Extension of the protocol of OECD guideline 407 (28-day repeated dose oral toxicity test in the rat) to detect potential immunotoxicity of chemicals

Human and Experimental Toxicology

Volumn 17, Issue 4, 1998, Pages 206-211

  Institoris L ^a   Siroki, Olga ^a   Desi I ^a   Lesznyak J ^b   Serenyi P ^b   Szekeres, Eva ^a   Petri, Ildikó ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Hollós József Hospital   (Hungary)

Author keywords

Azathioprine; Cyclosporin A; Immunotoxicity; Rats

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; BONE MARROW; BRAIN; CELL PROLIFERATION; COLON; CONTROLLED STUDY; IMMUNOTOXICITY; LUNG; LYMPH NODE; MALE; MESENTERY LYMPH NODE; NATURAL KILLER CELL; NONHUMAN; ORGAN WEIGHT; PEYER PATCH; PRACTICE GUIDELINE; PRIORITY JOURNAL; RAT; SPLEEN; T LYMPHOCYTE; THYMUS; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; AZATHIOPRINE; BLOOD CELL COUNT; BONE MARROW CELLS; CELL DIVISION; CYCLOSPORINE; CYTOTOXICITY, IMMUNOLOGIC; GUIDELINES; IMMUNOSUPPRESSIVE AGENTS; KILLER CELLS, NATURAL; LYMPHOID TISSUE; MALE; ORGAN SIZE; RATS; RATS, WISTAR; T-LYMPHOCYTES; TOXICITY TESTS;

ANIMALIA;

EID: 0031749957     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/096032798678908576     Document Type: Article

References (15)

1. Report of the Interlaboratory Comparison of the Effects of Azathioprine on the Pathology and Functional Tests of Immunotoxicity in the Rat. WHO/IPCS-ICICIS Report, 1996.
2. Report of the Interlaboratory Comparison of the Effects of Cyclosporin on the Pathology and Functional Tests of Immunotoxicity in the Rat. WHO/IPCS-ICICIS Report, 1996.
3. Luster MI et al. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fund Appl Toxicol 1992; 18: 200-210.
4. Bach J-F, Strom TB. Thiopurines (6-mercaptopurine, azathioprine, thioguanine). In: The mode of action of immunosuppressive agents. Türk JL (ed). Elsevier: Amsterdam, New York, Oxford. 1985, pp 105-158.
5. Kahan BD. Cyclosporine. New England J Med 1989; 321: 1725-1989.
6. Szekeres E, Petri I, Molnár J. The effects of phenothiazines on some functions of leukocytes 'in vitro'. In: Proc 6th Int Congr on Phenothiazines and Structurally Related Psychotropic Compounds. H Keyzer, (ed). Krieger Publ. Co: Malabar, Florida. 1992, pp 263-268.
7. Institdris L, Siroki O, Tóth S, Dési I. Immunotoxic effects of MPT-IP containing 60% methylparathion in mice. Human Exp Toxicol 1994; 11: 11-16.
8. Institóris L, Siroki O, Dési I. Immunotoxicity study of repeated small doses of dimethoate and methylparathion administered to rats over three generations. Human Exp Toxicol 1995; 14: 879-883.
9. Health impact of selected toxic agents. In: Principlals and Methods for Assessing Direct immunotoxicity Associated with Exposure to Chemicals. IPCS Environmental Health Criteria 180, WHO, Geneva, 1996, pp 90-91.
10. Spreafico F, Merendino A, Braceschi L, Sozanni S. Immunodepressive drugs as prototype immunotoxicants. In: Immunotoxicology Berlin A, Dean JH, Draper MH, Smith EMB, Van Der Venne M-TM (eds). Nijhoff Publ: Dordrecht, 1987, pp 192-207.
11. Weissgarten J, Freidman CNGE, Cardolla CJ. B lymphocytes from stable renal transplant patients do not respond to exogenous lymphokines: comparison of azathioprine and cyclosporin treated patients. Transplant Proc 1989; 21: 393-394.
12. Pedersen BK, Beyer JM. A longitudinal study of the influence of azathioprine on natural killer cell activity. Allergy 1986; 41: 286-289.
13. Versluis DJ, Bijma AM, Vaessen LMB, Weimar W. Changes in immunological parameters after conversion from cyclosporin A to azathioprine in renal transplant recipients. Int J Immunopharmacol 1989; 11: 157-164.
14. Whiting PH, Simpson JG, Davidson RJL, Thomson AW. Pathological changes in rats receiving cyclosporin A at immunotherapeutic dosage for 7 weeks. Br J Exp Path 1983; 64: 437-444.
15. Borel JF, Feurer C, Gubler HU, Stahelin H. Biological effects of cyclosporin A: a new antilymphotic agent. In: Agents and Actions Vol. 6(4), Birkhauser Verlag: Basel, 1976, pp 468-475.