Hypomethylation effects of curcumin, demethoxycurcumin and bisdemethoxycurcumin on WIF-1 promoter in non-small cell lung cancer cell lines

Molecular Medicine Reports

Volumn 4, Issue 4, 2011, Pages 675-679

  Liu, Yu Liang ^a   Yang, He Ping ^a   Liang, Gong ^a   Tang, Chun Lan ^a   Wang, Hai Jing ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Curcuminoids; Lung neoplasms; Promoter demethylation; Wnt inhibitory factor 1

Indexed keywords

CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1; WNT PROTEIN;

ARTICLE; CANCER CELL CULTURE; DEMETHYLATION; DNA METHYLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SEQUENCE; LUNG NON SMALL CELL CANCER; PROMOTER REGION; PROTEIN ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN METHYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CURCUMIN; DNA METHYLATION; HUMANS; LUNG NEOPLASMS; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS;

CURCUMA LONGA;

EID: 79957657100     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.473     Document Type: Article

References (29)

1. American Cancer Society: Cancer Facts and Figures 2010. American Cancer Society, Atlanta, 2010.
2. Tessema M, Willink R, Do K, et al: Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Res 68: 1707-1714, 2008. (Pubitemid 351416555)
3. Glazer CA, Smith IM, Ochs MF, et al: Integrative discovery of epigenetically derepressed cancer testis antigens in NSCLC. PLoS One 4: e8189, 2009.
4. Sun W, Iijima T, Kano J, et al: Frequent aberrant methylation of the promoter region of sterile alpha motif domain 14 in pulmonary adenocarcinoma. Cancer Sci 99: 2177-2184, 2008.
5. Mazieres J, He B, You L, et al: Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res 64: 4717-4720, 2004. (Pubitemid 38924512)
6. Batra S, Shi Y, Kuchenbecker KM, et al: Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem Biophys Res Commun 342: 1228-1232, 2006.
7. Vermeulen L, De Sousa EMF, van der Heijden M, et al: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 12: 468-476, 2010.
8. Chien AJ, Moore EC, Lonsdorf AS, et al: Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci USA 106: 1193-1198, 2009.
9. Tickenbrock L, Hehn S, Sargin B, et al: Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4. Int J Oncol 33: 1215-1221, 2008.
10. Mazieres J, He B, You L, Xu Z and Jablons DM: Wnt signaling in lung cancer. Cancer Lett 222: 1-10, 2005. (Pubitemid 40544841)
11. Wissmann C, Wild PJ, Kaiser S, et al: WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. J Pathol 201: 204-212, 2003. (Pubitemid 37258931)
12. Byun T, Karimi M, Marsh JL, Milovanovic T, Lin F and Holcombe RF: Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis. J Clin Pathol 58: 515-519, 2005. (Pubitemid 40646873)
13. Veeck J, Wild PJ, Fuchs T, et al: Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer 9: 217, 2009.
14. Yang Z, Wang Y, Fang J, Chen F, Liu J and Wu J: Expression and aberrant promoter methylation of Wnt inhibitory factor-1 in human astrocytomas. J Exp Clin Cancer Res 29: 26, 2010.
15. Lin YC, You L, Xu Z, et al: Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem Biophys Res Commun 341: 635-640, 2006. (Pubitemid 43152150)
16. Christman JK: 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21: 5483-5495, 2002.
17. Schneider-Stock R, Diab-Assef M, Rohrbeck A, et al: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. J Pharmacol Exp Ther 312: 525-536, 2005. (Pubitemid 40189549)
18. Brueckner B, Rius M, Markelova MR, et al: Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy. Mol Cancer Ther 9: 1256-1264, 2010.
19. Graham JS, Kaye SB and Brown R: The promises and pitfalls of epigenetic therapies in solid tumours. Eur J Cancer 45: 1129-1136, 2009.
20. Chainani-Wu N: Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med 9: 161-168, 2003.
21. Mishra S, Narain U, Mishra R and Misra K: Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/ alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties. Bioorg Med Chem 13: 1477-1486, 2005. (Pubitemid 40215234)
22. Sa G and Das T: Anti cancer effects of curcumin: cycle of life and death. Cell Div 3: 14, 2008.
23. Aggarwal BB, Kumar A and Bharti AC: Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23: 363-398, 2003. (Pubitemid 36361976)
24. Yodkeeree S, Chaiwangyen W, Garbisa S and Limtrakul P: Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the downregulation of MMPs and uPA. J Nutr Biochem 20: 87-95, 2009.
25. Liu Z, Xie Z, Jones W, et al: Curcumin is a potent DNA hypomethylation agent. Bioorg Med Chem Lett 19: 706-709, 2009.
26. Saito T, Oda Y, Kawaguchi K, et al: Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma. Hum Pathol 34: 841-849, 2003. (Pubitemid 37169612)
27. Kang JU, Koo SH, Kwon KC and Park JW: Frequent silence of chromosome 9p, homozygous DOCK8, DMRT1 and DMRT3 deletion at 9p24.3 in squamous cell carcinoma of the lung. Int J Oncol 37: 327-335, 2010.
28. Kim J, You L, Xu Z, et al: Wnt inhibitory factor inhibits lung cancer cell growth. J Thorac Cardiovasc Surg 133: 733-737, 2007. (Pubitemid 46274732)
29. Yang HP, Gong L, Tang CL, Li JM, and Wang HJ: A study of bisdemethoxycurcumin and its effects on the biological properties of human pulmonary adenocarcinoma cell line A549. Chongqing Med J (in Chinese) 34: 868-869, 2005.