Ablation of Gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-kB

Inflammatory Bowel Diseases

Volumn 16, Issue 2, 2010, Pages 320-331

  Sina, Christian ^a   Arlt, Alexander ^a   Gavrilova, Olga ^a   Midtling, Emilie ^a   Kruse, Marie Luise ^a   Müerköster, Susanne Sebens ^a   Kumar, Rajiv ^b   Fölsch, Ulrich R ^a   Schreiber, Stefan ^a   Rosenstiel, Philip ^a   Schäfer, Heiner ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b MAYO CLINIC   (United States)

Author keywords

Cytokines; Feedback regulation; Intestinal inflammation; Signal transduction

Indexed keywords

CHEMOKINE; CYTOKINE; DOCUSATE SODIUM; GLYCINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BLEEDING; BODY WEIGHT; CHRONIC DISEASE; CLINICAL FEATURE; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE EXACERBATION; GENE; GENE CONTROL; GENE X1; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CHEMOKINES; COLITIS; COLON; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMEDIATE-EARLY PROTEINS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEUTROPHILS; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 73949136139     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21066     Document Type: Article

References (50)

1. Dutta J, Fan Y, Gupta N, et al. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene. 2006;25:6800-6816.
2. Ghosh S, Hayden MS. New regulators of NF-kappaB in inflammation. Nat Rev Immunol. 2008;8:837-848.
3. Hayden MS, West AP, Ghosh S. NF-kappaB and the immune response. Oncogene. 2006;25:6758-6780.
4. Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749-759.
5. Neurath MF, Pettersson S, Meyer zum Buschenfelde KH, et al. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogates established experimental colitis in mice. Nat Med. 1996;2:998-1004.
6. Schreiber S, Nikolaus S, Hampe J. Activation of nuclear factor kappa B inflammatory bowel disease. Gut. 1998;42:477-484.
7. Rogler G, Brand K, Vogl D, et al. Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology. 1998;115:357-369.
8. Perkins ND. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene. 2006;25:6717-6730.
9. Hitotsumatsu O, Ahmad RC, Tavares R, et al. The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity. 2008;28:381-390.
10. Kondratyev AD, Chung KN, Jung MO. Identification and characterization of a radiation-inducible glycosylated human early response gene. Cancer Res. 1996;56:1498-1502.
11. Pietzsch A, Büchler C, Aslanidis C, et al. Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. Biochem Biophys Res Commun. 1997;235:4-9.
12. Charles CH, Yoon JK, Simske JS, et al. Genomic structure, cDNA sequence, and expression of gly96, a growth factorinducible immediate-early gene encoding a short-lived glycosylated protein. Oncogene. 1993;8:797-801.
13. Arlt A, Rosenstiel P, Kruse ML, et al. IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis. Biochim Biophys Acta. 2008;1783:941-952.
14. Arlt A, Minkenberg J, Kruse ML, et al. Immediate early gene-X1 interferes with 26 S proteasome activity by attenuating expression of the 19 S proteasomal components S5a/Rpn10 and S1/Rpn2. Biochem J. 2007;402:367-375.
15. Schafer H, Trauzold A, Siegel EG, et al. PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. Cancer Res. 1996;56:2641-2648.
16. Arlt A, Grobe O, Sieke A, et al. Expression of the NF-kB target gene p22PRG1/IEX-1 does not prevent cell death but instead triggers apoptosis in HeLa cells. Oncogene. 2001;20:69-77.
17. Schilling D, Pittelkow MR, Kumar R. IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes. Oncogene. 2001;20:7992-7997.
18. Arlt A, Kruse ML, Breitenbroich M, et al. The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death. Oncogene. 2003;22:3343-3351.
19. Osawa Y, Nagaki M, Banno Y, et al. Expression of the NF-kB target gene IEX-1 enhances TNF-a-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol. 2003;170:4053-4060.
20. Sebens Muerkoster S, Rausch AV, Isberner A, et al. The apoptosisinducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition. Oncogene. 2008;27:1122-1134.
21. Mittal A, Papa S, Franzoso G, et al. NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes. J Immunol. 2006;176:2183-2189.
22. Rocher G, Letourneux C, Lenormand P, et al. Inhibition of B56-containing protein phosphatase 2A by the early response gene IEX-1 leads to control of Akt activity. J Biol Chem. 2007;282:5468-5477.
23. Wu MX. Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. Apoptosis. 2003;8:11-18.
24. Nambiar PR, Nakanishi M, Gupta R, et al. Genetic signatures of highand low-risk aberrant crypt foci in a mouse model of sporadic colon cancer. Cancer Res. 2004;64:6394-6401.
25. Sasada T, Azuma K, Hirai T, et al. Prognostic significance of the immediate early response gene X-1 (IEX-1) expression in pancreatic cancer. Ann Surg Oncol. 2008;15:609-617.
26. Dilley WG, Kalyanaraman S, Verma S, et al. Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome. Mol Cancer. 2005;4:9.
27. Oakley F, Mann J, Nailard S, et al. Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. Am J Pathol. 2005;166:695-708.
28. Cao S, Zhang X, Edwards JP, et al. NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J Biol Chem. 2006;281:26041-26050.
29. Schreiber S, Rosenstiel P, Albrecht M, et al. Genetics of Crohn disease, an archetypal inflammatory barrier disease. Nat Rev Genet. 2005;6:376-388.
30. Podolsky DK. The future of IBD treatment. J Gastroenterol. 2003;38 (suppl 15):63-66.
31. Atreya I, Atreya R, Neurath MF. NF-kappaB in inflammatory bowel disease. J Intern Med. 2008;263:591-596.
32. Nikolaus S, Schreiber S. Diagnostics of inflammatory bowel disease. Gastroenterology. 2007;133:1670-1689.
33. Schulze HA, Hasler R, Mah N, et al. From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD. Genes Immun. 2008;9:240-248.
34. Costello CM, Mah N, Hasler R, et al. Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med. 2005;2:e199.
35. Elson CO, Sartor RB, Tennyson GS, et al. Experimental models of inflammatory bowel disease. Gastroenterology. 1995;109:1344-1367.
36. Egger B, Bajaj-Elliott M, MacDonald TT, et al. Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. Digestion. 2000;62:240-248.
37. Byrne FR, Viney JL. Mouse models of inflammatory bowel disease. Curr Opin Drug Discov Dev. 2006;9:207-217.
38. Sommer SL, Berndt TJ, Frank E, et al. Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J Appl Physiol. 2006;100:707-716.
39. Becker C, Fantini MC, Wirtz S, et al. In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy. Gut. 2005;54:950-954.
40. Siegmund B, Lehr HA, Fantuzzi G, et al. IL-1 beta-converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci U S A. 2001;98:13249-13254.
41. Muerkoster S, Arlt A, Sipos B, et al. Increased expression of the E3-ubiquitin ligase receptor subunit bTRCP1 relates to constitutive NFjB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res. 2005;65:1316-1324.
42. Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology. 1998;115:182-205.
43. Hanauer SB. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis. 2006;(suppl 1):S3-9.
44. Elewaut D, DiDonato JA, Kim JM, et al. NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria. J Immunol. 1999;163:1457-1466.
45. Reinecker HC, Loh EY, Ringler DJ, et al. Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology. 1995;108:40-50.
46. Daig R, Andus T, Aschenbrenner E, et al. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut. 1996;38:216-222.
47. Ito R, Shin-Ya M, Kishida T, et al. Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice. Clin Exp Immunol. 2006;146:330-238.
48. De Keulenaer GW, Wang Y, Feng Y, et al. Identification of IEX-1 as a biomechanically controlled nuclear factorkappaB target gene that inhibits cardiomyocyte hypertrophy. Circ Res. 2002;90:690-696.
49. Rogler G. Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol. 2004;20:311-317.
50. Itzkowitz SH, Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol. 2004;287:G7-17.