Anti-tumour and free radical scavenging activity of synthetic curcuminoids

International Journal of Pharmaceutics

Volumn 131, Issue 1, 1996, Pages 1-7

  Anto, Ruby John ^a   Kuttan, Girija ^a   Babu, K V Dinesh ^b   Rajasekharan, K N ^b   Kuttan, Ramadasan ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

^b UNIVERSITY OF KERALA   (India)

Author keywords

Antioxidant; Antitumour agent; Curcumin; Synthetic curcuminoid

Indexed keywords

4 ANISYL CURCUMINOID; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CURCUMIN; CURCUMINOID; DIMETHYLAMINO CURCUMINOID; FREE RADICAL; FURFURAL CURCUMINOID; HYDROXYL RADICAL; INDOLE 3 CURCUMINOID; LIPOSOME; PIPERONAL CURCUMINOID; PYRIDINE 3 CURCUMINOID; SALICYL CURCUMINOID; SCAVENGER; SUPEROXIDE; UNCLASSIFIED DRUG; VERATRYL CURCUMINOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASCITES TUMOR; CONTROLLED STUDY; CYTOTOXICITY; LIPID PEROXIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR GROWTH;

EID: 0029983062     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04254-7     Document Type: Article

References (25)

1. Bangham, A.D., Hill, M.W. and Miller, N.G.A., Preparation and use of liposomes as models of biological membranes. In: Korn, E.D. (Ed.), Methods in Membrane Biology. Vol.1, Chapter 1, Plenum Press, New York, 1974, pp. 1-64.
2. Bishayee, S. and Balasubramaniam, A.S., Assay of lipid peroxide formation. J. Neurochem., 18 (1971) 909-920.
3. Cerutti, P.A., Oxidative stress and carcinogenesis. Eur. J. Clin. Invest., 21 (1991) 1-5.
4. Conney, A.H., Lysz, T. and Abidi, T.F., Inhibitory effect of curcumin and some related dietary compounds on tumour promotion and arachidonic acid metabolism in mouse skin. Adv. Enzyme Regul., 31 (1991) 385-396.
5. Dinesh Babu, K.V. and Rajasekharan, K.N., Simplified conditions for synthesis of curcumin I and other curcuminoids. Org. Prep. Procedure Int., 26 (1994) 674-677.
6. Dwivedi, P.D., Verma, A.S. and Ray, P.K., Induction of immune rejection, of tumours by Protein A in mice bearing transplantable solid tissue Dalton's lymphoma tumours. Immunopharmacol. Immunotoxicol., 14 (1992) 105-128.
7. Elizabeth, K. and Rao, M.N.A., Oxygen radical scavenging activity of curcumin. Int. J. Pharm., 58 (1990) 237-240.
8. Huang, M.T., Smart, R.C., Wong, C.Q. and Conney, A.H., Inhibitory effect of curcumin, chlorogenic acid, caffeic acid and ferulic acid on tumour promotion in mouse skin by 12-0-tetradecanoyl phorbol-13-acetate. Cancer Res., 48 (1988) 5941-5946.
9. Kelloff, G.J., Boone, C.W., Crowell, J.A., Steele, V.E., Lubet, R. and Sigman, C.C., Chemopreventive drug development: perspective and progress: Cancer Epidemiol. Biomarkers. Prev., 3 (1994) 85-98.
10. Kuttan, R., Bhanumathy, P., Nirmala, K. and George, M.C., Possible anticancer activity of turmeric. Cancer Lett., 29 (1985) 197-202.
11. Kuttan, G., Vasudevan, D.M. and Kuttan, R., Isolation and identification of a tumour reducing component from mistletoe extract (Iscador). Cancer Lett., 41 (1988) 307-315.
12. Li, C.J., Zhang, L.J., Dezube, B.J., Crumpacker, C.S. and Pardee, A.B., Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. Proc. Natl. Acad. Sci. USA, 90 (1993) 1839-1842.
13. McCord, J.M. and Fridovich, I., Superoxide dismutase: an enzymatic function for erythrocuprein. J. Biol. Chem., 244 (1969) 6049-6055.
14. Mukundan, M.A., Chacko, M.C., Annapurna, V.V. and Krishnaswami, K., Effect of turmeric and curcumin on BP-DNA adducts. Carcinogenesis., 14 (1993) 493-496.
15. Nagabushan, M., Amonkar, A.J. and Bhide, S.V., In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem. Toxicol., 25 (1987) 545-547.
16. 60Co-irradiation. J. Clin. Biochem. Nutr., 13 (1992) 23-29.
17. Ohkawa, H., Ohishi, N. and Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95 (1979) 351-358.
18. Perchellet, J.P. and Perchellet, E.M., Antioxidants and multistep carcinogenesis in mouse skin. Free Rad. Biol. Med., 7(1989) 377-408.
19. Rao, C.V., Simi, B. and Reddy, B.S., Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis, 14 (1993) 109-112.
20. Ruby, A.J., Kuttan, G., Dinesh Babu, K.V., Rajasekharan, K.N. and Kuttan, R., Antitumour and antioxidant activity of natural curcuminoids. Cancer Lett., 94 (1995) 79-83.
21. Satoskar, R.R., Shah, S.J. and Shenoy, S.G., Evaluation of antiinflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int. J. Clin. Pharmacol. Ther. Toxicol., 24 (1986) 651-654.
22. Soudamini, K.K. and Kuttan, R., Cytotoxic and tumour reducing properties of curcumin. Indian J. Pharmacol., 20 (1988) 95-101.
23. Soudamini, K.K. and Kuttan, R., Inhibition of chemical carcinogenesis by curcumin. J. Ethnopharmacol., 27 (1989) 227-233.
24. Soudamini, K.K., Unnikrishnan, M.C., Soni, K.B. and Kuttan, R., Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin. Indian. J. Physiol. Pharmacol., 36 (1992) 239-243.
25. Unnikrishnan, M.K. and Rao, M.N.A., Anti-inflammatory activity of methionine, methionine sulfoxide and methionine sulfone. Agents Actions, 32 (1990) 110-112.