-
1
-
-
45349096041
-
-
American Cancer Society
-
American Cancer Society Cancer facts and figures www.cancer.org/ downloads/STT/2008CAFFfinalsecured.pdf 2008 Accessed May 5, 2010
-
(2008)
Cancer Facts and Figures
-
-
-
2
-
-
35648995976
-
Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
-
D.S. Hong, L.S. Angelo, and R. Kurzrock Interleukin-6 and its receptor in cancer: implications for translational therapeutics Cancer 110 2007 1911 1928
-
(2007)
Cancer
, vol.110
, pp. 1911-1928
-
-
Hong, D.S.1
Angelo, L.S.2
Kurzrock, R.3
-
3
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
T. Taga, M. Hibi, and Y. Hirata Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell 58 1989 573 581
-
(1989)
Cell
, vol.58
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
-
4
-
-
0028931604
-
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
-
N. Stahl, T.J. Farruggella, T.G. Boulton, Z. Zhong, J.E. Darnell Jr, and G.D. Yancopoulos Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors Science 267 1995 1349 1353
-
(1995)
Science
, vol.267
, pp. 1349-1353
-
-
Stahl, N.1
Farruggella, T.J.2
Boulton, T.G.3
Zhong, Z.4
Darnell Jr., J.E.5
Yancopoulos, G.D.6
-
5
-
-
0029968757
-
Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation
-
Y. Yamanaka, K. Nakajima, T. Fukada, M. Hibi, and T. Hirano Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation EMBO J 15 1996 1557 1565
-
(1996)
EMBO J
, vol.15
, pp. 1557-1565
-
-
Yamanaka, Y.1
Nakajima, K.2
Fukada, T.3
Hibi, M.4
Hirano, T.5
-
6
-
-
0027441586
-
Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
-
U.M. Wegenka, J. Buschmann, C. Lutticken, P.C. Heinrich, and F. Horn Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level Mol Cell Biol 13 1993 276 288
-
(1993)
Mol Cell Biol
, vol.13
, pp. 276-288
-
-
Wegenka, U.M.1
Buschmann, J.2
Lutticken, C.3
Heinrich, P.C.4
Horn, F.5
-
7
-
-
0037064542
-
The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex
-
S.A. Jones, and S. Rose-John The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex Biochim Biophys Acta 1592 2002 251 263
-
(2002)
Biochim Biophys Acta
, vol.1592
, pp. 251-263
-
-
Jones, S.A.1
Rose-John, S.2
-
8
-
-
0026782577
-
Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins
-
A. Mackiewicz, H. Schooltink, P.C. Heinrich, and S. Rose-John Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins J Immunol 149 1992 2021 2027
-
(1992)
J Immunol
, vol.149
, pp. 2021-2027
-
-
MacKiewicz, A.1
Schooltink, H.2
Heinrich, P.C.3
Rose-John, S.4
-
10
-
-
5644252874
-
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
-
C. Becker, M.C. Fantini, and C. Schramm TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling Immunity 21 2004 491 501
-
(2004)
Immunity
, vol.21
, pp. 491-501
-
-
Becker, C.1
Fantini, M.C.2
Schramm, C.3
-
11
-
-
0042834261
-
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: Blockade of arthritis severity by soluble glycoprotein 130
-
M.A. Nowell, P.J. Richards, and S. Horiuchi Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130 J Immunol 171 2003 3202 3209
-
(2003)
J Immunol
, vol.171
, pp. 3202-3209
-
-
Nowell, M.A.1
Richards, P.J.2
Horiuchi, S.3
-
12
-
-
38949164424
-
Transgenic blockade of Interleukin-6-trans-signaling abrogates inflammation
-
B. Rabe, A. Chalaris, and U. May Transgenic blockade of Interleukin-6-trans-signaling abrogates inflammation Blood 111 2008 1021 1028
-
(2008)
Blood
, vol.111
, pp. 1021-1028
-
-
Rabe, B.1
Chalaris, A.2
May, U.3
-
13
-
-
0028087834
-
Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism
-
S. Horiuchi, Y. Koyanagi, and Y. Zhou Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism Eur J Immunol 24 1994 1945 1948
-
(1994)
Eur J Immunol
, vol.24
, pp. 1945-1948
-
-
Horiuchi, S.1
Koyanagi, Y.2
Zhou, Y.3
-
14
-
-
0027074343
-
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor
-
J. Mullberg, H. Schooltink, T. Stoyan, P.C. Heinrich, and S. Rose-John Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor Biochem Biophys Res Commun 189 1992 794 800
-
(1992)
Biochem Biophys Res Commun
, vol.189
, pp. 794-800
-
-
Mullberg, J.1
Schooltink, H.2
Stoyan, T.3
Heinrich, P.C.4
Rose-John, S.5
-
15
-
-
0032719042
-
Myeloma cells release soluble interleukin-6R-alpha in relation to disease progression by two distinct mechanisms: Alternative splicing and proteolytic cleavage
-
W. Thabard, S. Barille, and M. Collette Myeloma cells release soluble interleukin-6R-alpha in relation to disease progression by two distinct mechanisms: alternative splicing and proteolytic cleavage Clin Cancer Res 5 1999 2693 2697
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2693-2697
-
-
Thabard, W.1
Barille, S.2
Collette, M.3
-
16
-
-
0028035051
-
Sequence, expression and function of an mRNA encoding a soluble form of the human interleukin-6 receptor (sIL-6R)
-
J.A. Lust, D.F. Jelinek, and K.A. Donovan Sequence, expression and function of an mRNA encoding a soluble form of the human interleukin-6 receptor (sIL-6R) Curr Top Microbiol Immunol 194 1995 199 206
-
(1995)
Curr Top Microbiol Immunol
, vol.194
, pp. 199-206
-
-
Lust, J.A.1
Jelinek, D.F.2
Donovan, K.A.3
-
17
-
-
0033080801
-
C-reactive protein: A physiological activator of interleukin 6 receptor shedding
-
S.A. Jones, D. Novick, S. Horiuchi, N. Yamamoto, A.J. Szalai, and G.M. Fuller C-reactive protein: a physiological activator of interleukin 6 receptor shedding J Exp Med 189 1999 599 604
-
(1999)
J Exp Med
, vol.189
, pp. 599-604
-
-
Jones, S.A.1
Novick, D.2
Horiuchi, S.3
Yamamoto, N.4
Szalai, A.J.5
Fuller, G.M.6
-
18
-
-
0036772859
-
Chemotactic agents induce IL-6R-alpha shedding from polymorphonuclear cells: Involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type
-
V. Marin, F. Montero-Julian, S. Gres, P. Bongrand, C. Farnarier, and G. Kaplanski Chemotactic agents induce IL-6R-alpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type Eur J Immunol 32 2002 2965 2970
-
(2002)
Eur J Immunol
, vol.32
, pp. 2965-2970
-
-
Marin, V.1
Montero-Julian, F.2
Gres, S.3
Bongrand, P.4
Farnarier, C.5
Kaplanski, G.6
-
19
-
-
0141866756
-
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
-
V. Matthews, B. Schuster, and S. Schutze Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE) J Biol Chem 278 2003 38829 38839
-
(2003)
J Biol Chem
, vol.278
, pp. 38829-38839
-
-
Matthews, V.1
Schuster, B.2
Schutze, S.3
-
20
-
-
34547691563
-
Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo
-
B. Coles, C.A. Fielding, S. Rose-John, J. Scheller, S.A. Jones, and V.B. O'Donnell Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo Am J Pathol 171 2007 315 325
-
(2007)
Am J Pathol
, vol.171
, pp. 315-325
-
-
Coles, B.1
Fielding, C.A.2
Rose-John, S.3
Scheller, J.4
Jones, S.A.5
O'Donnell, V.B.6
-
21
-
-
0027369308
-
Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer
-
M.M. Moradi, L.F. Carson, B. Weinberg, A.F. Haney, L.B. Twiggs, and S. Ramakrishnan Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer Cancer 72 1993 2433 2440
-
(1993)
Cancer
, vol.72
, pp. 2433-2440
-
-
Moradi, M.M.1
Carson, L.F.2
Weinberg, B.3
Haney, A.F.4
Twiggs, L.B.5
Ramakrishnan, S.6
-
22
-
-
0028203595
-
Interleukin-6 level in serum and ascites as a prognostic factor in patients with epithelial ovarian cancer
-
M. Plante, S.C. Rubin, G.Y. Wong, M.G. Federici, C.L. Finstad, and G.A. Gastl Interleukin-6 level in serum and ascites as a prognostic factor in patients with epithelial ovarian cancer Cancer 73 1994 1882 1888
-
(1994)
Cancer
, vol.73
, pp. 1882-1888
-
-
Plante, M.1
Rubin, S.C.2
Wong, G.Y.3
Federici, M.G.4
Finstad, C.L.5
Gastl, G.A.6
-
23
-
-
0028871101
-
Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer
-
G. Scambia, U. Testa, and P. Benedetti Panici Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer Br J Cancer 71 1995 354 356
-
(1995)
Br J Cancer
, vol.71
, pp. 354-356
-
-
Scambia, G.1
Testa, U.2
Benedetti Panici, P.3
-
24
-
-
33748992592
-
Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer
-
Z. Duan, R. Foster, and D.A. Bell Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer Clin Cancer Res 12 2006 5055 5063
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5055-5063
-
-
Duan, Z.1
Foster, R.2
Bell, D.A.3
-
25
-
-
6744262234
-
Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNF-alpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel
-
R.T. Penson, K. Kronish, and Z. Duan Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNF-alpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel Int J Gynecol Cancer 10 2000 33 41
-
(2000)
Int J Gynecol Cancer
, vol.10
, pp. 33-41
-
-
Penson, R.T.1
Kronish, K.2
Duan, Z.3
-
26
-
-
0034802899
-
Investigation of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130) in sera of cancer patients
-
E. Kovacs Investigation of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130) in sera of cancer patients Biomed Pharmacother 55 2001 391 396
-
(2001)
Biomed Pharmacother
, vol.55
, pp. 391-396
-
-
Kovacs, E.1
-
27
-
-
34250821793
-
Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice
-
T.M. Robinson-Smith, I. Isaacsohn, and C.A. Mercer Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice Cancer Res 67 2007 5708 5716
-
(2007)
Cancer Res
, vol.67
, pp. 5708-5716
-
-
Robinson-Smith, T.M.1
Isaacsohn, I.2
Mercer, C.A.3
-
28
-
-
9944223360
-
Correlation of tumor- and stromal-derived MT1-MMP expression with progression of human ovarian tumors in SCID mice
-
A.F. Drew, T.J. Blick, and M.A. Lafleur Correlation of tumor- and stromal-derived MT1-MMP expression with progression of human ovarian tumors in SCID mice Gynecol Oncol 95 2004 437 448
-
(2004)
Gynecol Oncol
, vol.95
, pp. 437-448
-
-
Drew, A.F.1
Blick, T.J.2
Lafleur, M.A.3
-
29
-
-
28244475975
-
Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
-
M.B. Nilsson, R.R. Langley, and I.J. Fidler Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine Cancer Res 65 2005 10794 10800
-
(2005)
Cancer Res
, vol.65
, pp. 10794-10800
-
-
Nilsson, M.B.1
Langley, R.R.2
Fidler, I.J.3
-
30
-
-
2442663092
-
Activated signal transducer and activator of transcription (STAT) 3: Localization in focal adhesions and function in ovarian cancer cell motility
-
D.L. Silver, H. Naora, J. Liu, W. Cheng, and D.J. Montell Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility Cancer Res 64 2004 3550 3558
-
(2004)
Cancer Res
, vol.64
, pp. 3550-3558
-
-
Silver, D.L.1
Naora, H.2
Liu, J.3
Cheng, W.4
Montell, D.J.5
-
31
-
-
0037123348
-
Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells
-
V. Syed, G. Ulinski, S.C. Mok, and S.M. Ho Reproductive hormone-induced, STAT3-mediated interleukin 6 action in normal and malignant human ovarian surface epithelial cells J Natl Cancer Inst 94 2002 617 629
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 617-629
-
-
Syed, V.1
Ulinski, G.2
Mok, S.C.3
Ho, S.M.4
-
32
-
-
0031795233
-
Shedding of the soluble IL-6 receptor is triggered by Ca2+ mobilization, while basal release is predominantly the product of differential mRNA splicing in THP-1 cells
-
S.A. Jones, S. Horiuchi, D. Novick, N. Yamamoto, and G.M. Fuller Shedding of the soluble IL-6 receptor is triggered by Ca2+ mobilization, while basal release is predominantly the product of differential mRNA splicing in THP-1 cells Eur J Immunol 28 1998 3514 3522
-
(1998)
Eur J Immunol
, vol.28
, pp. 3514-3522
-
-
Jones, S.A.1
Horiuchi, S.2
Novick, D.3
Yamamoto, N.4
Fuller, G.M.5
-
33
-
-
0018857471
-
Cytotoxicity on tumor cells of peripheral blood monocytes and tumor-associated macrophages in patients with ascites ovarian tumors
-
A. Mantovani, N. Polentarutti, and G. Peri Cytotoxicity on tumor cells of peripheral blood monocytes and tumor-associated macrophages in patients with ascites ovarian tumors J Natl Cancer Inst 64 1980 1307 1315
-
(1980)
J Natl Cancer Inst
, vol.64
, pp. 1307-1315
-
-
Mantovani, A.1
Polentarutti, N.2
Peri, G.3
-
34
-
-
0020068511
-
Mononuclear-cell infiltration in ovarian cancer. I. Inflammatory-cell infiltrates from tumour and ascites material
-
S. Haskill, S. Becker, W. Fowler, and L. Walton Mononuclear-cell infiltration in ovarian cancer I. Inflammatory-cell infiltrates from tumour and ascites material Br J Cancer 45 1982 728 736 (Pubitemid 12122863)
-
(1982)
British Journal of Cancer
, vol.45
, Issue.5
, pp. 728-736
-
-
Haskill, S.1
Becker, S.2
Fowler, W.3
Walton, L.4
-
35
-
-
1242316943
-
Phenotype and antitumor activity of ascitic fluid monocytes in patients with ovarian carcinoma
-
B. Melichar, C.A. Savary, R. Patenia, S. Templin, K. Melicharova, and R.S. Freedman Phenotype and antitumor activity of ascitic fluid monocytes in patients with ovarian carcinoma Int J Gynecol Cancer 13 2003 435 443
-
(2003)
Int J Gynecol Cancer
, vol.13
, pp. 435-443
-
-
Melichar, B.1
Savary, C.A.2
Patenia, R.3
Templin, S.4
Melicharova, K.5
Freedman, R.S.6
-
36
-
-
34548856204
-
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
-
A. Chalaris, B. Rabe, and K. Paliga Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils Blood 110 2007 1748 1755
-
(2007)
Blood
, vol.110
, pp. 1748-1755
-
-
Chalaris, A.1
Rabe, B.2
Paliga, K.3
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