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Volumn 1845, Issue 2, 2014, Pages 117-125

Role of the interleukin 6 receptor family in epithelial ovarian cancer and its clinical implications

Author keywords

Cytokine signaling; Epithelial; IL 6R; JAK STAT pathway; Ovarian cancer

Indexed keywords

ENZYME INHIBITOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 11 RECEPTOR; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ANTIBODY; JANUS KINASE 1 INHIBITOR; JANUS KINASE 2 INHIBITOR; LEPTIN RECEPTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR; ONCOSTATIN M RECEPTOR; PROTEIN INHIBITOR; RECEPTOR ANTIBODY; STAT3 INHIBITOR; UNCLASSIFIED DRUG;

EID: 84893108576     PISSN: 0304419X     EISSN: 18792561     Source Type: Journal    
DOI: 10.1016/j.bbcan.2013.12.003     Document Type: Review
Times cited : (28)

References (174)
  • 1
    • 79959990351 scopus 로고    scopus 로고
    • NBOCC, National Breast and Ovarian Cancer Centre
    • NBOCC, National Breast and Ovarian Cancer Centre Global Cancer Facts and Figures 2011.
    • (2011) Global Cancer Facts and Figures
  • 2
    • 77956495728 scopus 로고    scopus 로고
    • Ovarian cancer development and metastasis
    • Lengyel E. Ovarian cancer development and metastasis. Am. J. Pathol. 2010, 177:1053-1064.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1053-1064
    • Lengyel, E.1
  • 4
    • 41349105997 scopus 로고    scopus 로고
    • Histologic subtypes of ovarian carcinoma: an overview
    • Soslow R.A. Histologic subtypes of ovarian carcinoma: an overview. Int. J. Gynecol. Pathol. 2008, 27:161-174.
    • (2008) Int. J. Gynecol. Pathol. , vol.27 , pp. 161-174
    • Soslow, R.A.1
  • 5
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: biology, endocrinology, and pathology
    • Auersperg N., Wong A.S., Choi K.C., Kang S.K., Leung P.C. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 2001, 22:255-288.
    • (2001) Endocr. Rev. , vol.22 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.2    Choi, K.C.3    Kang, S.K.4    Leung, P.C.5
  • 6
    • 33747181109 scopus 로고    scopus 로고
    • Recent advances in the pathology and classification of ovarian sex cord-stromal tumors
    • Roth L.M. Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. Int. J. Gynecol. Pathol. 2006, 25:199-215.
    • (2006) Int. J. Gynecol. Pathol. , vol.25 , pp. 199-215
    • Roth, L.M.1
  • 7
    • 12344321041 scopus 로고    scopus 로고
    • Histologic types of epithelial ovarian cancer: have they different risk factors?
    • Kurian A.W., Balise R.R., McGuire V., Whittemore A.S. Histologic types of epithelial ovarian cancer: have they different risk factors?. Gynecol. Oncol. 2005, 96:520-530.
    • (2005) Gynecol. Oncol. , vol.96 , pp. 520-530
    • Kurian, A.W.1    Balise, R.R.2    McGuire, V.3    Whittemore, A.S.4
  • 9
    • 13244256870 scopus 로고    scopus 로고
    • Origins and molecular pathology of ovarian cancer
    • Bell D.A. Origins and molecular pathology of ovarian cancer. Mod. Pathol. 2005, 18(Suppl. 2):S19-S32.
    • (2005) Mod. Pathol. , vol.18 , Issue.SUPPL. 2
    • Bell, D.A.1
  • 10
    • 19744368302 scopus 로고    scopus 로고
    • Cancer of the ovary
    • Cannistra S.A. Cancer of the ovary. N. Engl. J. Med. 2004, 351:2519-2529.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2519-2529
    • Cannistra, S.A.1
  • 13
    • 56749103412 scopus 로고    scopus 로고
    • The cell of origin of ovarian epithelial tumours
    • Dubeau L. The cell of origin of ovarian epithelial tumours. Lancet Oncol. 2008, 9:1191-1197.
    • (2008) Lancet Oncol. , vol.9 , pp. 1191-1197
    • Dubeau, L.1
  • 14
    • 0034781481 scopus 로고    scopus 로고
    • Constitutive activation of Stat transcription factors in acute myelogenous leukemia
    • Spiekermann K., Biethahn S., Wilde S., Hiddemann W., Alves F. Constitutive activation of Stat transcription factors in acute myelogenous leukemia. Eur. J. Haematol. 2001, 67:63-71.
    • (2001) Eur. J. Haematol. , vol.67 , pp. 63-71
    • Spiekermann, K.1    Biethahn, S.2    Wilde, S.3    Hiddemann, W.4    Alves, F.5
  • 15
    • 50149102769 scopus 로고    scopus 로고
    • The origin of ovarian carcinomas: a developmental view
    • Auersperg N., Woo M.M., Gilks C.B. The origin of ovarian carcinomas: a developmental view. Gynecol. Oncol. 2008, 110:452-454.
    • (2008) Gynecol. Oncol. , vol.110 , pp. 452-454
    • Auersperg, N.1    Woo, M.M.2    Gilks, C.B.3
  • 16
    • 62749197305 scopus 로고    scopus 로고
    • Multicellular spheroids in ovarian cancer metastases: biology and pathology
    • Shield K., Ackland M.L., Ahmed N., Rice G.E. Multicellular spheroids in ovarian cancer metastases: biology and pathology. Gynecol. Oncol. 2009, 113:143-148.
    • (2009) Gynecol. Oncol. , vol.113 , pp. 143-148
    • Shield, K.1    Ackland, M.L.2    Ahmed, N.3    Rice, G.E.4
  • 17
    • 34547141141 scopus 로고    scopus 로고
    • Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis
    • Shield K., Riley C., Quinn M.A., Rice G.E., Ackland M.L., Ahmed N. Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis. J. Carcinog. 2007, 6:11.
    • (2007) J. Carcinog. , vol.6 , pp. 11
    • Shield, K.1    Riley, C.2    Quinn, M.A.3    Rice, G.E.4    Ackland, M.L.5    Ahmed, N.6
  • 18
    • 69249106131 scopus 로고    scopus 로고
    • Ovarian cancer: emerging concept on cancer stem cells
    • Ponnusamy M.P., Batra S.K. Ovarian cancer: emerging concept on cancer stem cells. J. Ovarian Res. 2008, 1:4.
    • (2008) J. Ovarian Res. , vol.1 , pp. 4
    • Ponnusamy, M.P.1    Batra, S.K.2
  • 19
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman M.M. Mechanisms of cancer drug resistance. Annu. Rev. Med. 2002, 53:615-627.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 21
    • 33645991795 scopus 로고    scopus 로고
    • Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    • Sica A., Schioppa T., Mantovani A., Allavena P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur. J. Cancer 2006, 42:717-727.
    • (2006) Eur. J. Cancer , vol.42 , pp. 717-727
    • Sica, A.1    Schioppa, T.2    Mantovani, A.3    Allavena, P.4
  • 22
    • 84877150482 scopus 로고    scopus 로고
    • Expression of M2-polarized macrophages is associated with poor prognosis for advanced epithelial ovarian cancer
    • Lan C., Huang X., Lin S., Huang H., Cai Q., Wan T., Lu J., Liu J. Expression of M2-polarized macrophages is associated with poor prognosis for advanced epithelial ovarian cancer. Technol. Cancer Res. Treat. 2013, 12:259-267.
    • (2013) Technol. Cancer Res. Treat. , vol.12 , pp. 259-267
    • Lan, C.1    Huang, X.2    Lin, S.3    Huang, H.4    Cai, Q.5    Wan, T.6    Lu, J.7    Liu, J.8
  • 24
    • 24744454001 scopus 로고    scopus 로고
    • Relative expression levels of Th1 and Th2 cytokine mRNA are independent prognostic factors in patients with ovarian cancer
    • Kusuda T., Shigemasa K., Arihiro K., Fujii T., Nagai N., Ohama K. Relative expression levels of Th1 and Th2 cytokine mRNA are independent prognostic factors in patients with ovarian cancer. Oncol. Rep. 2005, 13:1153-1158.
    • (2005) Oncol. Rep. , vol.13 , pp. 1153-1158
    • Kusuda, T.1    Shigemasa, K.2    Arihiro, K.3    Fujii, T.4    Nagai, N.5    Ohama, K.6
  • 27
    • 63149126854 scopus 로고    scopus 로고
    • Evaluation of immune inhibitory cytokine profiles in epithelial ovarian carcinoma
    • Chen L.L., Ye F., Lu W.G., Yu Y., Chen H.Z., Xie X. Evaluation of immune inhibitory cytokine profiles in epithelial ovarian carcinoma. J. Obstet. Gynaecol. Res. 2009, 35:212-218.
    • (2009) J. Obstet. Gynaecol. Res. , vol.35 , pp. 212-218
    • Chen, L.L.1    Ye, F.2    Lu, W.G.3    Yu, Y.4    Chen, H.Z.5    Xie, X.6
  • 30
    • 0030198856 scopus 로고    scopus 로고
    • A cytokine profile of normal and malignant ovary
    • Burke F., Relf M., Negus R., Balkwill F. A cytokine profile of normal and malignant ovary. Cytokine 1996, 8:578-585.
    • (1996) Cytokine , vol.8 , pp. 578-585
    • Burke, F.1    Relf, M.2    Negus, R.3    Balkwill, F.4
  • 34
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: from basic science to medicine - 40years in immunology
    • Kishimoto T. Interleukin-6: from basic science to medicine - 40years in immunology. Annu. Rev. Immunol. 2005, 23:1-21.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 37
    • 15844414541 scopus 로고    scopus 로고
    • Oncostatin M in the development of the nervous system
    • Morikawa Y. Oncostatin M in the development of the nervous system. Anat. Sci. Int. 2005, 80:53-59.
    • (2005) Anat. Sci. Int. , vol.80 , pp. 53-59
    • Morikawa, Y.1
  • 38
    • 70350345564 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more
    • Liongue C., Wright C., Russell A.P., Ward A.C. Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int. J. Biochem. Cell Biol. 2009, 41:2372-2375.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 2372-2375
    • Liongue, C.1    Wright, C.2    Russell, A.P.3    Ward, A.C.4
  • 39
    • 0034198919 scopus 로고    scopus 로고
    • Leptin: a multifunctional hormone
    • Huang L., Li C. Leptin: a multifunctional hormone. Cell Res. 2000, 10:81-92.
    • (2000) Cell Res. , vol.10 , pp. 81-92
    • Huang, L.1    Li, C.2
  • 40
    • 1542297244 scopus 로고    scopus 로고
    • IL-6 signal transduction and its physiological roles: the signal orchestration model
    • Kamimura D., Ishihara K., Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol. Biochem. Pharmacol. 2003, 149:1-38.
    • (2003) Rev. Physiol. Biochem. Pharmacol. , vol.149 , pp. 1-38
    • Kamimura, D.1    Ishihara, K.2    Hirano, T.3
  • 43
    • 1042302005 scopus 로고    scopus 로고
    • The Stats of cancer - new molecular targets come of age
    • Yu H., Jove R. The Stats of cancer - new molecular targets come of age. Nat. Rev. Cancer 2004, 4:97-105.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 44
    • 0036256644 scopus 로고    scopus 로고
    • What does Stat3 do?
    • Levy D.E., Lee C. What does Stat3 do?. J. Clin. Invest. 2002, 109:1143-1148.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1143-1148
    • Levy, D.E.1    Lee, C.2
  • 45
    • 84867499521 scopus 로고    scopus 로고
    • Interleukin-6/interleukin-6 receptor pathway as a new therapy target in epithelial ovarian cancer
    • Dijkgraaf E.M., Welters M.J., Nortier J.W., van der Burg S.H., Kroep J.R. Interleukin-6/interleukin-6 receptor pathway as a new therapy target in epithelial ovarian cancer. Curr. Pharm. Des. 2012, 18:3816-3827.
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 3816-3827
    • Dijkgraaf, E.M.1    Welters, M.J.2    Nortier, J.W.3    van der Burg, S.H.4    Kroep, J.R.5
  • 46
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge D.R., Hurt E.M., Farrar W.L. The role of IL-6 and STAT3 in inflammation and cancer. Eur. J. Cancer 2005, 41:2502-2512.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 47
    • 0036123185 scopus 로고    scopus 로고
    • Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade
    • Ahmed N., Pansino F., Clyde R., Murthi P., Quinn M.A., Rice G.E., Agrez M.V., Mok S., Baker M.S. Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade. Carcinogenesis 2002, 23:237-244.
    • (2002) Carcinogenesis , vol.23 , pp. 237-244
    • Ahmed, N.1    Pansino, F.2    Clyde, R.3    Murthi, P.4    Quinn, M.A.5    Rice, G.E.6    Agrez, M.V.7    Mok, S.8    Baker, M.S.9
  • 48
    • 84862304990 scopus 로고    scopus 로고
    • Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells
    • Wang Y., Li L., Guo X., Jin X., Sun W., Zhang X., Xu R.C. Interleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cells. Cytokine 2012, 59:228-236.
    • (2012) Cytokine , vol.59 , pp. 228-236
    • Wang, Y.1    Li, L.2    Guo, X.3    Jin, X.4    Sun, W.5    Zhang, X.6    Xu, R.C.7
  • 49
    • 77953611991 scopus 로고    scopus 로고
    • Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells
    • Wang Y., Niu X.L., Qu Y., Wu J., Zhu Y.Q., Sun W.J., Li L.Z. Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cancer Lett. 2010, 295:110-123.
    • (2010) Cancer Lett. , vol.295 , pp. 110-123
    • Wang, Y.1    Niu, X.L.2    Qu, Y.3    Wu, J.4    Zhu, Y.Q.5    Sun, W.J.6    Li, L.Z.7
  • 50
    • 34547897027 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis
    • Kim D.J., Chan K.S., Sano S., Digiovanni J. Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Mol. Carcinog. 2007, 46:725-731.
    • (2007) Mol. Carcinog. , vol.46 , pp. 725-731
    • Kim, D.J.1    Chan, K.S.2    Sano, S.3    Digiovanni, J.4
  • 51
    • 0347093460 scopus 로고    scopus 로고
    • Inhibitors of cytokine signal transduction
    • Wormald S., Hilton D.J. Inhibitors of cytokine signal transduction. J. Biol. Chem. 2004, 279:821-824.
    • (2004) J. Biol. Chem. , vol.279 , pp. 821-824
    • Wormald, S.1    Hilton, D.J.2
  • 52
    • 0035824188 scopus 로고    scopus 로고
    • Interleukin-6 and the network of several cytokines in multiple myeloma: an overview of clinical and experimental data
    • Lauta V.M. Interleukin-6 and the network of several cytokines in multiple myeloma: an overview of clinical and experimental data. Cytokine 2001, 16:79-86.
    • (2001) Cytokine , vol.16 , pp. 79-86
    • Lauta, V.M.1
  • 53
    • 20444467988 scopus 로고    scopus 로고
    • High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer
    • Bellone S., Watts K., Cane S., Palmieri M., Cannon M.J., Burnett A., Roman J.J., Pecorelli S., Santin A.D. High serum levels of interleukin-6 in endometrial carcinoma are associated with uterine serous papillary histology, a highly aggressive and chemotherapy-resistant variant of endometrial cancer. Gynecol. Oncol. 2005, 98:92-98.
    • (2005) Gynecol. Oncol. , vol.98 , pp. 92-98
    • Bellone, S.1    Watts, K.2    Cane, S.3    Palmieri, M.4    Cannon, M.J.5    Burnett, A.6    Roman, J.J.7    Pecorelli, S.8    Santin, A.D.9
  • 54
    • 2942616855 scopus 로고    scopus 로고
    • Serum interleukin-6 levels correlate with malnutrition and survival in patients with advanced non-small cell lung cancer
    • Songur N., Kuru B., Kalkan F., Ozdilekcan C., Cakmak H., Hizel N. Serum interleukin-6 levels correlate with malnutrition and survival in patients with advanced non-small cell lung cancer. Tumori 2004, 90:196-200.
    • (2004) Tumori , vol.90 , pp. 196-200
    • Songur, N.1    Kuru, B.2    Kalkan, F.3    Ozdilekcan, C.4    Cakmak, H.5    Hizel, N.6
  • 55
    • 0034106055 scopus 로고    scopus 로고
    • Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer
    • Belluco C., Nitti D., Frantz M., Toppan P., Basso D., Plebani M., Lise M., Jessup J.M. Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer. Ann. Surg. Oncol. 2000, 7:133-138.
    • (2000) Ann. Surg. Oncol. , vol.7 , pp. 133-138
    • Belluco, C.1    Nitti, D.2    Frantz, M.3    Toppan, P.4    Basso, D.5    Plebani, M.6    Lise, M.7    Jessup, J.M.8
  • 56
    • 14644435101 scopus 로고    scopus 로고
    • Interleukin-6 and C-reactive protein in metastatic renal cell carcinoma
    • Altundag O., Altundag K., Gunduz E. Interleukin-6 and C-reactive protein in metastatic renal cell carcinoma. J. Clin. Oncol. 2005, 23:1044-1045.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1044-1045
    • Altundag, O.1    Altundag, K.2    Gunduz, E.3
  • 57
    • 0037435011 scopus 로고    scopus 로고
    • Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
    • Wei L.H., Kuo M.L., Chen C.A., Chou C.H., Lai K.B., Lee C.N., Hsieh C.Y. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 2003, 22:1517-1527.
    • (2003) Oncogene , vol.22 , pp. 1517-1527
    • Wei, L.H.1    Kuo, M.L.2    Chen, C.A.3    Chou, C.H.4    Lai, K.B.5    Lee, C.N.6    Hsieh, C.Y.7
  • 58
    • 22144438698 scopus 로고    scopus 로고
    • IL-6, its receptors and its relationship with BCL-2 and BAX proteins in infiltrating and in situ human breast carcinoma
    • Garcia-Tunon I., Ricote M., Ruiz A., Fraile B., Paniagua R., Royuela M. IL-6, its receptors and its relationship with BCL-2 and BAX proteins in infiltrating and in situ human breast carcinoma. Histopathology 2005, 47:82-89.
    • (2005) Histopathology , vol.47 , pp. 82-89
    • Garcia-Tunon, I.1    Ricote, M.2    Ruiz, A.3    Fraile, B.4    Paniagua, R.5    Royuela, M.6
  • 59
    • 28244475975 scopus 로고    scopus 로고
    • Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
    • Nilsson M.B., Langley R.R., Fidler I.J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res. 2005, 65:10794-10800.
    • (2005) Cancer Res. , vol.65 , pp. 10794-10800
    • Nilsson, M.B.1    Langley, R.R.2    Fidler, I.J.3
  • 60
    • 0037347618 scopus 로고    scopus 로고
    • Chronic inflammation as inductor of pro-cancer microenvironment: pathogenesis of dysregulated feedback control
    • Schwartsburd P.M. Chronic inflammation as inductor of pro-cancer microenvironment: pathogenesis of dysregulated feedback control. Cancer Metastasis Rev. 2003, 22:95-102.
    • (2003) Cancer Metastasis Rev. , vol.22 , pp. 95-102
    • Schwartsburd, P.M.1
  • 61
    • 0025175532 scopus 로고
    • Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures
    • Watson J.M., Sensintaffar J.L., Berek J.S., Martínez-Maza O. Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures. Cancer Res. 1990, 50:6959-6965.
    • (1990) Cancer Res. , vol.50 , pp. 6959-6965
    • Watson, J.M.1    Sensintaffar, J.L.2    Berek, J.S.3    Martínez-Maza, O.4
  • 63
    • 84866420065 scopus 로고    scopus 로고
    • Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer
    • Alberti C., Pinciroli P., Valeri B., Ferri R., Ditto A., Umezawa K., Sensi M., Canevari S., Tomassetti A. Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer. Oncogene 2012, 31:4139-4149.
    • (2012) Oncogene , vol.31 , pp. 4139-4149
    • Alberti, C.1    Pinciroli, P.2    Valeri, B.3    Ferri, R.4    Ditto, A.5    Umezawa, K.6    Sensi, M.7    Canevari, S.8    Tomassetti, A.9
  • 64
    • 58149218143 scopus 로고    scopus 로고
    • Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas
    • Colomiere M., Ward A.C., Riley C., Trenerry M.K., Cameron-Smith D., Findlay J., Ackland L., Ahmed N. Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br. J. Cancer 2009, 100:134-144.
    • (2009) Br. J. Cancer , vol.100 , pp. 134-144
    • Colomiere, M.1    Ward, A.C.2    Riley, C.3    Trenerry, M.K.4    Cameron-Smith, D.5    Findlay, J.6    Ackland, L.7    Ahmed, N.8
  • 67
    • 0025853795 scopus 로고
    • Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer
    • (discussion 1042-1033)
    • Berek J.S., Chung C., Kaldi K., Watson J.M., Knox R.M., Martinez-Maza O. Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer. Am. J. Obstet. Gynecol. 1991, 164:1038-1042. (discussion 1042-1033).
    • (1991) Am. J. Obstet. Gynecol. , vol.164 , pp. 1038-1042
    • Berek, J.S.1    Chung, C.2    Kaldi, K.3    Watson, J.M.4    Knox, R.M.5    Martinez-Maza, O.6
  • 71
    • 0031049172 scopus 로고    scopus 로고
    • Effects of interleukin-6 on in vitro cell attachment, migration and invasion of human ovarian carcinoma
    • Obata N.H., Tamakoshi K., Shibata K., Kikkawa F., Tomoda Y. Effects of interleukin-6 on in vitro cell attachment, migration and invasion of human ovarian carcinoma. Anticancer Res. 1997, 17:337-342.
    • (1997) Anticancer Res. , vol.17 , pp. 337-342
    • Obata, N.H.1    Tamakoshi, K.2    Shibata, K.3    Kikkawa, F.4    Tomoda, Y.5
  • 74
    • 0032711015 scopus 로고    scopus 로고
    • Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype
    • Duan Z., Feller A.J., Penson R.T., Chabner B.A., Seiden M.V. Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype. Clin. Cancer Res. 1999, 5:3445-3453.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3445-3453
    • Duan, Z.1    Feller, A.J.2    Penson, R.T.3    Chabner, B.A.4    Seiden, M.V.5
  • 78
    • 77957028841 scopus 로고    scopus 로고
    • Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation
    • Takaishi K., Komohara Y., Tashiro H., Ohtake H., Nakagawa T., Katabuchi H., Takeya M. Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation. Cancer Sci. 2010, 101:2128-2136.
    • (2010) Cancer Sci. , vol.101 , pp. 2128-2136
    • Takaishi, K.1    Komohara, Y.2    Tashiro, H.3    Ohtake, H.4    Nakagawa, T.5    Katabuchi, H.6    Takeya, M.7
  • 79
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    • Allavena P., Sica A., Solinas G., Porta C., Mantovani A. The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit. Rev. Oncol. Hematol. 2008, 66:1-9.
    • (2008) Crit. Rev. Oncol. Hematol. , vol.66 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 82
    • 67650495415 scopus 로고    scopus 로고
    • IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway
    • Wang L., Yi T., Kortylewski M., Pardoll D.M., Zeng D., Yu H. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J. Exp. Med. 2009, 206:1457-1464.
    • (2009) J. Exp. Med. , vol.206 , pp. 1457-1464
    • Wang, L.1    Yi, T.2    Kortylewski, M.3    Pardoll, D.M.4    Zeng, D.5    Yu, H.6
  • 83
    • 84860775890 scopus 로고    scopus 로고
    • Induction of tolerogenic dendritic cells by IL-6-secreting CT26 colon carcinoma
    • Alshamsan A. Induction of tolerogenic dendritic cells by IL-6-secreting CT26 colon carcinoma. Immunopharmacol. Immunotoxicol. 2012, 34:465-469.
    • (2012) Immunopharmacol. Immunotoxicol. , vol.34 , pp. 465-469
    • Alshamsan, A.1
  • 84
    • 34548798737 scopus 로고    scopus 로고
    • Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma
    • Kryczek I., Wei S., Zhu G., Myers L., Mottram P., Cheng P., Chen L., Coukos G., Zou W. Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res. 2007, 67:8900-8905.
    • (2007) Cancer Res. , vol.67 , pp. 8900-8905
    • Kryczek, I.1    Wei, S.2    Zhu, G.3    Myers, L.4    Mottram, P.5    Cheng, P.6    Chen, L.7    Coukos, G.8    Zou, W.9
  • 86
    • 33746048791 scopus 로고    scopus 로고
    • Interleukin 11 signaling components signal transducer and activator of transcription 3 (STAT3) and suppressor of cytokine signaling 3 (SOCS3) regulate human endometrial stromal cell differentiation
    • Dimitriadis E., Stoikos C., Tan Y.L., Salamonsen L.A. Interleukin 11 signaling components signal transducer and activator of transcription 3 (STAT3) and suppressor of cytokine signaling 3 (SOCS3) regulate human endometrial stromal cell differentiation. Endocrinology 2006, 147:3809-3817.
    • (2006) Endocrinology , vol.147 , pp. 3809-3817
    • Dimitriadis, E.1    Stoikos, C.2    Tan, Y.L.3    Salamonsen, L.A.4
  • 87
    • 17444436189 scopus 로고    scopus 로고
    • The role of IL-11 in hematopoiesis as revealed by a targeted mutation of its receptor
    • Nandurkar H.H., Robb L., Begley C.G. The role of IL-11 in hematopoiesis as revealed by a targeted mutation of its receptor. Stem Cells 1998, 16(Suppl. 2):53-65.
    • (1998) Stem Cells , vol.16 , Issue.SUPPL. 2 , pp. 53-65
    • Nandurkar, H.H.1    Robb, L.2    Begley, C.G.3
  • 88
    • 84866517658 scopus 로고    scopus 로고
    • Interleukin-11 increases cell motility and up-regulates intercellular adhesion molecule-1 expression in human chondrosarcoma cells
    • Li T.M., Wu C.M., Huang H.C., Chou P.C., Fong Y.C., Tang C.H. Interleukin-11 increases cell motility and up-regulates intercellular adhesion molecule-1 expression in human chondrosarcoma cells. J. Cell. Biochem. 2012, 113:3353-3362.
    • (2012) J. Cell. Biochem. , vol.113 , pp. 3353-3362
    • Li, T.M.1    Wu, C.M.2    Huang, H.C.3    Chou, P.C.4    Fong, Y.C.5    Tang, C.H.6
  • 89
    • 84863602818 scopus 로고    scopus 로고
    • Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3
    • Lay V., Yap J., Sonderegger S., Dimitriadis E. Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3. Int. J. Oncol. 2012, 41:759-764.
    • (2012) Int. J. Oncol. , vol.41 , pp. 759-764
    • Lay, V.1    Yap, J.2    Sonderegger, S.3    Dimitriadis, E.4
  • 92
    • 84863980367 scopus 로고    scopus 로고
    • Multicenter, randomized study of genetically modified recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in cancer patients receiving chemotherapy
    • Wu S., Zhang Y., Xu L., Dai Y., Teng Y., Ma S., Ho S.H., Kim J.M., Yu S.S., Kim S., Song S. Multicenter, randomized study of genetically modified recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in cancer patients receiving chemotherapy. Support. Care Cancer 2012, 20:1875-1884.
    • (2012) Support. Care Cancer , vol.20 , pp. 1875-1884
    • Wu, S.1    Zhang, Y.2    Xu, L.3    Dai, Y.4    Teng, Y.5    Ma, S.6    Ho, S.H.7    Kim, J.M.8    Yu, S.S.9    Kim, S.10    Song, S.11
  • 93
    • 0023694753 scopus 로고
    • Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells
    • Hilton D.J., Nicola N.A., Metcalf D. Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:5971-5975.
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 5971-5975
    • Hilton, D.J.1    Nicola, N.A.2    Metcalf, D.3
  • 95
    • 0031979495 scopus 로고    scopus 로고
    • Expression of leukemia inhibitory factor and its receptor in breast cancer: a potential autocrine and paracrine growth regulatory mechanism
    • Dhingra K., Sahin A., Emami K., Hortobagyi G.N., Estrov Z. Expression of leukemia inhibitory factor and its receptor in breast cancer: a potential autocrine and paracrine growth regulatory mechanism. Breast Cancer Res. Treat. 1998, 48:165-174.
    • (1998) Breast Cancer Res. Treat. , vol.48 , pp. 165-174
    • Dhingra, K.1    Sahin, A.2    Emami, K.3    Hortobagyi, G.N.4    Estrov, Z.5
  • 96
    • 0029888789 scopus 로고    scopus 로고
    • Leukemia-inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways
    • Kellokumpu-Lehtinen P., Talpaz M., Harris D., Van Q., Kurzrock R., Estrov Z. Leukemia-inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways. Int. J. Cancer 1996, 66:515-519.
    • (1996) Int. J. Cancer , vol.66 , pp. 515-519
    • Kellokumpu-Lehtinen, P.1    Talpaz, M.2    Harris, D.3    Van, Q.4    Kurzrock, R.5    Estrov, Z.6
  • 98
    • 84862981130 scopus 로고    scopus 로고
    • Identification of differentially expressed genes according to chemosensitivity in advanced ovarian serous adenocarcinomas: expression of GRIA2 predicts better survival
    • Choi C.H., Choi J.J., Park Y.A., Lee Y.Y., Song S.Y., Sung C.O., Song T., Kim M.K., Kim T.J., Lee J.W., Kim H.J., Bae D.S., Kim B.G. Identification of differentially expressed genes according to chemosensitivity in advanced ovarian serous adenocarcinomas: expression of GRIA2 predicts better survival. Br. J. Cancer 2012, 107:91-99.
    • (2012) Br. J. Cancer , vol.107 , pp. 91-99
    • Choi, C.H.1    Choi, J.J.2    Park, Y.A.3    Lee, Y.Y.4    Song, S.Y.5    Sung, C.O.6    Song, T.7    Kim, M.K.8    Kim, T.J.9    Lee, J.W.10    Kim, H.J.11    Bae, D.S.12    Kim, B.G.13
  • 99
    • 47749094679 scopus 로고    scopus 로고
    • Expression of leukaemia inhibitory factor in epithelial ovarian carcinoma: correlation with clinical characteristics
    • Ye F., Hu Y., Lu W., Zhou C., Xie X. Expression of leukaemia inhibitory factor in epithelial ovarian carcinoma: correlation with clinical characteristics. Histopathology 2008, 53:224-228.
    • (2008) Histopathology , vol.53 , pp. 224-228
    • Ye, F.1    Hu, Y.2    Lu, W.3    Zhou, C.4    Xie, X.5
  • 100
    • 79955577703 scopus 로고    scopus 로고
    • IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-gamma
    • Jeannin P., Duluc D., Delneste Y. IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-gamma. Immunotherapy 2011, 3:23-26.
    • (2011) Immunotherapy , vol.3 , pp. 23-26
    • Jeannin, P.1    Duluc, D.2    Delneste, Y.3
  • 102
    • 0033536565 scopus 로고    scopus 로고
    • Oncostatin M: signal transduction and biological activity
    • Gomez-Lechon M.J. Oncostatin M: signal transduction and biological activity. Life Sci. 1999, 65:2019-2030.
    • (1999) Life Sci. , vol.65 , pp. 2019-2030
    • Gomez-Lechon, M.J.1
  • 105
    • 0033036489 scopus 로고    scopus 로고
    • Oncostatin M (OM) promotes the growth of DU 145 human prostate cancer cells, but not PC-3 or LNCaP, through the signaling of the OM specific receptor
    • Mori S., Murakami-Mori K., Bonavida B. Oncostatin M (OM) promotes the growth of DU 145 human prostate cancer cells, but not PC-3 or LNCaP, through the signaling of the OM specific receptor. Anticancer Res. 1999, 19:1011-1015.
    • (1999) Anticancer Res. , vol.19 , pp. 1011-1015
    • Mori, S.1    Murakami-Mori, K.2    Bonavida, B.3
  • 106
    • 79955818331 scopus 로고    scopus 로고
    • Oncostatin M promotes proliferation of ovarian cancer cells through signal transducer and activator of transcription 3
    • Li Q., Zhu J., Sun F., Liu L., Liu X., Yue Y. Oncostatin M promotes proliferation of ovarian cancer cells through signal transducer and activator of transcription 3. Int. J. Mol. Med. 2011, 28:101-108.
    • (2011) Int. J. Mol. Med. , vol.28 , pp. 101-108
    • Li, Q.1    Zhu, J.2    Sun, F.3    Liu, L.4    Liu, X.5    Yue, Y.6
  • 109
    • 77955559142 scopus 로고    scopus 로고
    • High IL-12 p35 and IL-23 p19 mRNA expression is associated with superior outcome in ovarian cancer
    • Wolf A.M., Rumpold H., Reimer D., Marth C., Zeimet A.G., Wolf D. High IL-12 p35 and IL-23 p19 mRNA expression is associated with superior outcome in ovarian cancer. Gynecol. Oncol. 2010, 118:244-250.
    • (2010) Gynecol. Oncol. , vol.118 , pp. 244-250
    • Wolf, A.M.1    Rumpold, H.2    Reimer, D.3    Marth, C.4    Zeimet, A.G.5    Wolf, D.6
  • 110
    • 33645351160 scopus 로고    scopus 로고
    • Correlation of serum and ascitic IL-12 levels with second-look laparotomy results and disease progression in advanced epithelial ovarian cancer patients
    • Bozkurt N., Yuce K., Basaran M., Gariboglu S., Kose F., Ayhan A. Correlation of serum and ascitic IL-12 levels with second-look laparotomy results and disease progression in advanced epithelial ovarian cancer patients. Int. J. Gynecol. Cancer 2006, 16:83-86.
    • (2006) Int. J. Gynecol. Cancer , vol.16 , pp. 83-86
    • Bozkurt, N.1    Yuce, K.2    Basaran, M.3    Gariboglu, S.4    Kose, F.5    Ayhan, A.6
  • 111
    • 84885321751 scopus 로고    scopus 로고
    • Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer
    • Anwer K., Kelly F.J., Chu C., Fewell J.G., Lewis D., Alvarez R.D. Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer. Gynecol. Oncol. 2013, 131:169-173.
    • (2013) Gynecol. Oncol. , vol.131 , pp. 169-173
    • Anwer, K.1    Kelly, F.J.2    Chu, C.3    Fewell, J.G.4    Lewis, D.5    Alvarez, R.D.6
  • 112
    • 79952199192 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study
    • Zhao Q., Wang C., Zhu J., Wang L., Dong S., Zhang G., Tian J. RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. J. Exp. Clin. Cancer Res. 2011, 30:26.
    • (2011) J. Exp. Clin. Cancer Res. , vol.30 , pp. 26
    • Zhao, Q.1    Wang, C.2    Zhu, J.3    Wang, L.4    Dong, S.5    Zhang, G.6    Tian, J.7
  • 113
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation
    • Kastelein R.A., Hunter C.A., Cua D.J. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu. Rev. Immunol. 2007, 25:221-242.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 117
    • 34249828162 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders
    • Touw I.P., van de Geijn G.J. Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders. Front. Biosci. 2007, 12:800-815.
    • (2007) Front. Biosci. , vol.12 , pp. 800-815
    • Touw, I.P.1    van de Geijn, G.J.2
  • 118
    • 44449087304 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis
    • Panopoulos A.D., Watowich S.S. Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. Cytokine 2008, 42:277-288.
    • (2008) Cytokine , vol.42 , pp. 277-288
    • Panopoulos, A.D.1    Watowich, S.S.2
  • 119
    • 25144473042 scopus 로고    scopus 로고
    • G-CSF: a key regulator of neutrophil production, but that's not all!
    • Roberts A.W. G-CSF: a key regulator of neutrophil production, but that's not all!. Growth Factors 2005, 23:33-41.
    • (2005) Growth Factors , vol.23 , pp. 33-41
    • Roberts, A.W.1
  • 120
    • 0742272158 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor receptor signals for β1-integrin expression and adhesion in bladder cancer
    • Chakraborty A., White S.M., Lerner S.P. Granulocyte colony-stimulating factor receptor signals for β1-integrin expression and adhesion in bladder cancer. Urology 2004, 63:177-183.
    • (2004) Urology , vol.63 , pp. 177-183
    • Chakraborty, A.1    White, S.M.2    Lerner, S.P.3
  • 121
    • 33748082302 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo
    • Gutschalk C.M., Herold-Mende C.C., Fusenig N.E., Mueller M.M. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo. Cancer Res. 2006, 66:8026-8036.
    • (2006) Cancer Res. , vol.66 , pp. 8026-8036
    • Gutschalk, C.M.1    Herold-Mende, C.C.2    Fusenig, N.E.3    Mueller, M.M.4
  • 122
    • 0036269105 scopus 로고    scopus 로고
    • Erythropoietin and G-CSF receptors in human tumor cells: expression and aspects regarding functionality
    • Westphal G., Niederberger E., Blum C., Wollman Y., Knoch T.A., Rebel W., Debus J., Friedrich E. Erythropoietin and G-CSF receptors in human tumor cells: expression and aspects regarding functionality. Tumori 2002, 88:150-159.
    • (2002) Tumori , vol.88 , pp. 150-159
    • Westphal, G.1    Niederberger, E.2    Blum, C.3    Wollman, Y.4    Knoch, T.A.5    Rebel, W.6    Debus, J.7    Friedrich, E.8
  • 123
    • 0031917218 scopus 로고    scopus 로고
    • RhG-CSF affects genes involved in mitogen signalling and early gene expression in the ovarian cancer cell line HEY
    • Brandstetter T., Ninci E., Falken U., Wagner E., Hess R., Bauknecht T. rhG-CSF affects genes involved in mitogen signalling and early gene expression in the ovarian cancer cell line HEY. Int. J. Cancer 1998, 75:847-854.
    • (1998) Int. J. Cancer , vol.75 , pp. 847-854
    • Brandstetter, T.1    Ninci, E.2    Falken, U.3    Wagner, E.4    Hess, R.5    Bauknecht, T.6
  • 127
    • 84855419737 scopus 로고    scopus 로고
    • Prognostic relevance of granulocyte colony-stimulating factor in ovarian carcinomas
    • Munstedt K., Hackethal A., Eskef K., Hrgovic I., Franke F.E. Prognostic relevance of granulocyte colony-stimulating factor in ovarian carcinomas. Arch. Gynecol. Obstet. 2010, 282:301-305.
    • (2010) Arch. Gynecol. Obstet. , vol.282 , pp. 301-305
    • Munstedt, K.1    Hackethal, A.2    Eskef, K.3    Hrgovic, I.4    Franke, F.E.5
  • 128
    • 0028793332 scopus 로고
    • C-Jun expression and growth stimulation in human ovarian carcinoma cell lines following exposure to cytokines
    • Spinner D.M., Brandstetter T., Kiechle-Schwarz M., Du Bois A., Angel P., Bauknecht T. c-Jun expression and growth stimulation in human ovarian carcinoma cell lines following exposure to cytokines. Int. J. Cancer 1995, 63:423-427.
    • (1995) Int. J. Cancer , vol.63 , pp. 423-427
    • Spinner, D.M.1    Brandstetter, T.2    Kiechle-Schwarz, M.3    Du Bois, A.4    Angel, P.5    Bauknecht, T.6
  • 129
    • 84891877810 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer
    • (in press)
    • Kumar J., Fraser F.W., Riley C., Ahmed N., McCulloch D.R., Ward A.C. Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer. Br. J. Cancer 2014, (in press). 10.1038/bjc.2013.673.
    • (2014) Br. J. Cancer
    • Kumar, J.1    Fraser, F.W.2    Riley, C.3    Ahmed, N.4    McCulloch, D.R.5    Ward, A.C.6
  • 130
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • Tartaglia L.A. The leptin receptor. J. Biol. Chem. 1997, 272:6093-6096.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6093-6096
    • Tartaglia, L.A.1
  • 131
    • 0031056665 scopus 로고    scopus 로고
    • Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130
    • Nakashima K., Narazaki M., Taga T. Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130. FEBS Lett. 1997, 403:79-82.
    • (1997) FEBS Lett. , vol.403 , pp. 79-82
    • Nakashima, K.1    Narazaki, M.2    Taga, T.3
  • 132
    • 58149499180 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • Villanueva E.C., Myers M.G. Leptin receptor signaling and the regulation of mammalian physiology. Int. J. Obes. (Lond.) 2008, 32(Suppl. 7):S8-S12.
    • (2008) Int. J. Obes. (Lond.) , vol.32 , Issue.SUPPL. 7
    • Villanueva, E.C.1    Myers, M.G.2
  • 133
    • 0030685790 scopus 로고    scopus 로고
    • Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts
    • Chua S.C., Koutras I.K., Han L., Liu S.M., Kay J., Young S.J., Chung W.K., Leibel R.L. Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 1997, 15:264-270.
    • (1997) Genomics , vol.15 , pp. 264-270
    • Chua, S.C.1    Koutras, I.K.2    Han, L.3    Liu, S.M.4    Kay, J.5    Young, S.J.6    Chung, W.K.7    Leibel, R.L.8
  • 135
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • Saxena N.K., Sharma D., Ding X., Lin S., Marra F., Merlin D., Anania F.A. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res. 2007, 67:2497-2507.
    • (2007) Cancer Res. , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3    Lin, S.4    Marra, F.5    Merlin, D.6    Anania, F.A.7
  • 136
    • 34250315764 scopus 로고    scopus 로고
    • Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to Cyclin D1 promoter via activation of Stat3
    • Saxena N.K., Vertino P.M., Anania F.A., Sharma D. Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to Cyclin D1 promoter via activation of Stat3. J. Biol. Chem. 2007, 282:13316-13325.
    • (2007) J. Biol. Chem. , vol.282 , pp. 13316-13325
    • Saxena, N.K.1    Vertino, P.M.2    Anania, F.A.3    Sharma, D.4
  • 137
    • 33745108419 scopus 로고    scopus 로고
    • Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways
    • Sharma D., Saxena N.K., Vertino P.M., Anania F.A. Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways. Endocr. Relat. Cancer 2006, 13:629-640.
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 629-640
    • Sharma, D.1    Saxena, N.K.2    Vertino, P.M.3    Anania, F.A.4
  • 138
    • 4143118039 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin
    • Yin N., Wang D., Zhang H., Yi X., Sun X., Shi B., Wu H., Wu G., Wang X., Shang Y. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res. 2004, 64:5870-5875.
    • (2004) Cancer Res. , vol.64 , pp. 5870-5875
    • Yin, N.1    Wang, D.2    Zhang, H.3    Yi, X.4    Sun, X.5    Shi, B.6    Wu, H.7    Wu, G.8    Wang, X.9    Shang, Y.10
  • 139
    • 0037146224 scopus 로고    scopus 로고
    • Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development
    • Hu X., Juneja S.C., Maihle N.J., Cleary M.P. Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development. J. Natl. Cancer Inst. 2002, 94:1704-1711.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 1704-1711
    • Hu, X.1    Juneja, S.C.2    Maihle, N.J.3    Cleary, M.P.4
  • 140
    • 84858019563 scopus 로고    scopus 로고
    • Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways
    • Yan D., Avtanski D., Saxena N.K., Sharma D. Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires beta-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J. Biol. Chem. 2012, 287:8598-8612.
    • (2012) J. Biol. Chem. , vol.287 , pp. 8598-8612
    • Yan, D.1    Avtanski, D.2    Saxena, N.K.3    Sharma, D.4
  • 141
    • 84869740357 scopus 로고    scopus 로고
    • Evidence of an autocrine role for leptin and leptin receptor in human breast cancer
    • Wazir U., Al Sarakbi W., Jiang W.G., Mokbel K. Evidence of an autocrine role for leptin and leptin receptor in human breast cancer. Cancer Genomics Proteomics 2012, 9:383-387.
    • (2012) Cancer Genomics Proteomics , vol.9 , pp. 383-387
    • Wazir, U.1    Al Sarakbi, W.2    Jiang, W.G.3    Mokbel, K.4
  • 142
    • 84862284805 scopus 로고    scopus 로고
    • The adipocyte-derived hormone leptin has proliferative actions on androgen-resistant prostate cancer cells linking obesity to advanced stages of prostate cancer
    • Hoda M.R., Theil G., Mohammed N., Fischer K., Fornara P. The adipocyte-derived hormone leptin has proliferative actions on androgen-resistant prostate cancer cells linking obesity to advanced stages of prostate cancer. J. Oncol. 2012, 2012:280-386.
    • (2012) J. Oncol. , vol.2012 , pp. 280-386
    • Hoda, M.R.1    Theil, G.2    Mohammed, N.3    Fischer, K.4    Fornara, P.5
  • 143
    • 0035216734 scopus 로고    scopus 로고
    • Evidence of leptin expression in normal and polycystic human ovaries
    • Loffler S., Aust G., Kohler U., Spanel-Borowski K. Evidence of leptin expression in normal and polycystic human ovaries. Mol. Hum. Reprod. 2001, 7:1143-1149.
    • (2001) Mol. Hum. Reprod. , vol.7 , pp. 1143-1149
    • Loffler, S.1    Aust, G.2    Kohler, U.3    Spanel-Borowski, K.4
  • 144
    • 70449377000 scopus 로고    scopus 로고
    • Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
    • Uddin S., Bu R., Ahmed M., Abubaker J., Al-Dayel F., Bavi P., Al-Kuraya K.S. Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer. Mol. Cancer 2009, 8:74.
    • (2009) Mol. Cancer , vol.8 , pp. 74
    • Uddin, S.1    Bu, R.2    Ahmed, M.3    Abubaker, J.4    Al-Dayel, F.5    Bavi, P.6    Al-Kuraya, K.S.7
  • 145
    • 12244271468 scopus 로고    scopus 로고
    • Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells
    • Choi J.H., Park S.H., Leung P.C., Choi K.C. Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells. J. Clin. Endocrinol. Metab. 2005, 90:207-210.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 207-210
    • Choi, J.H.1    Park, S.H.2    Leung, P.C.3    Choi, K.C.4
  • 146
    • 84879555168 scopus 로고    scopus 로고
    • Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells
    • Ptak A., Kolaczkowska E., Gregoraszczuk E.L. Leptin stimulation of cell cycle and inhibition of apoptosis gene and protein expression in OVCAR-3 ovarian cancer cells. Endocrine 2013, 43:394-403.
    • (2013) Endocrine , vol.43 , pp. 394-403
    • Ptak, A.1    Kolaczkowska, E.2    Gregoraszczuk, E.L.3
  • 147
    • 84873692225 scopus 로고    scopus 로고
    • Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing Cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways
    • Chen C., Chang Y.C., Lan M.S., Breslin M. Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing Cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways. Int. J. Oncol. 2013, 42:1113-1119.
    • (2013) Int. J. Oncol. , vol.42 , pp. 1113-1119
    • Chen, C.1    Chang, Y.C.2    Lan, M.S.3    Breslin, M.4
  • 148
    • 79953705077 scopus 로고    scopus 로고
    • Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth
    • Choi J.H., Lee K.T., Leung P.C. Estrogen receptor alpha pathway is involved in leptin-induced ovarian cancer cell growth. Carcinogenesis 2011, 32:589-596.
    • (2011) Carcinogenesis , vol.32 , pp. 589-596
    • Choi, J.H.1    Lee, K.T.2    Leung, P.C.3
  • 149
    • 0142250392 scopus 로고    scopus 로고
    • Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence
    • Trikha M., Corringham R., Klein B., Rossi J.F. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin. Cancer Res. 2003, 9:4653-4665.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.F.4
  • 151
    • 33645514605 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
    • Wallner L., Dai J., Escara-Wilke J., Zhang J., Yao Z., Lu Y., Trikha M., Nemeth J.A., Zaki M.H., Keller E.T. Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. Cancer Res. 2006, 66:3087-3095.
    • (2006) Cancer Res. , vol.66 , pp. 3087-3095
    • Wallner, L.1    Dai, J.2    Escara-Wilke, J.3    Zhang, J.4    Yao, Z.5    Lu, Y.6    Trikha, M.7    Nemeth, J.A.8    Zaki, M.H.9    Keller, E.T.10
  • 152
    • 77953091816 scopus 로고    scopus 로고
    • Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer
    • Dorff T.B., Goldman B., Pinski J.K., Mack P.C., Lara P.N., Van Veldhuizen P.J., Quinn D.I., Vogelzang N.J., Thompson I.M., Hussain M.H. Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer. Clin. Cancer Res. 2010, 16:3028-3034.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3028-3034
    • Dorff, T.B.1    Goldman, B.2    Pinski, J.K.3    Mack, P.C.4    Lara, P.N.5    Van Veldhuizen, P.J.6    Quinn, D.I.7    Vogelzang, N.J.8    Thompson, I.M.9    Hussain, M.H.10
  • 153
    • 77649172209 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma
    • Puchalski T., Prabhakar U., Jiao Q., Berns B., Davis H.M. Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma. Clin. Cancer Res. 2010, 16:1652-1661.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1652-1661
    • Puchalski, T.1    Prabhakar, U.2    Jiao, Q.3    Berns, B.4    Davis, H.M.5
  • 155
    • 74849102659 scopus 로고    scopus 로고
    • Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone
    • Garnero P., Thompson E., Woodworth T., Smolen J.S. Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone. Arthritis Rheum. 2010, 62:33-43.
    • (2010) Arthritis Rheum. , vol.62 , pp. 33-43
    • Garnero, P.1    Thompson, E.2    Woodworth, T.3    Smolen, J.S.4
  • 157
    • 84867082115 scopus 로고    scopus 로고
    • Clinical trials: phase III trial results for tofacitinib bring new oral DMARD therapy a step closer for patients with rheumatoid arthritis
    • Leah E. Clinical trials: phase III trial results for tofacitinib bring new oral DMARD therapy a step closer for patients with rheumatoid arthritis. Nat. Rev. Rheumatol. 2012, 8:561.
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 561
    • Leah, E.1
  • 159
    • 33750982120 scopus 로고    scopus 로고
    • Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
    • Schust J., Sperl B., Hollis A., Mayer T.U., Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem. Biol. 2006, 13:1235-1242.
    • (2006) Chem. Biol. , vol.13 , pp. 1235-1242
    • Schust, J.1    Sperl, B.2    Hollis, A.3    Mayer, T.U.4    Berg, T.5
  • 161
    • 85008726865 scopus 로고    scopus 로고
    • Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo
    • Kandala P.K., Srivastava S.K. Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo. Drug Discov. Ther. 2012, 6:94-101.
    • (2012) Drug Discov. Ther. , vol.6 , pp. 94-101
    • Kandala, P.K.1    Srivastava, S.K.2
  • 163
    • 58849152837 scopus 로고    scopus 로고
    • CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells
    • Duan Z., Ames R.Y., Ryan M., Hornicek F.J., Mankin H., Seiden M.V. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother. Pharmacol. 2009, 63:681-689.
    • (2009) Cancer Chemother. Pharmacol. , vol.63 , pp. 681-689
    • Duan, Z.1    Ames, R.Y.2    Ryan, M.3    Hornicek, F.J.4    Mankin, H.5    Seiden, M.V.6
  • 164
    • 77952077836 scopus 로고    scopus 로고
    • Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells
    • Saydmohammed M., Joseph D., Syed V. Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells. J. Cell. Biochem. 2010, 110:447-456.
    • (2010) J. Cell. Biochem. , vol.110 , pp. 447-456
    • Saydmohammed, M.1    Joseph, D.2    Syed, V.3
  • 166
    • 78751484422 scopus 로고    scopus 로고
    • Inhibition of STAT3 reverses drug resistance acquired in temozolomide-resistant human glioma cells
    • Lee E.S., Ko K.K., Joe Y.A., Kang S.G., Hong Y.K. Inhibition of STAT3 reverses drug resistance acquired in temozolomide-resistant human glioma cells. Oncol. Lett. 2011, 2:115-121.
    • (2011) Oncol. Lett. , vol.2 , pp. 115-121
    • Lee, E.S.1    Ko, K.K.2    Joe, Y.A.3    Kang, S.G.4    Hong, Y.K.5
  • 167
    • 0035930669 scopus 로고    scopus 로고
    • Stem cell self renewal specified by Jak-Stat activation in response to a support cell cue
    • Kiger A.A., Jones D.L., Schulz C., Rogers M.B., Fuller M.T. Stem cell self renewal specified by Jak-Stat activation in response to a support cell cue. Science 2001, 294:2542-2545.
    • (2001) Science , vol.294 , pp. 2542-2545
    • Kiger, A.A.1    Jones, D.L.2    Schulz, C.3    Rogers, M.B.4    Fuller, M.T.5
  • 168
    • 0141960055 scopus 로고    scopus 로고
    • Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation
    • Yahata Y., Shirakata Y., Tokumaru S., Yamasaki K., Sayama K., Hanakawa Y., Detmar M., Hashimoto K. Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. J. Biol. Chem. 2003, 278:40026-40031.
    • (2003) J. Biol. Chem. , vol.278 , pp. 40026-40031
    • Yahata, Y.1    Shirakata, Y.2    Tokumaru, S.3    Yamasaki, K.4    Sayama, K.5    Hanakawa, Y.6    Detmar, M.7    Hashimoto, K.8
  • 170
    • 25844447751 scopus 로고    scopus 로고
    • A phase II study of nilutamide in men with prostate cancer after the failure of flutamide or bicalutamide therapy
    • Davis N.B., Ryan C.W., Stadler W.M., Vogelzang N.J. A phase II study of nilutamide in men with prostate cancer after the failure of flutamide or bicalutamide therapy. BJU Int. 2005, 96:787-790.
    • (2005) BJU Int. , vol.96 , pp. 787-790
    • Davis, N.B.1    Ryan, C.W.2    Stadler, W.M.3    Vogelzang, N.J.4


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