organ-specific autoimmune diseases: do they really help us to understand human autoimmunity? Springer Semin Immunopathol 24, 297-321.
    • (2002) Springer Semin Immunopathol , vol.24 , pp. 297-321
    • Lam-Tse, W.K.W.1    Lernmark, A.A.2    Drexhage, H.A.H.3
  • 49
    • 0034833605 scopus 로고    scopus 로고
    • Whole blood cytokine response as a measure of immunotoxicity
    • Langezaal, I., Coecke, S., and Hartung, T. (2001). Whole blood cytokine response as a measure of immunotoxicity. Toxicol In Vitro 15, 313-318.
    • (2001) Toxicol in Vitro , vol.15 , pp. 313-318
    • Langezaal, I.1    Coecke, S.2    Hartung, T.3
  • 50
    • 12244309482 scopus 로고    scopus 로고
    • Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release
    • Langezaal, I., Hoffmann, S., Hartung, T., and Coecke, S. (2002). Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release. Altern Lab Anim 30, 581-595.
    • (2002) Altern Lab Anim , vol.30 , pp. 581-595
    • Langezaal, I.1    Hoffmann, S.2    Hartung, T.3    Coecke, S.4
  • 51
    • 77449154369 scopus 로고    scopus 로고
    • In vitro testing for direct immunotoxicity: State of the art
    • Lankveld, D., Van Loveren, H., and Baken, K. (2010). In vitro testing for direct immunotoxicity: State of the art. Meth Mol Biol 598, 401-423.
    • (2010) Meth Mol Biol , vol.598 , pp. 401-423
    • Lankveld, D.1    Van Loveren, H.2    Baken, K.3
  • 52
    • 0028987883 scopus 로고
    • Macrophages and inflammatory mediators in tissue injury
    • Laskin, D. L. and Pendino, K. J. (1995). Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 35, 655-677.
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 655-677
    • Laskin, D.L.1    Pendino, K.J.2
  • 53
    • 0031059247 scopus 로고    scopus 로고
    • Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins
    • Leist, M., Gantner, F., Naumann, H., et al. (1997). Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins. Gastroenterology 112, 923-934.
    • (1997) Gastroenterology , vol.112 , pp. 923-934
    • Leist, M.1    Gantner, F.2    Naumann, H.3
  • 55
    • 84858789018 scopus 로고    scopus 로고
    • Immunotoxicant screening and prioritization in the twenty-first century
    • Luebke, R. (2012). Immunotoxicant screening and prioritization in the twenty-first century. Toxicol Pathol 40, 294-299.
    • (2012) Toxicol Pathol , vol.40 , pp. 294-299
    • Luebke, R.1
  • 56
    • 77957188471 scopus 로고
    • Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests
    • Luster, M. I., Portier, C., Pait, D. G., et al. (1992). Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fund Appl Toxicol 18, 200-210.
    • (1992) Fund Appl Toxicol , vol.18 , pp. 200-210
    • Luster, M.I.1    Portier, C.2    Pait, D.G.3
  • 57
  • 58
    • 77957180613 scopus 로고
    • Risk assessment in immunotoxicology. II. Relationship between immune and host resistance tests
    • Luster, M. I., Portier, C., Pait, D. G., et al. (1993). Risk assessment in immunotoxicology. II. Relationship between immune and host resistance tests. Fund Appl Toxicol 21, 71-82.
    • (1993) Fund Appl Toxicol , vol.21 , pp. 71-82
    • Luster, M.I.1    Portier, C.2    Pait, D.G.3
  • 59
    • 0035977878 scopus 로고    scopus 로고
    • Role of inflammation in chemical-induced hepatotoxicity
    • Luster, M. I., Simeonova, P. P., Gallucci, R. M., et al. (2001). Role of inflammation in chemical-induced hepatotoxicity. Toxicol Lett 120, 317-321.
    • (2001) Toxicol Lett , vol.120 , pp. 317-321
    • Luster, M.I.1    Simeonova, P.P.2    Gallucci, R.M.3
  • 60
    • 77449148295 scopus 로고    scopus 로고
    • Immunotoxicology testing: Past and future
    • Luster, M. I. and Gerberick, G. F. (2010). Immunotoxicology testing: past and future. Methods Mol Biol 598, 3-13.
    • (2010) Methods Mol Biol , vol.598 , pp. 3-13
    • Luster, M.I.1    Gerberick, G.F.2
  • 62
    • 0014125320 scopus 로고
    • Immunization of dissociated spleen cell cultures from normal mice
    • Mishell, R. I. R. and Dutton, R. W. R. (1967). Immunization of dissociated spleen cell cultures from normal mice. J Exp Med 126, 423-442.
    • (1967) J Exp Med , vol.126 , pp. 423-442
    • Mishell, R.I.R.1    Dutton, R.W.R.2
  • 63
    • 0020578627 scopus 로고
    • Clinical application of a whole blood assay for human natural killer (nk) cell activity
    • Morales, A. and Ottenhof, P. C. (1983). Clinical application of a whole blood assay for human natural killer (NK) cell activity. Cancer 52, 667-670.
    • (1983) Cancer , vol.52 , pp. 667-670
    • Morales, A.1    Ottenhof, P.C.2
  • 64
    • 0034927102 scopus 로고    scopus 로고
    • In vitro bone marrow granulocyte-macrophage progenitor cultures in the assessment of hematotoxic potential of the new drugs
    • Negro, G. D., Bonato, M., and Gribaldo, L. (2001). In vitro bone marrow granulocyte-macrophage progenitor cultures in the assessment of hematotoxic potential of the new drugs. Cell Biol Toxicol 17, 95-105.
    • (2001) Cell Biol Toxicol , vol.17 , pp. 95-105
    • Negro, G.D.1    Bonato, M.2    Gribaldo, L.3
  • 65
    • 78049526283 scopus 로고    scopus 로고
    • The role of intestinal endotoxin in liver injury: A long and evolving history
    • Nolan, J. P. (2010). The role of intestinal endotoxin in liver injury: A long and evolving history. Hepatology 52, 1829-1835.
    • (2010) Hepatology , vol.52 , pp. 1829-1835
    • Nolan, J.P.1
  • 66
    • 0034762255 scopus 로고    scopus 로고
    • Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (cfu-gm) assay
    • Pessina, A., Albella, B., Bueren, J., et al. (2001). Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay. Toxicol In Vitro 15, 729-740.
    • (2001) Toxicol in Vitro , vol.15 , pp. 729-740
    • Pessina, A.1    Albella, B.2    Bueren, J.3
  • 67
    • 77749315395 scopus 로고    scopus 로고
    • The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events
    • Pfaller, T. T., Colognato, R. R., Nelissen, I. I., et al. (2010). The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events. Nanotoxicology 4, 52-72.
    • (2010) Nanotoxicology , vol.4 , pp. 52-72
    • Pfaller, T.T.1    Colognato, R.R.2    Nelissen, I.I.3
  • 68
    • 5444256371 scopus 로고    scopus 로고
    • Inflammation as a tumor promoter in cancer induction
    • Philip, M., Rowley, D. A., and Schreiber, H. (2004). Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol 4, 433-439.
    • (2004) Semin Cancer Biol , vol.4 , pp. 433-439
    • Philip, M.1    Rowley, D.A.2    Schreiber, H.3
  • 69
    • 33845218187 scopus 로고    scopus 로고
    • Detection of autoimmunity by pharmaceu ticals
    • Pieters, R. (2007). Detection of autoimmunity by pharmaceu ticals. Methods 41, 112-117.
    • (2007) Methods , vol.41 , pp. 112-117
    • Pieters, R.1
  • 72
    • 0018868919 scopus 로고
    • A new immunodeficiency disorder in humans involving nk cells
    • Roder, J. C. J., Haliotis, T. T., Klein, M. M., et al. (1980). A new immunodeficiency disorder in humans involving NK cells. Nature 284, 553-555.
    • (1980) Nature , vol.284 , pp. 553-555
    • Roder, J.C.J.1    Haliotis, T.T.2    Klein, M.M.3
  • 73
    • 84890394751 scopus 로고    scopus 로고
    • Immunotoxicology and its application in risk assessment
    • Rooney, A. A., Luebke, R. W., Selgrade, M. J., and Germolec, D. R. (2012). Immunotoxicology and its application in risk assessment. Conserv Genet 101, 251-287.
    • (2012) Conserv Genet , vol.101 , pp. 251-287
    • Rooney, A.A.1    Luebke, R.W.2    Selgrade, M.J.3    Germolec, D.R.4
  • 74
    • 73949132615 scopus 로고    scopus 로고
    • Re-evaluation of animal numbers and costs for in vivo tests to accomplish reach legislation requirements for chemicals - A report by the transatlantic think tank for toxicology (t4)
    • Rovida, C. and Hartung, T. (2009). Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t4). ALTEX 26, 187-208.
    • (2009) ALTEX , vol.26 , pp. 187-208
    • Rovida, C.1    Hartung, T.2
  • 75
    • 84455189560 scopus 로고    scopus 로고
    • How are reproductive toxicity and developmental toxicity addressed in reach dossiers?
    • Rovida, C., Longo, F., and Rabbit, R. R. (2011). How are reproductive toxicity and developmental toxicity addressed in REACH dossiers? ALTEX 28, 273-294.
    • (2011) ALTEX , vol.28 , pp. 273-294
    • Rovida, C.1    Longo, F.2    Rabbit, R.R.3
  • 76
    • 84886537592 scopus 로고    scopus 로고
    • Toxicogenomics-based identification of mechanisms for direct immunotoxicity
    • Epub ahead of print
    • Shao, J., Katika, M. R., Schmeits, P. C., Hendriksen, P. J., et al. (2013). Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Toxicol Sci, Epub ahead of print.
    • (2013) Toxicol Sci
    • Shao, J.1    Katika, M.R.2    Schmeits, P.C.3    Hendriksen, P.J.4
  • 77
    • 10344243492 scopus 로고    scopus 로고
    • Cryopreservation of human whole blood for pyrogenicity testing
    • Schindler, S., Asmus, S., von Aulock, S., et al. (2004). Cryopreservation of human whole blood for pyrogenicity testing. J Immunol Methods 294, 89-100.
    • (2004) J Immunol Methods , vol.294 , pp. 89-100
    • Schindler, S.1    Asmus, S.2    Von Aulock, S.3
  • 78
    • 33750033234 scopus 로고    scopus 로고
    • International validation of pyrogen tests based on cryopreserved human primary blood cells
    • Schindler, S., Spreitzer, I., Loschner, B., et al. (2006). International validation of pyrogen tests based on cryopreserved human primary blood cells. J Immunol Methods 316, 42-51.
    • (2006) J Immunol Methods , vol.316 , pp. 42-51
    • Schindler, S.1    Spreitzer, I.2    Loschner, B.3
  • 79
    • 79952198005 scopus 로고    scopus 로고
    • Development, validation and applications of the monocyte activation test for pyrogens based on human whole blood
    • Schindler, S., Aulock von, S., Daneshian, M., and Hartung, T. (2009). Development, validation and applications of the monocyte activation test for pyrogens based on human whole blood. ALTEX 26, 265-277.
    • (2009) ALTEX , vol.26 , pp. 265-277
    • Schindler, S.1    Von, A.S.2    Daneshian, M.3    Hartung, T.4
  • 80
    • 0035192543 scopus 로고    scopus 로고
    • Induction of the chemokines il-8 and mcp-1 in human whole blood by a cell-lysate of human fibroblast cells
    • Schneider, M. and Hartung, T. (2001). Induction of the chemokines IL-8 and MCP-1 in human whole blood by a cell-lysate of human fibroblast cells. Immunol Lett 75, 163-165.
    • (2001) Immunol Lett , vol.75 , pp. 163-165
    • Schneider, M.1    Hartung, T.2
  • 82
    • 0036074141 scopus 로고    scopus 로고
    • Lipopolysaccharides in liver injury: Molecular mechanisms of kupffer cell activation
    • Su, G. L. (2002). Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 283, G256-G265.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Su, G.L.1
  • 83
    • 0027942587 scopus 로고
    • Workshop: Immunotoxicology and in vitro possibilities
    • Sundwall, A., Andersson, B., Balls, M., et al. (1994). Workshop: Immunotoxicology and in vitro possibilities. Toxicol In Vitro 8, 1067-1074.
    • (1994) Toxicol in Vitro , vol.8 , pp. 1067-1074
    • Sundwall, A.1    Andersson, B.2    Balls, M.3
  • 85
    • 1642498164 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor (filgrastim) treatment primes for increased ex vivo inducible prostanoid release
    • von Aulock, S., Boneberg, E. M., Diterich, I., and Hartung, T. (2004). Granulocyte colony-stimulating factor (filgrastim) treatment primes for increased ex vivo inducible prostanoid release. J Pharmacol Exp Ther 308, 754-759.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 754-759
    • Von Aulock, S.1    Boneberg, E.M.2    Diterich, I.3    Hartung, T.4
  • 86
    • 33746253323 scopus 로고    scopus 로고
    • Dirty little secrets" - Endotoxin contamination of recombinant proteins
    • Wakelin, S. J., Sabroe, I., Gregory, C. D., et al. (2006). "Dirty little secrets" - Endotoxin contamination of recombinant proteins. Immunol Lett 106, 1-7.
    • (2006) Immunol Lett , vol.106 , pp. 1-7
    • Wakelin, S.J.1    Sabroe, I.2    Gregory, C.D.3
  • 87
    • 80053280757 scopus 로고    scopus 로고
    • Immune modulation by chemotherapy or immunotherapy to enhance cancer vaccines
    • Weir, G. M., Liwski, R. S., and Mansour, M. (2011). Immune modulation by chemotherapy or immunotherapy to enhance cancer vaccines. Cancers 3, 3114-3142.
    • (2011) Cancers , vol.3 , pp. 3114-3142
    • Weir, G.M.1    Liwski, R.S.2    Mansour, M.3
  • 88
    • 77957184551 scopus 로고
    • Integration of the human lymphocyte into immunotoxicological investigations
    • Wood, S. C., Karras, J. G., and Holsapple, M. P. (1992). Integration of the human lymphocyte into immunotoxicological investigations. Fundamental Appl Toxicol 18, 450-459.
    • (1992) Fundamental Appl Toxicol , vol.18 , pp. 450-459
    • Wood, S.C.1    Karras, J.G.2    Holsapple, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.