Hepatoprotective role of bis-demethoxy curcumin analog on the expression of matrix metalloproteinase induced by alcohol and polyunsaturated fatty acid in rats

Toxicology Mechanisms and Methods

Volumn 20, Issue 5, 2010, Pages 252-259

  Rajagopalan, Rukkumani ^a   Sridharana, Subhashree ^c   Menon, Venugopal P ^b  

^a PONDICHERRY UNIVERSITY   (India)

^b ANNAMALAI UNIVERSITY   (India)

^c NONE

Author keywords

Alcohol; Collagen; Curcumin analog; Liver fribrosis; Matrix metalloproteinase; Polyunsaturated fatty acid; Tissue inhibitor of matrix metalloproteinase

Indexed keywords

ALCOHOL; COLLAGEN; DIDEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN DERIVATIVE; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; POLYUNSATURATED FATTY ACID; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; FIBROGENESIS; HISTOPATHOLOGY; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WISTAR ALBINO GLAXO RAT;

ANIMALS; BIOLOGICAL MARKERS; COLLAGEN; CURCUMIN; ETHANOL; FATTY ACIDS, UNSATURATED; LIVER; LIVER CIRRHOSIS; MALE; MATRIX METALLOPROTEINASES; PROTECTIVE AGENTS; RATS; RATS, WISTAR; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

RATTUS; RATTUS NORVEGICUS;

EID: 77952804276     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.482961     Document Type: Article

References (31)

1. Alessandro C. 2000. Alcohol induced fatty liver and inflammation: where do Kupffer cells act? J Hepatol 32:1026-1030.
2. Ambili M, Radhakrishna PM, Sudhakaran PR. 1997. Characteristics of 60 K gelatinase involved in rat mammary gland involution. Ind J Biochem Biophys 34:347-353.
3. Ambili M, Sudhakaran PR. 1998. Assay of matrix metalloproteinases in substrate impregnated gels in multiwells. Ind J Biochem Biophys 35:317-320.
4. Anto RJ, Kuttan G, Dinesh Babu KV, Rajasekharan KW, Kuttan T. 1996. Antitumor and free radical scavenging activity of synthetic curcuminoids. Int J Pharm 131:1-7.
5. Arthur MJP. 1995. Collagenases and liver fibrosis. J Hepatol 22:43-48.
6. Arthur MJP. 1997. Matrix degradation in liver: a role in injury and repair. Hepatology 26:1069-1071.
7. Arthur MJP. 1998. Fibrosis and altered matrix degradation. Digestion 59:376-380.
8. Aruna K, Kalpana C, Viswanathan P, Menon VP. 2002. Toxic effects of sunflower oil on ethanol treated rats. Hepatol Res 24:125-135.
9. Baragi VM, Shaw BJ, Renkiewicz RR, Kuipers PJ, Welgus HG, Mathrubutham M, Cohen JR, Rao SK. 2000. A versatile assay for gelatinase using succinylated gelatin. Matrix Biol 19:267-273.
10. Bissell DM. 1998. Hepatic fibrosis as wound repair; a progress report. J Gastrenterol 33:295-302.
11. Boeker KHW, Haberkorn CI, Michels D, Flemming P, Manns MP, Lichtinghagen R. 2002. Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C. Clin Chim Acta 316:71-81.
12. Callejas NA, Cosado M, Maria JM, Guerra D, Bosca L, Sanz PM. 2001. Expression of cyclooxygenase-2 promotes the release of matrix metalloproteinase-2 and -9 in fetal rat hepatocytes. Hepatology 33:860-867.
13. Castelluccio C, Bolwell GP, Gerrish C, Rice Evans C. 1996. Differential distribution of ferulic acid to the major plasma constituents in relation to its potential as an antioxidant. Biochem J 316:691-694.
14. Dinesh Babu KV, Rajasekharan KN. 1994. Simplified conditions for the synthesis of curcumin I and other curcuminoids. Org Prep Proc Int 24:674-677.
15. Friedman SL. 2000. Molecular regulation of hepatic fibrosis an integrated cellular response to tissue injury. J Biol Chem 275:2247-2250.
16. Iredale JP. 1997. Tissue inhibitors of metalloproteinases in liver fibrosis. Int J Biochem Cell Biol 29:43-54.
17. Iype T, Jayasree K, Sudhakaran PR. 2001. Modulation of alpha2 beta1 integrin changes during mammary gland development by beta-oestradiol. Biochim Biophys Acta 1499:232-241.
18. Lichtinghagen R, Michels D, Haberkorn Cl, Arndt B, Bahr M, Flemming P, Manns MP, Boeker KHW. 2001. J Hepatol 34:239-247.
19. Milani S, Herbst H, Schuppan D, Grappone SC, Pellegrini G, Pinzani M, Casini A, Calabro A, Ciancio G, Stefanini F, Burroughs AK, Surrenti C. 1991. Differential expression of metalloproteinase-1 and 2 genes in normal and fibrotic human liver. Am J Pathol 139:1221-1229.
20. Motterlini R, Foresti R, Bassi R, Green CJ. 2000. Curcumin, an antioxidant and anti-inflammatory agent induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28:1303-1312.
21. Murphy FR, Issa R, Zhou X, Ratnarajah S, Nagase H, Arthur MJ, Benyon C, Iredale JP. 2002. Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem 277:11069-11076.
22. Nagase H, Woessner JF. 1999. Matrix metalloproteinases. J Biol Chem 274:21491-21494.
23. Nie Q-H, Duan G-R, Luo X-D, Xie Y-M, Luo H, Zhou Y-X, Pan B-R. 2004. Expression of TIMP-1 and TIMP-2 in rats with hepatic fibrosis. World J Gastroenterol 10:86-90.
24. Olaso E, Friedman SL. 1998. Molecular regulation of hepatic fibrogenisis. J Hepatol 29:836-847.
25. Rukkumani R, Aruna K, Suresh Varma P, Menon VP. 2004a. Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. Ital J Biochem 53:61-66.
26. Rukkumani R, Aruna K, Suresh Varma P, Menon VP. 2004b. Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J Pharm Pharm Sci 7:274-283.
27. Scott L, Friedman. 2003. Liver fibrosis-from bench to bedside. J Hepatol 38:S38-S53.
28. Surh Y. 1999. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substrates. Mutat Res 428: 305-327.
29. Walsh KM, Timms P, Campbell S, Macsween RN, Morris AJ. 1991. Plasma levels of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of metalloproteinase-1 and 2 (TIMP-1 and TIMP-2) as non-invasive markers of liver disease in chronic hepatitis C. Comparison using ROC analysis. Dig Dis Sci 44:624-630.
30. Winwood PJ, Schuppan D, Iredale JP, Kawser CA, Docherty AJP, Arthur MJP. 1995. Kupffer cell-derived 95KDa type IV collagenase gelatinase B: characterization and expression in cultured 'cells'. Hepatology 22:304-315.
31. Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, Thurman RG. 1999. Essential role of tumour necrosis factor alpha in alcohol induced liver injury in mice. Gastroenterology 117: 942-952.