Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 148, Issue 1, 2010, Pages 73-80

  Cai, Liying ^a   Zhang, Guangmei ^a   Tong, Xiaojing ^a   You, Qi ^a   An, Yuan ^a   Wang, Yuguang ^a   Guo, Lei ^a   Wang, Tianzhen ^a   Zhu, Daling ^a   Zheng, Jianhua ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Human; Ovarian cancer; RNA interference; STAT3

Indexed keywords

CYCLIN D1; SMALL INTERFERING RNA; STAT3 PROTEIN; SURVIVIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; WESTERN BLOTTING;

EID: 72049088819     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2009.09.018     Document Type: Article

References (29)

1. Vernooij F., Heintz P., Witteveen E., and van der Graaf Y. The outcomes of ovarian cancer treatment are better when provided by gynecologic oncologists and in specialized hospitals: a systematic review. Gynecol Oncol 105 (2007) 801-812
2. Edwards B.K., Brown M.L., Wingo P.A., et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 97 (2005) 1407-1427
3. Landen Jr. C.N., Lin Y.G., Armaiz Pena G.N., et al. Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer. Cancer Res 67 (2007) 10389-10396
4. Silver D.L., Naora H., Liu J., Cheng W., and Montell D.J. Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res 64 (2004) 3550-3558
5. Duan Z., Foster R., Bell D.A., et al. Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer. Clin Cancer Res 12 (2006) 5055-5063
6. Nefedova Y., and Gabrilovich D.I. Targeting of Jak/STAT pathway in antigen presenting cells in cancer. Curr Cancer Drug Targets 7 (2007) 71-77
7. Zhang H.Y., Zhang P.N., and Sun H. Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. Eur J Obstet Gynecol Reprod Biol (2009)
8. Groner B, Lucks P, Borghouts C. The function of Stat3 in tumor cells and their microenvironment. Semin Cell Dev Biol 2008; doi:10.1016/j.semcdb.2008.06.005.
9. Qiu Z., Huang C., Sun J., et al. RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci 98 (2007) 1099-1106
10. Liu X., Li J.Y., and Zhang J. STAT3-decoy ODN inhibits cytokine autocrine of murine tumor cells. Cell Mol Immunol 4 (2007) 309-313
11. Duan Z., Foster R., Bell D.A., et al. Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer. Clin Cancer Res 12 (2006) 5055-5063
12. Masuda M., Suzui M., Yasumatu R., et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 62 (2002) 3351-3355
13. Sinibaldi N., Wharton W., Turkson J., Bowman T., Pledger W.J., and Jove R. Induction of p21WAF1/CIP1and cyclin D1expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene 19 (2000) 5419-5427
14. AlasS, and Bonavida B. Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin'sl ymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytotoxic drugs. Cancer Res 61 (2001) 5137-5144
15. Puthier D., Bataille R., and Amiot M. IL-6 up-regulates mcl-1 in human myeloma cells through JAK/STAT rather than ras/MAP kinase pathway. Eur J Immunol 29 (1999) 3945-3950
16. Aoki Y., Feldman G.M., and Tosato G. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 101 (2003) 1535-1542
17. Dechow T.N., Pedranzini L., Leitch A., et al. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci USA 101 (2004) 10602-10607
18. Gariboldi M.B., Ravizza R., Molteni R., Osella D., Gabano E., and Monti E. Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line. Cancer Lett 258 (2007) 181-188
19. de Araújo V.C., Furuse C., Cury P.R., Altemani A., and de Araújo N.S. STAT3 expression in salivary gland tumours. Oral Oncology 44 (2008) 439-445
20. Ni Z., Lou W., Leman E.S., and Gao A.C. Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells. Cancer Res 60 (2000) 1225-1228
21. Xiaoxia S., Jian Z., Lihua W., and Zhigang T. Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN. Cancer Letters 262 (2008) 201-213
22. Bachelder R.E., Crago A., Chung J., et al. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res 61 (2001) 5736-5740
23. Jackson M.W., Roberts J.S., Heckford S.E., et al. A potential autocrine role for vascular endothelial growth factor in prostate cancer. Cancer Res 62 (2002) 854-859
24. Graves P.R., Yu L., Schwarz J.K., et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem 275 (2000) 5600-5605
25. Duxbury M.S., and Whang E.E. RNA interference: a practical approach. J Surg Res 117 (2004) 339-344
26. Dave R.S., and Pomerantz R.J. RNA interference: on the road to an alternate therapeutic strategy!. Rev Med Virol 13 (2003) 373-385
27. Sui G., Soohoo C., Affar el B., et al. A DNA vectorbased RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 99 (2002) 5515-5520
28. Zhang L., Gao L., Li Y., et al. Effects of plasmid-based Stat3-specific short hairpin RNA and GRIM-19 on PC-3 M tumor cell growth. Clin Cancer Res 14 (2008) 559-568
29. Zhang L., Gao L., Zhao L., et al. Intratumoral delivery and suppression of prostate tumor growth by attenuated Salmonella enterica serovar typhimurium carrying plasmid-based small interfering RNAs. Clin Cancer Res 67 (2007) 5859-5864